JP2003503699A5 - - Google Patents
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- JP2003503699A5 JP2003503699A5 JP2001506866A JP2001506866A JP2003503699A5 JP 2003503699 A5 JP2003503699 A5 JP 2003503699A5 JP 2001506866 A JP2001506866 A JP 2001506866A JP 2001506866 A JP2001506866 A JP 2001506866A JP 2003503699 A5 JP2003503699 A5 JP 2003503699A5
- Authority
- JP
- Japan
- Prior art keywords
- oligonucleotide
- nanoparticles
- nucleic acid
- attached
- substrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108091034117 Oligonucleotide Proteins 0.000 description 329
- 239000002105 nanoparticle Substances 0.000 description 281
- 150000007523 nucleic acids Chemical class 0.000 description 191
- 108020004707 nucleic acids Proteins 0.000 description 185
- 102000039446 nucleic acids Human genes 0.000 description 185
- 238000000034 method Methods 0.000 description 134
- 239000000758 substrate Substances 0.000 description 132
- 239000000523 sample Substances 0.000 description 111
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 77
- 230000000295 complement effect Effects 0.000 description 71
- 238000001514 detection method Methods 0.000 description 27
- 239000012266 salt solution Substances 0.000 description 22
- 238000009396 hybridization Methods 0.000 description 19
- 150000003839 salts Chemical class 0.000 description 16
- 239000007864 aqueous solution Substances 0.000 description 14
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 14
- 229910052737 gold Inorganic materials 0.000 description 14
- 239000010931 gold Substances 0.000 description 14
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 12
- 238000005259 measurement Methods 0.000 description 12
- 229910052709 silver Inorganic materials 0.000 description 12
- 239000004332 silver Substances 0.000 description 12
- 239000002773 nucleotide Substances 0.000 description 10
- 125000003729 nucleotide group Chemical group 0.000 description 10
- 230000005070 ripening Effects 0.000 description 7
- 108091028043 Nucleic acid sequence Proteins 0.000 description 6
- 239000002086 nanomaterial Substances 0.000 description 6
- 230000003287 optical effect Effects 0.000 description 6
- 239000002502 liposome Substances 0.000 description 5
- 229910052751 metal Inorganic materials 0.000 description 5
- 239000002184 metal Substances 0.000 description 5
- 239000004065 semiconductor Substances 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 125000001165 hydrophobic group Chemical group 0.000 description 4
- 108020004414 DNA Proteins 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- 239000004020 conductor Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 125000000524 functional group Chemical group 0.000 description 2
- 239000008363 phosphate buffer Substances 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 description 1
- 239000005695 Ammonium acetate Substances 0.000 description 1
- 108020000946 Bacterial DNA Proteins 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 108020000949 Fungal DNA Proteins 0.000 description 1
- 108020004711 Nucleic Acid Probes Proteins 0.000 description 1
- 238000012408 PCR amplification Methods 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- 108020005202 Viral DNA Proteins 0.000 description 1
- 108020000999 Viral RNA Proteins 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 229940043376 ammonium acetate Drugs 0.000 description 1
- 235000019257 ammonium acetate Nutrition 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002082 metal nanoparticle Substances 0.000 description 1
- 229910000510 noble metal Inorganic materials 0.000 description 1
- 239000002853 nucleic acid probe Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
- 108700026220 vif Genes Proteins 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/344,667 US6361944B1 (en) | 1996-07-29 | 1999-06-25 | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| US09/344,667 | 1999-06-25 | ||
| US20016100P | 2000-04-26 | 2000-04-26 | |
| US60/200,161 | 2000-04-26 | ||
| PCT/US2000/017507 WO2001000876A1 (en) | 1999-06-25 | 2000-06-26 | Nanoparticles having oligonucleotides attached thereto and uses therefor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003503699A JP2003503699A (ja) | 2003-01-28 |
| JP2003503699A5 true JP2003503699A5 (enExample) | 2007-08-09 |
Family
ID=26895535
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001506866A Pending JP2003503699A (ja) | 1999-06-25 | 2000-06-26 | オリゴヌクレオチドが付着しているナノ粒子およびその利用法 |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1198591B1 (enExample) |
| JP (1) | JP2003503699A (enExample) |
| AT (1) | ATE502117T1 (enExample) |
| AU (1) | AU784040B2 (enExample) |
| CA (1) | CA2376623C (enExample) |
| DE (1) | DE60045739D1 (enExample) |
| WO (1) | WO2001000876A1 (enExample) |
Families Citing this family (108)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1818417B1 (en) | 1996-07-29 | 2014-02-12 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| US6984491B2 (en) | 1996-07-29 | 2006-01-10 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| US6582921B2 (en) | 1996-07-29 | 2003-06-24 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses thereof |
| US7169556B2 (en) | 1996-07-29 | 2007-01-30 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| US6506564B1 (en) | 1996-07-29 | 2003-01-14 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| US7098320B1 (en) | 1996-07-29 | 2006-08-29 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| US6750016B2 (en) | 1996-07-29 | 2004-06-15 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| US6974669B2 (en) | 2000-03-28 | 2005-12-13 | Nanosphere, Inc. | Bio-barcodes based on oligonucleotide-modified nanoparticles |
| AU1241000A (en) | 1998-10-27 | 2000-05-15 | Clinical Micro Sensors, Inc. | Detection of target analytes using particles and electrodes |
| ATE366932T1 (de) | 1998-11-30 | 2007-08-15 | Nanosphere Inc | Nanopartikel mit polymerschalen |
| JP2004501340A (ja) | 2000-01-13 | 2004-01-15 | ナノスフェアー インコーポレイテッド | オリゴヌクレオチドを付着させたナノ粒子とその使用方法 |
| AU4116401A (en) * | 2000-03-16 | 2001-09-24 | Matsushita Electric Industrial Co., Ltd. | Nucleotide detector, process for producing the same and process for forming fineparticle membrane |
| US6706474B1 (en) | 2000-06-27 | 2004-03-16 | Board Of Trustees Of The University Of Illinois | Nucleic acid enzyme biosensors for ions |
| ATE324465T1 (de) | 2000-07-11 | 2006-05-15 | Univ Northwestern | Nachweismethode mittels verstärkter silberfärbung |
| US7887885B2 (en) | 2000-10-20 | 2011-02-15 | Northwestern University | Nanolithography methods and products therefor and produced thereby |
| DE10109777A1 (de) * | 2001-03-01 | 2002-09-19 | Infineon Technologies Ag | Verfahren zum Erfassen von makromolekularen Biopolymeren mittels mindestens einer Einheit zum Immobilisieren von makromolekularen Biopolymeren |
| US7147687B2 (en) | 2001-05-25 | 2006-12-12 | Nanosphere, Inc. | Non-alloying core shell nanoparticles |
| WO2002096262A2 (en) | 2001-05-25 | 2002-12-05 | Northwestern University | Non-alloying core shell nanoparticles |
| WO2002098364A2 (en) | 2001-06-06 | 2002-12-12 | The General Hospital Corporation | Magnetic-nanoparticle conjugates and methods of use |
| EP1401850A1 (en) | 2001-06-20 | 2004-03-31 | Nuevolution A/S | Nucleoside derivatives for library preparation |
| US7297553B2 (en) | 2002-05-28 | 2007-11-20 | Nanosphere, Inc. | Method for attachment of silylated molecules to glass surfaces |
| AU2002365115A1 (en) | 2001-07-20 | 2003-09-02 | North Carolina State University | Light addressable electrochemical detection of duplex structures |
| DE10145700A1 (de) * | 2001-09-17 | 2003-04-10 | Infineon Technologies Ag | Biochip-Anordnung, Sensor-Anordnung und Verfahren zum Betreiben einer Biochip-Anordnung |
| GR1003966B (el) * | 2001-10-16 | 2002-08-06 | Εμβαπτιζομενος χαρτης αποξηραμενων αντιδραστηριων και μεθοδος για την ανιχνευση η και προσδιορισμο ειδικων αλληλουχιων νουκλεικων οξεων | |
| ATE403751T1 (de) | 2001-11-09 | 2008-08-15 | Nanosphere Inc | Biokonjugat-nanopartikelsonden |
| AU2002360446A1 (en) * | 2001-11-30 | 2003-06-17 | Northwestern University | Direct write nanolithographic deposition of nucleic acids from nanoscopic tips |
| CN101006177B (zh) | 2002-03-15 | 2011-10-12 | 纽韦卢森公司 | 改善的用于合成模制分子的方法 |
| US20030211488A1 (en) | 2002-05-07 | 2003-11-13 | Northwestern University | Nanoparticle probs with Raman spectrocopic fingerprints for analyte detection |
| US6890719B2 (en) | 2002-05-10 | 2005-05-10 | The Board Of Trustess Of The University Of Illinois | Fluorescence based biosensor |
| US7534560B2 (en) | 2002-05-10 | 2009-05-19 | The Board Of Trustees Of The University Of Illinois | Simple catalytic DNA biosensors for ions based on color changes |
| EP1511862A4 (en) * | 2002-05-14 | 2006-01-18 | Nanosphere Inc | ELECTRICAL DETECTION OF DNA HYBRIDIZATION AND SPECIFIC BINDING EVENTS |
| DE10228260A1 (de) * | 2002-06-25 | 2004-01-22 | Bayer Ag | Methode und Vorrichtung zum impedimetrischen Nachweis eines oder mehrerer Analyten in einer Probe |
| DE60325743D1 (de) | 2002-07-02 | 2009-02-26 | Nanosphere Inc | Nanopartikel-polyanion-konjugate sowie verfahren zur verwendung davon beim nachweis von analyten |
| AU2003247266A1 (en) | 2002-08-01 | 2004-02-23 | Nuevolution A/S | Multi-step synthesis of templated molecules |
| CN106337046B (zh) | 2002-10-30 | 2021-03-23 | 纽韦卢森公司 | 合成双功能复合物的方法 |
| ATE450609T1 (de) | 2002-12-19 | 2009-12-15 | Nuevolution As | Durch quasizufallsstrukturen und funktionen geführte synthesemethode |
| US20070026397A1 (en) | 2003-02-21 | 2007-02-01 | Nuevolution A/S | Method for producing second-generation library |
| EP1597399A2 (en) * | 2003-02-27 | 2005-11-23 | Nanosphere, Inc. | Label-free gene expression profiling with universal nanoparticle probes in microarray assay format |
| US7612185B2 (en) | 2003-03-07 | 2009-11-03 | The Board Of Trustees Of The University Of Illinois | Nucleic acid biosensors |
| US7915201B2 (en) | 2003-03-20 | 2011-03-29 | Nuevolution A/S | Ligational encoding of small molecules |
| US20050250094A1 (en) * | 2003-05-30 | 2005-11-10 | Nanosphere, Inc. | Method for detecting analytes based on evanescent illumination and scatter-based detection of nanoparticle probe complexes |
| AU2004254367B2 (en) | 2003-06-27 | 2008-06-19 | Nanosphere, Inc. | Bio-barcode based detection of target analytes |
| ATE447626T1 (de) | 2003-09-18 | 2009-11-15 | Nuevolution As | Methode zur gewinnung struktureller informationen kodierter moleküle und zur selektion von verbindungen |
| US7485419B2 (en) | 2004-01-13 | 2009-02-03 | The Board Of Trustees Of The University Of Illinois | Biosensors based on directed assembly of particles |
| DE602005017370D1 (de) | 2004-03-22 | 2009-12-10 | Nuevolution As | Ligationscodierung unter verwendung von oligonukleotidbausteinen |
| US20080274454A1 (en) * | 2004-04-07 | 2008-11-06 | Mirkin Chad A | Reversible and Chemically Programmable Micelle Assembly With Dna Block-Copolymer Amphiphiles |
| EP2330208B1 (en) * | 2004-05-24 | 2017-10-18 | Midatech Ltd. | Nanoparticles comprising RNA ligands |
| ATE515711T1 (de) | 2005-05-09 | 2011-07-15 | Gen Hospital Corp | Sensoren auf wasserrelaxationsbasis |
| WO2006138145A1 (en) | 2005-06-14 | 2006-12-28 | Northwestern University | Nucleic acid functionalized nanoparticles for therapeutic applications |
| US7892734B2 (en) | 2005-08-11 | 2011-02-22 | The Board Of Trustees Of The University Of Illinois | Aptamer based colorimetric sensor systems |
| WO2007027843A2 (en) | 2005-08-31 | 2007-03-08 | T2 Biosystems, Inc. | Nmr device for detection of analytes involving magnetic particles |
| LT3018206T (lt) | 2005-12-01 | 2021-12-10 | Nuevolution A/S | Fermentiniai kodavimo būdai, skirti didelių bibliotekų efektyviai sintezei |
| WO2007109500A1 (en) | 2006-03-16 | 2007-09-27 | The Board Of Trustees Of The University Of Illinois | Lateral flow devices |
| WO2008057578A1 (en) | 2006-11-08 | 2008-05-15 | T2 Biosystems, Inc. | Nmr systems for in vivo detection of analytes |
| JP4969236B2 (ja) * | 2006-12-22 | 2012-07-04 | ローム株式会社 | 生体分子または生体関連物質の測定方法 |
| JP2008154493A (ja) | 2006-12-22 | 2008-07-10 | Rohm Co Ltd | 分離精製方法とマイクロ流体回路 |
| US8415461B2 (en) | 2007-01-19 | 2013-04-09 | The Board Of Trustees Of The University Of Illinois | Amphiphilic substances and functionalized lipid vesicles including the same |
| KR101488800B1 (ko) | 2007-02-09 | 2015-02-04 | 노오쓰웨스턴 유니버시티 | 세포내 타겟 검출용 입자 |
| US8058415B2 (en) | 2007-04-24 | 2011-11-15 | The Board Of Trustees Of The University Of Illinois | Aptamer- and nucleic acid enzyme-based systems for simultaneous detection of multiple analytes |
| CA3055145A1 (en) | 2007-05-30 | 2008-12-11 | Northwestern University | Nucleic acid functionalized nanoparticles for therapeutic applications |
| US7807372B2 (en) | 2007-06-04 | 2010-10-05 | Northwestern University | Screening sequence selectivity of oligonucleotide-binding molecules using nanoparticle based colorimetric assay |
| JP2010531975A (ja) * | 2007-06-13 | 2010-09-30 | ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム | 金属ナノ粒子電極触媒増幅のための方法及び装置 |
| WO2009012309A2 (en) | 2007-07-16 | 2009-01-22 | The Board Of Trustees Of The University Of Illinois | Nucleic acid based fluorescent sensor for divalent copper ion detection |
| JP2010535938A (ja) * | 2007-07-24 | 2010-11-25 | ノースウェスタン ユニバーシティ | 被覆されたコロイド物質 |
| US8568690B2 (en) | 2007-07-31 | 2013-10-29 | The Board Of Trustees Of The University Of Illinois | MRI contrast agents and high-throughput screening by MRI |
| WO2009045632A2 (en) | 2007-08-10 | 2009-04-09 | The Board Of Trustees Of The University Of Illinois | Nucleic acid based fluorescent sensor for mercury detection |
| WO2009026164A1 (en) | 2007-08-17 | 2009-02-26 | The General Hospital Corporation | Magnetic resonance-based viscometers and methods |
| US8421458B2 (en) | 2007-09-28 | 2013-04-16 | T2 Biosystems, Inc. | NMR diagnostics by means of a plastic sample container |
| WO2009061481A1 (en) | 2007-11-06 | 2009-05-14 | T2 Biosystems, Inc. | Small magnet and rf coil for magnetic resonance relaxometry |
| US8062893B2 (en) | 2008-10-10 | 2011-11-22 | The Board Of Trustees Of The University Of Illinois | Fluorescent sensor for mercury |
| EP2348976B1 (en) | 2008-10-29 | 2020-12-02 | T2 Biosystems, Inc. | Nmr detection of coagulation time |
| CN106955360A (zh) | 2008-11-24 | 2017-07-18 | 西北大学 | 多价rna纳米颗粒组合物 |
| US20100233270A1 (en) | 2009-01-08 | 2010-09-16 | Northwestern University | Delivery of Oligonucleotide-Functionalized Nanoparticles |
| JP5391744B2 (ja) * | 2009-03-09 | 2014-01-15 | 住友ベークライト株式会社 | アレイ用基板 |
| CA2779099C (en) | 2009-10-30 | 2021-08-10 | Northwestern University | Templated nanoconjugates |
| US8927271B1 (en) | 2010-01-21 | 2015-01-06 | Jack T. Johansen | Compositions and methods for detecting target analytes |
| CA2832672A1 (en) | 2010-04-16 | 2011-10-20 | Nuevolution A/S | Bi-functional complexes and methods for making and using such complexes |
| USD674112S1 (en) | 2010-10-22 | 2013-01-08 | T2 Biosystems, Inc. | Modular cartridge assembly |
| BR112013010952B1 (pt) | 2010-10-22 | 2020-08-25 | T2 Biosystems, Inc. | métodos para detectar a presença de um analito de ácido nucleico e uma espécie de candida em uma amostra líquida, para detectar a presença de um patógeno, um vírus e um ácido nucleico alvo em uma amostra de sangue total, e para amplificação de um ácido nucleico de patógeno alvo em uma amostra de sangue total, bem como sistema para a detecção de um ou mais analitos e cartucho removível dimensionado para facilitar inserção e remoção de um sistema |
| US8409807B2 (en) | 2010-10-22 | 2013-04-02 | T2 Biosystems, Inc. | NMR systems and methods for the rapid detection of analytes |
| US9828696B2 (en) | 2011-03-23 | 2017-11-28 | Nanohmics, Inc. | Method for assembly of analyte filter arrays using biomolecules |
| US9252175B2 (en) | 2011-03-23 | 2016-02-02 | Nanohmics, Inc. | Method for assembly of spectroscopic filter arrays using biomolecules |
| CN103917658B (zh) | 2011-07-13 | 2016-09-21 | T2生物系统公司 | 用于监测血块形成的nmr方法 |
| EP2755692B1 (en) | 2011-09-14 | 2020-11-25 | Northwestern University | Nanoconjugates able to cross the blood-brain barrier |
| US10620205B2 (en) | 2011-09-21 | 2020-04-14 | T2 Biosystems, Inc. | NMR methods for endotoxin analysis |
| US9335292B2 (en) | 2011-10-13 | 2016-05-10 | Auburn University | Electrochemical proximity assay |
| US9562271B2 (en) | 2012-04-20 | 2017-02-07 | T2 Biosystems, Inc. | Compositions and methods for detection of Candida species |
| EP2900409B1 (en) | 2012-09-27 | 2019-05-22 | Rhodia Operations | Process for making silver nanostructures and copolymer useful in such process |
| US9739733B2 (en) | 2012-12-07 | 2017-08-22 | T2 Biosystems, Inc. | Methods for monitoring tight clot formation |
| WO2015013673A1 (en) | 2013-07-25 | 2015-01-29 | Aurasense Therapeutics, Llc | Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use |
| CA2919273A1 (en) | 2013-07-25 | 2015-01-29 | Exicure, Inc. | Spherical nucleic acid-based constructs as immunoregulatory agents |
| US10301622B2 (en) | 2013-11-04 | 2019-05-28 | Northwestern University | Quantification and spatio-temporal tracking of a target using a spherical nucleic acid (SNA) |
| US10434064B2 (en) | 2014-06-04 | 2019-10-08 | Exicure, Inc. | Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications |
| CA2968531A1 (en) | 2014-11-21 | 2016-05-26 | Northwestern University | The sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates |
| US11988662B2 (en) | 2015-12-07 | 2024-05-21 | Nanohmics, Inc. | Methods for detecting and quantifying gas species analytes using differential gas species diffusion |
| US10386365B2 (en) | 2015-12-07 | 2019-08-20 | Nanohmics, Inc. | Methods for detecting and quantifying analytes using ionic species diffusion |
| US10386351B2 (en) | 2015-12-07 | 2019-08-20 | Nanohmics, Inc. | Methods for detecting and quantifying analytes using gas species diffusion |
| CA3011901A1 (en) | 2016-01-21 | 2017-07-27 | T2 Biosystems, Inc. | Nmr methods and systems for the rapid detection of bacteria |
| KR102617833B1 (ko) | 2016-05-06 | 2023-12-27 | 엑시큐어 오퍼레이팅 컴퍼니 | 인터류킨 17 수용체 mRNA의 특이적 녹다운을 위한 안티센스 올리고뉴클레오티드 (ASO)를 제시하는 리포좀성 구형 핵산 (SNA) 구축물 |
| WO2018039629A2 (en) | 2016-08-25 | 2018-03-01 | Northwestern University | Micellar spherical nucleic acids from thermoresponsive, traceless templates |
| WO2018165566A1 (en) | 2017-03-09 | 2018-09-13 | Auburn University | Differential circuit for background correction in electrochemical measurements |
| US11696954B2 (en) | 2017-04-28 | 2023-07-11 | Exicure Operating Company | Synthesis of spherical nucleic acids using lipophilic moieties |
| WO2018209270A1 (en) | 2017-05-11 | 2018-11-15 | Northwestern University | Adoptive cell therapy using spherical nucleic acids (snas) |
| WO2019010341A1 (en) | 2017-07-07 | 2019-01-10 | Innamed, Inc. | APTAMERS FOR MEASURING LIPOPROTEIN RATES |
| US11560565B2 (en) | 2018-06-13 | 2023-01-24 | Auburn University | Electrochemical detection nanostructure, systems, and uses thereof |
| CN112698020B (zh) * | 2020-11-12 | 2022-08-26 | 中山大学 | 基于DNA-AuNP编码的交叉响应系统的多峰耦合分析方法 |
| CN114705855B (zh) * | 2022-03-31 | 2023-06-09 | 四川大学 | 一种基于比色生物传感器的粪样幽门螺杆菌快速检测试剂盒 |
| EP4503923A1 (en) | 2022-04-04 | 2025-02-12 | The Regents of the University of California | Genetic complementation compositions and methods |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4794089A (en) * | 1986-03-25 | 1988-12-27 | Midwest Research Microscopy, Inc. | Method for electronic detection of a binding reaction |
| WO1990002205A1 (en) * | 1988-08-25 | 1990-03-08 | Angenics, Inc. | Detection of nucleic acid sequences using particle agglutination |
| GB9019512D0 (en) * | 1990-09-06 | 1990-10-24 | Ici Plc | Assay method |
| US5846708A (en) * | 1991-11-19 | 1998-12-08 | Massachusetts Institiute Of Technology | Optical and electrical methods and apparatus for molecule detection |
| IL103674A0 (en) * | 1991-11-19 | 1993-04-04 | Houston Advanced Res Center | Method and apparatus for molecule detection |
| US5384265A (en) * | 1993-03-26 | 1995-01-24 | Geo-Centers, Inc. | Biomolecules bound to catalytic inorganic particles, immunoassays using the same |
| US5521289A (en) * | 1994-07-29 | 1996-05-28 | Nanoprobes, Inc. | Small organometallic probes |
| JPH0875746A (ja) * | 1994-09-02 | 1996-03-22 | Tokuyama Corp | 免疫学的凝集反応用担体粒子の凝集特性評価方法 |
| EP1818417B1 (en) * | 1996-07-29 | 2014-02-12 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| US5922537A (en) * | 1996-11-08 | 1999-07-13 | N.o slashed.AB Immunoassay, Inc. | Nanoparticles biosensor |
| JP2002509443A (ja) * | 1997-10-31 | 2002-03-26 | ジェン−プローブ・インコーポレーテッド | 核酸検出法 |
| WO2001018246A1 (en) * | 1999-08-26 | 2001-03-15 | The Trustees Of Princeton University | Microfluidic and nanofluidic electronic devices for detecting changes in capacitance of fluids and methods of using |
| CA2402955C (en) * | 2000-03-28 | 2010-03-09 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
-
2000
- 2000-06-26 JP JP2001506866A patent/JP2003503699A/ja active Pending
- 2000-06-26 CA CA2376623A patent/CA2376623C/en not_active Expired - Lifetime
- 2000-06-26 EP EP00941713A patent/EP1198591B1/en not_active Expired - Lifetime
- 2000-06-26 WO PCT/US2000/017507 patent/WO2001000876A1/en not_active Ceased
- 2000-06-26 AT AT00941713T patent/ATE502117T1/de not_active IP Right Cessation
- 2000-06-26 DE DE60045739T patent/DE60045739D1/de not_active Expired - Lifetime
- 2000-06-26 AU AU56378/00A patent/AU784040B2/en not_active Ceased
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