JP2003502631A - 生物学的由来流体を試験する方法及び装置 - Google Patents
生物学的由来流体を試験する方法及び装置Info
- Publication number
- JP2003502631A JP2003502631A JP2001503504A JP2001503504A JP2003502631A JP 2003502631 A JP2003502631 A JP 2003502631A JP 2001503504 A JP2001503504 A JP 2001503504A JP 2001503504 A JP2001503504 A JP 2001503504A JP 2003502631 A JP2003502631 A JP 2003502631A
- Authority
- JP
- Japan
- Prior art keywords
- spectrum
- concentration
- absorption
- measured
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims description 103
- 239000012530 fluid Substances 0.000 title claims description 10
- 238000012360 testing method Methods 0.000 title abstract description 30
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 claims abstract description 137
- 108010054147 Hemoglobins Proteins 0.000 claims abstract description 72
- 102000001554 Hemoglobins Human genes 0.000 claims abstract description 72
- 238000000862 absorption spectrum Methods 0.000 claims abstract description 66
- 238000001228 spectrum Methods 0.000 claims abstract description 57
- 150000002632 lipids Chemical class 0.000 claims abstract description 27
- 210000004369 blood Anatomy 0.000 claims abstract description 14
- 239000008280 blood Substances 0.000 claims abstract description 14
- 239000000523 sample Substances 0.000 claims description 70
- 238000010521 absorption reaction Methods 0.000 claims description 24
- 238000005259 measurement Methods 0.000 claims description 23
- 230000001427 coherent effect Effects 0.000 claims description 6
- 238000000338 in vitro Methods 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 5
- 238000002405 diagnostic procedure Methods 0.000 claims description 3
- 230000005856 abnormality Effects 0.000 claims description 2
- 239000012491 analyte Substances 0.000 claims description 2
- 239000012472 biological sample Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 238000005375 photometry Methods 0.000 claims description 2
- 238000000691 measurement method Methods 0.000 claims 2
- 238000011156 evaluation Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 abstract description 12
- 230000003287 optical effect Effects 0.000 description 29
- 210000002966 serum Anatomy 0.000 description 24
- 238000012937 correction Methods 0.000 description 18
- 230000003595 spectral effect Effects 0.000 description 17
- 230000008033 biological extinction Effects 0.000 description 12
- 238000012544 monitoring process Methods 0.000 description 12
- 239000011159 matrix material Substances 0.000 description 10
- 230000002452 interceptive effect Effects 0.000 description 9
- 238000004611 spectroscopical analysis Methods 0.000 description 8
- 206010023126 Jaundice Diseases 0.000 description 6
- 238000004847 absorption spectroscopy Methods 0.000 description 6
- 210000002381 plasma Anatomy 0.000 description 5
- 238000005070 sampling Methods 0.000 description 5
- 239000012895 dilution Substances 0.000 description 4
- 238000010790 dilution Methods 0.000 description 4
- 229910052736 halogen Inorganic materials 0.000 description 4
- 150000002367 halogens Chemical class 0.000 description 4
- 238000007654 immersion Methods 0.000 description 4
- 229940028435 intralipid Drugs 0.000 description 4
- 230000002159 abnormal effect Effects 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 238000013178 mathematical model Methods 0.000 description 3
- 206010018910 Haemolysis Diseases 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000008588 hemolysis Effects 0.000 description 2
- 238000009533 lab test Methods 0.000 description 2
- 239000013307 optical fiber Substances 0.000 description 2
- 239000012088 reference solution Substances 0.000 description 2
- 238000013519 translation Methods 0.000 description 2
- 108010068323 Hemoglobin E Proteins 0.000 description 1
- 101000777301 Homo sapiens Uteroglobin Proteins 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 102100031083 Uteroglobin Human genes 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 238000000149 argon plasma sintering Methods 0.000 description 1
- 239000013060 biological fluid Substances 0.000 description 1
- 238000010241 blood sampling Methods 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 125000003636 chemical group Chemical group 0.000 description 1
- 238000001311 chemical methods and process Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000012470 diluted sample Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 231100001261 hazardous Toxicity 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 239000012898 sample dilution Substances 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
- G01N21/274—Calibration, base line adjustment, drift correction
Landscapes
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Mathematical Physics (AREA)
- Theoretical Computer Science (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99810517A EP1059522A1 (en) | 1999-06-11 | 1999-06-11 | Method and apparatus for examining fluids of biological origin |
| EP99810517.5 | 1999-06-11 | ||
| PCT/EP2000/005237 WO2000077494A1 (en) | 1999-06-11 | 2000-06-07 | Method and apparatus for examining fluids of biological origin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003502631A true JP2003502631A (ja) | 2003-01-21 |
| JP2003502631A5 JP2003502631A5 (enExample) | 2007-04-26 |
Family
ID=8242873
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001503504A Pending JP2003502631A (ja) | 1999-06-11 | 2000-06-07 | 生物学的由来流体を試験する方法及び装置 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US6882425B1 (enExample) |
| EP (2) | EP1059522A1 (enExample) |
| JP (1) | JP2003502631A (enExample) |
| WO (1) | WO2000077494A1 (enExample) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005315680A (ja) * | 2004-04-28 | 2005-11-10 | Hitachi Chem Co Ltd | 分光装置及び全反射ラマン分光装置 |
| JP2008275625A (ja) * | 2007-05-03 | 2008-11-13 | F Hoffmann La Roche Ag | オキシメーター |
| WO2010055890A1 (ja) * | 2008-11-17 | 2010-05-20 | 株式会社日立ハイテクノロジーズ | 自動分析装置 |
| JP2014521095A (ja) * | 2011-07-18 | 2014-08-25 | シーメンス ヘルスケア ダイアグノスティクス プロダクツ ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | 体液中の物質の濃度を測定するための方法及びシステム |
| JP2015524924A (ja) * | 2012-07-30 | 2015-08-27 | フェンウォール、インコーポレイテッド | 脂質の光学的検出 |
| JP2018040796A (ja) * | 2016-09-05 | 2018-03-15 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 信号オフセットの決定及び補正 |
| JP2020008578A (ja) * | 2018-07-03 | 2020-01-16 | シーメンス ヘルスケア ダイアグノスティクス プロダクツ ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | 体液試料中の脂質、ヘモグロビンおよびビリルビンを決定するための方法 |
| JP2020527713A (ja) * | 2017-07-19 | 2020-09-10 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッドＳｉｅｍｅｎｓ Ｈｅａｌｔｈｃａｒｅ Ｄｉａｇｎｏｓｔｉｃｓ Ｉｎｃ． | ハイパースペクトルイメージングを用いた検体評価方法及び検体評価装置 |
| US20220228976A1 (en) * | 2017-01-31 | 2022-07-21 | Labrador Diagnostics Llc | Methods and devices for improved signal detection from biological samples |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1802959A1 (en) | 2004-10-11 | 2007-07-04 | Thermo Fisher Scientific Oy | Method for automatically detecting factors that disturb analysis by a photometer |
| US7375815B2 (en) * | 2004-10-12 | 2008-05-20 | Agilent Technologies, Inc. | Optical devices, systems and method for producing a collimated light path |
| WO2008077007A1 (en) * | 2006-12-19 | 2008-06-26 | Cytyc Corporation | Method for analyzing blood content of cytological specimens |
| JP5859439B2 (ja) * | 2009-08-13 | 2016-02-10 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド | 臨床分析機によって分析される液体サンプルおよび容器の中の干渉物質および物理的寸法を確定するための方法ならびに装置 |
| EP3051271A1 (de) | 2015-01-27 | 2016-08-03 | Siemens Healthcare Diagnostics Products GmbH | Verfahren zur Bestimmung von Lipiden und anderen Störsubstanzen in Körperflüssigkeitsproben |
| JP6454211B2 (ja) * | 2015-03-31 | 2019-01-16 | シスメックス株式会社 | 検体分析装置、血液凝固分析装置、検体分析方法、及びコンピュータプログラム |
| CN105116156B (zh) * | 2015-07-22 | 2017-12-12 | 江苏英诺华医疗技术有限公司 | 一种优化的适合医学检验的生化检测方法 |
| EP3165900A1 (en) | 2015-11-09 | 2017-05-10 | F. Hoffmann-La Roche AG | Multi-wavelength illumination for spectral interference detection |
| CN112912712B (zh) * | 2018-11-21 | 2023-11-21 | 北京迈瑞医疗器械有限公司 | 样本吸光度差的测量方法、样本分析仪和存储介质 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4263512A (en) * | 1977-10-31 | 1981-04-21 | Hitachi, Ltd. | Colorimetric method for liquid sampler including disturbing chromogens |
| JPS6118693B2 (enExample) * | 1977-10-31 | 1986-05-14 | Hitachi Ltd | |
| JPH1164217A (ja) * | 1997-08-26 | 1999-03-05 | Iseki & Co Ltd | 分光分析機における成分量検出装置 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2020009B (en) * | 1978-04-08 | 1982-12-01 | Bodenseewerk Perkin Elmer Co | Apparatus for determining the concentration of components of a sample |
| DE3043984A1 (de) * | 1980-11-21 | 1982-06-03 | Langhals, Heinz, Dr., 5880 Lüdenscheid | Verfahren zur bestimmung der zusammensetzung binaerer fluessigkeitsgemische |
| US5137023A (en) * | 1990-04-19 | 1992-08-11 | Worcester Polytechnic Institute | Method and apparatus for monitoring blood analytes noninvasively by pulsatile photoplethysmography |
| US5070246A (en) * | 1989-09-22 | 1991-12-03 | Ada Technologies, Inc. | Spectrometer for measuring the concentration of components in a fluid stream and method for using same |
| JPH05272993A (ja) * | 1992-03-24 | 1993-10-22 | Shimadzu Corp | 測定データのベースライン決定方法 |
| US5424840A (en) * | 1992-07-21 | 1995-06-13 | The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University | In situ chlorophyl absorption meter |
| US5573952A (en) * | 1994-08-12 | 1996-11-12 | E. I. Du Pont De Nemours And Company | Process for controlling concentration of a solution of a solvent and polymer |
| DE4433827C2 (de) * | 1994-09-22 | 1999-01-07 | Zeiss Carl Jena Gmbh | Anordnung und Verfahren zur Messung von Stoffparametern in Schichten von Medien, insbesondere zur eichungsfreien in vivo Messung der Sauerstoffsättigung in optisch zugängigen Blutgefäßen |
| US6195158B1 (en) | 1995-11-21 | 2001-02-27 | Cme Telemetrix Inc. | Apparatus and method for rapid spectrophotometric pre-test screen of specimen for a blood analyzer |
| IE980923A1 (en) * | 1997-11-10 | 1999-05-19 | Jeacle Ltd | Photometric analysis of water suspensions |
-
1999
- 1999-06-11 EP EP99810517A patent/EP1059522A1/en not_active Withdrawn
-
2000
- 2000-06-07 WO PCT/EP2000/005237 patent/WO2000077494A1/en not_active Ceased
- 2000-06-07 US US10/018,080 patent/US6882425B1/en not_active Expired - Fee Related
- 2000-06-07 JP JP2001503504A patent/JP2003502631A/ja active Pending
- 2000-06-07 EP EP00936867A patent/EP1185852A1/en not_active Ceased
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4263512A (en) * | 1977-10-31 | 1981-04-21 | Hitachi, Ltd. | Colorimetric method for liquid sampler including disturbing chromogens |
| JPS6118693B2 (enExample) * | 1977-10-31 | 1986-05-14 | Hitachi Ltd | |
| JPH1164217A (ja) * | 1997-08-26 | 1999-03-05 | Iseki & Co Ltd | 分光分析機における成分量検出装置 |
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005315680A (ja) * | 2004-04-28 | 2005-11-10 | Hitachi Chem Co Ltd | 分光装置及び全反射ラマン分光装置 |
| JP2008275625A (ja) * | 2007-05-03 | 2008-11-13 | F Hoffmann La Roche Ag | オキシメーター |
| WO2010055890A1 (ja) * | 2008-11-17 | 2010-05-20 | 株式会社日立ハイテクノロジーズ | 自動分析装置 |
| JP5319696B2 (ja) * | 2008-11-17 | 2013-10-16 | 株式会社日立ハイテクノロジーズ | 自動分析装置 |
| US8936754B2 (en) | 2008-11-17 | 2015-01-20 | Hitachi High-Technologies Corporation | Automatic analysis device |
| JP2014521095A (ja) * | 2011-07-18 | 2014-08-25 | シーメンス ヘルスケア ダイアグノスティクス プロダクツ ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | 体液中の物質の濃度を測定するための方法及びシステム |
| JP2015524924A (ja) * | 2012-07-30 | 2015-08-27 | フェンウォール、インコーポレイテッド | 脂質の光学的検出 |
| JP2018040796A (ja) * | 2016-09-05 | 2018-03-15 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 信号オフセットの決定及び補正 |
| JP7109166B2 (ja) | 2016-09-05 | 2022-07-29 | エフ．ホフマン－ラ ロシュ アーゲー | 信号オフセットの決定及び補正 |
| US20220228976A1 (en) * | 2017-01-31 | 2022-07-21 | Labrador Diagnostics Llc | Methods and devices for improved signal detection from biological samples |
| JP2020527713A (ja) * | 2017-07-19 | 2020-09-10 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッドＳｉｅｍｅｎｓ Ｈｅａｌｔｈｃａｒｅ Ｄｉａｇｎｏｓｔｉｃｓ Ｉｎｃ． | ハイパースペクトルイメージングを用いた検体評価方法及び検体評価装置 |
| JP7057820B2 (ja) | 2017-07-19 | 2022-04-20 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッド | ハイパースペクトルイメージングを用いた検体評価方法及び検体評価装置 |
| US11333553B2 (en) | 2017-07-19 | 2022-05-17 | Siemens Healthcare Diagnostics Inc. | Methods and apparatus for specimen characterization using hyperspectral imaging |
| JP2020008578A (ja) * | 2018-07-03 | 2020-01-16 | シーメンス ヘルスケア ダイアグノスティクス プロダクツ ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | 体液試料中の脂質、ヘモグロビンおよびビリルビンを決定するための方法 |
| JP7373315B2 (ja) | 2018-07-03 | 2023-11-02 | シーメンス ヘルスケア ダイアグノスティクス プロダクツ ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | 体液試料中の脂質、ヘモグロビンおよびビリルビンを決定するための方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000077494A1 (en) | 2000-12-21 |
| EP1185852A1 (en) | 2002-03-13 |
| US6882425B1 (en) | 2005-04-19 |
| EP1059522A1 (en) | 2000-12-13 |
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