JP2003268254A - 発酵法による紅麹色素の製造方法 - Google Patents
発酵法による紅麹色素の製造方法Info
- Publication number
- JP2003268254A JP2003268254A JP2002074658A JP2002074658A JP2003268254A JP 2003268254 A JP2003268254 A JP 2003268254A JP 2002074658 A JP2002074658 A JP 2002074658A JP 2002074658 A JP2002074658 A JP 2002074658A JP 2003268254 A JP2003268254 A JP 2003268254A
- Authority
- JP
- Japan
- Prior art keywords
- culture
- pigment
- monascus
- monascorbulin
- yeast rice
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 39
- 239000000049 pigment Substances 0.000 title claims abstract description 37
- 241000228347 Monascus <ascomycete fungus> Species 0.000 title claims abstract description 22
- 238000000034 method Methods 0.000 title description 16
- 238000000855 fermentation Methods 0.000 title description 2
- 230000004151 fermentation Effects 0.000 title description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims abstract description 66
- 230000002378 acidificating effect Effects 0.000 claims abstract description 14
- 244000005700 microbiome Species 0.000 claims abstract description 12
- 239000007788 liquid Substances 0.000 claims abstract description 8
- 229940026314 red yeast rice Drugs 0.000 claims description 25
- 239000001053 orange pigment Substances 0.000 abstract description 7
- 239000001048 orange dye Substances 0.000 abstract description 3
- 241001326554 Elaphomycetaceae Species 0.000 abstract 1
- 239000000975 dye Substances 0.000 description 21
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 14
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 14
- 239000000243 solution Substances 0.000 description 14
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 12
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 12
- 239000002609 medium Substances 0.000 description 12
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 8
- 238000012258 culturing Methods 0.000 description 8
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 8
- 239000003002 pH adjusting agent Substances 0.000 description 8
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 239000002253 acid Substances 0.000 description 6
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 229910052500 inorganic mineral Inorganic materials 0.000 description 6
- 239000011707 mineral Substances 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 5
- 239000001963 growth medium Substances 0.000 description 5
- 238000004128 high performance liquid chromatography Methods 0.000 description 5
- 150000007524 organic acids Chemical class 0.000 description 5
- 235000005985 organic acids Nutrition 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 4
- 150000007513 acids Chemical class 0.000 description 4
- 239000003086 colorant Substances 0.000 description 4
- 239000000284 extract Substances 0.000 description 4
- 239000004310 lactic acid Substances 0.000 description 4
- 235000014655 lactic acid Nutrition 0.000 description 4
- 238000009630 liquid culture Methods 0.000 description 4
- 229940057059 monascus purpureus Drugs 0.000 description 4
- 239000001054 red pigment Substances 0.000 description 4
- 239000001052 yellow pigment Substances 0.000 description 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- 244000113306 Monascus purpureus Species 0.000 description 3
- 235000002322 Monascus purpureus Nutrition 0.000 description 3
- 238000005273 aeration Methods 0.000 description 3
- -1 amino compound Chemical class 0.000 description 3
- 229940041514 candida albicans extract Drugs 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- 238000005119 centrifugation Methods 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- XXKNHBAFFJINCK-RVEJDSBJSA-N monascin Chemical compound C([C@@H]1[C@H](C(O[C@@]1(C)C1=O)=O)C(=O)CCCCC)C2=C1COC(\C=C\C)=C2 XXKNHBAFFJINCK-RVEJDSBJSA-N 0.000 description 3
- GFSMXLMQRWMHON-UHFFFAOYSA-N monascin Natural products CCCCCC(=O)C1C2C=C3C=C(OC=C3C(=O)C2(C)OC1=O)C=CC GFSMXLMQRWMHON-UHFFFAOYSA-N 0.000 description 3
- GIKQHOXMDCDAPT-UHFFFAOYSA-N monascusone B Natural products CC=CC1=CC2=C(CO1)C(=O)C3(C)OC(=O)C(C3C2)C(=O)C GIKQHOXMDCDAPT-UHFFFAOYSA-N 0.000 description 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 3
- 238000011218 seed culture Methods 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000012138 yeast extract Substances 0.000 description 3
- AQTJNEHGKRUSLT-ODTNPMSZSA-N (3s,3ar,9ar)-9a-methyl-3-octanoyl-6-[(e)-prop-1-enyl]-3,3a,4,8-tetrahydrofuro[3,2-g]isochromene-2,9-dione Chemical compound C([C@@H]1[C@H](C(O[C@@]1(C)C1=O)=O)C(=O)CCCCCCC)C2=C1COC(\C=C\C)=C2 AQTJNEHGKRUSLT-ODTNPMSZSA-N 0.000 description 2
- SULYDLFVUNXAMP-WKOQKXSESA-N (9ar)-3-hexanoyl-9a-methyl-6-[(e)-prop-1-enyl]furo[3,2-g]isochromene-2,9-dione Chemical compound C1=C2C=C(\C=C\C)OC=C2C(=O)[C@@]2(C)C1=C(C(=O)CCCCC)C(=O)O2 SULYDLFVUNXAMP-WKOQKXSESA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 108010023063 Bacto-peptone Proteins 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 2
- 244000068988 Glycine max Species 0.000 description 2
- 235000010469 Glycine max Nutrition 0.000 description 2
- 241000031003 Monascus ruber Species 0.000 description 2
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 2
- SULYDLFVUNXAMP-UHFFFAOYSA-N Rubropunctatin Natural products C1=C2C=C(C=CC)OC=C2C(=O)C2(C)C1=C(C(=O)CCCCC)C(=O)O2 SULYDLFVUNXAMP-UHFFFAOYSA-N 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 241000209140 Triticum Species 0.000 description 2
- 235000021307 Triticum Nutrition 0.000 description 2
- 238000013019 agitation Methods 0.000 description 2
- ORJQJZWWJUNMQV-UHFFFAOYSA-N ankaflavin Natural products CCCCCCCC(=O)C1C2C=C3C=C(OC=C3C(=O)C2(C)OC1=O)C=CC ORJQJZWWJUNMQV-UHFFFAOYSA-N 0.000 description 2
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 238000012136 culture method Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000011785 micronutrient Substances 0.000 description 2
- 235000013369 micronutrients Nutrition 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 230000003472 neutralizing effect Effects 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- WTEXYKPGDKLLCW-KCSPPWDSSA-N (3Z,9aR)-3-(1-hydroxyhexylidene)-9a-methyl-6-[(E)-prop-1-enyl]furo[3,2-g]isoquinoline-2,9-dione Chemical compound CCCCC\C(O)=C1\C(=O)O[C@]2(C)C1=Cc1cc(\C=C\C)ncc1C2=O WTEXYKPGDKLLCW-KCSPPWDSSA-N 0.000 description 1
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 description 1
- 239000005695 Ammonium acetate Substances 0.000 description 1
- 241000228245 Aspergillus niger Species 0.000 description 1
- IIPVSGPTPPURBD-UHFFFAOYSA-N Monascorubrin Natural products C1=C2C=C(C=CC)OC=C2C(=O)C2(C)C1=C(C(=O)CCCCCCC)C(=O)O2 IIPVSGPTPPURBD-UHFFFAOYSA-N 0.000 description 1
- 241000030999 Monascus pilosus Species 0.000 description 1
- 238000005481 NMR spectroscopy Methods 0.000 description 1
- 241001079672 Nascus Species 0.000 description 1
- 229930182559 Natural dye Natural products 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- 108010080698 Peptones Proteins 0.000 description 1
- 108010009736 Protein Hydrolysates Proteins 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- 244000061456 Solanum tuberosum Species 0.000 description 1
- 235000002595 Solanum tuberosum Nutrition 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 238000000862 absorption spectrum Methods 0.000 description 1
- 159000000021 acetate salts Chemical class 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 235000019257 ammonium acetate Nutrition 0.000 description 1
- 229940043376 ammonium acetate Drugs 0.000 description 1
- 239000002518 antifoaming agent Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 235000012813 breadcrumbs Nutrition 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 210000000692 cap cell Anatomy 0.000 description 1
- 238000004737 colorimetric analysis Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000000576 food coloring agent Substances 0.000 description 1
- 239000000845 maltitol Substances 0.000 description 1
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 1
- 229940035436 maltitol Drugs 0.000 description 1
- 235000010449 maltitol Nutrition 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- IIPVSGPTPPURBD-HAOIVFDCSA-N monascorubrin Chemical compound C1=C2C=C(\C=C\C)OC=C2C(=O)[C@@]2(C)C1=C(C(=O)CCCCCCC)C(=O)O2 IIPVSGPTPPURBD-HAOIVFDCSA-N 0.000 description 1
- AJDUTMFFZHIJEM-UHFFFAOYSA-N n-(9,10-dioxoanthracen-1-yl)-4-[4-[[4-[4-[(9,10-dioxoanthracen-1-yl)carbamoyl]phenyl]phenyl]diazenyl]phenyl]benzamide Chemical compound O=C1C2=CC=CC=C2C(=O)C2=C1C=CC=C2NC(=O)C(C=C1)=CC=C1C(C=C1)=CC=C1N=NC(C=C1)=CC=C1C(C=C1)=CC=C1C(=O)NC1=CC=CC2=C1C(=O)C1=CC=CC=C1C2=O AJDUTMFFZHIJEM-UHFFFAOYSA-N 0.000 description 1
- 239000000978 natural dye Substances 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 239000012264 purified product Substances 0.000 description 1
- 239000001044 red dye Substances 0.000 description 1
- 235000020095 red wine Nutrition 0.000 description 1
- OVOAWDOEFJNCGI-UHFFFAOYSA-N rubropunctatamine Natural products CCCCCC(=O)C1=C2C=C3C=C(NC=C3C(=O)C2(C)OC1=O)C=CC OVOAWDOEFJNCGI-UHFFFAOYSA-N 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 239000001043 yellow dye Substances 0.000 description 1
Landscapes
- Coloring Foods And Improving Nutritive Qualities (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002074658A JP2003268254A (ja) | 2002-03-18 | 2002-03-18 | 発酵法による紅麹色素の製造方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002074658A JP2003268254A (ja) | 2002-03-18 | 2002-03-18 | 発酵法による紅麹色素の製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2003268254A true JP2003268254A (ja) | 2003-09-25 |
Family
ID=29203990
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002074658A Pending JP2003268254A (ja) | 2002-03-18 | 2002-03-18 | 発酵法による紅麹色素の製造方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2003268254A (ja�@�@) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006052171A (ja) * | 2004-08-12 | 2006-02-23 | Gunze Ltd | Ａｃｅ阻害剤 |
| JP2006075003A (ja) * | 2004-09-07 | 2006-03-23 | Gunze Ltd | 大豆紅麹およびそれを含む飲食物 |
| CN102924964A (zh) * | 2012-10-24 | 2013-02-13 | 江南大学 | 一种不含桔霉素的红曲红色素提取纯化生产工艺 |
| CN103013161A (zh) * | 2011-09-28 | 2013-04-03 | 北大方正集团有限公司 | 从洛伐他汀结晶母液中提取水溶性红色素的方法 |
| CN103013165A (zh) * | 2012-12-18 | 2013-04-03 | 山东中惠食品有限公司 | 一种利用固定化酶制备红曲红色素的方法 |
| CN103013166A (zh) * | 2012-12-18 | 2013-04-03 | 山东中惠食品有限公司 | 高品质低桔霉素水溶性红曲红色素的制备方法 |
| CN103113755A (zh) * | 2013-03-01 | 2013-05-22 | 江门科隆生物技术股份有限公司 | 一种红曲霉菌丝体残渣中色素的提取方法 |
| CN110437644A (zh) * | 2019-08-19 | 2019-11-12 | 长江大学 | 一种红曲橙色素的分离纯化方法 |
| CN112143759A (zh) * | 2020-09-16 | 2020-12-29 | 长江大学 | 一种提高红曲菌菌丝体中橙色素得率的方法及应用 |
| CN114058648A (zh) * | 2021-12-14 | 2022-02-18 | 广东天益生物科技有限公司 | 一种利用紫色红曲菌发酵高产胞外红曲红色素的方法 |
| CN119391551A (zh) * | 2024-12-30 | 2025-02-07 | 北京科佑爱科技有限责任公司 | 一种高产红曲素和/或红曲黄素的红曲霉菌及其应用 |
-
2002
- 2002-03-18 JP JP2002074658A patent/JP2003268254A/ja active Pending
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006052171A (ja) * | 2004-08-12 | 2006-02-23 | Gunze Ltd | Ａｃｅ阻害剤 |
| JP2006075003A (ja) * | 2004-09-07 | 2006-03-23 | Gunze Ltd | 大豆紅麹およびそれを含む飲食物 |
| CN103013161A (zh) * | 2011-09-28 | 2013-04-03 | 北大方正集团有限公司 | 从洛伐他汀结晶母液中提取水溶性红色素的方法 |
| CN102924964A (zh) * | 2012-10-24 | 2013-02-13 | 江南大学 | 一种不含桔霉素的红曲红色素提取纯化生产工艺 |
| CN102924964B (zh) * | 2012-10-24 | 2014-09-17 | 江南大学 | 一种不含桔霉素的红曲红色素提取纯化生产工艺 |
| CN103013166B (zh) * | 2012-12-18 | 2014-07-30 | 山东中惠食品有限公司 | 高品质低桔霉素水溶性红曲红色素的制备方法 |
| CN103013165B (zh) * | 2012-12-18 | 2014-05-28 | 山东中惠食品有限公司 | 一种利用固定化酶制备红曲红色素的方法 |
| CN103013166A (zh) * | 2012-12-18 | 2013-04-03 | 山东中惠食品有限公司 | 高品质低桔霉素水溶性红曲红色素的制备方法 |
| CN103013165A (zh) * | 2012-12-18 | 2013-04-03 | 山东中惠食品有限公司 | 一种利用固定化酶制备红曲红色素的方法 |
| CN103113755A (zh) * | 2013-03-01 | 2013-05-22 | 江门科隆生物技术股份有限公司 | 一种红曲霉菌丝体残渣中色素的提取方法 |
| CN110437644A (zh) * | 2019-08-19 | 2019-11-12 | 长江大学 | 一种红曲橙色素的分离纯化方法 |
| CN110437644B (zh) * | 2019-08-19 | 2020-08-07 | 长江大学 | 一种红曲橙色素的分离纯化方法 |
| CN112143759A (zh) * | 2020-09-16 | 2020-12-29 | 长江大学 | 一种提高红曲菌菌丝体中橙色素得率的方法及应用 |
| CN112143759B (zh) * | 2020-09-16 | 2022-06-17 | 长江大学 | 一种提高红曲菌菌丝体中橙色素得率的方法及应用 |
| CN114058648A (zh) * | 2021-12-14 | 2022-02-18 | 广东天益生物科技有限公司 | 一种利用紫色红曲菌发酵高产胞外红曲红色素的方法 |
| CN114058648B (zh) * | 2021-12-14 | 2023-11-21 | 广东天益生物科技有限公司 | 一种利用紫色红曲菌发酵高产胞外红曲红色素的方法 |
| CN119391551A (zh) * | 2024-12-30 | 2025-02-07 | 北京科佑爱科技有限责任公司 | 一种高产红曲素和/或红曲黄素的红曲霉菌及其应用 |
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