JP2003220116A - Medical fluid container - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a medical fluid container having a plurality of preferable chambers into which medical fluids are poured before adding the medical fluids to medical infusion. <P>SOLUTION: This medical fluid container 20 is provided with a first segment for storing medical fluid containing vitamin B<SB>2</SB>, a second segment B for storing a medical fluid containing an iron supply source, and communicating mechanisms 52, 54 which can feed the medical fluids into an infusion container. The first segment is divided into a first chamber A1, a second chamber A2, and an auxiliary chamber 28. The first chamber stores the medical fluid containing vitamin B<SB>2</SB>and the second chamber stores medical fluid containing vitamin A, vitamin D, vitamin E or vitamin K. <P>COPYRIGHT: (C)2003,JPO

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a liquid medicine container having a plurality of chambers. More specifically, infusion preparations supplied by infusion to the human body, for example, high calorie infusion, amino acid infusion, electrolyte infusion, saccharide infusion, and other medical infusions,
The present invention relates to a drug solution container provided with a plurality of chambers suitable for injecting a drug solution that easily causes a reaction before use.

[0002]

2. Description of the Related Art Conventionally, infusion components supplied to the human body by drip, such as amino acid solution and glucose solution, change in quality when mixed, and therefore, are placed in an infusion container, particularly in an infusion bag, which is partitioned by a separable separating means. It has been devised to store each in a plurality of individual chambers, and to press the infusion bag from the outside to separate the isolation means and mix them at the time of use. Such a technique is disclosed in, for example, JP-A-62-176451. JP-A-8-182739, JP-A-8-509631
It is disclosed in Japanese Patent Publication No. When an infusion is administered to a patient by intravenous drip, depending on the patient's condition, a small amount of various medicinal solutions such as amino acid solution and glucose solution, for example, trace minerals (trace elements), vitamins, analgesics, fat infusions, antibiotics, and antibiotics. It is necessary to mix substances, minerals, cardiotonics, etc. Usually, the operation (mixed injection) of mixing a small amount of liquid medicine with an infusion preparation is performed in a clean booth in a hospital, and the liquid medicine to be mixed is injected into the infusion liquid in an infusion bag using a syringe. In this case, care is taken to prevent bacterial infection of the drug solution. These mixed injection operations are complicated, and it is desired that the mixed injection can be performed by a simple operation.

On the other hand, in recent years, home medical treatment has been favored and increased, and infusions of liquids are often administered to patients at home. Infusions are often two infusion bags with a daily dose of about 1kg, and are relatively heavy, and when the infusion of medicinal fluids for home medical infusions is performed at the hospital, it does not deteriorate after the infusion. In order to administer to patients, it is necessary to frequently carry infusions from hospitals, which makes home care burden heavy.

Japanese Patent Laid-Open No. 10-24088 discloses a drug-encapsulated container set for the purpose of providing an infusion container in which a drug-encapsulated vial and the like are simply connected with a small number of parts in a state where sterility is guaranteed. This medicine-enclosed container set is a resin container and has a plurality of chambers, and at least a part of a separating strip portion between the chambers is formed by a peel seal portion or a weak seal portion that can be opened from the outside. The chamber contains the drug solution, the second chamber is connected to the filling container, the filling container contains the drug mixed with the drug solution, and the lid body or the film body closing the opening of the filling container presses from the outside of the second chamber. Thus, the second chamber and the inside of the filling container are communicated with each other by pushing the lid body or the film body into the filling container. The high-pressure steam sterilized resin container and the vial containing the drug are connected in a sterile and dust-free chamber, and then only the second chamber is subjected to electron irradiation sterilization, and the outer surface of the filling container once exposed to the outside in the second chamber. Together with sterilization.

Japanese Utility Model Publication No. 6-42676 discloses an infusion bag for the purpose of easily and safely adding a drug in a vial to a drug solution for drip in the bag. This infusion bag has a mouth member capable of connecting the mouth of a vial sealed with a rubber stopper. The mouth member has a lower outer peripheral surface fused to one open end of a synthetic resin film, a lower end sealed with a sealing film, and a cylindrical member 3 with a bottom having a male screw on the outer circumference of the upper part, a cylindrical member with a bottom. The hollow needle 6 having a puncture blade at the tip.
Is fixed and the lower end is provided with a rod-shaped part 4 having a puncture blade at the lower end, a female screw threaded to a male screw of a bottomed cylindrical part, and a small-diameter part and a small-diameter part and a partition part. It has the 2nd component 5 which has a large diameter part which fits, and a hollow needle penetrates a division part, and the seal 10 which blocks the open end of the large diameter part of a 2nd component. Instead of the puncture blade at the tip, a rubber plug 63 fixed to the end of the rod-shaped component can be provided.

[0006]

DISCLOSURE OF THE INVENTION In examining a drug solution container that can be co-injected into an infusion preparation and can be co-injected with various small amounts of drug solution with a small amount of operations, each drug solution can cause contamination or decomposition by mixing. Need to consider. Particularly, not only the deterioration of quality of vitamin preparations due to light and temperature is promoted, but also insoluble precipitates or fine particles may be generated or decomposition thereof may be promoted when blended with trace elements.

In many cases, vitamin B _{2 and} other vitamin agents, and iron source and other trace element preparations containing a plurality of trace elements are co-injected into the sugar / electrolyte / amino acid solution for high calorie infusion. The quality of the drug solution obtained by mixing the vitamin preparation and the trace element preparation deteriorates in a short period of time, and in particular, the deposits derived from the iron source contained in the vitamin B ₂ and the trace element preparation can be confirmed. Factors such as temperature, light, reducing substances, and oxygen are involved in the formation of these precipitates, but it is difficult to fill them in the same container because they are formed in an extremely short time.

According to the present invention, it is possible to safely and easily perform, in a hospital, the work of co-injecting a small amount of a medical solution required for a patient into an infusion bag containing a high-calorie infusion solution, an amino acid infusion solution, an electrolyte infusion solution, a saccharide infusion solution, and other drug solutions. It is an object of the present invention to provide a drug solution container capable of performing mixed injection work in a home where home care is possible. The present invention also provides a drug solution container capable of eliminating the interaction that causes quality deterioration between different drug solutions to be co-injected and selectively containing the drug solution in a plurality of chambers that are selectively isolated by partition means. Then the purpose is. Other objects of the present invention will be clarified in the following description.

[0009]

A drug solution container of the present invention stores a drug solution from a first compartment containing a drug solution containing vitamin B ₂ , a second compartment containing a drug solution containing an iron source, and both compartments. A communication mechanism capable of being delivered into the infusion container is provided. The chemical liquid containing an iron source contains a zinc source, a copper source, a manganese source or an iodine source. The first section is the first
A chamber (A1), a second chamber and a sub-chamber are divided, a drug solution containing vitamin B ₂ is contained in the first chamber, and a drug solution containing vitamin A, vitamin D, vitamin E or vitamin K is contained in the second chamber. It is contained, vitamin B ₁₂ or folic acid is contained in the drug solution in the first chamber or the second chamber, and the sub chamber is provided with a communication mechanism. As the communication mechanism, the communication mechanism described in Japanese Patent Application No. 2000-32487 can be used.

The first chamber and the sub chamber are partitioned by the first separating unit, the second chamber and the sub chamber are partitioned by the second separating unit, and the first separating unit and the second separating unit are It is opened by pressing the chemical liquid in the first chamber or the second chamber from the outside. The first chamber is divided into a first chamber and a second chamber, the first chamber contains a drug solution containing vitamin B ₁ , the second chamber contains a drug solution containing vitamin C, and the vitamin B ₂ is first. It is contained in the liquid medicine contained in the small chamber or the second small chamber. Vitamin B ₆ , nicotinic acids, pantothenic acids, or biotin is contained in the drug solution in either the first compartment or the second compartment.

The communication mechanism includes a passage that connects the inside of the infusion container and one of the compartments or chambers of the liquid medicine container, a closing body that closes the passage, and a passage that moves the closing body or forms a through passage in the closing body. Including means for opening.

The drug solution container of the present invention includes a first compartment for containing a drug solution containing vitamins, a second compartment for containing a drug solution containing an iron supply source, and a communication capable of delivering the drug solution into the infusion container from both compartments. It has a mechanism. The first section and the second section are
The flexible resin film is formed by partitioning the bag-like space formed by firmly adhering the peripheral portions of the flexible resin film to each other with a strong sealing portion, and the communication mechanism is arranged in each of the first section and the second section. Preferably, the first partition is divided into a first chamber, a second chamber and a sub-chamber, and the second chamber and the sub-chamber are partitioned by the second isolating means, and the first isolating means and the second isolating means. Is opened by externally pressing the chemical liquid in the first chamber or the second chamber. The first separating means and the second separating means are formed by weakly adhering the resin film.

In the liquid medicine container of the present invention, two side edge portions, an upper edge portion and a lower edge portion of two flexible resin films that are stacked are firmly bonded to each other to form a bag-shaped space, and the bag-shaped space is formed. It includes four chambers (E, V1, V2, V3) formed by partitions by three weak seals (72, 73, 74). A communication mechanism capable of delivering the drug solution in the room into the infusion container is arranged at the lower edge, and the three weak seals (75, 73, 74) are strongly bonded to the communication mechanism 52 farther away, and are opened to the farther away. Is configured so that a large pressing force is required.

The chemical liquid container of the present invention is made of a thermoplastic resin such as glass, polyethylene, polypropylene, poly-4-methylpentene or cycloolefin polymer (Cyclo Olefine Polymer (COP), trade name Zeonoa, manufactured by Zeon Corporation). be able to. As the liquid medicine container of the present invention, a thermoplastic resin having excellent moldability and flexibility is preferably used. Among the vitamin agents, particularly fat-soluble vitamins (vitamin A, vitamin D, vitamin E and vitamin K) are adsorbed. It is preferable to use a difficult-to-use thermoplastic resin, and the cycloolefin polymer (trade name: Zeonor, manufactured by Nippon Zeon Co., Ltd.), which has excellent characteristics, is particularly preferable. Further, it is preferable that a cycloolefin polymer and polyethylene are laminated in two or three layers by a T-die extruder or an inflation molding machine to form a multilayer film, which is used as a drug solution container. Further, instead of polyethylene, a multilayer film of polypropylene or a resin having a mixed composition of polyethylene and polypropylene may be formed.

As the communicating mechanism of the present invention, a needle body having a sharp tip made of metal or thermoplastic resin, or a communicating needle having an obtuse tip for preventing needle stick accidents during mixed injection operation can be preferably used. In addition, as a communication mechanism when each chamber of the chemical liquid container partitioned by the isolation means is made of glass or a rigid or quasi-rigid thermoplastic resin, Japanese Patent Application 2000
A plug body that is movable by an operating rod described in Japanese Patent Laid-Open No. 321487 may be used as the closing body. Further, two tubular bodies having different lengths may be adjacent to each other, or a double-cylindrical needle body having an inner tubular tube having a small diameter may be used as the communication mechanism.

When each drug solution is mixed and poured into the infusion container using the drug solution container of the present invention, the communication mechanism can be easily joined to the communication port portion of the infusion container side, and the communication mechanism is provided to perform the mixed injection operation quickly. It is preferable to increase the rigidity of the lower part of the liquid medicine container. In particular, in the case where each chamber containing the chemical liquid is made of a flexible resin, if the rigidity of the lower portion is set higher than that of the chemical liquid storage chamber, preferable mixed injection operability can be obtained. When partitioning a plurality of chambers with a flexible resin film, the film is formed on a lower member made of a thermoplastic resin having a needle body on the lower surface, a rib for welding on the upper surface, and having a chemical liquid passage therein. Is preferably adhered. When the rigidity of the low member is adjusted so as not to be easily deformed, the bonding accuracy and the bonding speed of the flexible film are improved, and the mixed injection operability is improved, which is a particularly preferable mode.

When only one communication mechanism is provided in the liquid medicine container of the present invention, a chemical liquid containing a trace element is contained in a chamber adjacent to the communication mechanism, and a vitamin which is hard to mix with the trace element in the upper layer of the chamber. A chamber containing a drug solution containing A, Vitamin D, Vitamin E and Vitamin K is provided through a weakly bonded partition wall, and Vitamin A, Vitamin D, Vitamin E and Vitamin are further provided on the upper layer of the chamber containing Vitamin A and others. It is preferable to provide a chamber for accommodating a water-soluble vitamin group other than K, such as vitamin B2, through a partition wall that is weakly adhered. At this time, by adjusting the adhesive strength of the weakly bonded partition walls so that the lower layer side communicates with the lower layer side with a weaker pressing force than the upper layer, the mixed injection operation is started, and the chamber containing the trace elements first becomes the infusion container. It is injected, and then the drug solution containing vitamin A, vitamin D, vitamin E and vitamin K is used to wash out trace elements, and finally the drug solution containing trace elements and vitamin B _2, etc., which easily mix and change, is injected. It is preferable. The adhesive strength of the weakly bonded portion can be adjusted by the partition wall width and its shape, and can also be controlled by adjusting the temperature, pressure and pressurizing time at the time of sealing.

It is preferable that the communication mechanism of the drug solution container of the present invention is provided with a sealing means that can be removed or opened by a communication mechanism, for example, a needle body before the mixed injection operation. Furthermore,
In the liquid medicine container partitioned by the isolation means of the present invention, the isolation means may be mechanically and artificially cut so that each chamber can be separated in a liquid-tight state. With this, for example, the drug solution container of the present invention that has undergone the sterilization step can be separately packaged with the chamber part containing the drug solution containing the trace element and the chamber part containing the vitamin preparation, and the infusion container can be used. It can be used as a drug solution container when only vitamin preparations should be co-injected or only trace elements should be co-injected. The drug solution container of the present invention is preferably sealed with an oxygen scavenger in an oxygen-impermeable outer bag made of a colored light-shielding film or an aluminum laminate film to form a final product.

The vitamin preparations to be co-injected into the high calorie infusion include vitamins A, B ₁ , B ₆ , B ₁₂ , C, D,
There may be mentioned 13 kinds of essential vitamins such as E, K, pantothenic acid, biotin, nicotinic acid and folic acid. Thirteen
Optimum p
Since H is present and the composition may change between vitamins when mixed in the same drug solution, it is preferable to separate the appropriate groups and fill and store them in each chamber. The amount of the drug solution containing the vitamin preparation is preferably 1 to 5 ml, but each chamber should be filled with an inert gas such as nitrogen gas or carbon dioxide gas together with the drug solution to adjust the capacity of the drug solution container with good operability. Is preferred. If the volume of the drug solution storage part of the drug solution container is too small, less than 5 ml, the mixed injection operation becomes difficult, and 200 ml
With the above-mentioned volume, it becomes difficult to carry out mixed injection with one hand, and the cost of the container material is high, which is not preferable.

Examples of the iron source to be mixed with the chemical solution containing trace elements include iron sulfate, ferrous chloride, ferric chloride and iron gluconate. Examples of the zinc source include zinc sulfate, zinc chloride, zinc gluconate, zinc lactate, and zinc acetate. Examples of the manganese supply source include manganese sulfate, and examples of the copper supply source include copper sulfate. With respect to a preferable combination of each source of the trace element preparation, ferric chloride (hexahydrate), manganese chloride (tetrahydrate), zinc sulfate (seven sulfates) described in Table 1 of Japanese Patent Application No. 2001-54370 is used. Hydrate), copper sulfate (pentahydrate) and potassium iodide are preferably contained. In addition, Japanese Patent Application 2000
The trace element-containing preparation described in -394260 does not contain manganese as a trace element preparation to be mixed-injected for patients with hepatic dysfunction and is therefore suitably used as a drug solution.

The drug solution container of the present invention is preferably filled and housed with a multivitamin preparation and a trace element preparation, but in addition to it, it is also possible to house various medicines marketed as injection solutions. Inorganic salt agents that can change the infusion composition depending on the patient's condition, injectable amino acid preparations containing arginine and glutamine that can increase the dose of arginine and glutamine, and fat-containing injections such as soybean oil And anticoagulants such as sodium heparin injection may also be included.

Vitamin C blended as a vitamin preparation
May be vitamin C itself, a derivative thereof or a salt thereof. Specifically, vitamin C (ascorbic acid), sodium ascorbate, ascorbyl palmitate, ascorbyl dipalmitate,
Examples include ascorbic acid phosphoric acid ester magnesium salt and the like. As vitamin B1, any of those conventionally used can be used, for example, thiamine may be used, and its derivative, specifically, prosultiamine, actothiamine, thiamine disulfide, fursultiamine, etc. Alternatively, their salts such as thiamine hydrochloride and thiamine nitrate may be used. As the vitamin B1, any of those conventionally used can be used, for example, thiamin may be used, and its derivative, specifically, prosultiamine, actothiamine,
It may be thiamine disulfide, fursultiamine or the like, or a salt thereof such as thiamine hydrochloride or thiamine nitrate.

Vitamin A, vitamin D, vitamin E and vitamin K may be as they are or in the form of derivatives thereof. Specifically, vitamin A and its derivatives include vitamin A ₁ (retinol), vitamin A ₂ (3-dehydroretinol), vitamin A ₃ (subvitamin A), retinene (vitamin A aldehyde), vitamin A acid, Examples thereof include retinol palmitate and retinol acetate. Examples of vitamin D and its derivatives include vitamin D ₂ (ergocalciferol), vitamin D ₃ (cholecalciferol), vitamin D ₄ , provitamin D ₂ (ergosterin), provitamin D ₃ (dehydrocholesterine), etc. You can Examples of vitamin E and its derivatives include α-tocopherol, tocopherol acetate, β-tocopherol, γ-tocopherol, and δ-tocopherol. As vitamin K and its derivatives, vitamin K1
(Phylloquinone, phytonadione), vitamin K ₂ (farnoquinone), vitamin K ₃ (menadione), vitamin K ₄ , vitamin K ₅ , vitamin K ₆ , vitamin K _{7 and the} like.

[0024]

1 to 6 are schematic plan views showing the chemical liquid containers of the first to sixth embodiments of the chemical liquid container of the present invention, and similar parts or parts are designated by the same reference numerals. However, redundant description will be omitted. The drug solution container 10 of the first embodiment of the present invention shown in FIG. 1 includes a first compartment A containing a drug solution containing vitamin B ₂ , a second compartment B containing a drug solution containing an iron source, and both compartments. Communication mechanism 5 for delivering chemicals
2, 53 are provided. The first section A and the second section B of the chemicals container 10 are formed of a flexible resin film having two side edges 12, 12, an upper edge 14, a lower edge 18, and a connecting edge 16. The communication mechanisms 52, 53 of the chemical liquid container 10 are configured by hollow needles, communication tools described later with reference to FIG. 9, and the like. The outer surfaces of the communication mechanisms 52 and 53 are covered with a protective cover 53 and maintained in a sterile state immediately before use. Second section B
The chemical solution containing an iron source in the above contains a zinc source, a copper source, a manganese source, or an iodine source.

In the drug solution container 20 of the second embodiment shown in FIG. 2, the portion corresponding to the first section A of FIG.
Thus, it is divided into a first chamber A1, a second chamber A2 and a sub chamber 28. The first weak seal 2 is between the first chamber A1 and the sub chamber 28.
4, the second chamber A2 and the sub chamber 28 are partitioned by the second weak seal 25. First weak seal 24, second
Numeral 25 separates the drug solution in the first chamber A1 or the second chamber A2 by pressing it from the outside, and sends the drug solution in each chamber to the infusion container (not shown) through the sub chamber 28 and the communication mechanism 52. It can be mixed. Second section B
Contains a drug solution containing an iron source. The chemical solution in the second section B may contain a zinc source, a copper source, a manganese source or an iodine source. The first chamber A1 of the drug solution container 20 contains a drug solution containing vitamin B ₂ .
The second chamber A2 contains a drug solution containing vitamin A, vitamin D, vitamin E or vitamin K. Vitamin B ₁₂
Alternatively, folic acid is contained in the drug solution in the first chamber or the second chamber.

In the liquid medicine container 30 of the third embodiment shown in FIG. 3, the portion corresponding to the first chamber A1 shown in FIG.
Thus, it is divided into a first small chamber A11 and a second small chamber A12. The third weak seal 24 is between the first small chamber A11 and the sub chamber 28.
The second weak chamber A12 and the sub chamber 28 are partitioned by the fourth weak seal 242. Third weak seal 24
The first and fourth weak seals 242 can be peeled off by externally pressing the chemical liquid in the first small chamber A11 or the second small chamber A12, respectively, and the chemical liquid in each chamber is not shown via the sub chamber 28 and the communication mechanism 52. It can be delivered into an infusion container and mixed with the infusion. The second section B contains a chemical solution containing an iron supply source. The chemical solution in the second section B is a zinc supply source,
It contains a copper source, a manganese source or an iodine source.

The first small chamber A11 contains a drug solution containing vitamin B ₁ , and the second small chamber A12 contains a drug solution containing vitamin C. Vitamin B2 is contained in the drug solution contained in the first small chamber A11 or the second small chamber A12. Second room A
2 contains a drug solution containing vitamin A, vitamin D, vitamin E or vitamin K. The chemical liquid containing the iron supply source in the second section B contains a zinc supply source, a copper supply source, a manganese supply source, or an iodine supply source.

A chemical liquid container 60 of the fourth embodiment of the present invention shown in FIG.
Is the two side edges 1 of the two flexible resin films stacked together.
2, 12, the upper edge portion 14, the lower edge portion 18, and the connecting edge portion 16 are firmly bonded to form a bag-shaped space, and the bag-shaped space is partitioned by three weak seals 72, 73, 74. 4
It has two chambers E, V1, V2 and V3. The chamber E contains a chemical solution containing an iron supply source and includes a communication mechanism 52. The outer surface of the communication mechanism 52 is covered with a protective cover 53 and kept aseptic until just before use. Chamber V1 is shown in FIG.
The first small chamber A11 contains the same chemical liquid, the chamber V2 contains the same chemical liquid as the second small chamber A12 in FIG. 3, and the chamber V3 contains
It contains the same chemical liquid as the second chamber A2.

A chemical liquid container 60 of the fourth embodiment of the present invention shown in FIG.
In, the three weak seals 72, 73, and 74 are required to have a large pressing force in order to bond more strongly to the one farther from the communication mechanism 52 and to open the one farther from the communicating mechanism 52. With such a configuration of the weak seals 72, 73, and 74, when the drug solution in the drug solution container 60 is delivered into the infusion container (not shown) via the communication mechanism 52, the communication mechanism is provided by applying pressure to the drug solution container 60 from the outside. The drug solution is sequentially delivered from the chamber closer to 52. Therefore, the mixing amount of the chemical liquids in different chambers in the chemical liquid container 60 is minimized, and the change due to the mixing is minimized.

The chemical solution container 70 of the fifth embodiment shown in FIG. 5 has two side edge portions 12, 12 of a flexible resin film which are stacked on each other.
The upper edge portion 14, the lower edge portion 18, and the connecting edge portion 16 are firmly bonded to form a bag-shaped space, and the bag-shaped space is formed into one strong seal 1.
It has four chambers E, V1, V2, V3 formed by 6 and two weak seals 73, 74. Room E is
A communication mechanism 54 for accommodating a chemical solution containing an iron supply source
Equipped with. The chamber V1 includes a communication mechanism 52. The ends of the communication mechanisms 52 and 54 on the chamber V1 side and the chamber E side are covered with weak seals 75 and 76, respectively. Chamber E, V1, V2, V3
Are the chambers E of the chemical liquid container 60 of the fourth embodiment of FIG.
It contains the same chemicals as V1, V2, and V3. Further, the three weak seals 75, 73 and 74 are strongly bonded to each other farther from the communication mechanism 52, and a larger pressing force is required to open the farther one. The peel strength of the weak seal 75 that covers the end portion of the communication mechanism 52 is larger than that of the weak seal 76, so that the chemical liquid in the chamber E can be delivered before the chemical liquid in the other chambers.

The chemical liquid container 80 of the sixth embodiment shown in FIG.
The chemical liquid container 70 of the fifth embodiment is partially modified, and a sub chamber 88 is provided, and instead of two communication mechanisms,
One communication mechanism 52 is provided. Subchamber 88 may be empty or may contain a suitable liquid or drug. The sub-chamber 88 and the chamber E are partitioned by the weak seal 76, and the sub-chamber 88 and the chamber E are partitioned by the weak seal 76. Other structures and the chemical solution contained in each chamber can be the same as those in the fifth embodiment of FIG.

FIG. 7 is a schematic plan view showing an infusion bag (infusion container) 100 capable of injecting a drug from the drug solution container of the present invention, and FIG. 8 shows an injection port body 90 incorporated in the infusion bag of FIG. It is a perspective view shown. 2 infusion bags 100
Two side edges 112, 1 of the flexible resin film stacked
12, the upper edge portion 114, and the lower edge portion 118 are firmly bonded to form a bag-shaped space, and the bag-shaped space is formed into one weak seal 1.
Two chambers 101 and 102 formed by being divided by 07
Have. As is well known, the chambers 101 and 102 contain an amino acid solution and a glucose solution, respectively, in order to avoid a change in mixture of infusion components. The upper edge 114 of the infusion bag is provided with the inlet main body 90 and the hanging holes 104, 105, 106.
The lower edge 128 of the infusion bag comprises the port 112 covered with a protective cap. Infusion in the infusion bag is port 1
The stopper in 12 is pierced with a hollow needle and administered to the patient via the hollow needle, the tube, and the like.

The injection port main body 90 includes four injection ports 91 to 9
Have 4. The inlets 91 and 92 are provided with a stopper body having a slit, and can receive a pair of communication mechanisms whose tips are not sharp. The inlets 93, 94 are provided with stoppers without slits and can receive a pair of sharp communication mechanisms such as hollow needles. The inlets 91 to 94 are covered with a protective cap (not shown) just before use to prevent contamination.

FIG. 9 is a schematic sectional view showing a state where the communication mechanism 52 of the medicine container 10 is in the communication state. In the embodiment of FIG. 9, the communication device 1 is obtained by piercing the stopper 151 arranged on the drug container 10 side with the hollow communication device 144.
A communication passage that connects the inside of the drug container 10 and the first chamber 101 of the infusion bag 100 is formed via the passage 142 in the unit 44. The communication tool 144 extends inside the support 156 and has an end portion 141 inside the drug container 10, and the passage 1 in the communication tool 144.
42 communicates with the inside of the infusion bag at the end 141.
The communication tool 144 is manually pressed from the outside of the flexible infusion bag toward the drug container 10 to provide a sharp tip 145.
Pierces the stopper 151 that closes the tubular mouth portion of the drug container 10, the distal end opening 143 of the communication tool 144 is positioned inside the drug container 10, and the inside of the drug container 10 and the infusion bag 100 are opened 143 and the passage 142. To be in fluid communication via.
The communication tool 144 engages with the support hole 114 at its outer peripheral portion,
A plurality of ribs 146 for maintaining the position of the communication tool 144 before and after piercing the stopper 151 are provided.

A procedure for assembling the medicine container and the infusion bag shown in FIG. 9 will be described. First, the somewhat enlarged end portion 141 of the communication mechanism 52 is inserted into the inlet 91 of the inlet main body 90 of the flexible infusion bag 100. Next, the sharp tip 145 of the communication tool 144 is advanced through the partition wall 140 and the plug 151, and the tip opening 143 adjacent to the tip 145 is opened.
The inside of the infusion bag 100 and the inside of the medicine container 10 are communicated with each other through the tip opening 143 and the passage 142. The medicine in the medicine container 10 is caused to flow into the infusion bag 100 through this communication passage, and the mixed liquid is injected into the medicine bag 1
It forms within 00. Next, using the hanging holes 104 to 106, the drug solution bag 100 is engaged with a drip mount (not shown), the stopper of the drug solution outlet 112 is punctured with a hollow needle, and a hollow needle and a tube connected to the hollow needle And the like, and administer the mixed drug solution to the patient by infusion.

FIG. 10 is a schematic plan view showing a chemical liquid container 170 according to the seventh embodiment of the present invention. This chemical solution container is shown in FIG.
It has a structure similar to that of the chemical liquid container 70, and the communication mechanism is changed. The communication mechanism 52 of the chemical liquid container 170 is shown in FIG.
1 and FIG. 12, as shown in the side view when viewed from different angles of 90 degrees, the disk-shaped portion 51, the plate-shaped projection 55, and the double hollow needle 1
21 is included. 13 is a side cross-sectional view showing an eccentric inner and outer hollow portion of the double hollow needle 121, and FIG.
FIG. 3 is a plan view of the double hollow needle of FIG.

The circumferential portion of the communication mechanism 52 is firmly adhered to the inner surface of the resin film forming the lower edge portion 28, and the edge 56 of the plate-like projection 55 is formed of the resin film forming the connecting edge portion 16. Firmly adhered to the inner surface.

[0038]

The drug solution container of the present invention is a high calorie infusion solution,
Amino acid infusion, electrolyte infusion, saccharide infusion, and other infusion bags containing medicinal fluids can be safely and easily infused in a hospital with a small amount of a medicinal fluid required for the patient. Allows mixed injection work. The chemical liquid container of the present invention can eliminate the interaction that causes quality deterioration between different kinds of chemical liquids to be mixed and selectively store the chemical liquids in a plurality of chambers separated by the partition means.

[Brief description of drawings]

FIG. 1 is a schematic plan view showing a chemical liquid container according to a first embodiment of the present invention.

FIG. 2 is a schematic plan view showing a chemical liquid container according to a second embodiment of the present invention.

FIG. 3 is a schematic plan view showing a chemical liquid container according to a third embodiment of the present invention.

FIG. 4 is a schematic plan view showing a chemical liquid container according to a fourth embodiment of the present invention.

FIG. 5 is a schematic plan view showing a chemical liquid container according to a fifth embodiment of the present invention.

FIG. 6 is a schematic plan view showing a chemical liquid container according to a sixth embodiment of the present invention.

FIG. 7 is a schematic plan view showing an infusion bag capable of injecting a drug from the drug solution container of the present invention.

8 is a perspective view showing an injection port body incorporated in the infusion bag of FIG.

FIG. 9 is a cross-sectional view showing the communication tool applicable to the drug container of the present invention attached to the inlet main body of an infusion bag.

FIG. 10 is a schematic plan view showing a chemical liquid container according to a seventh embodiment of the present invention.

11 is a side view of the communication mechanism of FIG.

12 is a side view of the communication mechanism of FIG. 10, which is a side view rotated 90 degrees from FIG. 11.

13 is a side sectional view of the double hollow needle of FIG.

FIG. 14 is a plan view of the double hollow needle of FIG. 13 as seen from below.

[Explanation of symbols]

10, 20, 30, 40: chemical liquid container, 12: side edge feather,
14: upper edge part, 18: lower edge part, 23: isolation means, 28:
Sub-chamber, 52: communication mechanism, 53: protective cover, 72-7
4: Weak seal, A: first section, B: second section, A11:
First small chamber, A12: second small chamber, A2: second small chamber.

Claims (10)

[Claims] 1. A first compartment (A) containing a drug solution containing vitamin B ₂ , a second compartment (B) containing a drug solution containing an iron source, and a drug solution delivered from both compartments into an infusion container. A drug solution container with a possible communication mechanism. 2. The chemical liquid container according to claim 1, wherein the chemical liquid containing an iron supply source contains a zinc supply source, a copper supply source, a manganese supply source, or an iodine supply source. 3. The first compartment (A) comprises a first chamber (A1) and a second chamber.
Divided into chamber (A2) and sub-chamber (28), the first chamber contains a drug solution containing vitamin B ₂ , and the second chamber contains a drug solution containing vitamin A, vitamin D, vitamin E or vitamin K. Vitamin B ₁₂ or folic acid is contained in the drug solution in the first chamber or the second chamber, the sub chamber is provided with a communication mechanism (52), and the first chamber and the sub chamber are partitioned by the first isolation means. , The second chamber and the sub chamber are partitioned by the second separating unit, and the first separating unit and the second separating unit are opened by externally pressing the chemical liquid in the first chamber or the second chamber. Item 2 drug solution container. 4. The first chamber is divided into a first small chamber (A11) and a second small chamber (A12), the first small chamber contains a drug solution containing vitamin B ₁ and the second small chamber contains vitamin C. The drug solution container according to claim 3, wherein the drug solution is contained and vitamin B ₂ is contained in the drug solution contained in the first small chamber or the second small chamber. 5. The drug solution container according to claim 4, wherein vitamin B ₆ , nicotinic acid, pantothenic acid or biotin is contained in the drug solution in either the first compartment or the second compartment. 6. The communication mechanism includes a passage (142) for communicating the compartment or chamber of the infusion container and the drug solution container, a closing body (151) for closing the passage, and moving or closing the closing body. The drug solution container according to any one of claims 1 to 5, further comprising means (144) for forming a through passage in the body to open the passage. 7. A first containing a liquid medicine containing a vitamin.
A compartment (A), a second compartment (B) for accommodating a drug solution containing an iron supply source, and a drug solution container including a communication mechanism capable of delivering the drug solution from both compartments into an infusion container, the first compartment (A )
The second section (B) is formed by partitioning a bag-like space formed by firmly adhering the peripheral portions of the flexible resin film to each other with a strong sealing section (16), and the communication mechanism is the first section. A drug solution container placed in each of the first section and the second section. 8. The first compartment (A) comprises a first chamber (A1) and a second chamber.
It is divided into a chamber (A2) and a sub-chamber (28), and the second chamber and the sub-chamber are partitioned by a second separating means, and the first separating means and the second separating means are the first chamber or the second chamber. The liquid medicine container according to claim 7, which is opened by externally pressing the liquid medicine. 9. The chemical solution container according to claim 8, wherein the first separating means and the second separating means are formed by weakly adhering a resin film. 10. A bag-shaped space is formed by firmly adhering two side edges, an upper edge, and a lower edge of two flexible resin films stacked on each other, and the bag-shaped space is provided with three weak seals ( 72, 73, 7
4) partitioned by four chambers (E, V1, V
2, V3), and a communication mechanism capable of delivering the drug solution in the room into the infusion container is arranged at the lower edge, and has three weak seals (75,
73, 74) is a chemical liquid container configured such that the farther away from the communication mechanism 52, the stronger the adhesion, and the farther away, the greater the pressing force is required to open.