JPH11313871A - Infusion vessel - Google Patents
Infusion vesselInfo
- Publication number
- JPH11313871A JPH11313871A JP10122190A JP12219098A JPH11313871A JP H11313871 A JPH11313871 A JP H11313871A JP 10122190 A JP10122190 A JP 10122190A JP 12219098 A JP12219098 A JP 12219098A JP H11313871 A JPH11313871 A JP H11313871A
- Authority
- JP
- Japan
- Prior art keywords
- compartment
- chamber
- compartments
- infusion container
- infusion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
Description
【０００１】[0001]
【発明の属する技術分野】本発明は、２つ以上の成分を
混合して患者に投与するための輸液容器に関する。特
に、使用直前に薬液と薬剤とを無菌的に混合して使用す
ることができ、在宅医療患者に適用できる輸液容器に関
する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an infusion container for mixing and administering two or more components to a patient. In particular, the present invention relates to an infusion container that can be used by aseptically mixing a drug solution and a drug immediately before use, and is applicable to home medical patients.
【０００２】[0002]
【従来の技術】従来より、還元糖とアミノ酸を含有する
輸液、分解し易いアミノ酸、例えばＬ−トリプトファ
ン、Ｌ−システインを含有する輸液には製造時（高圧蒸
気滅菌などの熱滅菌時）あるいは保存時の分解・着色を
防ぐために、１）輸液のｐＨを３.０〜６.０の範囲に調
整し、かつ安定剤として亜硫酸塩を添加することによ
り、一剤化しているもの、２）剥離可能な隔壁を有する
二室容器としているもの（特開昭６３−１９１４９号公
報）、またｐＨや安定剤の亜硫酸塩に影響を受け易い薬
剤、例えばビタミン類や抗生物質等を輸液に添加する場
合は、３）薬剤とキット化しているもの（特開平１０−
２４０８８号公報）、４）使用直前に混合するためにプ
レフィルドシリンジとしているもの（特開平７−５１３
６９号公報）などが提案されている。2. Description of the Related Art Conventionally, infusions containing reducing sugars and amino acids, and infusions containing easily decomposable amino acids, such as L-tryptophan and L-cysteine, are manufactured or stored during heat sterilization such as autoclaving. In order to prevent decomposition and coloring at the time, 1) the pH of the infusion solution is adjusted to the range of 3.0 to 6.0, and sulfite is added as a stabilizer to form a single agent. 2) Peeling A two-chamber container having a possible partition (Japanese Patent Application Laid-Open No. 63-19149), and a case where a drug which is susceptible to a pH or a sulfite of a stabilizer, for example, a vitamin or an antibiotic is added to an infusion solution. (3) What is made into a kit with a drug
No. 24088), 4) Prefilled syringe for mixing immediately before use (JP-A-7-513)
No. 69) has been proposed.
【０００３】[0003]
【発明が解決しようとする課題】しかし、従来の容器は
薬剤添加の簡便性や在宅医療などへの適用には改良の余
地がある。そこで本発明の課題は、薬液に他の薬剤を添
加する場合、例えば電解質輸液、アミノ酸輸液、高カロ
リー輸液及び経腸栄養剤にビタミン類や抗生物質等を添
加して在宅医療等に用いる場合、添加した薬剤が分解す
ることなく安全に、しかも簡便に調製できる輸液容器を
提供することにある。However, there is room for improvement in the conventional container in terms of simplicity of drug addition and application to home medical treatment. Therefore, an object of the present invention is to add another drug to a drug solution, for example, when using an electrolyte infusion, an amino acid infusion, a high calorie infusion and an enteral nutritional supplement with vitamins or antibiotics for home medical treatment, etc. An object of the present invention is to provide an infusion container which can be prepared safely and simply without the added drug being decomposed.
【０００４】[0004]
【課題を解決するための手段】すなわち、本発明は、こ
れらの既存の形態の容器に空室を設け、以下の輸液容器
を提供することにより上記課題が解決されたものであ
る。 １）熱可塑性樹脂製フィルムからなる袋体に連通可能な
隔離手段により液密に区切られた複数の分室と、前記複
数の分室の一つに排出部位、他の分室の一つに注入部位
が形成された輸液容器において、前記排出部位を有する
分室には薬液又は固形剤が収容され、注入部位を有する
分室は空室であることを特徴とする輸液容器である。 ２）熱可塑性樹脂製フィルムからなる袋体に連通可能な
隔離手段により液密に区切られた二つの分室のうちの第
１分室に排出部位、第２分室に注入部位が形成された輸
液容器において、前記第１分室に薬液が収容され、第２
分室は空室であり、かつ隔離手段は前記分室のいずれか
一方を外面より押圧して生じる内圧によって解除される
ことを特徴とする輸液容器である。 ３）熱可塑性樹脂製フィルムからなる袋体に連通可能な
隔離手段により液密に区切られた三つの分室の第１分室
に排出部位、第２分室に固着端部及び第３分室に注入部
位が形成された輸液容器において、前記第１分室及び第
２分室には薬液又は固形剤が収容され、第３分室は空室
であり、かつ隔離手段は前記分室のいずれかを外面より
押圧して生じる内圧によって解除されることを特徴とす
る輸液容器。 ４）前記隔離手段が、熱可塑性樹脂製フィルムからなる
袋体の内壁同士を加熱、押圧して形成された熱シールで
あることを特徴とする輸液容器である。 ５）前記分室にはｐＨが３.０〜６.０に維持され、安定
剤として亜硫酸塩を含有する輸液が収容されていること
を特徴とする輸液容器である。That is, the present invention has solved the above-mentioned problems by providing empty containers in these existing containers and providing the following infusion containers. 1) A plurality of compartments separated in a liquid-tight manner by an isolating means capable of communicating with a bag made of a thermoplastic resin film, a discharge site in one of the plurality of compartments, and an injection site in one of the other compartments. In the formed infusion container, a liquid medicine or a solid agent is stored in the compartment having the discharge portion, and the compartment having the injection portion is empty. 2) In an infusion container in which a discharge section is formed in a first compartment and an injection section is formed in a second compartment of two compartments liquid-tightly separated by an isolating means that can communicate with a bag made of a thermoplastic resin film. A chemical solution is contained in the first compartment;
The compartment is an empty room, and the isolation means is released by an internal pressure generated by pressing one of the compartments from the outer surface. 3) A discharge section is provided in the first compartment of the three compartments which are liquid-tightly separated by a separating means capable of communicating with a bag made of a thermoplastic resin film, a fixed end portion is provided in the second compartment, and an injection portion is provided in the third compartment. In the formed infusion container, the first compartment and the second compartment contain a drug solution or a solid agent, the third compartment is empty, and the separating means is formed by pressing one of the compartments from the outer surface. An infusion container that is released by internal pressure. 4) The infusion container, wherein the isolation means is a heat seal formed by heating and pressing inner walls of a bag made of a thermoplastic resin film. 5) An infusion container characterized in that the compartment has a pH maintained at 3.0 to 6.0 and contains an infusion containing a sulfite as a stabilizer.
【０００５】前記隔離手段１は熱シールが施されてい
る。熱シール強度の調整は、特に限定しないが、シール
温度、シール時間及びシール圧力の変化によって、また
熱シール部分の幅や深さなどにより調整することができ
る。更に、隔離手段は特に限定する必要はなく、熱可塑
性樹脂製フィルムからなる袋体の内壁同士を加熱、押圧
して形成された熱シールや、袋体の外面から挟むシール
バー、隔離部に形成されるクリックチップなどが挙げら
れる。[0005] The isolation means 1 is heat-sealed. Although the adjustment of the heat sealing strength is not particularly limited, it can be adjusted by changing the sealing temperature, the sealing time and the sealing pressure, or by the width and depth of the heat sealing portion. Further, there is no particular limitation on the isolation means, and a heat seal formed by heating and pressing the inner walls of the bag made of a thermoplastic resin film, a seal bar sandwiched from the outer surface of the bag, and an isolation portion are formed. Click tip and the like.
【０００６】また、輸液容器における隔離手段１の熱シ
ールの形成方法としては、特に限定されず、通常使用さ
れている熱シールバー等を用いて行うことができる。ま
た、オートクレーブ滅菌等の熱滅菌時に隔離手段１の部
位を外側から狭持体で保持したまま高圧蒸気滅菌し、そ
の際に生じる樹脂のブロッキングによってシールする方
法を用いても良い。[0006] The method of forming the heat seal of the isolation means 1 in the infusion container is not particularly limited, and it can be performed by using a generally used heat seal bar or the like. Alternatively, a method may be used in which high-pressure steam sterilization is performed while holding the portion of the isolation means 1 from the outside with a holding body during heat sterilization such as autoclave sterilization, and sealing is performed by blocking the resin generated at that time.
【０００７】本発明において隔離手段の強度の実測値
は、通常の人が平面上にのせて上から手の平で押圧して
解除できる範囲であれば特に限定されない。例を挙げる
と、隔離手段を１０〜９０ｇ／cm2、好ましくは２０〜
６０ｇ／cm2の内圧を加えることにより解除されるよう
設定する。In the present invention, the actual measured value of the strength of the isolation means is not particularly limited as long as it can be released by a normal person placed on a flat surface and pressed by the palm of the hand from above. For example, the isolation means may be 10 to 90 g / cm 2 , preferably 20 to 90 g / cm 2 .
It is set to be released by applying an internal pressure of 60 g / cm 2 .
【０００８】また、分室の数は二室に限らず、三室又は
それ以上の分室が形成されていてもよい。そして、複数
の分室の一つに排出部位、他の分室の一つに注入部位が
設けられる。特に、注入部位側の分室を空室とするのが
好ましい。The number of compartments is not limited to two, but three or more compartments may be formed. A discharge site is provided in one of the plurality of compartments, and an injection site is provided in one of the other compartments. In particular, it is preferable to make the compartment on the injection site side empty.
【０００９】更に、三室又はそれ以上の分室が形成され
ている場合、それぞれの分室を開通させるための隔離手
段の強度を変化させることもできる。Further, when three or more compartments are formed, the strength of the isolation means for opening each compartment can be changed.
【００１０】また、一端には排出部位として固着シール
部６に挟まれるようにして排出管２が設けられ、他端に
は注入部位として固着シール部７に挟まれるようにして
排出管２より細径の注入管４が設けられ、各々栓体３、
栓体５によって封止されている。また、必要により吊り
下げるための穴１０が設けられる。A discharge pipe 2 is provided at one end so as to be sandwiched by the fixed seal portion 6 as a discharge portion, and the other end is narrower than the discharge tube 2 by being sandwiched by a fixed seal portion 7 as an injection portion. Injection tubes 4 of a diameter are provided, each of which has a plug 3,
It is sealed by the plug 5. In addition, a hole 10 for hanging is provided as needed.
【００１１】本発明の輸液容器に用いられる熱可塑性樹
脂製フィルムは、直鎖状低密度ポリエチレンからなり、
チューブ状樹脂のシートはインフレーション成形により
形成されたものであるが、インフレーション成形物であ
る必要はなく、押し出し成形物、真空成形物、射出成形
物、ブロー成形物等でも良い。[0011] The thermoplastic resin film used for the infusion container of the present invention is made of linear low-density polyethylene,
The tubular resin sheet is formed by inflation molding, but need not be an inflation molded product, and may be an extruded molded product, a vacuum molded product, an injection molded product, a blow molded product, or the like.
【００１２】本発明における熱可塑性樹脂としては、特
に限定する必要はなく、ポリエチレン、ポリプロピレ
ン、ポリ塩化ビニル、エチレン−酢酸ビニル共重合体、
ポリアミド、ポリビニリデンクロライド、ポリビニルフ
ルオライド、ポリトリフルオルクロルエチレン、ポリエ
チレンテレフタレート、ポリエステル、ポリオレフィン
系樹脂およびこれらの混合物や積層体が挙げられる。本
発明の輸液容器は衛生面、安全面を考慮して製造後、高
圧蒸気滅菌等の熱滅菌や、高周波滅菌などの滅菌処理を
することが好ましく、それらに耐えられる材質が良い。The thermoplastic resin in the present invention is not particularly limited, and may be polyethylene, polypropylene, polyvinyl chloride, ethylene-vinyl acetate copolymer,
Examples include polyamide, polyvinylidene chloride, polyvinyl fluoride, polytrifluorochloroethylene, polyethylene terephthalate, polyester, polyolefin-based resins, and mixtures and laminates thereof. The infusion container of the present invention is preferably subjected to heat sterilization such as high-pressure steam sterilization or sterilization treatment such as high-frequency sterilization after production in consideration of hygiene and safety, and is preferably made of a material that can withstand them.
【００１３】本発明の輸液容器の空室には、予め、医師
又は看護婦が輸液と同時に投与したい薬剤を入れておく
ことができる。これにより、１）添加したい薬剤入りの
ダブルバックを簡単に調製できる（薬剤ごとに組み合わ
せたダブルバッグを購入しないで病院で多種類の薬剤と
の組み合わせが可能である。２）バッグに入っている薬
液に薬剤を添加すると安定性に問題が生じる時、予めナ
ースセンターで調製し、使用直前に混合することができ
る。３）病室では隔離手段を解除することより簡単に混
合でき、医療現場の合理化に役立つ。４）在宅医療にも
有用である。In the empty space of the infusion container of the present invention, a medicine which a doctor or a nurse wishes to administer simultaneously with the infusion can be previously stored. Thus, 1) a double bag containing a medicine to be added can be easily prepared (a combination with various kinds of medicines is possible at a hospital without purchasing a double bag combined with each medicine. 2) It is contained in a bag. When a problem occurs in stability when a drug is added to a drug solution, it can be prepared in a nurse center in advance and mixed immediately before use. 3) In the hospital room, mixing can be performed more easily by releasing the isolation means, which contributes to rationalization of medical practice. 4) It is also useful for home care.
【００１４】従って、本発明の輸液容器を用いることに
より、電解質輸液、アミノ酸輸液、高カロリー輸液及び
経腸栄養剤などの薬液に他の薬剤を混合して在宅医療に
適用する場合でも、簡便な操作で混合でき、薬剤が分解
することなく安全に投与することができる。Therefore, the use of the infusion container of the present invention makes it easy to use the infusion solution at home even when other drugs are mixed with drug solutions such as electrolyte infusion, amino acid infusion, high calorie infusion and enteral nutrition. It can be mixed by operation and can be administered safely without decomposition of the drug.
【００１５】[0015]
【発明の実施の形態】本発明の輸液容器について、以下
の図面を参照しながら詳述するが、何らこれらに限定さ
れるものではない。図１は本発明の輸液容器の第一実施
例の正面図である。輸液容器の端部６、７は、完全に固
着シールされ、袋体のシート内壁同士の熱シールにより
形成された可能な隔離手段１により、第１分室８、第２
分室９が形成され、第１分室８には排出管２が設けら
れ、第２分室９には注入管４が設けられている。分室８
には薬液が無菌状態で封入され、分室９は空室となって
いる。BEST MODE FOR CARRYING OUT THE INVENTION The infusion container of the present invention will be described in detail with reference to the following drawings, but is not limited thereto. FIG. 1 is a front view of a first embodiment of the infusion container of the present invention. The ends 6, 7 of the infusion container are completely tightly sealed and sealed by a possible isolation means 1 formed by heat sealing between the inner sheet walls of the bag, so that the first compartment 8, 8
A compartment 9 is formed. The first compartment 8 is provided with the discharge pipe 2, and the second compartment 9 is provided with the injection pipe 4. Branch 8
Is filled with a medicinal solution in an aseptic condition, and the compartment 9 is empty.
【００１６】図２は本発明の輸液容器の第二実施例の正
面図である。輸液容器の端部６、７は、完全に固着シー
ルされ、袋体のシート内壁同士の熱シールにより形成さ
れた可能な隔離手段１により、第１分室８、第２分室９
及び第３分室１１が形成され、第１分室８には排出管２
が設けられ、第３分室１１には注入管４が設けられ、第
２分室９の側部には薬剤充填後、固着端部が形成され
る。分室８、９には薬液が無菌状態で封入され、分室１
１は空室となっている。FIG. 2 is a front view of a second embodiment of the infusion container of the present invention. The ends 6, 7 of the infusion container are completely firmly sealed and sealed, and the first and second compartments 8, 9 are provided by a possible isolation means 1 formed by heat sealing between the inner sheets of the bag.
And a third compartment 11, and the first compartment 8 has a discharge pipe 2.
An injection tube 4 is provided in the third compartment 11, and a fixed end is formed on the side of the second compartment 9 after filling the medicine. Chemicals are aseptically sealed in compartments 8 and 9 and compartment 1
1 is vacant.
【００１７】図３は本発明の輸液容器の第三実施例の正
面図である。輸液容器の端部６、７は、完全に固着シー
ルされ、袋体のシート内壁同士の熱シールにより形成さ
れた可能な隔離手段１により、第１分室８、第２分室９
及び第３分室１１が形成され、第１分室８には排出管２
が設けられ、第３分室１１には注入管４が設けられ、第
２分室９の側部には薬剤充填後、固着端部が形成され
る。分室８には薬液が、分室９には粉末剤が無菌状態で
封入され、分室１１は空室となっている。FIG. 3 is a front view of a third embodiment of the infusion container of the present invention. The ends 6, 7 of the infusion container are completely firmly sealed and sealed, and the first and second compartments 8, 9 are provided by a possible isolation means 1 formed by heat sealing between the inner sheets of the bag.
And a third compartment 11, and the first compartment 8 has a discharge pipe 2.
An injection tube 4 is provided in the third compartment 11, and a fixed end is formed on the side of the second compartment 9 after filling the medicine. A chemical solution is filled in the compartment 8 and a powder is filled in the compartment 9 in an aseptic state, and the compartment 11 is empty.
【００１８】図４は本発明の輸液容器の第四実施例の正
面図である。輸液容器の端部６、７は、完全に固着シー
ルされた袋体から構成されている。さらに前記袋体の適
当な位置でシールバー１２により袋体の両側から挟んで
閉鎖され、第１分室８、第２分室９が形成され、第１分
室８には排出管２が設けられ、第２分室９には注入管４
が設けられている。分室８には薬液が無菌状態で封入さ
れ、分室９は空室となっている。FIG. 4 is a front view of a fourth embodiment of the infusion container of the present invention. The ends 6, 7 of the infusion container consist of a completely fixedly sealed bag. Further, at an appropriate position of the bag, the bag is closed by being sandwiched from both sides of the bag by a seal bar 12, a first compartment 8 and a second compartment 9 are formed, and the first compartment 8 is provided with a discharge pipe 2, Injection tube 4 in 2 compartment 9
Is provided. The compartment 8 is filled with a medicinal solution under aseptic conditions, and the compartment 9 is empty.
【００１９】図５は本発明の輸液容器の第五実施例の正
面図である。輸液容器の端部６、７は、完全に固着シー
ルされた袋体から構成されている。さらに前記袋体の適
当な位置でクリックチップが内壁に挟まれるように液密
に取り付けられ、第１分室８、第２分室９が形成され、
第１分室８には排出管２が設けられ、第２分室９には注
入管４が設けられている。分室８には薬液が無菌状態で
封入され、分室９は空室となっている。FIG. 5 is a front view of a fifth embodiment of the infusion container of the present invention. The ends 6, 7 of the infusion container consist of a completely fixedly sealed bag. Further, the click tip is mounted in a liquid-tight manner so that the click tip is sandwiched between the inner walls at an appropriate position of the bag body, and a first compartment 8 and a second compartment 9 are formed.
The first compartment 8 is provided with the discharge pipe 2, and the second compartment 9 is provided with the injection pipe 4. The compartment 8 is filled with a medicinal solution under aseptic conditions, and the compartment 9 is empty.
【００２０】次に、本発明の輸液容器の使用方法につい
て説明する。使用方法１として隔離手段に熱シールが施
されている二室容器の場合、栓体５より注射器等を用い
て第２分室９に必要に応じてビタミン剤や抗生物質等の
薬剤を無菌的に注入する。ついで、使用直前に分室のい
ずれか一つ、好ましくは排出部位から近いほうの分室の
外面を手で押圧することにより生じる分室内の内圧によ
って隔離手段１の熱シールを剥離させ、第１分室８内の
薬液と第２分室９内の薬剤とを混合する。その後、栓体
３より瓶針等を差し込み混合液を排出させる。Next, a method for using the infusion container of the present invention will be described. In the case of a two-chamber container in which the isolation means is heat-sealed as the method of use 1, as needed, a drug such as a vitamin or an antibiotic is aseptically injected into the second compartment 9 using a syringe or the like from the stopper 5. inject. Then, immediately before use, the heat seal of the isolating means 1 is peeled off by the internal pressure generated by manually pressing one of the compartments, preferably the outer surface of the compartment closer to the discharge site, and the first compartment 8 And the drug solution in the second compartment 9 are mixed. Thereafter, a bottle needle or the like is inserted from the stopper 3 to discharge the mixture.
【００２１】使用方法２として隔離手段に熱シールが施
されている三室容器の場合、栓体５より注射器等を用い
て第３分室１１に必要に応じてビタミン剤や抗生物質等
の薬剤を無菌的に注入する。ついで、使用直前に分室の
いずれかを、好ましくは排出部位から近いほうの分室の
外面を手で押圧することにより、それにより生じる分室
内の内圧によって隔離手段１の熱シールを同時もしくは
連鎖的に剥離させ、第１分室８、第２分室９内の薬液及
び第３分室１１内の薬剤とを混合する。その後、栓体３
より瓶針等を差し込み混合液を排出させる。In the case of a three-compartment container in which the isolation means is heat-sealed as the method of use 2, a syringe such as a syringe is used from the stopper 5 to sterilize the third compartment 11 with a drug such as a vitamin or antibiotic as necessary. Injection. Then, immediately before use, one of the compartments is pressed, preferably by hand against the outer surface of the compartment closer to the discharge site, whereby the internal pressure in the compartment causes the heat seal of the isolating means 1 to be simultaneous or chained. The exfoliation is performed, and the drug solution in the first compartment 8 and the second compartment 9 and the drug in the third compartment 11 are mixed. Then, plug 3
A bottle needle is inserted and the mixture is discharged.
【００２２】使用方法３として隔離手段にシールバー方
式が用いられている場合、栓体５より注射器等を用いて
第２分室９に必要に応じてビタミン剤や抗生物質等の薬
剤を無菌的に注入する。ついで、使用直前にシールバー
１２を解除することにより第１分室８と第２分室９を連
通させ、混合する。その後、栓体３より瓶針等を差し込
み混合液を排出させる。When the seal bar method is used as the isolation means as the method of use 3, if necessary, a medicine such as a vitamin or an antibiotic is aseptically injected into the second compartment 9 using a syringe or the like from the stopper 5. inject. Then, the first and second compartments 8 and 9 are communicated by releasing the seal bar 12 immediately before use, and mixing is performed. Thereafter, a bottle needle or the like is inserted from the stopper 3 to discharge the mixture.
【００２３】使用方法４として隔離手段にクリックチッ
プが用いられている場合、栓体５より注射器等を用いて
第２分室９に必要に応じてビタミン剤や抗生物質等の薬
剤を無菌的に注入する。ついで、クリックチップの閉止
端の先端を折り取ることにより、開放型とし、第１分室
８と第２分室９を連通させ、混合する。その後、栓体３
より瓶針等を差し込み混合液を排出させる。When a click tip is used as the isolation means as the method of use 4, as needed, aseptically inject drugs such as vitamins and antibiotics into the second compartment 9 from the stopper 5 using a syringe or the like. I do. Then, the tip of the closed end of the click tip is cut off to make it open, and the first compartment 8 and the second compartment 9 are communicated and mixed. Then, plug 3
A bottle needle is inserted and the mixture is discharged.
【００２４】なお、特に上述した使用方法に限定され
ず、瓶針等は隔離手段を解除する前に、予め栓体３に刺
し込んでおいても良い。また、吊り下げるための穴１０
を介して吊り下げることにより効率よく投与が可能とな
る。It is to be noted that the method of use is not particularly limited to the above, and the bottle needle or the like may be pierced into the stopper 3 before releasing the isolation means. Also, a hole 10 for hanging
The drug can be efficiently administered by suspending the drug through the vial.
【００２５】分室８又は９に収容する薬液としては、特
に限定しないが、重炭酸塩、グルコース、アミノ酸、ペ
プチド、脂肪、有機酸等を配合した輸液又はそれらの粉
末剤が挙げられる。また通常、注入部位側の分室が空室
とされ、必要に応じてビタミン類、抗生物質等の薬剤が
注入される。The chemical solution contained in the compartment 8 or 9 is not particularly limited, and examples thereof include infusion solutions containing bicarbonate, glucose, amino acids, peptides, fats, organic acids and the like, and powders thereof. Usually, the compartment on the injection site side is vacant, and drugs such as vitamins and antibiotics are injected as needed.
【００２６】本発明の輸液容器は、以下の方法により製
造される。なお、これらの製造方法に限定する必要はな
い。The infusion container of the present invention is manufactured by the following method. It is not necessary to limit to these manufacturing methods.
【００２７】[0027]
【実施例】本発明の輸液容器は、インフレーション成形
して作製したチューブ状のシートを所定の大きさに裁断
し、その両端部に熱溶着により完全な固着シール部の形
成と同時に排出管、注入管が設けられる。その容器の所
定位置には袋体の外側から連通可能な隔離手段１が形成
される。そして、隔離手段により容器に複数の分室が形
成される。DESCRIPTION OF THE PREFERRED EMBODIMENTS The infusion container of the present invention is obtained by cutting a tubular sheet produced by inflation molding into a predetermined size, and simultaneously forming a completely fixed sealing portion by heat welding at both ends thereof, and simultaneously discharging and filling the tube. A tube is provided. Isolation means 1 is formed at a predetermined position of the container so as to communicate with the outside of the bag. Then, a plurality of compartments are formed in the container by the isolation means.
【００２８】第一実施例は、上記のようにして作製した
容器の第１分室８には排出管２よりアミノ酸輸液が充填
され、排出管２が栓体３で封止される。第２分室９は空
室とし、注入部位４を栓体５で封止される。日本薬局方
の蒸気滅菌の基準に基づいて、オートクレーブ滅菌処理
が１０５〜１３０℃の範囲で行われた。In the first embodiment, the first compartment 8 of the container prepared as described above is filled with an amino acid infusion from the discharge pipe 2, and the discharge pipe 2 is sealed with the stopper 3. The second compartment 9 is empty, and the injection site 4 is sealed with the plug 5. Autoclave sterilization was performed in the range of 105 to 130 ° C based on the steam sterilization standard of the Japanese Pharmacopoeia.
【００２９】第二実施例は、上記のようにして作製した
容器の第１分室８には排出管２より糖質輸液が充填さ
れ、排出管２が栓体３で封止される。次に第２分室９の
側部には薬剤充填用の開口部が形成され、かかる開口部
からアミノ酸輸液が充填された後、開口部が熱溶着シー
ル密封され、固着端部１７が形成される。第３分室１１
は空室とし、注入管４を栓体５で封止される。日本薬局
方の蒸気滅菌の基準に基づいて、オートクレーブ滅菌処
理が１０５〜１３０℃の範囲で行われた。In the second embodiment, the first compartment 8 of the container prepared as described above is filled with the saccharide infusion from the discharge pipe 2, and the discharge pipe 2 is sealed with the stopper 3. Next, an opening for filling the medicine is formed on the side of the second compartment 9. After the opening is filled with the amino acid infusion solution, the opening is sealed by heat sealing to form the fixed end 17. . Third branch 11
Is an empty room, and the injection tube 4 is sealed with a stopper 5. Autoclave sterilization was performed in the range of 105 to 130 ° C based on the steam sterilization standard of the Japanese Pharmacopoeia.
【００３０】第三実施例は、上記のようにして作製した
容器の第１分室８には排出管２より糖質輸液が充填さ
れ、排出管２は栓体３で封止される。第３分室１１は空
室とされ、注入管４は栓体５で封止される。次に日本薬
局方の蒸気滅菌の基準に基づいて、オートクレーブ滅菌
処理が１０５〜１３０℃の範囲で行われた。次に第２分
室９の側部には薬剤充填用の開口部が形成され、かかる
開口部から炭酸水素ナトリウムが充填された後、開口部
が熱溶着シール密封され、固着端部１７が形成される。
そして、第２分室が電子線照射滅菌される。In the third embodiment, the first compartment 8 of the container prepared as described above is filled with a carbohydrate infusion from the discharge tube 2, and the discharge tube 2 is sealed with the stopper 3. The third compartment 11 is made empty, and the injection tube 4 is sealed with the stopper 5. Next, autoclave sterilization was performed in the range of 105 to 130 ° C. based on the steam sterilization standard of the Japanese Pharmacopoeia. Next, an opening for filling the medicine is formed on the side of the second compartment 9, and after the opening is filled with sodium bicarbonate, the opening is heat-sealed and sealed to form the fixed end 17. You.
Then, the second compartment is sterilized by electron beam irradiation.
【００３１】第四実施例は、上記のようにして作製した
容器の所定胴部にシールバーを用いた隔離手段により、
分室を形成した後、排出管２よりアミノ酸輸液を第１分
室８に充填し、排出管２が栓体３で封止される。第２分
室９は空室とし、注入管が栓体５で封止される。日本薬
局方の蒸気滅菌の基準に基づいて、オートクレーブ滅菌
処理が１０５〜１３０℃の範囲で行われた。In the fourth embodiment, the container manufactured as described above is provided with a separating means using a seal bar at a predetermined body portion.
After forming the compartment, the amino acid infusion is filled into the first compartment 8 through the discharge pipe 2, and the discharge pipe 2 is sealed with the stopper 3. The second compartment 9 is empty, and the injection tube is sealed with the stopper 5. Autoclave sterilization was performed in the range of 105 to 130 ° C based on the steam sterilization standard of the Japanese Pharmacopoeia.
【００３２】第五実施例は、上記のようにして作製した
容器の所定胴部にクリックチップを用いた隔離手段によ
り、分室を形成した後、排出管２よりアミノ酸輸液を第
１分室８に充填し、排出管２が栓体３で封止される。第
２分室９は空室とし、注入管が栓体５で封止される。日
本薬局方の蒸気滅菌の基準に基づいて、オートクレーブ
滅菌処理が１０５〜１３０℃の範囲で行われた。In the fifth embodiment, the first compartment 8 is filled with the amino acid transfusion from the discharge pipe 2 after the compartment is formed in the predetermined body of the container prepared as described above by the isolation means using the click tip. Then, the discharge pipe 2 is sealed with the stopper 3. The second compartment 9 is empty, and the injection tube is sealed with the stopper 5. Autoclave sterilization was performed in the range of 105 to 130 ° C based on the steam sterilization standard of the Japanese Pharmacopoeia.
【００３３】[0033]
【発明の効果】本発明の輸液容器は、電解質輸液、アミ
ノ酸輸液、高カロリー輸液及び経腸栄養剤等の薬液にビ
タミン類や抗生物質などの薬剤を用時混合して使用する
ことができるので、在宅医療患者に適用するまで薬剤の
分解する虞がない。The infusion container of the present invention can be used by mixing medicines such as vitamins and antibiotics with medicines such as electrolyte infusion, amino acid infusion, high calorie infusion and enteral nutrition at the time of use. There is no fear that the drug will be decomposed until applied to home medical patients.
【図１】本発明の輸液容器の第一実施例の正面図であ
る。FIG. 1 is a front view of a first embodiment of an infusion container according to the present invention.
【図２】本発明の輸液容器の第二実施例の正面図であ
る。FIG. 2 is a front view of a second embodiment of the infusion container of the present invention.
【図３】本発明の輸液容器の第三実施例の正面図であ
る。FIG. 3 is a front view of a third embodiment of the infusion container of the present invention.
【図４】本発明の輸液容器の第四実施例の正面図であ
る。FIG. 4 is a front view of a fourth embodiment of the infusion container of the present invention.
【図５】本発明の輸液容器の第五実施例の正面図であ
る。FIG. 5 is a front view of a fifth embodiment of the infusion container of the present invention.
１：隔離手段 ２：排出部位 ３、５：栓体 ４：注入部位 ６、７：固着シール部 ８：第一分室 ９：第二分室 １０：吊り下げるための穴 １１：第三分室 １２：シールバー １３、１４：薬液 １５：固形剤 １６：輸液容器 １７：固着端部 １８：クリックチップ 1: Isolation means 2: Drainage site 3, 5: Plug body 4: Injection site 6, 7: Fixed seal portion 8: First compartment 9: Second compartment 10: Hanging hole 11: Third compartment 12: Seal Bars 13, 14: Chemical solution 15: Solid agent 16: Infusion container 17: Fixed end 18: Click tip
Claims (5)
連通可能な隔離手段により液密に区切られた複数の分室
と、前記複数の分室の一つに排出部位、他の分室の一つ
に注入部位が形成された輸液容器において、前記排出部
位を有する分室には薬液又は固形剤が収容され、注入部
位を有する分室は空室であることを特徴とする輸液容
器。1. A plurality of compartments separated in a liquid-tight manner by an isolation means capable of communicating with a bag made of a thermoplastic resin film, a discharge site in one of the plurality of compartments, and a discharge site in one of the other compartments. An infusion container having an injection site formed therein, wherein the compartment having the discharge site contains a drug solution or a solid agent, and the compartment having the injection site is empty.
連通可能な隔離手段により液密に区切られた二つの分室
の第１分室に排出部位、第２分室に注入部位が形成され
た輸液容器において、前記第１分室に薬液が収容され、
第２分室は空室であり、かつ隔離手段は前記分室のいず
れか一方を外面より押圧して生じる内圧によって解除さ
れることを特徴とする輸液容器。2. An infusion container in which a discharge section is formed in a first compartment and an injection section is formed in a second compartment of two compartments liquid-tightly separated by an isolating means which can communicate with a bag made of a thermoplastic resin film. In the above, a chemical solution is stored in the first compartment,
The infusion container, wherein the second compartment is an empty room, and the isolation means is released by an internal pressure generated by pressing one of the compartments from the outer surface.
連通可能な隔離手段により液密に区切られた三つの分室
の第１分室に排出部位、第２分室に固着端部及び第３分
室に注入部位が形成された輸液容器において、前記第１
分室及び第２分室には薬液又は固形剤が収容され、第３
分室は空室であり、かつ隔離手段は前記分室のいずれか
を外面より押圧して生じる内圧によって解除されること
を特徴とする輸液容器。3. A discharge section in a first compartment of three compartments separated in a liquid-tight manner by an isolation means capable of communicating with a bag made of a thermoplastic resin film, a fixed end portion in a second compartment and a third compartment in a third compartment. The infusion container having an injection site formed therein, wherein the first
The compartment and the second compartment contain a drug solution or a solid agent,
The infusion container, wherein the compartment is an empty room, and the isolation means is released by an internal pressure generated by pressing one of the compartments from the outer surface.
ムからなる袋体の内壁同士を加熱、押圧して形成された
熱シールであることを特徴とする請求項１〜３のいずれ
かに記載の輸液容器。4. The method according to claim 1, wherein the isolation means is a heat seal formed by heating and pressing inner walls of a bag made of a thermoplastic resin film. Infusion container.
され、安定剤として亜硫酸塩を含有する輸液が収容され
ていることを特徴とする請求項１〜４のいずれかに記載
の輸液容器。5. The method according to claim 1, wherein the compartment has a pH maintained at 3.0 to 6.0 and contains an infusion solution containing a sulfite as a stabilizer. An infusion container as described.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10122190A JPH11313871A (en) | 1998-05-01 | 1998-05-01 | Infusion vessel |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10122190A JPH11313871A (en) | 1998-05-01 | 1998-05-01 | Infusion vessel |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008204997A Division JP4944850B2 (en) | 2008-08-08 | 2008-08-08 | Drug pre-preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH11313871A true JPH11313871A (en) | 1999-11-16 |
Family
ID=14829808
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10122190A Pending JPH11313871A (en) | 1998-05-01 | 1998-05-01 | Infusion vessel |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH11313871A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004080369A1 (en) * | 2003-03-10 | 2004-09-23 | Lei Wang | A vacuum soft packaging bag for injection powder and a connector used by the same |
| JP2007007117A (en) * | 2005-06-30 | 2007-01-18 | Ss Pharmaceut Co Ltd | Soft bag for sealing enteral nutrient |
| WO2010110366A1 (en) * | 2009-03-25 | 2010-09-30 | 株式会社モリモト医薬 | Medicinal composition container |
| CN103385799A (en) * | 2012-05-11 | 2013-11-13 | 四川汇利实业有限公司 | Sealing structure on transfusion soft bag |
-
1998
- 1998-05-01 JP JP10122190A patent/JPH11313871A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004080369A1 (en) * | 2003-03-10 | 2004-09-23 | Lei Wang | A vacuum soft packaging bag for injection powder and a connector used by the same |
| JP2007007117A (en) * | 2005-06-30 | 2007-01-18 | Ss Pharmaceut Co Ltd | Soft bag for sealing enteral nutrient |
| WO2010110366A1 (en) * | 2009-03-25 | 2010-09-30 | 株式会社モリモト医薬 | Medicinal composition container |
| CN102438575A (en) * | 2009-03-25 | 2012-05-02 | 株式会社盛本医药 | Medicinal composition container |
| JPWO2010110366A1 (en) * | 2009-03-25 | 2012-10-04 | 株式会社モリモト医薬 | Pharmaceutical composition container |
| CN103385799A (en) * | 2012-05-11 | 2013-11-13 | 四川汇利实业有限公司 | Sealing structure on transfusion soft bag |
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