JP2005137426A - Multi-chamber transfusion container and multi-chamber transfusion container containing medicament - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a multi-chamber transfusion container with a plurality of small chambers, practically capable of productive, easy and speedy mixing. <P>SOLUTION: The multi-chamber transfusion container consists of a first container and a second container with chambers to store medicament. The first and second containers are made of flexible materials and are integrated and divided by a partition member. The partition member comprises a cylinder member for connecting two adjacent containers to communicate with each other, a partition body for dividing the adjacent containers liquid-tightly, and a fracturable thin part in the connection part of the partition body and the cylinder member. The first container has at least two large chambers divided by a partition means to communicate, and the second container has at least two small chambers divided by a separable weak sealing part. The small chambers of the second container include a first small chamber adjacent to the partition member and a second small chamber adjacent to the first small chamber via the weak sealing part. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

  The present invention relates to a multi-chamber infusion container and a multi-chamber infusion container containing a medicine.

Conventionally, resin containers and glass containers have been used to store and store medicines and nutrients.
Infusion solutions such as injections, infusions for intravenous administration, dialysis solutions, eye drops, ophthalmic perfusates, and organ preservation solutions are filled almost liquid-tightly and sterilized or sterilized.
One of these product forms is a kit product, which is marketed. A kit product is a combination of a drug and a medical device or two or more drugs as a single administration system.
Examples of kit products are prefilled disposable injections (prefilled syringe products), two-chamber mixed-type infusions called double bags, such as “PN Twin” (trade name) manufactured by Ajinomoto Pharma.
The kit product has advantages such as reduction of burden during dispensing in a medical institution, prevention of bacterial contamination, prevention of contamination, prevention of errors during dispensing, and quick response in an emergency.

Kit products are available in two or three compartments. To add additional drugs or nutrients such as small-volume antibiotics or vitamins, depending on the patient's condition. In addition, there is often a mixed injection operation in which the mixture is injected into the container and mixed at the time of use.
For example, in high-calorie infusion therapy, micronutrients such as vitamins are mixed in a double bag containing amino acids, carbohydrates, and electrolytes necessary to maintain normal metabolism in the body just before administration to patients. It has been administered parenterally to patients. This mixed injection immediately before administration is because it is not always sufficient as a preparation to add a drug such as vitamins in a double bag in advance.
When mixed injection work is performed, a considerable part of the advantages of previous kit products is lost.
In some cases, the co-infusion operation of a plurality of types of medicines is repeated.

Therefore, an infusion container having three or more drug rooms has been proposed in order to perform infusion safely without performing mixed injection work.
For example, an infusion container having a breakable flow path blocker made of a relatively hard resin and a communicable portion made of a wall structure provided in a partition partitioning a plurality of drug chambers has been proposed (for example, , See Patent Document 1).
Also, a synthetic resin multi-chamber container having a plurality of storage chambers, the periphery of which is sealed, wherein at least some of the plurality of storage chambers are separated from a strong seal portion that cannot be peeled off, and a strong seal portion at a connection portion There has been proposed a multi-chamber container that is liquid-tightly divided by a peelable weak seal portion that is connected to (see, for example, Patent Document 2). In this multi-chamber container, a large number of locations of strong seal portions that cannot be peeled off and weak seal portions that can be peeled are arranged at specific positions.

In addition, as an example in which a third chamber made of a flexible container is provided while substantially maintaining the shape of a conventional double bag made up of two chambers, a chemical solution containing pouch equipped with an easily peelable seal portion is suspended in the chemical solution containing chamber. A chemical solution container with a chemical solution storage pouch has been proposed in which a chemical solution storage pouch is strongly sealed on both wall surfaces that define the chemical solution storage chamber (see, for example, Patent Document 3). The pouch portion is easy to break the bag immediately before use.
In addition, as an example in which a third chamber made of a rigid container is provided while substantially maintaining the shape of a conventional double bag consisting of two chambers, a separation wall that can communicate between the A chamber and the B chamber is provided. Alternatively, the infusion supply section is provided in the B chamber, the C chamber is contained in the infusion supply section, and there is a proposal of a three-chamber infusion container having a communication member that communicates with the A chamber or the B chamber by breaking. (For example, refer to Patent Document 4).

In addition, the possibility of delamination due to unforeseen force is extremely low, the communication cross-sectional area is wide, and it is possible to mix quickly. A large multi-chamber container has been proposed. For example, a hollow part that connects two adjacent containers so as to communicate with each other, and a lid that seals at least one end of the hollow part are formed, and a connection part between the lid and the main body of the partition member includes: A multi-chamber infusion container using a partition member in which a thin portion is formed has been proposed (see, for example, Patent Document 5). Here, a container containing two kinds of medicines in two chambers is disclosed.
JP 2000-5275 (page 7, FIG. 10) JP 2002-160771 A JP 2003-62038 A JP 2000-273035 A JP 2001-87350 A

  In the infusion container described in Patent Document 1, it is possible to open the communication port of the drug chamber by breaking the channel blockage body and the easily breakable wall structure, and the drug can be mixed. , And there is a risk of impeding rapid response in an emergency.

In the multi-chamber container described in Patent Document 2, a large number of places of strong seal portions that cannot be peeled off and weak seal portions that can be peeled are arranged at specific positions. Therefore, in order to make all the weak seals of complicated shape into a multi-chamber container that can be peeled off with the desired opening strength, it is necessary to make the weak seals precisely as designed. Precise manufacturing equipment and manufacturing conditions are required to stably manufacture the container. In addition, since the inner surface of the multi-chamber infusion container body is bonded to each other by a seal portion, the entire container that combines a large chamber with a large capacity and a large thickness and a small chamber with a small capacity and a small thickness is filled with infusion fluid, etc. After that, fine irregularities occur, and if the convex part is pressed during transportation or storage, the weak seal part may be peeled off, and careful handling is required.
Further, the peelable weak seal portion formed longer than the communication opening has a corner portion where stress concentrates when stress is applied from the outside during transfer or storage, and is easily peeled off.
In addition, since the small chamber and the large chamber are liquid-tightly closed by a communication opening made of a weak seal portion that can be peeled off, the communication opening has a peel strength sufficient to withstand the pressure received by the large chamber in the event of an unexpected event. Required by the department.

Moreover, since the container inner surface of the outer container is restrained by the sachet portion of the container described in Patent Document 3, irregularities are generated in the container shape, and stress tends to concentrate on the sachet portion. Complicated container design that takes into account the prevention of bag breakage is required.
The infusion container described in Patent Document 4 uses the same configuration as that of the small-capacity C chamber, and if the number of chambers is further increased, the number of chambers becomes complicated. As the number increases, the number of operations for mixing all the drugs increases.

In the multi-chamber infusion containers of Patent Documents 1 to 4, a peelable weak seal portion is used as a liquid-tight partition that communicates immediately before administration of the infusion solution.
This weak seal part is preferable because it has a wide communication cross-sectional area after peeling and can be quickly mixed, but the filling pressure of the contents in the manufacturing process, the internal pressure generated at a high temperature during sterilization, the external pressure during transportation and storage, etc. It may peel off by unexpected force.
When the number of chambers is increased by using the weak seal portion, the possibility of peeling due to such an unexpected force is further increased.

Patent Document 5 has no description of a multi-chamber container containing three or more chambers containing medicines.
For these reasons, there has been a demand for a multi-chamber infusion container having a plurality of small chambers, which is practically capable of productivity, patency, and quick mixing.
This invention is made | formed in view of this situation, and makes it a subject to provide the multi-chamber infusion container which improved the said subject.

  The present inventors have conducted extensive research on a multi-chamber infusion container that can be rapidly mixed aseptically by a simple operation at the time of use without causing erroneous mixing of the drug until immediately before use, and easy to handle and multi-chamber. As a result, it has been found that the above problems can be solved by a multi-chamber infusion container in which a first container having a large chamber and a second container which is an assembly of small chambers are separated and integrated by a specific communicating partition member. Has been completed.

That is, the present invention relates to the multi-chamber infusion container described below.
1) In a multi-chamber infusion container in which a first container having a chamber for storing a medicine and a second container are integrated, the first container and the second container made of a flexible material are integrated by a partition member and first A multi-chamber infusion container partitioned between the container and the second container,
The partition member includes a cylindrical member that connects two adjacent containers so as to communicate with each other, a partition body that partitions the two adjacent containers in a liquid-tight manner, and a ruptureable thin portion at a connecting portion between the partition body and the cylindrical member. Have
The first container has two or more large chambers partitioned by a partition means capable of communication, and the second container has two or more small chambers partitioned by a peelable weak seal portion, The chamber of the second container includes a first chamber adjacent to the partition member and a second chamber adjacent to the first chamber via the weak seal portion, and the first container is placed under the first container. When the second container is disposed on the side, at least one of the weak seal portions in the second container is a strong seal portion at the lower end of the second container and a strong seal portion at the upper end or the side portion of the second container. A multi-chamber infusion container characterized by being partitioned between the two.

2) In a multi-chamber infusion container in which a first container having a chamber for storing a medicine and a second container are integrated, the first container and the second container made of a flexible material are integrated by a partition member and the first container A multi-chamber infusion container partitioned between the container and the second container,
The partition member includes a cylindrical member that connects two adjacent containers so as to communicate with each other, a partition body that partitions the two adjacent containers in a liquid-tight manner, and a ruptureable thin portion at a connecting portion between the partition body and the cylindrical member. Have
The first container has two or more large chambers partitioned by a partition means capable of communication, and the second container has two or more small chambers partitioned by a peelable weak seal portion, The chamber of the second container includes a first chamber adjacent to the partition member and a second chamber adjacent to the first chamber via the weak seal portion, and the first container is placed under the first container. When the second container is disposed on the side, the weak seal portion is formed so as to connect both side portions of the second container, and is formed between the weak seal portion and the strong seal portion at the upper end of the second container. A multi-chamber infusion container characterized in that a plurality of second small chambers are partitioned by a second strong seal portion extending from a part of the strong seal portion at the upper end.

3) In a multi-chamber infusion container in which a first container having a chamber for storing a medicine and a second container are integrated, the first container and the second container made of a flexible material are integrated by a partition member and the first container A multi-chamber infusion container partitioned between the container and the second container,
The partition member includes a cylindrical member that connects two adjacent containers so as to communicate with each other, a partition body that partitions the two adjacent containers in a liquid-tight manner, and a ruptureable thin portion at a connecting portion between the partition body and the cylindrical member. Have
The first container has two or more large chambers partitioned by a partition means capable of communication, and the second container has two or more small chambers partitioned by a peelable weak seal portion, The second container chamber includes a first chamber adjacent to the partition member, a second chamber adjacent to the first chamber via the weak seal portion, and the second chamber via the weak seal portion. A multi-chamber infusion container comprising a third chamber adjacent to the other chamber.

4) When the first container is disposed on the lower side and the second container is disposed on the upper side, a weak seal is formed so as to tie both ends facing the partition members of the two strong seal portions at the lower end of the second container provided across the partition member. A first small chamber surrounded by the weak seal portion, the two lower end strong seal portions, and the partition member, and the upper end strong seal portion of the second container from each of the lower end strong seal portions on both sides. The multiple chamber according to 3), wherein a weak seal portion is provided so as to connect the two, and a second small chamber is formed by being surrounded by the weak seal portion and the upper end strong seal portion. Infusion container.

5) When the first container is disposed on the lower side and the second container is disposed on the upper side, two weak seal portions are provided so as to connect both side portions of the second container, and at least one of the weak seal portions is 3. The multi-chamber infusion container according to 3) above, which has a bent part having a corner part.

6) In a multi-chamber infusion container in which a first container having a chamber for storing a medicine and a second container are integrated, the first container and the second container made of a flexible material are integrated by a partition member and the first container A multi-chamber infusion container partitioned between the container and the second container,
The partition member includes a cylindrical member that connects two adjacent containers so as to communicate with each other, a partition body that partitions the two adjacent containers in a liquid-tight manner, and a ruptureable thin portion at a connecting portion between the partition body and the cylindrical member. Have
The first container has two or more large chambers partitioned by a communicating partition means, and the small chamber of the second container includes a first small chamber adjacent to the partition member and the weak seal portion. A second chamber adjacent to the first chamber, and when the first container is disposed on the lower side and the second container is disposed on the upper side, the second container has a partition member and the partition member. The outer periphery is formed by a lower end composed of a strong seal portion extending horizontally from both sides of the upper end and an arc-shaped strong seal portion extending from both ends of the lower end, and the weak seal portion in the second container is the second container. A multi-chamber infusion container characterized in that it is formed by partitioning a strong seal portion at the lower end of an arc and a strong arc-shaped seal portion.

7) The first container and the second container are integrated by a partition member and a strong seal portion, and at least one of the strong seal portions is provided with an opening for inserting a finger from the front to the back of the multi-chamber infusion container. The multi-chamber infusion container according to any one of 1) to 6), which is characterized in that

8) All the chambers in the first container and the second container can communicate with each other only by pressing the first container once after the thin-walled portion is broken. The multi-chamber infusion container according to any one of the above.

9) The multi-chamber infusion container according to any one of 1) to 8) above, wherein at least one of the chambers of the second container is shielded from light by a light shielding member.

10) The multi-chamber infusion container according to any one of 1) to 9) above, wherein the innermost layer of the second container is made of a material having low adsorptivity to the fat-soluble vitamin.

11) The multiple chambers according to any one of 1) to 10) above, wherein all weak seal portions of the second container are weak seal portions at the periphery of the first small chamber adjacent to the partition member. Infusion container.

12) The multi-chamber infusion container according to any one of 1) to 11) above, wherein at least one chamber of the second container is a preliminary chamber having an injection port.

13) In the multi-chamber infusion container according to any one of 1) to 12) above, a medicine containing any one or more of sugar, electrolyte, and amino acid is accommodated in the chamber of the first container, and the second container A drug-containing multi-chamber infusion container characterized in that a medicine containing any one or more of water-soluble vitamins, fat-soluble vitamins and trace elements is contained in the chamber.

  In the multi-chamber infusion container of the present invention, the first container and the second container made of a flexible material are integrated by a partition member that can communicate, and the medicine is accommodated in each chamber in each container. Until this is done, there is no risk of leakage or mixing of each drug, and each drug can be easily and quickly mixed immediately before administration.

In the multi-chamber infusion container of the present invention, the large chamber of the first container and the small chamber of the second container are separated by a partition member, and until administration is performed without communication between the large chamber and the small chamber due to accidental force. There is no risk of leakage or mixing of each drug.
In the multi-chamber infusion container of the present invention, the large chamber of the first container and the small chamber of the second container are separated by a partition member, and the small chamber is not affected by the force applied to the large chamber, and is provided with a peelable weak seal portion. Multiple chambers of the second container are easy.

Hereinafter, the present invention will be described in detail.
In the present invention, as shown in FIG. 1, the top, bottom, left and right are defined so that the second container 2 side is up and the first container 1 side is down, the length in the left-right direction is the width, and the length in the top and bottom is the height. explain. The side portions are left and right end portions extending vertically.
The weak seal part does not peel easily during cleaning, dispensing, or sterilization of a multi-chamber infusion container, and in use, pressure is manually applied to the medicine filled in the chamber via the flexible material constituting the container. Thus, the seal portion can be easily peeled and communicated between a plurality of chambers without damaging the container body. The strong seal portion is a seal portion that cannot be peeled off during normal use.

The multi-chamber infusion container Y of the present invention is a multi-chamber infusion container in which a first container 1 and a second container 2 made of a flexible material are integrated by a partition member 4 capable of communicating with each other. A partition member 4 that partitions the two containers 2 is provided.
The first container 1 is provided with two or more large chambers 9 and 9 that can accommodate a larger amount of medicine than the chamber of the second container 2 and a port 7 for discharging and / or injecting the medicine. The second container 2 is provided with two or more small chambers 10 having a smaller capacity than the chamber of the first container 1. Here, the large chamber 9 and the small chamber 10 are sections for explanation in the present invention, and the large chamber 9 means that the volume is larger than that of the small chamber 10, and is a saccharide preparation, a protein amino acid preparation, and a blood substitute. It accommodates a relatively large volume of medicine. The volume of these chambers is not particularly limited, but about 100 mL is the boundary. Each chamber contains a liquid medicine or a powder medicine. In the present invention, the first small chamber refers to a small chamber facing the partition member in the small chamber 10, and the second small chamber refers to a small chamber adjacent to the first small chamber via a weak seal portion. The third chamber is a chamber other than the first chamber adjacent to the second chamber through the weak seal portion.

FIG. 1 shows an example of a multi-chamber infusion container of the present invention.
In FIG. 1A, a synthetic resin film is used as a flexible material, and the periphery of two synthetic resin films is heat-sealed to form a strong seal portion 3, and the first container 1 and the second container 2 are integrated into a bag shape. The container. The first container 1 and the second container 2 are connected and integrated with each other by a partition member 4, a strong seal part 5 at the upper part of the first container, and a strong seal part 6 at the lower part of the second container. A port 7 used for discharging and injecting contents is welded to the lower portion of the first container 1. FIG. 1B is an example in which a cylindrical film obtained by inflation molding or the like is used for both the first container 1 and the second container 2 instead of the two synthetic resin films of FIG. 1A. In FIG. 1B, only the upper and lower portions of the tubular film are heat-sealed to form a strong seal portion 3. Although not shown, only one of the first container and the second container may be a tubular film.

(First container)
The 1st container 1 shown in the lower part of FIG. 1 is an example of the 1st container used for the multi-chamber infusion container Y of this invention. 1A and 1B, the inside of the first container 1 is divided into two large chambers 9 and 9 by a weak seal portion 8 extending horizontally.
As shown in FIG. 5, the port 7 welded to the lower portion of the first container 1 is typically provided with an elastic body 72 such as a rubber stopper through which a hollow needle can be inserted on the upper portion of a cylindrical cylindrical member 71. It is used for discharging and injecting contents. In this port 7, instead of a cylindrical member having a hollow circular cross section, an elliptical shape, a rhombus shape, a boat shape, or a combination thereof can be used, and a flexible tube can be used instead of the hard port 7. Good. As for the material of the port 7, it is preferable to select a material whose outer surface can be welded to the innermost layer of the first container 1.
As another example of the first container according to the present invention, FIG. 2 shows an example in which there are three large chambers instead of the two large chambers 9 and 9 shown in FIG. The chamber of the first container 1 shown in FIGS. 1 and 2 is an assembly of the large chamber 9, and contains a larger volume of content than the small chamber 10 of the second container 2. When a plurality of chambers are provided in the first container 1, the partitioning portion between the large chambers is partitioned by a weak seal portion 8 that extends horizontally, similar to that used in conventional double bags.
In addition, it is preferable to use a weak seal portion as the partition means because rapid mixing is possible after the partition means communicates, but instead of the weak seal portion, the partition member, pipe breakage method, partition used in the present invention can be used. You may employ | adopt partitioning means, such as a jig | tool system. In the pipe breakage method, a breakable tube having a closed end is sandwiched between non-peelable seal portions of a partition portion. Communicate by breaking the tube when in use. In the partitioning jig method, both chambers are partitioned by sandwiching a flexible sheet with a removable partitioning jig such as a clip.

(Second container)
The second container 2 in the present invention is a bag-like container having at least two small chambers 10 having a small capacity as compared with the large chamber 9 of the first container 1. The plurality of small chambers 10 in the second container 2 are weaker than the weak seal portion 8 that partitions the large chambers 9 and 9 communicates with each other because the partitioning portion on the periphery of the chamber is not in contact with the large chamber 9 that is susceptible to unexpected force. It can be set as the weak seal part 11 connected by force. Moreover, for this reason, the freedom degree of a shape increases and it can be set as arbitrary shapes. In addition, the innermost surface of the flexible material that can form the weak seal portion 11 has a characteristic that it can form a weak seal portion having an appropriate peel strength, and is also in direct contact with the contents. It is required to satisfy the required characteristics such as the absence of eluate from the innermost surface of the functional material to the contents, the adsorption of the contents, and the decomposition of the contents. However, since none of the small chambers 10 of the second container 2 of the present invention are in contact with the large chamber 9, the condition of having a physical property capable of forming a weak seal portion having an appropriate peel strength is relaxed, A wider range of materials can be selected. As a result, even a small volume of 10 mL or less can be reliably separated and held in the small chamber 10 until just before use.

Next, some examples of the shape of the second container 2 will be given.
FIG. 3A shows the first small chamber 10a adjacent to the central partition member 4 and the upper end of the upper end opposite to the strong seal portion 6 with the lower end connected to the strong seal portion 6 at the bottom of the second container and extending in the vertical direction. There are two second small chambers 10b, 10b adjacent to the first small chamber 10a via weak seal portions 11, 11 connected to the strong seal portion 3.
Since all the weak seal portions 11 of the second container 2 are weak seal portions on the periphery of the first small chamber 10a in contact with the partition member 4, all of the medicine flowing from the first container 1 after the partition member 4 communicates is weak. The liquid pressure generated by the force applied to the first container 1 in contact with the seal part 11 is easily applied directly to all the weak seal parts 11 of the second container 2 through the drug, and the weak seal parts 11 in the second container, 11 is easy to peel off and communication is easy. The filling and sealing of the medicine can be performed by, for example, providing the upper strong seal portion 3 after filling all the chambers from above.

  FIG. 3B shows that all the sections are formed by weak seal portions 11 and 12, and the weak seal portion 11 extending in the vertical direction and the weak seal portion extending in the width direction and connecting the weak seal portion 11 and the widthwise end of the second container. 12 and has a first small chamber 10a adjacent to the central partition member 4 and two second small chambers 10b and 10b adjacent to the first small chamber 10a via weak seal portions 11 and 12. ing. In FIG. 3B, there is an intersecting portion 10A between weak seal portions. The crossing portion 10A between the weak seal portions tends to be peeled off when a little force is applied even when the stress is concentrated and it is not necessary to mix the chemicals. However, the force for peeling off such a weak seal portion is usually a large amount. Is generated by the stress applied to the large chamber filled with the chemical solution, and the force generated in the first container 1 is blocked by the partition member 4 in the second container 2 in the present invention. The possibility that the force will work is extremely low. Therefore, it is possible to partition the small chambers 10a, 10b, and 10b stably until just before the chemical solution is mixed.

3C and 3D, the second container 2 is divided into three sections by two weak seal portions 11 extending in the vertical direction, and one of the sections is partitioned by the weak seal sections 12 extending in the width direction. This is an example in which a chamber is provided. Also in these cases, each of the small chambers 10 other than the first small chamber 10a adjacent to the central partition member 4 is adjacent to the first small chamber 10a via the weak seal portions 11 and 12, and the second small chamber 10b. It has become.
Although not shown, the sections other than the first small chamber in FIG. 3D may be partitioned by seals extending in the width direction, and a total of five small chambers may be provided.

  In FIG. 3E, a weak seal portion similar to the configuration of FIG. 3A is provided, but the weak seal portion 13 in this example is inclined with respect to the vertical direction, and the first small chamber 10a adjacent to the partition member 4 is downward. It is a symmetrical trapezoidal chamber with a narrower upper part. Since the angle on the first small chamber 10a side of the intersecting portion 18 of the strong seal portion 6 and the weak seal portion 13 at the lower portion of the second container is an acute angle, when hydraulic pressure is applied from the first small chamber 10a, FIG. It is easier to peel off than the weak seal portion 11 of the second container. Therefore, even when the weak seal portion 13 in the second container is not partially peeled, at least the intersection 18 is peeled off. Since the intersection 18 is located at the lowermost part of the second container 2, the medicine in the second container 2 can surely flow into the first container 1.

FIG. 3F shows that the height of the strong seal portion 6 ′ at the lower part of the second container 2 is provided below the second container 2 so that the center side is lower than the side surface side, and the center of the strong seal portion 6 ′ is low. A partition member 4 is provided at the position. Accordingly, there is an effect that the mixed medicine after mixing the medicines in the first container 1 and the second container 2 is discharged from the discharge port (partition member 4) at the lower part of the first container 1 without remaining.
FIG. 3G is an example combining the ideas of FIG. 3E and FIG. 3F. That is, the height of the strong seal portion 6 ′ at the lower portion of the second container 2 is provided below the second container 2 so that the center portion side is lower than the side surface side, and the lower position at the center of the strong seal portion 6 ′. The partition member 4 is provided, the weak seal portion 13 is inclined with respect to the vertical direction, and the first small chamber 10a in contact with the partition member 4 has a symmetrical shape in which the upper width is narrowed from below. It has become.

  3H and 3I are examples in which the position of the partition member that partitions the first container 1 and the second container 2 so as to communicate with each other is provided on the left small chamber 10a side. In the example of FIG. 3H, the partition member 4 is substantially in the center, and the left small chamber 10a is larger than the right small chamber 10b. As described above, the size of the small chamber 10 can be appropriately set according to the amount of the chemical solution injected into the second container 2. As shown in FIG. 3I, the partition member 4 does not necessarily have to be positioned at the center in the width direction, and the position of the partition member can be selected as appropriate.

  FIG. 3J shows an example in which a chamber is formed by partitioning a strong seal portion and a weak seal portion. The partition member 4 is provided up to a position where the weak seal portion 12 in the width direction extending over the entire width of the second container 2 and the second strong seal portion 14 extending from the strong seal portion 3 at the upper end in the vertical direction abut against the weak seal portion 12. This is an example having a first small chamber 10a adjacent to the first small chamber 10a and a second small chamber 10b adjacent to the first small chamber 10a via a weak seal portion. The two second small chambers 10 b are partitioned by the second strong seal portion 14. In this example, there is one weak seal portion 12 that is more difficult to manufacture than the strong seal portion, and it is possible to maintain a high yield in production. In FIG. 3J, there is one second strong seal portion 14 extending from the upper end. However, a plurality of second strong seal portions 14 may be provided, and three or more small chambers 10b contacting the upper end portion may be provided. If it is the 2nd container in this invention, even if the number of the above 2nd strong seal parts 14 increases, the ease to complete mixing does not change.

In FIG. 3K, the end of the partition member 4 on the second container side is made lower than the end of the strong seal portion 6 'on the second container side, and the two strong seal portions 6 at the lower end of the second container provided with the partition member interposed therebetween. A weak seal portion 15 is provided so as to connect both ends of the partition members 4 'and 6' facing each other, and the first seal chamber surrounded by the weak seal portion 15 and the strong seal portions 6 'and 6' and the partition member 4 is provided. 10a is formed.
In addition, weak seal portions 13 and 13 extending obliquely from the strong seal portions 6 'and 6' on both sides across the partition member 4 to the strong seal portion 3 on the upper side of the second container are provided. A second small chamber 10b is formed by being surrounded by the two weak seal portions 13, 13, 15 and the upper end strong seal portion 3 facing the strong seal portions 6 ', 6'. The second small chamber 10b is adjacent to the first small chamber 10a via a weak seal portion 15. A third small chamber 10c adjacent to the second small chamber is provided on both sides of the second small chamber 10b, and a total of four small chambers are provided in the second container 2. Since the first small chamber 10a has a very small volume, the weak seal portion 15 between the first small chamber 10a and the second small chamber 10b is easily peeled off after the thin portion of the partition member is broken. By pressing the first container once in substantially the same manner as shown in 3E, all the chambers in the first container 1 and the second container 2 can be reliably communicated.

  In FIG. 3L, all the chambers are formed by partitioning with weak seal portions, two weak seal portions 12, 16 extending in the width direction with the full width of the second container 2 are provided, and the first adjacent to the partition member 4 is provided. It has a small chamber 10a, 10b adjacent to the first small chamber 10a via the weak seal portion 12, and a third small chamber 10c adjacent to the second small chamber 10b via the weak seal portion 16. Further, the upper weak seal portion 16 has a bent portion 17 having a corner portion at a part thereof, and is easily peeled off from the lower weak seal portion 12. In addition, although not shown, if the weak seal portion spreading in the width direction is sealed so as to be inclined so that the central portion is low and the side portion is high, the drug is not peeled even if the weak seal portion does not peel over the entire width. This is preferable because it flows into the first container without staying inside the second container. The filling and sealing of the medicine can be performed by forming the upper strong seal portion 3 and then strongly filling the side portions after filling the chambers with the medicine from all the sides.

  In FIG. 3M, the partition member 4 is arranged close to one side, and the inside of the second container is divided into three by two weak seal portions 11 and 11 ′ extending in the vertical direction and adjacent to the partition member 4. This is an example in which a first small chamber 10a, 10b adjacent to the first small chamber 10a via the weak seal portion 11 and a third small chamber 10c adjacent to the second small chamber 10b via the weak seal portion 11 ′ are provided. .

3N shows a partition member provided at the center of the second container lower end strong seal portion, and a weak seal extending obliquely upward from the strong seal portions at both ends of the partition member and connected to the strong seal portion on the second container side portion. A first small chamber adjacent to the partition member 4 is provided between the weak seal portion and the strong seal portion at the upper end of the second container, and the first small chamber 10a is interposed via the weak seal portion 19. This is an example in which a second small chamber 10b adjacent to is provided.
FIG. 3O is an example in which a strong seal portion having a convex arc shape is provided in place of the strong seal portions at the upper end portion and both side portions of the second container, and is provided at the central portion of the second container lower end strong seal portion. The partition member and the weak seal portions 20 and 20 extending obliquely upward from the strong seal portions at both ends of the partition member and connected to the arc-shaped strong seal portion are provided. Thereby, the first small chamber 10a adjacent to the partition member 4 in the center of the second container, and the second small chamber adjacent to the first small chamber 10a via the weak seal portion 20, Those skilled in the art can easily make various changes based on the above-described example.

3A, 3G, and 3K, the acute angle portion 18 of the strong seal portion and the weak seal portion, and the bent portion 17 having the corner portion of the weak seal portion as shown in FIG. When the internal pressure in the interior increases, it becomes the part that peels first.
The multi-chamber multi-chamber container that combines a small chamber and a large chamber divided only by the weak seal portion seen in the conventional example is in contact with the large chamber and the small chamber through the weak seal portion, and there is an unexpected force applied to the large chamber. Since it is added to the weak seal portion, it is difficult to stably separate the large chamber and the small chamber before mixing. Therefore, the stress concentration portion as described above is usually designed to be avoided for stable separation and storage until it is used. However, the multi-chamber infusion container of the present invention has a large-capacity chamber and a small-capacity chamber. Since it is completely partitioned by the partition member, the force generated in the large-capacity chamber before the partition member communicates is not applied to the seal portion that partitions the small-capacity chamber, so that the large-capacity and small-capacity are partitioned. A seal part that is easier to peel than the seal part can be employed in the second container, the degree of freedom in designing the second container is increased, and rapid and reliable complete mixing is possible.
Therefore, in the multi-chamber infusion container of the present invention, the second container is preferably a second container consisting only of a small chamber, and a combination of a first container consisting only of a large chamber and a second container consisting only of a small chamber. Is more preferable.

In the example shown in A to J and N to O in FIG. 3, all the small chambers 10 b other than the first small chamber 10 a in the second container 2 are in contact with the first small chamber 10 a through the weak seal portion. . For this reason, since the content flowing in from the first container after the partition member 4 communicates directly touches at least a part of the weak seal portions at the peripheral edge of all the small chambers 10b, it peels off quickly during use. This is preferable because rapid and complete mixing is possible.
Furthermore, among the examples shown in A to J and N to O, the examples shown in A, E to J, and N to O are the first in which all weak seal portions of the second container are adjacent to the partition member. It is the weak seal part of the periphery of the small chamber 10a. That is, although the weak seal part which is not the weak seal part of the periphery of the 1st small chamber 10a adjacent to a partition member exists in the 2nd container in the example shown to B-D, A, E-J, and N- In the example shown by O, the weak seal part other than the periphery of the first small chamber 10a does not exist in the second container. For this reason, since the contents that flowed in from the first container after the partition member 4 communicates directly touch all the weak seals in the second container, they can be peeled off more quickly and more quickly and completely mixed. preferable.

  In FIG. 3, all the examples other than J are all weakly sealed sections divided into small chambers in the second container. When the compartment of a multi-chamber infusion container is partitioned by a combination of a strong seal portion and a weak seal portion, depending on how the strong seal portion is provided, the movement in the direction of peeling the inner surfaces of the containers is restricted, and several times It is easy to require pressing operation. In particular, the smaller the compartment, the more the strong seal part, the stronger the restraint. For this reason, it takes time to communicate and complete mixing. If all of the compartments in the second container are weakly sealed portions, they are not restrained and can be easily peeled off, allowing quick and reliable complete mixing easily.

  In FIG. 3, B, C, D, J and L have a weak seal portion 12 extending in the width direction in the second container 2 in contact with the partition member. Since these weak seal portions in the width direction need to be provided at a certain distance from the partition member 4 because of the thickness of the partition member 4, the first small chamber 10a in contact with the partition member 4 is made small. There is a limit. Therefore, depending on the size of the second container 2, particularly the height in the vertical direction, it may not be desirable to provide a weak seal portion in the width direction. Further, in FIG. 3, if the small chamber is defined only by the weak seal portion in the vertical direction like A, E, F, G, H, I and M, the plurality of chambers of the second container 2 can be filled simultaneously. This is preferable because it can be performed at a time.

  Moreover, it is preferable to optimize the structure of the chamber according to the contents of the chamber of the second container. As will be described later, a thermoplastic resin is used as a material constituting the first container 1 and the second container 2, and a relatively transparent thermoplastic resin is often used. For example, light such as antibiotics, oxygen, moisture, etc. In the case of a content that is easily decomposed, it is preferable to cover the outer surface with a light shielding member such as a film having high light shielding properties and / or barrier properties, and aluminum foil. Furthermore, in the room containing fat-soluble vitamins such as vitamin D, vitamin A, vitamin E, vitamin K, vitamin H, etc., polyethersulfone or cyclic polyolefin with low adsorptivity to fat-soluble vitamins is placed on the inner surface. It is preferable to use it.

When a chamber is made by dividing a large-sized multi-chamber infusion container over the entire surface into a large film, it is necessary to use the same material for the entire inner surface when optimized for specific contents. However, in the present invention, it is sufficient to optimize only the inner surface of the second container 2 and less material is required for the optimization. Therefore, it is preferable.
In addition, it is also preferable to preliminarily protect the medicine in a specific chamber by performing printing with ultraviolet absorbing ink or the like on a partial region of the flexible material forming the second container 2.

Although not shown, it is also preferable to provide an injection port such as a mixed injection port in at least one chamber of the second container 2.
Although the multi-chamber infusion container of the present invention can separate and accommodate various drugs, it is not always realistic to prepare a multi-chamber multi-chamber infusion container considering various combinations of drugs. I don't think so. Therefore, it is also a preferred aspect that one chamber of the second container 2 is a vacant chamber provided with a mixed injection port and a spare chamber filled only with a solution such as physiological saline and distilled water. It is possible to store and hold drugs that need to be mixed at the time of use and are not desirable to be mixed with other drugs for a long time in the spare room. It is. Therefore, under a sterile environment, the filling of the medicine into the spare chamber can be performed collectively for a plurality of multi-chamber infusion containers. This eliminates the need for co-infusion every time it is administered, reduces the burden of dispensing at medical institutions, prevents bacterial contamination, prevents foreign matter contamination, prevents errors during dispensing, and enables quick response in emergencies. The advantage of the kit product is that it is possible to prepare a multi-chamber infusion container containing various drugs according to the patient's pathology, which has the advantage that the range of home therapy can be expanded and extremely useful It is. Such an embodiment in which the spare chamber is provided is made possible by the multi-chamber container in which the multi-chamber of the present invention can be easily formed, and is a preferable application example of the present invention.

(Flexible material)
The flexible material used for the main body of the first container 1 and the second container 2 in the present invention is flexible for easy discharge of contents, transparent for confirmation of contents, and high-pressure steam sterilization. Therefore, it is made of a material having heat resistance. This flexible material mainly consists of a single layer or multilayer film or sheet made of synthetic resin. Examples of materials include polyolefins such as polyethylene and polypropylene, polyesters such as polyethylene terephthalate, polybutylene terephthalate, polyethylene naphthalate, and alicyclic copolyesters, ethylene-vinyl acetate copolymers and saponified products thereof, polyamide resins, and vinyl chloride. , Thermoplastic resins such as polyvinylidene chloride, polyethersulfone, and cyclic polyolefin.

In the example of FIG. 1A, the bag forming the container is a film obtained by cutting the cylindrical film obtained by inflation molding of the first container 1 and the second container 2, and a flat film obtained by T-die molding, or Further, the periphery of two films obtained by lamination molding or the like is heat sealed to form a strong seal portion.
Another example is one obtained by blow molding the first container. An example is shown in FIG. In this case, it may be integrally formed with the partition member.

  In addition, the first container 1 and the second container 2 can be made of flexible materials made of different materials in consideration of suitability of the medicines contained therein. The flexible material is preferably a material and a layer structure that can be welded to the partition member 4, the port 7, the first container 1 and the second container 2, respectively. Further, as described above, the content may be appropriately selected in consideration of the adsorptivity of the contents.

(Partition member)
The partition member 4 in the present invention can be ruptured into a cylindrical member that connects two adjacent containers so as to communicate with each other, a partition body that liquid-tightly partitions two adjacent containers, and a connecting portion between the partition body and the partition member It has a thin part. If the hollow part which connects two adjacent containers so that communication is possible is provided in the center part of this cylinder member, the cross-sectional shape of a communication part can be made into arbitrary shapes.
A specific example of the partition member is shown in FIG.

  The partition in FIG. 4A is provided at the end of the cylindrical member and has a shape that covers the cylindrical member. The partition member 4 has a cylindrical member that is long in the width direction of the first container 1 and the second container 2 and flat in the thickness direction of the container. The partition member 4 is formed with a cylindrical member 43 having a hollow portion 41 communicating from the upper surface to the bottom surface, and a strip-shaped partition body 42 that seals the bottom surface side of the hollow portion 41, and the partition member 42 and the cylindrical member 43 are formed. A thin portion is formed at the connecting portion, and a support member 46 is inserted into the hollow portion 41 of the partition member 4. A thick part is formed in a part of the thin part. The width direction end 43a of the cylindrical member 43 has a boat shape, and two inclined surfaces 43b that are inclined from both surface sides of the cylindrical member 43 are formed. A plurality of ribs 47 are provided on the surface of the partition body 42 on the hollow portion 41 side along the width direction of the partition body 42.

  The thin portion formed in the connecting portion between the partition body 42 and the cylindrical member 43 is a portion that can be broken by an external deforming operation on the partition member 4, and the thick portion is formed by an external deforming operation. Also, the partition 42 and the cylindrical member 43 are connected without breaking. The thickness of the thin portion is preferably 0.1 to 0.2 mm. If the thickness of the thin portion 44 is less than 0.1 mm, there is a risk of breaking due to the own weight of the drug 12 or the internal pressure during retort sterilization of the first container 1. It is not appropriate because sometimes it requires an unnecessarily high force.

  The inclined surfaces 43b and 43b formed in the width direction end 43a of the cylindrical member 43 form the first container 1 when heat-sealing the partition member 4 and the upper end of the first container 1, for example. It is for welding the sheet of synthetic resin and the partition member 4 without a gap. When the width direction end portion 43 a of the cylindrical member 43 is a curved surface, a pinhole may occur between the two synthetic resin films and the side surface of the cylindrical member 43. The rib 47 increases the strength in the width direction of the partition 42, increases the difference in stress generated from the partition 42 and the tubular member 43 with respect to external force applied by an external deformation operation, and the tubular member 43 of the partition 42. It is intended to encourage peeling. In addition, the rib 47 comes into contact with the end surface of the cylindrical member 43 after the partition body 42 is peeled off from the cylindrical member 43 and becomes caught, thereby separating the drug in the first container and the drug in the second container. This is to prevent the body 42 from sealing the hollow portion 41 again.

  In such a partition member 4, as shown to FIG. 4 (A), the force of the same direction is applied to the width direction edge part 43a of the both sides of the partition member 4 in the thickness direction of a container, and it is simultaneously a partition member 4 by applying a force in the direction opposite to the width direction end portion 43a to the width direction center portion 4 to bend the partition member 4 in a dogleg shape, thereby different from the partition body 42 and the cylindrical member 43 with respect to external force. Stress is generated, and the thin portion formed at the connecting portion between the partition body 42 and the cylindrical member 43 can be broken by the difference in stress, and the partition body 42 can be opened to the outside of the partition member 4. Thus, the 1st container 1 and the 2nd container 2 are connected, and the chemical | medical agent in a 1st container and the chemical | medical agent in a 2nd container can be mixed now. At this time, since the lid body 42 is connected to the partition member main body 43 by the thick part provided in a part of the thin part, it can be prevented from falling off.

FIGS. 4B and 4C are diagrams showing another example of the partition member 4. (B) is a perspective view and (C) is a side view.
A partition member 4 ′ shown in FIGS. 4B and 4C has a partition body 42 that partitions the central portion of the hollow portion 41 of the tubular member 43, and a connecting portion between the partition body 42 and the tubular member 43 is provided at the connection portion. A thin portion 44 that can be broken when the partition member 42 receives force is formed.
The cross-sectional shape of the communicating portion of the cylindrical member 43 in FIG. 4B is the same as that of the cylindrical member 43 in FIG.
The partition body 42 is a member that is held on the inner surface of the cylindrical member 43 via the thin wall portion 44, partitions the hollow portion 41, and reliably separates the container contents before using them. When the partition member 4 and the container are welded, In addition, it has the function of preventing the partition member 4 from being deformed together with the thin portion 44.

It is preferable that at least one support member 46 is provided in the hollow portion 41 of the cylindrical member 43. In the example of FIGS. 4B and 4C, two support members 46 are provided.
The support member 46 includes a plurality of ribs 46b extending in the width direction of the hollow portion, and a connecting member 46a extending in the longitudinal direction of the hollow portion 41 so as to connect the central portion of the rib 46b. The support member 46 can more reliably prevent deformation of the partition member main body 43 when the partition member main body 43 and the container are welded, and prevent deformation and breakage of the thin portion when an excessive force is applied during welding. It becomes possible to do. The length in the vertical direction of the support member 46 is not particularly limited, but is preferably ¼ or less of the length in the vertical direction of the hollow portion 41 before communication.

The partition member 4 'shown in FIG. 4B also applies a force in the same direction in the thickness direction of the container to the width direction end portions on both sides of the partition member 4', and at the same time at the center portion in the width direction of the partition member 4 '. By applying a force in the direction opposite to the end in the width direction and bending the partition member 4 'into a dogleg shape, different stresses are generated from the partition member 42 and the cylindrical member 43 with respect to the external force, respectively. Due to the difference, the thin portion 44 formed at the connecting portion between the partition body 42 and the partition member main body 43 can be broken. As shown in FIGS. 4B and 4C, when two support members 46 are provided on both sides of the partition member 4, even if the partition body 42 is separated from the cylindrical member 43 due to the breakage of the thin portion 44. In addition, it is blocked by the support member 46 and does not exit from the hollow portion 41 to the outer side of the second container 2 or the first container 1.
The partition member illustrated in FIGS. 4 (A) and 4 (B) is not particularly limited because the cross-section of the partition member is required to be flat to some extent, but the width / thickness is preferably 3 or more. It is preferable that a force is applied by a human hand, and the width is preferably about 3 to 20 cm. Further, when the partition member is provided at the center of the wide multi-chamber infusion container, in order to facilitate the bending operation of the partition member, as shown in FIG. 8 (A), strong seal portions provided at both ends of the partition member. At least one of them is provided with an opening through which a finger can be inserted from the front to the back of the multi-chamber infusion container, or as shown in FIG. 8B, the first container and the second container are integrated with only the partition member. Is also preferable. FIG. 8B shows a multi-chamber infusion container in which the first container and the second container are integrated only by the partition member. However, as shown in FIGS. If it integrates, since a 1st container and a 2nd container will be integrated more firmly, it is preferable.

(how to use)
The method of mixing the contents when using the multi-chamber infusion container of the present invention may be, for example, by pressing the first container 1 once after the partition member 4 is communicated. By pressing the first container 1 to increase the internal pressure, the contents of the first container 1 flow into the second container 2 from the partition member 4 that can communicate. Thereby, each weak seal part of the 1st container 1 and the 2nd container 2 peels and connects, and the contents are mixed. Thus, it can be made to mix by making the partition member 4 communicate, raising the internal pressure of the contents of the 1st container 1, and these two operation procedures. Even when the number of small chambers in the second container 2 increases, the operation procedure and the number of times do not change.
In addition, you may press the 1st container 1 before a partition member communication, and may peel the weak seal part in the 1st container 1. FIG.

  In order to increase the internal pressure of the first container 1, a method of placing the multi-chamber infusion container Y on a flat surface and pressing it manually from above, or squeezing the first container 1 from both sides in a suspended state There is. Even when the multi-chamber infusion container Y of the present invention is in a suspended state, it is possible to communicate the partition member 4 with both hands by placing the thumb at the center of the partition member 4 in the width direction and bending it. Even if it is necessary, even in a place where there is no flat surface, it is possible to carry out complete mixing easily and quickly.

(Manufacturing method of drug-containing multi-chamber infusion container)
A method for filling a multi-chamber infusion container of the present invention with a drug and producing a multi-chamber infusion container containing a drug is not particularly limited, but one example is shown in FIG.
(1) The partition member is manufactured by injection molding. In the example of FIG. 6, the partition member 4 is an example using the type shown in FIG. 4A and having no support member 46.

(2) Production of first container 1) A film 61 is prepared as a flexible material, and a strong seal portion 62 and a weak seal portion 63 are formed in the shape shown in (2) -1) of FIG. In the example of FIG. 6, a tubular film is used.
On the left side surface of the strong seal portion 62, a narrow portion 62a of the strong seal portion is provided in order to form filling ports both above and below the weak seal portion 63.
2) Along the strong seal portion 62, cut from the tubular film 61 into a first container shape. This shape has an opening 64 at the top and an opening 65 for port attachment at the bottom.
3) Insert the port 7 into the lower opening 65 and seal it fluid-tight.

(3) Production of second container 1) A film 66 is prepared as a flexible material. This flexible material may be the same as the flexible material used for the first container, or may be a different flexible material as long as it can be welded to the partition member 4. In the example of FIG. 6, a tubular film is used.
2) A weak seal portion 67 is provided at a position where the second container is divided into the small chambers. Strong seal portions 68 are provided at both ends of each weak seal portion to prevent peeling.

(4) Integration of the first container, the second container, and the partition member 1) The top opening of the first container with the bottom surface side (side on which the partition body is formed) of the hollow portion of the cylindrical member in the partition member 4 facing downward The partition member 4 is inserted into the portion 64 (4) -1), and the support 69 is inserted into the hollow portion 41 of the cylindrical member (4) -1) -1.
2) The first container 1 and the partition member 4 are strongly sealed by heat sealing.
3) The upper part of the first container 1 with the partition member 4 is covered with a second container opening lower part 81. At this time, the strong seal portion 68 below the weak seal portion 67 of the second container is made to hit the strong seal portion 5 of the first container.
4) The support body 69 is inserted from the second container opening upper part 82 through the second container from the top to the bottom, and inserted into the cylindrical member hollow part 41.
5) The lower part of the second container is welded onto the strong seal part 5 which is the welded part between the first container 1 and the partition member 4. At this time, the strong seal portion 6 of the second container may be welded directly to the second container and the partition member without overlapping the strong seal portion of the first container. Furthermore, the side part of the second container is also strongly sealed.

(5) Drug filling into the second container 1) The drugs e, f and g are filled from the openings 82a, 82b and 82c above the second container.
2) After filling the medicine, the upper part of the second container 2 is strongly sealed, and the suspension hole 83 is provided in the strong seal part.

(6) Drug filling into the first container 1) The left side surface of the first container 1 (one-dot chain line portion i) is cut to open the filling port 84.
2) The drugs 1 and m are filled from the opened filling port 84.
3) After filling the medicine, the left side surface of the first container is strongly sealed so as to close the opened filling port.

(7) Trimming of outer shape and heat sterilization 1) Cut and trim the side surface of the obtained multi-chamber infusion container.
2) Perform heat sterilization such as retort sterilization (high-temperature steam sterilization).

The drug needs to be filled in an aseptic environment, but may be appropriately performed such as washing before filling or filling in an aseptic environment.
In the above example, the first container is filled from the side, but may be filled from the port 7.

In the above example, the upper part of the first container 1 with the partition member 4 is covered and sealed with the second container opening lower part 81 to integrate the first container and the second container. After creating the second container with a partition member, the first container and the second container may be integrated by covering and sealing with the upper opening of the first container.
In the above example, the partition member is inserted and sealed in the first container, and then the first container 1 and the second container 2 are integrated and then the medicine is filled. However, the second container 2 is filled with the medicine. After that, the first container 1 may be integrated. In this case, the partition member shown in FIG. 4B is inserted and sealed in the second container 2, and then the second container 2 filled with the drug and the first container 1 are connected.
As described above, when the partition member 4 ′ of FIG. 4B is used as the partition member, the support 69 used in the steps of FIGS. 6 (4) -1) -1 and (4) -4) becomes unnecessary, and the sealing device. There is an advantage that the connection to the first container becomes possible after the drug is filled in the second container.

For the sealing, methods such as heat sealing, impulse sealing, and ultrasonic sealing can be used.
The method of forming the weak seal portion is not particularly limited. For example, the innermost surface of the container is formed with a layer made of a resin composition having different melting points and compatibility such as a composition layer of polyethylene and polypropylene. A method of sealing using a flexible material at a temperature lower than the temperature of the high melting point resin, a method of sealing using a flexible material cross-linked with an electron beam or the like in the vicinity of the weak seal portion, and a strong fusion portion and low fusion. Examples include a method of sealing using a seal bar that generates a portion with a specific area ratio, and a method of sealing by sandwiching an easily peelable resin tape between two flexible materials.
Any conventional method can be used as the heat sterilization method, and examples thereof include high-pressure steam sterilization, hot water immersion sterilization, hot water shower sterilization, γ-ray sterilization, and electron beam sterilization.

(Medicine infusion container)
Although it does not specifically limit as a chemical | medical agent accommodated in the chamber of the 1st container 1 in the multi-chamber infusion container Y of this invention, Sugar, an electrolyte, an amino acid, etc. are mentioned, Sugars which made these chemical | medical agents a formulation Contains preparations, protein amino acid preparations, blood substitutes, and the like.
The medicine accommodated in the chamber of the second container 2 in the multi-chamber infusion container Y of the present invention is not particularly limited, but vitamins, trace elements, correction calcium chloride, insulin, antibiotics, anti Examples include cancer drugs, peptic ulcer agents, liver damage agents, cardiotonic agents, analgesics, antipyretic analgesics, anti-inflammatory agents, anesthetics, fat emulsions, antihypertensive agents, vasodilators, hormonal agents and the like. These drugs are stored as liquid or powdered solids. Examples of the solution include physiological saline and distilled water.

The multi-chamber infusion container Y of the present invention is used as a container for transcentric parenteral nutrition kit preparations, transperipheral parenteral nutrition kit preparations used in transcentral parenteral nutrition, and component nutrients used in enteral nutritional methods. Can do.
For example, as a preferred embodiment of a high-calorie infusion used as a starter liquid or a maintenance liquid as a kit preparation for transcentral parenteral nutrition for transcentral parenteral nutrition, the first container chamber may contain any of sugar, electrolyte, and amino acid. A medicine containing at least one kind is accommodated, and a medicine containing any one or more of water-soluble vitamins, fat-soluble vitamins and trace elements is accommodated in the chamber of the second container.
Examples of the trace element include trace metals such as copper, iron, manganese, and zinc, and iodine. Trace metals are stored as aqueous solutions or solid drugs, and vitamins (including provitamins) such as water-soluble vitamins and fat-soluble vitamins are stored as lyophilized products (solid drugs) or aqueous solutions.

  The multi-chamber infusion container Y of the present invention illustrated in FIGS. 1 to 3 is configured such that the second container 2 and the first container 1 having at least two chambers partitioned liquid-tightly by a peelable weak seal portion are bent and communicated. All the medicines can be easily and quickly mixed by two operations of the partition member bending communication operation and the first container pressing operation.

  In conventional transcentral parenteral nutrition therapy using high-calorie infusion, mixed injection work in a sterile preparation chamber is often required. By injecting the liver injury solvent, it becomes possible to make a drug container for high-calorie infusion therapy at home.

These are figures which show the example of an embodiment of the multi-chamber infusion container of this invention. These are figures which show 1 example of implementation of a 1st container. These are figures which show the example of an embodiment of a 2nd container. These are figures which show the example of an embodiment of a partition member. FIG. 4 is a diagram illustrating an example of implementation of a port. These are figures which show an example of the manufacturing method of the multi-chamber infusion container containing a medicine. These are figures which show the example of an embodiment using the 1st container obtained by blow molding. These are figures which show the example of an embodiment of the multi-chamber infusion container by which the device for making bending | flexion operation of a partition member easy was made | formed.

Explanation of symbols

1: first container, 2: second container, 3, 5, 6, 6 ′: strong seal part,
8, 11, 12, 13, 15, 16, 19, 20: weak seal part,
4, 4 ': partition member, 10a: first chamber, 10b: second chamber,
10c: 3rd chamber, 14: 2nd strong seal part, 41: Hollow part, 42: Partition body,
43: cylinder member, 44: thin part, Y: multi-chamber infusion container

Claims (13)

In a multi-chamber infusion container in which a first container having a chamber for storing a medicine and a second container are integrated, the first container and the second container made of a flexible material are integrated by a partition member, and the first container and A multi-chamber infusion container partitioned between second containers,
The partition member includes a cylindrical member that connects two adjacent containers so as to communicate with each other, a partition body that partitions the two adjacent containers in a liquid-tight manner, and a ruptureable thin portion at a connecting portion between the partition body and the cylindrical member. Have
The first container has two or more large chambers partitioned by a partition means capable of communication, and the second container has two or more small chambers partitioned by a peelable weak seal portion, The chamber of the second container includes a first chamber adjacent to the partition member and a second chamber adjacent to the first chamber via the weak seal portion, and the first container is placed under the first container. When the second container is disposed on the side, at least one of the weak seal portions in the second container is a strong seal portion at the lower end of the second container and a strong seal portion at the upper end or the side portion of the second container. A multi-chamber infusion container characterized by being partitioned between the two. In a multi-chamber infusion container in which a first container having a chamber for storing a medicine and a second container are integrated, the first container and the second container made of a flexible material are integrated by a partition member, and the first container and A multi-chamber infusion container partitioned between second containers,
The partition member includes a cylindrical member that connects two adjacent containers so as to communicate with each other, a partition body that partitions the two adjacent containers in a liquid-tight manner, and a ruptureable thin portion at a connecting portion between the partition body and the cylindrical member. Have
The first container has two or more large chambers partitioned by a partition means capable of communication, and the second container has two or more small chambers partitioned by a peelable weak seal portion, The small chamber of the second container includes a first small chamber adjacent to the partition member and a plurality of second small chambers adjacent to the first small chamber via the weak seal portion. When the second container is disposed on the lower side, the weak seal portion is formed so as to connect both side portions of the second container, and is formed between the weak seal portion and the strong seal portion at the upper end of the second container. A plurality of second small chambers partitioned by a second strong seal portion extending from a part of the strong seal portion at the upper end. In a multi-chamber infusion container in which a first container having a chamber for storing a medicine and a second container are integrated, the first container and the second container made of a flexible material are integrated by a partition member, and the first container and A multi-chamber infusion container partitioned between second containers,
The partition member includes a cylindrical member that connects two adjacent containers so as to communicate with each other, a partition body that partitions the two adjacent containers in a liquid-tight manner, and a ruptureable thin portion at a connecting portion between the partition body and the cylindrical member. Have
The first container has two or more large chambers partitioned by a partitioning means capable of communication, and the second container has two or more small chambers partitioned by a peelable weak seal portion,
The chambers of the second container include a first chamber adjacent to the partition member, a second chamber adjacent to the first chamber via the weak seal portion, and the first chamber via the weak seal portion. A multi-chamber infusion container comprising a third chamber adjacent to the two chambers.   When the first container is disposed on the lower side and the second container is disposed on the upper side, the weak seal portion is connected so as to connect both ends facing the partition members of the two strong seal portions at the lower end of the second container provided across the partition member. A first small chamber is formed, surrounded by the weak seal portion, the two lower end strong seal portions, and the partition member, and connects the upper end strong seal portion of the second container from each of the lower end strong seal portions on both sides. The multi-chamber infusion container according to claim 3, wherein a weak seal portion is provided, and a second small chamber is formed surrounded by the weak seal portion and the upper end strong seal portion. .   When the first container is disposed on the lower side and the second container is disposed on the upper side, two weak seal portions are provided so as to connect both side portions of the second container, and at least one of the weak seal portions is a part thereof. 4. The multi-chamber infusion container according to claim 3, further comprising a bent portion having a corner portion. In a multi-chamber infusion container in which a first container having a chamber for storing a medicine and a second container are integrated, the first container and the second container made of a flexible material are integrated by a partition member, and the first container and A multi-chamber infusion container partitioned between second containers,
The partition member includes a cylindrical member that connects two adjacent containers so as to communicate with each other, a partition body that partitions the two adjacent containers in a liquid-tight manner, and a ruptureable thin portion at a connecting portion between the partition body and the cylindrical member. Have
The first container has two or more large chambers partitioned by a communicating partition means, and the small chamber of the second container includes a first small chamber adjacent to the partition member and the weak seal portion. A second chamber adjacent to the first chamber, and when the first container is disposed on the lower side and the second container is disposed on the upper side, the second container has a partition member and the partition member. The outer periphery is formed by a lower end composed of a strong seal portion extending horizontally from both sides of the upper end and an arc-shaped strong seal portion extending from both ends of the lower end, and the weak seal portion in the second container is the second container. A multi-chamber infusion container characterized in that it is formed by partitioning a strong seal portion at the lower end of an arc and a strong arc-shaped seal portion.   The first container and the second container are integrated by a partition member and a strong seal part, and at least one of the strong seal parts is provided with an opening through which a finger can be inserted from the front to the back of the multi-chamber infusion container. The multi-chamber infusion container according to any one of claims 1 to 6.   Any one of the first container and the second container can communicate with each other only by pressing the first container once after the thin-walled portion is broken. The multi-chamber infusion container according to Item 1.   The multi-chamber infusion container according to any one of claims 1 to 8, wherein at least one of the chambers of the second container is shielded from light by a light shielding member.   10. The multi-chamber infusion container according to claim 1, wherein the innermost layer of the second container is made of a material having a low adsorptivity to the fat-soluble vitamin.   11. The multi-chamber infusion container according to claim 1, wherein all weak seal portions of the second container are weak seal portions at the periphery of the first small chamber adjacent to the partition member.   The multi-chamber infusion container according to any one of claims 1 to 11, wherein at least one chamber of the second container is a preliminary chamber having an injection port. The multi-chamber infusion container according to any one of claims 1 to 12, wherein a medicine containing any one or more of sugar, electrolyte and amino acid is accommodated in the chamber of the first container, and the second container A drug-containing multi-chamber infusion container characterized by containing a drug containing at least one of water-soluble vitamins, fat-soluble vitamins and trace elements in a chamber.

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