JP2011131104A - Medical double-chamber container - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a medical double-chamber container capable of reliably sterilizing a space formed by setting a communication inhibiting weak seal part which inhibits communication between a medicine chamber and a discharge port and is releasable. <P>SOLUTION: The medical double-chamber container 1 includes: a container body 2 divided into a first medicine chamber 21 and a second medicine chamber 22 by the partitioning weak seal part 9; a discharge port 3 communicated with the first medicine chamber; a first medicine stored in the first medicine chamber; a second medicine stored in the second medicine chamber; and a releasable communication inhibiting weak seal part 10 for inhibiting the communication between the first medicine chamber and the discharge port. Into a space formed by the communication inhibiting weak seal part and the discharge port and a lower end side seal part 6, 0.005-0.1 ml of liquid per space volume 1 ml is added. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

  The present invention relates to a medical multi-chamber container that is divided into two drug chambers by a peelable weak seal portion and each drug chamber is filled with a drug.

Among drugs that administer nutritional components intravenously to patients, there are unstable drugs that tend to change over time when pre-mixed. For example, when an amino acid solution and a glucose solution are blended and stored in advance, the mixed solution is colored (brown) by the Maillard reaction. Moreover, when a calcium compound is blended with a phosphate compound, precipitation of calcium phosphate occurs in a solution having a high pH, and the product value is significantly reduced. When such a drug is administered to a patient, for example, as shown in Japanese Patent No. 2675075 (patent document 1), a medical multi-chamber container that individually accommodates components before mixing is used, and then mixed before administration. Is starting to do.
This medical multi-chamber container includes a plurality of chambers for individually storing different component drugs, and a partition weak seal that separates the chambers and peels and opens them by pressure from the outside.
However, in many cases, the multiple medical containers contain the liquid agent in the storage part on the discharge port side, and the bottle needle is inserted into the rubber stopper without peeling off the weak seal for partitioning, and the liquid agent is discharged from the discharge port. There is a possibility of taking it out.
For this reason, a method has been devised to ensure that drugs stored in each storage unit are mixed and then administered to the patient, and to prevent accidents in which the drug is administered to the patient without accidental mixing. For example, as shown in Japanese Patent Laid-Open No. 9-327498 (Patent Document 2) and Japanese Patent Application Laid-Open No. 2002-136570 (Patent Document 3), a weak seal portion for preventing communication is provided that separates a medicine discharge port from a compartment for storing the medicine. A multi-chamber container has been proposed.

Japanese Patent No. 2675075 JP-A-9-327498 JP 2002-136570 A

In the ones shown in Patent Documents 2 and 3, the possibility of inserting the bottle needle into the stopper and taking out the liquid agent from the discharge port without peeling off the partitioning weak seal portion is considerably reduced. However, adhesion due to blocking occurs between the weak seal portion for blocking communication that separates the drug discharge port and the compartment for storing the drug, and conversely, weak communication for blocking communication due to the proximity to the drug discharge port. A seal failure may occur in the seal portion. When adhesion due to blocking occurs, it takes time to remove the weak seal portion for communication inhibition. In addition, when a poor seal occurs at the weak seal portion for inhibiting communication, there is a concern that the medicine is administered without peeling off the weak seal for partitioning. In addition, it is considered possible to prevent blocking by allowing a certain amount of liquid to exist between the weak seal portion for preventing communication and the medicine discharge port, but in this case, there is a risk that only the existing liquid is administered. .
An object of the present invention is to separate the weak seal part for blocking communication by blocking in a medical multi-chamber container which is divided into two drug chambers by a peelable partition weak seal part and the drug chamber is filled with the drug. Medical multi-chamber container that prevents the formation of a peeled state, can be easily prepared for administration, and does not cause poor sealing of the weak seal portion for communication inhibition, and prevents the medicine from being administered without being mixed. Is to provide.
In the medical multi-chamber container as described above, a space (third chamber) is formed by providing a weak seal portion for inhibiting communication. Since the medicine discharged from the multi-chamber container passes through this space, it is necessary to ensure sterilization.
Therefore, the medical multi-chamber container of the present invention provides a medical multi-chamber container that can surely sterilize the inside of the space formed by providing the weak seal portion for preventing communication.

What achieves the above object is as follows.
(1) A container body which is made of a flexible material and is divided into a first drug chamber and a second drug chamber by a partition weak seal portion from which an internal space can be peeled, and a lower end of the first drug chamber A medical multi-chamber container comprising a discharge port capable of communicating with a portion, a first medicine housed in the first medicine chamber, and a second medicine housed in the second medicine chamber The multi-chamber container for medical use includes a weak seal portion for inhibiting communication that prevents the first drug chamber from communicating with the discharge port, and further includes a weak seal portion for inhibiting communication. Has a first portion extending to the partitioning weak seal portion side from the closing portion to which the discharge port is attached, and extends in a direction that is continuous with the first portion and substantially perpendicular to the central axis of the discharge port. A second portion, continuous with the second portion and extending toward the closing portion, and A third portion that reaches the closing portion, and is formed so as to surround an upper portion of the distal end portion of the discharge port, and the discharge port is a cylindrical body having a main body portion and the distal end portion; The section has a smaller cross-sectional area than the main body, and further, the distance between the tip of the tip of the discharge port and the discharge port side edge of the second portion of the weak seal portion for blocking communication Is a medical multi-chamber container of 6-15 mm.
(2) The medical multi-chamber container according to (1), wherein a distal end portion of the discharge port has a flat shape.
(3) The medical multi-chamber container according to (1), wherein a distal end portion of the discharge port is tapered in a tapered shape toward the second partial direction of the communication inhibiting weak seal portion.

Moreover, what achieves the said objective is as follows.
(4) A container body which is made of a flexible material and is divided into a first drug chamber and a second drug chamber by a partition weak seal portion from which an internal space can be peeled, and a lower end of the first drug chamber A medical multi-chamber container comprising a discharge port capable of communicating with a portion, a first medicine housed in the first medicine chamber, and a second medicine housed in the second medicine chamber The multi-chamber container for medical use includes a weak seal portion for inhibiting communication that prevents the first drug chamber from communicating with the discharge port, and further includes a weak seal portion for inhibiting communication. Has a first portion extending to the partitioning weak seal portion side from the closing portion to which the discharge port is attached, and extends in a direction that is continuous with the first portion and substantially perpendicular to the central axis of the discharge port. A second portion, continuous with the second portion and extending toward the closing portion, and A third portion that reaches the closed portion, and is formed so as to surround an upper portion of the discharge port; and the discharge port is a cylindrical shape having substantially the same outer diameter, and a distal end portion of the discharge port A medical multi-chamber container in which the distance between the distal end of the first and the discharge port side end edge of the second portion of the weak seal portion for inhibiting communication is 15 to 30 mm.
(5) The closing portion includes a straight portion extending in a side portion direction of the container main body formed on both side portions of the discharge port at the edge on the first drug chamber side, and the weak seal portion for communication inhibition The discharge port side edge in the second portion is located on the partition weak seal portion side from the imaginary line connecting the respective straight portions of the blocking portions located on both sides of the discharge port (1) Thru | or the medical multi-chamber container in any one of (4).
(6) An imaginary line connecting the respective straight portions of the blocking portions located on both sides of the discharge port is closer to the second portion of the communication inhibiting weak seal portion than the tip of the discharge port. The medical multi-chamber container according to any one of (1) to (4) above.
(7) The medical multi-chamber according to any one of (1) to (6), wherein a liquid is added to a space formed by the weak seal portion for blocking communication, the discharge port, and the closed portion. container.
(8) The multi-chamber container for medical use according to any one of (1) to (6), wherein the partition weak seal portion and the communication inhibition weak seal portion are formed by heat sealing.
Moreover, what achieves the said objective is as follows.
(9) Liquid is added to the space formed by the weak seal portion for blocking communication, the discharge port, and the lower end side seal portion to which the discharge port is fixed, and the liquid into the space is added. The medical multi-chamber container according to any one of (1) to (8), wherein the added amount is 0.02 to 0.1 ml per 1 ml of volume in the space.
(10) A liquid is added to a space formed by the weak seal portion for blocking communication, the discharge port, and a lower end side seal portion to which the discharge port is fixed, and the liquid into the space is added. The medical multi-chamber container according to any one of (1) to (8), wherein the added amount is 0.005 to 0.1 ml per 1 ml of volume in the space.
(11) The medical multi-chamber container according to (9) or (10), wherein the medical multi-chamber container is sterilized by high-pressure steam.
Moreover, what achieves the said objective is as follows.
(12) A container body that is made of a flexible material and is divided into a first drug chamber and a second drug chamber by a partition weak seal portion that can be peeled off, and a lower end side seal portion of the container body And a discharge port communicating with the lower end of the first drug chamber, a first drug stored in the first drug chamber, and a second drug stored in the second drug chamber And a weak seal portion for preventing communication between the first drug chamber and the discharge port, and a weak seal portion for preventing communication that can be peeled off, and the weak seal portion for blocking communication and the discharge port. And a medical multi-chamber container in which 0.005 to 0.1 ml of liquid is added per 1 ml of volume in the space formed by the lower end side seal portion.
(13) The medical multi-chamber container according to (12), wherein the medical multi-chamber container is sterilized by high-pressure steam.
(14) The medical multi-chamber container according to (12) or (13), wherein the amount of the liquid added to the space is 0.02 to 0.1 ml per 1 ml of volume in the space.
(15) The medical multi-chamber container according to (12) or (13), wherein the amount of the liquid added to the space is 0.01 to 0.05 ml per 1 ml of volume in the space.

  According to the medical multi-chamber container of the present invention, the distance between the weak seal portion for preventing communication and the tip of the tip of the discharge port is accurate according to the shape of the tip of the discharge port. In addition, it is possible to prevent adhesion due to blocking of the resin sheet forming the medical multi-chamber container between the weak seal portion for preventing communication and the discharge port, and forming a difficult peeling state of the weak seal portion for blocking communication due to blocking. Stop. Also, because the distance between the weak seal part for blocking communication and the tip of the tip part of the discharge port is appropriate for the shape of the tip part of the discharge port, the seal of the weak seal part for blocking communication is poor. Will not occur.

FIG. 1 is a front view of an embodiment of the medical multi-chamber container of the present invention. 2 is a partially enlarged view of the vicinity of the discharge port of the medical multi-chamber container of FIG. FIG. 3 is a cross-sectional view taken along line AA in FIG. FIG. 4 is an enlarged partial sectional view of the vicinity of the discharge port of another embodiment of the medical multi-chamber container of the present invention. FIG. 5 is a front view of another embodiment of the medical multi-chamber container of the present invention. FIG. 6 is a partially enlarged view of the vicinity of the discharge port of the medical multi-chamber container of FIG. 7 is a cross-sectional view taken along line BB in FIG. FIG. 8 is a front view of another embodiment of the medical multi-chamber container of the present invention. FIG. 9 is a partially enlarged view of the vicinity of the discharge port of the medical multi-chamber container of FIG. 10 is a cross-sectional view taken along the line CC of FIG. FIG. 11 is a front view of another embodiment of the medical multi-chamber container of the present invention. FIG. 12 is a partially enlarged view of the vicinity of the discharge port of the medical multi-chamber container of FIG. FIG. 13 is a front view of the discharge port used in the medical multi-chamber container of FIG. 14 is a side view of the discharge port shown in FIG. 15 is a cross-sectional view taken along the line DD of FIG. 16 is a cross-sectional view taken along line EE in FIG. FIG. 17 is an explanatory diagram for explaining the operation of the discharge port shown in FIG. 13.

The medical multi-chamber container of the present invention will be described using an embodiment shown in the drawings.
FIG. 1 is a front view of an embodiment of the medical multi-chamber container of the present invention, FIG. 2 is a partially enlarged view of the vicinity of the discharge port of the medical multi-chamber container of FIG. 1, and FIG. FIG. 4 is an enlarged partial cross-sectional view of the vicinity of the discharge port of another embodiment of the medical multi-chamber container of the present invention. In addition, the upper side in the figure is described as “upper end” and the lower side is described as “lower end”.
The medical multi-chamber container 1 of this embodiment is formed of a flexible material and is divided into a first drug chamber 21 and a second drug chamber 22 by a partition weak seal portion 9 that can be peeled off. The container main body 2, the discharge port 3 that can communicate with the lower end of the first drug chamber 21, the first drug stored in the first drug chamber 21, and the first drug stored in the second drug chamber 22. A medicine-equipped medical multi-chamber container comprising two medicines. The medical multi-chamber container 1 includes a weak seal portion 10 for inhibiting communication that inhibits communication between the first drug chamber 21 and the discharge port 3 and can be peeled off. Furthermore, the weak seal portion 10 for inhibiting communication is connected to the first portion 11 extending from the closed portion 6 (6a), to which the discharge port 3 is attached, to the partition weak seal portion 9 side. And a second portion 12 extending in a direction substantially orthogonal to the central axis of the discharge port 3, and a third portion that is continuous with the second portion 12 and extends toward the blocking portion 6 (6b) and reaches the blocking portion. The portion 13 is formed so as to surround the upper end of the discharge port 3. The discharge port 3 is a cylindrical body having a main body 30a and a tip 30b. The tip 30b has a smaller cross-sectional area than the main body 30a. The distance H1 between the distal end 30d and the discharge port side edge 12a in the second portion 12 of the communication inhibiting weak seal portion 10 is 6 to 15 mm. Preferably, it is 8-10 mm.
The medical multi-chamber container 1 of this embodiment includes a container main body 2 formed of a sheet-like cylindrical body, and a partition weak seal portion 9 that partitions an internal storage portion is formed in the container main body. The storage section is divided into a first drug chamber 21 and a second drug chamber 22.
Further, as shown in FIG. 1, on the upper end side and the lower end side of the container body 2, a first closing portion (one end seal portion, in other words, a lower end side seal portion) 6 and a second closing portion (the other end) Part seal part, in other words, an upper end side seal part) 5 is provided. Further, the medical multi-chamber container 1 of this embodiment includes a medicine discharge port 3 provided on the first medicine chamber 21 side.
The container body 2 of the medical multi-chamber container 1 is formed of a soft synthetic resin. The container body 2 is preferably formed into a cylindrical shape by an inflation molding method. The container body 2 may be manufactured by various methods such as a blow molding method. In addition, the container body 2 has a cylindrical body as shown in FIG. 1 that is sealed on the entire circumference (four sides), only the upper and lower ends (two sides) are sealed, and two sheet materials are stacked. It may be a bag-like object such as one in which the entire outer periphery is sealed, or one sheet is folded in two and three sides other than the bent part are sealed. When the container body is a multilayer, it can be molded by a coextrusion inflation molding method or the like. In addition, a hole 25 for suspending the medical multi-chamber container 1 on a hanger or the like is provided at a substantially central portion of the seal portion 5 on the upper end side of the container body 2.

The container body 2 includes a drug container fixing portion 18 (non-seal portion) for fixing the drug container 4 at a position near the end of the other end side seal portion (second closing portion) 5, and one end side. (Lower end side) A central portion of the seal portion 6 is provided with a discharge port fixing portion 19 (non-seal portion) for fixing the discharge port 3.
The container body 2 preferably has a water vapor barrier property. As the degree of water vapor barrier property, the water vapor permeability is preferably 50 g / m ² · 24 hrs · 40 ° C. · 90% RH or less, more preferably 10 g / m ² · 24 hrs · 40 ° C. · 90% RH or less. More preferably, it is 1 g / m ² · 24 hrs · 40 ° C. · 90% RH or less. This water vapor permeability is measured by the method described in JISK7129 (Method A).
Thus, the container main body 2 has a water vapor barrier property, so that the evaporation of moisture from the inside of the medical multi-chamber container 1 can be prevented. As a result, it is possible to prevent reduction and concentration of the medicine (specifically, chemical solution) to be filled. Moreover, the invasion of water vapor from the outside of the medical multi-chamber container 1 can be prevented.

When polyolefin is contained as a material for forming such a container body 2, the usefulness of the present invention is great. Therefore, in the present invention, it is preferable that the material for forming the container body 2 includes polyolefins. Particularly preferable materials for forming the container body 2 include polyolefins such as polyethylene (PE), polypropylene (PP), polybutadiene, and ethylene-vinyl acetate copolymer (EVA), styrene-butadiene copolymer and styrene. -Styrene thermoplastic elastomers such as ethylene-butylene-styrene block copolymers or soft blends of olefinic thermoplastic elastomers such as ethylene-propylene copolymers, ethylene-butene copolymers, propylene-α olefin copolymers A resin may be used. This material has excellent transparency, high strength and flexibility, high heat resistance (especially heat resistance during sterilization), high water resistance, excellent workability, and can reduce manufacturing costs Is preferable.
Further, when the above blend resin is used, two or more materials having different melting points are used, and the seal portion 5 and the seal portion 6 of the container body 2 and the side seal portion 7 of the first drug chamber 21 are used. 8 and 8, setting of each sealing condition of the partition weak seal portion 9 and the communication inhibiting weak seal portion 10 described later, and stabilization of the seal strength of each seal portion can be achieved easily and satisfactorily.

In addition, the container body may have a single layer structure (single layer body) made of the material as described above, and the inner surface portion (inner surface) with the material described above for various purposes. A multilayer laminate in which a plurality of layers (particularly layers of different materials) formed with a surface layer) may be stacked. In the case of a multilayer laminate, a plurality of resin layers may be stacked, or a metal layer may be stacked on at least one resin layer. In the case where a plurality of resin layers are stacked, the advantages of the respective resins can be provided together. For example, the impact resistance of the container body 2 can be improved or anti-blocking properties can be imparted. Further, in the case of a metal layer, the gas barrier property of the container body 2 can be improved. For example, when a film such as an aluminum foil is laminated, the light barrier property can be imparted with the improvement of the gas barrier property. In addition, when a layer made of an oxide such as titanium oxide, aluminum oxide, or silicon oxide is formed, the transparency of the container body 2 can be maintained while the gas barrier property is improved, and the internal visibility is ensured. Can do.
The thickness of the sheet material constituting the container body 2 is appropriately determined according to the layer configuration and the characteristics of the material used (flexibility, strength, water vapor permeability, heat resistance, etc.), and is not particularly limited. However, it is usually preferably about 100 to 550 μm, and more preferably about 200 to 400 μm.

And the container main body 2 is provided with the weak seal part 9 for a partition, and the inside is divided into 2 chambers by this. The partition weak seal portion 9 may include a peelable weak seal portion that traverses the container body 2 in the entire lateral direction and a substantially non-peelable strong seal portion provided at both ends of the weak seal portion. Good. The seal strength (initial peel strength) of the partition weak seal portion 9 described above is not particularly limited, but it is usually preferably about 0.12 to 4.5 kgf / 20 mm width, preferably 0.35 to 2. More preferably, the width is 7 kgf / 20 mm. If the seal strength is within this range, the partition weak seal portion 9 will not be accidentally peeled off during transportation or storage, and the work of peeling off the partition weak seal portion 9 is easy.
The weak seal portion is preferably formed by heat sealing. Specifically, it is preferably performed by a hot press, and the mold temperature can be formed by a temperature lower by 10 ° C. or more than the melting temperature of the forming material of the container body 2.
The partition weak seal portion 9 in this embodiment is formed by fusing the sheet material of the container body 2 in a strip shape. The partition weak seal portion 9 presses, for example, the first drug chamber 21 or the second drug chamber 22 of the container body 2 by hand, and the first drug chamber 21 or the second drug chamber 22 By increasing the internal pressure, or by manually squeezing the first drug chamber 21 or the second drug chamber 22 of the container body 2 with the medical multi-chamber container 1 hung on the hanger, the first drug chamber 21 or the second medicine chamber 22 is provided with a seal strength that can be peeled off by increasing the internal pressure. Thereby, the interruption | blocking by the weak seal part 9 for a partition is cancelled | released by a simple operation | work, without using a special instrument etc., and the chemical | medical agent of the 1st chemical | medical agent chamber 21 and the 2nd chemical | medical agent chamber 22 can be mixed.

In addition, the volume of the medical multi-chamber container 1 varies depending on the type of medicine accommodated therein, but it is usually preferable that the volume of the first medicine chamber is about 50 to 3000 mL, and the second medicine The chamber volume is preferably about 50 to 3000 mL.
By dividing the drug chamber into the first drug chamber 21 and the second drug chamber 22 in this way, it can be stored separately until a liquid containing a substance that causes alteration or deterioration due to reaction or the like is used. In use, it can be applied when it is preferable to mix both solutions. As a medicine stored in each medicine room, a medicine, a powder, etc. can be considered. In particular, in the medical multi-chamber container of the present invention, the first drug is preferably a chemical solution. The second drug may be either a chemical solution or a powder. A chemical solution is preferable. As a combination of the first drug and the second drug, for example, in the case of an infusion solution, in order to prevent coloring due to the Maillard reaction, a combination of an amino acid electrolyte solution and a glucose solution, or in addition, a glucose solution and a sodium bicarbonate solution In addition, the pH of the side on which glucose is added as a peritoneal dialysis solution is adjusted to 3 to 5, and the other electrolyte solution is mixed, and then adjusted so that the pH is almost neutral at the time of administration. It is done.
In the present invention, the first drug and the second drug are not particularly limited. For example, physiological saline, electrolyte solution, Ringer's solution, high-calorie infusion, glucose solution, amino acid infusion, fat infusion, water for injection, peritoneum Any of dialysate, oral and enteral nutrients, etc. may be used.

A drug discharge port 3 that can communicate with the first drug chamber 21 is provided at one end (lower end) of the container body 2. The medicine discharge port 3 is a non-blocking portion (unsealed portion) that is formed so as to penetrate in the axial direction (the container vertical direction) in the one-end-side seal portion (first closed portion) 6. It is inserted between the materials, fused by the seal portion 17, and fixed to the container body 2 in a liquid-tight manner.
The medicine discharge port 3 is for discharging the medicine (chemical solution) filled in the container body 2. As shown in FIGS. 1 to 3, the discharge port 3 in this embodiment includes a cylindrical body 30 having an open upper end (tip portion) and a drug discharge needle attached in a liquid-tight manner to the lower end side of the cylindrical member. The communication part which can be communicated is provided. The communicating portion includes a cap member 31 and an elastic member 32 that seals the rear end opening and allows the needle for discharging the medicine to pass through. The communicating part is not limited to such a form.

  The elastic member 32 can be pierced with a needle tube (not shown) such as a bottle needle or a cannula needle. When necessary, the elastic member 32 is pierced through the needle tube to discharge the medicine from the container body 2 or into the container body 2. It is possible to add other chemicals. In addition, the elastic member has a self-occlusion property, and after the needle tube is extracted from the elastic member, the puncture hole is instantaneously closed to prevent the medicine from leaking. As the constituent material of the elastic member, various thermoplastic elastomers such as styrene elastomer, olefin elastomer, polyamide elastomer, polyester elastomer, natural rubber, isoprene rubber, silicone rubber, butadiene rubber, styrene-butadiene rubber, etc. Elastic materials such as rubber materials, or combinations of any two or more of these (blends, laminates, etc.), polyolefins such as polyethylene, polypropylene, ethylene-propylene copolymers, or ethylene-vinyl acetate Examples thereof include those blended with a polymer material such as a copolymer, a cross-linked ethylene-vinyl acetate copolymer, polyester, polyvinyl chloride, polyurethane, and polyamide.

  As a constituent material of the cylindrical body 30 and the cap member 31 of the medicine discharge port 3, a material having conditions according to its use and function, for example, hardness, strength, toughness, chemical resistance, transparency, and other conditions is used. These materials are preferably composed of relatively hard materials. Examples of these materials include polyolefins such as polyethylene and polypropylene (low density to high density), polyvinyl chloride (soft to hard), polycarbonate, polystyrene. , Polymethyl methacrylate, polyester (PET, PBT, etc.), polyamide, ABS resin, AS resin, polyacetal, polyphenylene sulfide, fluorine-based resin, and the like, and can be appropriately selected and used according to the conditions described above. .

In the medical multi-chamber container 1 of this embodiment, a weak seal portion 10 for preventing communication is formed so as to surround the medicine discharge port 3. The weak seal portion 10 for inhibiting communication is detachable, and inhibits communication between the first drug chamber 21 and the discharge port 3 in a state where the weak seal portion 10 is not peeled. A third chamber 23 isolated from the first drug chamber 21 is formed by the weak seal portion 10 for inhibiting communication. That is, a space (third chamber 23) is formed by the weak seal portion 10 for inhibiting communication, the discharge port 3, and the blocking portions 6 (6a, 6b). This space (third room) 23 is an empty room. However, it is preferable that a liquid that is harmless even when administered to a living body (for example, water or physiological saline) is added to the third chamber. By putting the liquid in the third chamber 23 in this way, the sterilization inside the third chamber is ensured. The amount of liquid placed in the third chamber 23 varies depending on the size of the third chamber, but is preferably about 0.1 to 0.5 ml. Moreover, it is preferable that the addition amount of the liquid per 1 ml capacity of the third chamber is about 0.02 to 0.1 ml. The weak seal portion 10 for inhibiting communication can be formed by heat-sealing a sheet material in a band shape (thermal fusion, high frequency fusion, ultrasonic fusion, etc.).
The medical multi-chamber container 1 of the present invention is made of a flexible material, and is divided into a first drug chamber 21 and a second drug chamber 22 by a partition weak seal portion 9 whose internal space can be peeled off. The container body 2, the discharge port 3 fixed to the lower end side seal portion 6 of the container body 2 and communicating with the lower end portion of the first drug chamber 21, and the first drug stored in the first drug chamber 21 And a second medicine housed in the second medicine chamber 22 and a weak seal portion 10 for inhibiting communication that inhibits the separation between the first medicine chamber 21 and the discharge port 3 and can be peeled off. Then, 0.005 to 0.1 ml of liquid is added per 1 ml of volume in the space formed by the weak seal portion 10 for inhibiting communication, the discharge port 3 and the lower end side seal portion 6.
Like this medical multi-chamber container 1, by providing the weak seal portion 10 for inhibiting communication between the first drug chamber 21 and the discharge port 3 and capable of being peeled off, the weak seal portion 9 for partitioning is provided. It is preferable that only the first medicine in the first medicine chamber 21 is prevented from being administered without being peeled off. However, a space (third chamber 23) is formed by providing the weak seal portion 10 for inhibiting communication. Since the medicine discharged from the multi-chamber container 1 passes through this space, it is necessary to ensure sterilization.
Therefore, the medical multi-chamber container of the present invention provides a medical multi-chamber container that can surely sterilize the space formed by providing the above-described weak communication seal 10 for inhibiting communication.
In order to achieve this object, as described above, a small amount of liquid is added in the space 23 formed by providing the weak seal portion 10 for preventing communication. As the liquid, a liquid that is harmless even when administered to a living body (for example, water or physiological saline) is used. Then, in this state where a small amount of liquid is added (encapsulated) in the space 23 formed by providing the weak seal portion 10 for preventing communication, the added liquid is sterilized by high-pressure steam sterilization. Then, it is vaporized in the third chamber 23 which is a closed space, and the inner surface and the space in the third chamber 23 are sterilized. The amount of liquid added to the third chamber 23 is preferably 0.005 ml to 0.1 ml per 1 ml volume in the space of the third chamber. In particular, it is desirable that the volume is 0.01 to 0.05 ml per 1 ml of volume in the space of the third chamber. As described above, water (for example, sterile water, RO water, distilled water), physiological saline and the like are preferable as the liquid to be added. The medical multi-chamber container 1 of the present invention is sealed after the liquid is added to the third chamber 23 and sterilized by high-pressure steam.

The medical multi-chamber container 1 is provided in the vicinity of the discharge port 3 and includes a weak seal portion 10 for blocking communication that inhibits the separation between the first drug chamber 21 and the discharge port 3 and can be peeled off. The seal strength (initial peel strength) of the weak seal portion 10 for inhibiting communication is not particularly limited, but usually it is preferably about 0.5 to 6.0 kgf / 20 mm width, and 1.0 to 5.0 kgf. More preferably, the width is 20 mm.
It is preferable that the sealing strength of the weak seal portion 10 for inhibiting communication is substantially the same as that of the weak sealing portion 9 for partitioning, or slightly weaker or slightly stronger. When it is recommended to peel off the two weak seal portions 9 and 10 by the compression of the first drug chamber 21 portion, the seal strength of the weak seal portion 10 for blocking communication is almost equal to the seal strength of the weak seal portion 9 for partitioning. Preferably they are the same or slightly stronger. By doing in this way, when the 1st chemical | medical agent chamber 21 part of the container main body 2 is compressed, the weak seal part 10 for communication inhibition does not peel ahead of the weak seal part 9 for a partition.
Further, it may be recommended to peel off the two weak seal portions 9 and 10 by compressing the second drug chamber 22 portion. In this case, the seal strength of the weak seal portion 10 for inhibiting communication is peeled off. Any level is possible if possible. It is preferable that the seal strength of the partition weak seal portion 9 is substantially the same as or slightly stronger or slightly weaker.

  The medical multi-chamber container 1 is a cylindrical body and includes the one end (lower end) seal portion 6 formed on the side to which the discharge port 3 is attached as described above. As shown in FIG. 2, the communication-inhibiting weak seal portion 10 is continuous with the first portion 11, one end of which extends from the closing portion 6 (6 a) toward the partition weak seal portion 9, and the first portion 11. And a second portion 12 extending in a direction substantially perpendicular to the central axis of the discharge port 3, a continuous portion of the second portion 12 and extending toward the blocking portion 6 (6b) and into the blocking portion 6 (6b). A third portion 13 is provided, and is formed so as to surround the upper end of the discharge port 3.

As shown in FIGS. 2 and 3, the discharge port 3 includes a cylindrical body 30 having a substantially cylindrical tip portion 30a and a flat tip portion 30b. For this reason, the front end portion 30b of the discharge port 3 has a smaller cross-sectional area than the main body portion 30a. Specifically, the cylindrical body 30 has a flat tip portion 30b, and an end portion (tip portion) is open. The opening area of the tip 30d of the discharge port is preferably larger than the cross-sectional area of the internal flow of the needle tube connected to the discharge port during use from the viewpoint of securing the flow rate. The opening area of the tip 30d of the discharge port is preferably 5 mm ² or more, and particularly preferably 10 mm ² or more. In addition, the discharge port has an inner diameter that allows the needle tube connected to the discharge port to enter during use and a length that allows entry so that the needle tube does not fall out. The inner diameter of the main body of the discharge port is preferably 5 mm or more, and particularly preferably 8 mm or more. As length of the flat part 30b of the cylindrical body 30, about 10-15 mm is suitable. As thickness (thickness between outer surfaces) in the flat part 30b of the cylindrical body 30, about 2-8 mm is suitable, and 3-5 mm is especially preferable. Moreover, as thickness W of the internal channel | path in the flat part 30b of the cylindrical body 30, about 0.5-2.5 mm is suitable. Moreover, as an outer diameter of the cylindrical part of the cylindrical body 30, about 10-20 mm is suitable, and 14-16 mm is especially preferable.

The distance H1 between the distal end 30d of the distal end portion of the discharge port 3 and the discharge port side edge 12a in the second portion 12 of the communication inhibiting weak seal portion 10 is 6 to 15 mm. In particular, the distance H1 is preferably 8 to 10 mm. In this embodiment, as shown in FIGS. 2 and 3, the distal end portion 30 b of the discharge port 3 has a flat shape, and therefore the distal end 30 d of the distal end portion of the discharge port 3 is connected to the weak seal portion 10 for preventing communication. Even if the second portion 12 is close to the second portion 12, the second portion 12 of the weak seal portion 10 for inhibiting communication is hardly spread. For this reason, a poor seal is rarely generated in the weak seal portion 10 for inhibiting communication. Further, as described above, the tip 30d of the tip of the discharge port 3 can be brought close to the second portion 12 of the weak seal portion 10 for inhibiting communication, so that the sheet forming the third chamber 23 is in close contact with it. Can be reduced, and unexpected blocking can be prevented.
Further, in the medical multi-chamber container 1 of this embodiment, as shown in FIG. 2, the one end (lower end) seal portion 6 (6a, 6b) is a discharge port at the edge on the first drug chamber 21 side. 3 are provided with straight portions 16a and 16b formed on both sides. The discharge port side end edge 12a in the second portion 12 of the communication inhibiting weak seal portion 10 has discharge port side ends P1 of the straight portions 16a and 16b of the blocking portions 6a and 6b located on both sides of the discharge port 3, respectively. , P2 is located closer to the partitioning weak seal portion 9 than the phantom line. The distance L between the discharge port side edge 12a and the imaginary line connecting the discharge port side ends P1 and P2 of the linear portions 16a and 16b is preferably 0 to 7 mm. In particular, the distance L is preferably 1 to 5 mm.

Furthermore, in the medical multi-chamber container 1 of this embodiment, as shown in FIG. 2, the discharge port side ends P1, of the straight portions 16a, 16b of the blocking portions 6a, 6b located on both sides of the discharge port 3, respectively. An imaginary line connecting P2 is closer to the communication inhibiting weak seal portion 10 than the tip 30d of the tip of the discharge port 3. That is, the tip 30d of the tip of the discharge port 3 protrudes toward the weak seal portion 10 for inhibiting communication from the imaginary line connecting the discharge port side ends P1, P2 of the straight portions 16a, 16b of the blocking portions 6a, 6b. It is not to be.
By doing so, the communication-inhibiting weak seal portion 10 has a shape that does not protrude greatly toward the drug chamber 21 side, and the external pressure during transportation or the like can be obtained without increasing the seal strength of the communication-inhibiting weak seal portion 10. There is no peeling of the seal part.

And the distance (H1-L) between the front-end | tip 30d of the front-end | tip part of the discharge port 3 and the virtual line which ties each discharge port side end P1, P2 of said linear part 16a, 16b is 1-15 mm. It is preferable. In particular, the distance (H1-L) is preferably 4 to 8 mm.
Furthermore, in the medical multi-chamber container 1 of this embodiment, as shown in FIG. 1, the other end (upper end) of the container body 2 was fixed so as to enter the second drug chamber 22. A medicine container 4 is provided. The medicine container 4 is a non-blocking portion (unsealed portion) formed so as to penetrate in the axial direction (the container vertical direction) in the other end side (upper end side) seal portion (second closing portion). It is inserted between the sheet materials of the parts, fused by the seal portion 15, and fixed liquid-tightly to the container body 2. The medicine container 4 has a medicine container main body part, an operation part 4a, and a lid part 4b. The medicine container 4 is fixed to the container body 2 so that the operation unit 4 a protrudes into the second medicine chamber 22. The medicine container 4 stores the medicine inside, and the medicine in the medicine container flows into the second medicine chamber 22 by performing the breaking operation of the operation portion 4a.

Drugs stored in the drug container 4 are those that are mixed and dissolved in an infusion solution. For example, antibiotics, vitamins (general vitamins), various amino acids, heparin and other antithrombotic agents, insulin, antitumor Agents, analgesics, cardiotonic agents, intravenous anesthetics, anti-Parkinson agents, ulcer treatment agents, corticosteroid agents, arrhythmia agents, correction electrolytes, antiviral agents, immunostimulants, and the like. Moreover, although the inside of the chemical | medical agent container 4 may be a normal pressure, it is good also as a pressure reduction or a vacuum state.
The constituent material of the drug container 4 includes hard polyvinyl chloride, polyethylene, polypropylene, polybutadiene, cyclic polyolefin [specifically, ZEONEX (manufactured by ZEON Corporation), APEL (manufactured by Mitsui Chemicals, Inc.)], polypropylene homopolymer , Polyolefins such as high density polyethylene, polystyrene, poly- (4-methylpentene-1), polycarbonate, ABS resin, acrylic resin, polymethyl methacrylate (PMMA), polyacetal, polyarylate, polyacrylonitrile, polyvinylidene fluoride, ionomer , Acrylonitrile-butadiene-styrene copolymer, polyethylene terephthalate (PET), polyester such as polybutylene terephthalate (PBT), butadiene-styrene copolymer, Family or various resins such as aliphatic polyamides, or include a combination of these as desired. Among these, hard polyvinyl chloride, polyethylene, polypropylene, and polyester are preferable in terms of high safety and excellent adhesion to the container body 2.

Further, in the above-described embodiment, the cylindrical body 30 used for the discharge port 3 has an abrupt deformed portion 30c continuous with the main body portion 30a, and the inner end of the deformed portion 30c is substantially the same thickness on the end side. It has a passage. However, the present invention is not limited to such a configuration, and a flat tip portion 50b having an inclined shape in which the thickness of the internal passage gradually becomes smaller than that of the main body portion 50a, as in the cylindrical member 50 shown in FIG. It may be a thing.
The cylindrical body 50 is opened at the tip 50d of the flat tip 50b. The opening area of the tip 50d of the discharge port is preferably larger than the cross-sectional area of the internal flow of the needle tube connected to the discharge port during use from the viewpoint of securing the flow rate. The opening area of the tip 50d of the discharge port is preferably 5 mm ² or more, and particularly preferably 10 mm ² or more. In addition, the discharge port has an inner diameter that allows the needle tube connected to the discharge port to enter during use and a length that allows entry so that the needle tube does not fall out. The inner diameter of the main body of the discharge port is preferably 5 mm or more, and particularly preferably 8 mm or more. As length of the flat part 50b of the cylindrical body 50, about 10-15 mm is suitable. As thickness (between outer surfaces) in the flat part 50b of the cylindrical body 50, about 2-8 mm is suitable, and 3-5 mm is especially preferable. Moreover, as an outer diameter of the cylindrical part of the cylindrical body 50, about 10-20 mm is suitable, and 14-16 mm is especially preferable. Also in this embodiment, the distance between the tip 50d of the tip of the discharge port 3 and the discharge port side edge 12a of the second portion 12 of the communication inhibiting weak seal portion 10 is 6 to 15 mm. It is preferably 8 to 10 mm.

Next, the medical multi-chamber container 20 of the embodiment shown in FIGS. 5 to 7 will be described.
FIG. 5 is a front view of another embodiment of the medical multi-chamber container of the present invention, FIG. 6 is a partially enlarged view of the vicinity of the discharge port of the medical multi-chamber container of FIG. 5, and FIG. It is the BB sectional view taken on the line of FIG.
The medical multi-chamber container 20 of this embodiment is formed of a flexible material, and is divided into a first drug chamber 21 and a second drug chamber 22 by a partition weak seal portion 9 that can be peeled off. The container main body 2, the discharge port 3 that can communicate with the lower end of the first drug chamber 21, the first drug stored in the first drug chamber 21, and the first drug stored in the second drug chamber 22. A medicine-equipped medical multi-chamber container comprising two medicines. The medical multi-chamber container 20 is a cylindrical body, and obstructs communication between the closed portion 6 formed on the side where the discharge port 3 is attached and the first drug chamber 21 and the discharge port 3 and can be peeled off. A weak seal portion 10 for preventing communication is provided. Furthermore, the weak seal portion 10 for blocking communication has a first portion 11 having one end extending from the closing portion 6 (6a) toward the partition weak seal portion 9 side, the first portion 11 and the center of the discharge port 3. A second portion 12 extending in a direction substantially perpendicular to the axis, and a third portion 13 continuous with the second portion 12 and extending toward the closing portion 6 (6b) and reaching the closing portion, and discharging It is formed so as to surround the upper end of the port 3. The discharge port 3 is a cylindrical body having a tip portion with a reduced diameter, and the discharge port side edge 12a of the tip 60a of the tip portion of the discharge port 3 and the second portion 12 of the weak seal portion 10 for inhibiting communication. The distance H2 is 8 to 15 mm.

The basic configuration of the medical multi-chamber container 20 of this embodiment is the same as the medical multi-chamber container 1 described above. The same reference numerals are given to the same components, and the above description is referred to. The difference between the medical multi-chamber container 20 and the medical multi-chamber container 1 described above is the shape of the distal end portion 60 b of the discharge port 3.
As shown in FIGS. 6 and 7, the discharge port 3 in the medical multi-chamber container 20 of this embodiment uses a cylindrical body 60 having a tip portion 60 b whose diameter is reduced to a conical shape. The distance between the distal end 60d of the distal end portion of the discharge port 3 and the discharge port side edge 12a in the second portion 12 of the communication inhibiting weak seal portion 10 is 8 to 15 mm. The discharge port 3 has a distal end portion 60b that is continuous with the main body portion 60a and decreases in a taper shape toward the second portion 12 direction of the weak seal portion 10 for preventing communication, and has an end portion (front end portion) 60d. And a cylindrical member 60 opened. The opening area of the tip 60d of the discharge port is preferably larger than the cross-sectional area of the internal flow of the needle tube connected to the discharge port during use from the viewpoint of securing the flow rate. The opening area of the tip 60d of the discharge port is preferably 5 mm ² or more, and particularly preferably 10 mm ² or more. In addition, the discharge port has an inner diameter that allows the needle tube connected to the discharge port to enter during use and a length that allows entry so that the needle tube does not fall out. The inner diameter of the main body of the discharge port is preferably 5 mm or more, and particularly preferably 8 mm or more. The length of the reduced diameter portion 60b of the cylindrical body 60 is preferably about 10 to 15 mm. As a tip outer diameter of the cylindrical body 60, about 2-8 mm is suitable, and 3-5 mm is especially preferable. Moreover, as a tip internal diameter of the cylindrical body 60, about 0.5-2.5 mm is suitable. Moreover, as an outer diameter of the cylindrical part of the cylindrical body 60, about 10-20 mm is suitable, and 14-16 mm is especially preferable.

  The distance H2 between the distal end 60d of the distal end portion of the discharge port 3 and the discharge port side edge 12a in the second portion 12 of the communication inhibiting weak seal portion 10 is 6 to 15 mm. In particular, the distance H2 is preferably 8 to 10 mm. In this embodiment, as shown in FIG. 6, the distal end portion 60 b of the discharge port 3 has a conical shape (specifically, a truncated cone shape). Even if the second portion 12 of the weak seal portion 10 for use is brought close to the second portion 12, the second portion 12 of the weak seal portion 10 for inhibiting communication is hardly spread. For this reason, a poor seal is rarely generated in the weak seal portion 10 for inhibiting communication. Further, as described above, the tip 60a of the tip of the discharge port 3 can be brought close to the second portion 12 of the weak seal portion 10 for inhibiting communication, so that the sheet forming the third chamber 23 is in close contact with it. Can be reduced, and unexpected blocking can be prevented.

Next, the medical multi-chamber container 40 of the embodiment shown in FIGS. 8 to 10 will be described.
8 is a front view of another embodiment of the medical multi-chamber container of the present invention, FIG. 9 is a partially enlarged view of the vicinity of the discharge port of the medical multi-chamber container of FIG. 8, and FIG. It is CC sectional view taken on the line of FIG.
The medical multi-chamber container 40 of this embodiment is formed of a flexible material, and is divided into a first drug chamber 21 and a second drug chamber 22 by a partition weak seal portion 9 that can be peeled off. The container main body 2, the discharge port 3 that can communicate with the lower end of the first drug chamber 21, the first drug stored in the first drug chamber 21, and the first drug stored in the second drug chamber 22. A medicine-equipped medical multi-chamber container comprising two medicines. The medical multi-chamber container 40 is a cylindrical body, and obstructs communication between the closed portion 6 formed on the side where the discharge port 3 is attached and the first drug chamber 21 and the discharge port 3 and can be peeled off. A weak seal portion 10 for preventing communication is provided. Furthermore, the weak seal portion 10 for blocking communication has a first portion 11 having one end extending from the closing portion 6 (6a) toward the partition weak seal portion 9 side, the first portion 11 and the center of the discharge port 3. A second portion 12 extending in a direction substantially perpendicular to the axis, and a third portion 13 continuous with the second portion 12 and extending toward the closing portion 6 (6b) and reaching the closing portion, and discharging It is formed so as to surround the upper end of the port 3. The discharge port 3 has a cylindrical shape having substantially the same outer diameter. The discharge port 3 has a tip 70a at the tip of the discharge port 3 and a discharge port side edge 12a in the second portion 12 of the weak seal portion 10 for inhibiting communication. The distance H3 is 20 to 25 mm.

The basic configuration of the medical multi-chamber container 40 of this embodiment is the same as the medical multi-chamber container 1 described above. The same reference numerals are given to the same components, and the above description is referred to. The difference between the medical multi-chamber container 40 and the above-described medical multi-chamber container 1 is the shape of the distal end portion of the discharge port 3.
As shown in FIGS. 9 and 10, the discharge port 3 in the medical multi-chamber container 40 of this embodiment uses a cylindrical body 70 having a distal end portion extending to the upper end side with substantially the same outer diameter. A distance H3 between the distal end 70d of the distal end portion of the discharge port 3 and the discharge port side end edge 12a in the second portion 12 of the communication inhibiting weak seal portion 10 is 20 to 25 mm. The discharge port 3 includes a cylindrical member 70 having a distal end portion formed by the distal end of a cylindrical main body portion 70a and having an end portion (front end portion) opened. The inner diameter of the distal end 70d of the distal end portion of the cylindrical member 70 is preferably about 10 to 14 mm. Moreover, as an outer diameter of the cylindrical part of the cylindrical member 70, about 14-18 mm is suitable.

The distance H3 between the distal end 70d of the distal end portion of the discharge port 3 and the discharge port side edge 12a in the second portion 12 of the communication inhibiting weak seal portion 10 is 15 to 30 mm. In particular, the distance H3 is preferably 20 to 25 mm.
And the formation method of the weak seal part 9 for a partition and the weak seal part 10 for communication inhibition in the medical multiple-chamber container of all the Examples mentioned above is not specifically limited, The heating mold for heat seals normally used ( It can be performed using a heat seal bar) or the like. Moreover, you may use the method of producing blocking in the site | part of the weak seal part 9 for a partition and the weak seal part 10 for communication inhibition at the time of heat sterilization, such as high pressure steam sterilization.

Next, the medical multi-chamber container 80 of the embodiment shown in FIGS. 11 to 17 will be described.
11 is a front view of another embodiment of the medical multi-chamber container of the present invention, and FIG. 12 is a partially enlarged view of the vicinity of the discharge port of the medical multi-chamber container of FIG. FIG. 13 is a front view of the discharge port used in the medical multi-chamber container of FIG. 14 is a side view of the discharge port shown in FIG. 15 is a cross-sectional view taken along the line DD of FIG. 16 is a cross-sectional view taken along line EE in FIG. FIG. 17 is an explanatory diagram for explaining the operation of the discharge port shown in FIG. 13.
The difference between the medical multi-chamber container 80 of this embodiment and the medical multi-chamber container 1 of the above-described embodiment is only the configuration of the discharge port 90 and the form of the weak seal portion 100 for communication inhibition, and the others are the same. The same reference numerals are attached and the above description is referred to.

In this medical multi-chamber container 80 as well, the communication inhibiting weak seal portion 100 includes a first portion 101 having one end extending toward the partition weak seal portion 9 from the closed portion 6 (6a) to which the discharge port 90 is attached. A second portion 102 that is continuous with the first portion 101 and extends in a direction substantially orthogonal to the central axis of the discharge port 90; and a second portion 102 that is continuous with the second portion 102 and extends toward the closing portion 6 (6b). In addition, the third portion 103 that reaches the closing portion is provided, and is formed so as to surround the upper end of the discharge port 90.
As shown in FIG. 12, the discharge port 90 is a cylindrical body 93 having a main body portion 93a and a front end portion 94 closed at the front end, and the front end portion 94 has a smaller cross-sectional area than the main body portion 93a. Furthermore, the distance H1 between the distal end 94a of the distal end portion 94 of the discharge port 90 and the discharge port side end edge 102a in the second portion 102 of the communication inhibiting weak seal portion 100 is 6 to 15 mm. Preferably, it is 8-10 mm.

The cylindrical body 93 provided in the discharge port 90 includes a main body portion 93a and a flat tip portion 94 that can be closed and broken. In this embodiment, the distal end side of the distal end portion 94 is a transition region so that the distance between the outer surfaces becomes shorter toward the distal end 94a. Specifically, it is an inclined portion 94b in which the distance between the outer surfaces becomes shorter toward the tip 94a. In addition, it is not limited to an inclined part, The curved part from which the distance between outer surfaces becomes short toward the front-end | tip 94a may be sufficient. By providing such a transition region, the distance between the outer surfaces of the tip 94 a at the tip 94 a is the shortest at the tip 94.
And it is preferable from the point of ensuring flow volume that the opening area of the discharge port after a fracture | rupture is larger than the cross-sectional area of the internal flow of the needle tube connected to a discharge port at the time of use. The opening area of the discharge port after breakage is preferably 5 mm ² or more, and particularly preferably 10 mm ² or more. In addition, the discharge port has an inner diameter that allows the needle tube connected to the discharge port to enter during use and a length that allows entry so that the needle tube does not fall out. The inner diameter of the main body of the discharge port is preferably 5 mm or more, and particularly preferably 8 mm or more. The length of the flat portion 94 of the cylindrical body is preferably about 10 to 15 mm. As thickness (thickness between outer surfaces) in the flat part 94 of a cylindrical body, about 2-8 mm is suitable, and 3-5 mm is especially preferable. Moreover, as an outer diameter of the cylindrical part (main-body part 93a) of a cylindrical body, about 10-20 mm is suitable, and 14-16 mm is especially preferable.

The discharge port 90 used for the medical multi-chamber container 80 includes a cylindrical body 93 having an open rear end portion and a seal member 95 that seals the rear end portion of the cylindrical body 93. The portion is formed of an elastic member 95a capable of puncturing a needle tube.
And the cylindrical body 93 for medical containers is the cylindrical body for medical containers used for a medical container provided with a container main body, Comprising: The cylindrical body 93 is formed with the hard or semi-rigid material, Further, the cylindrical body 93 is provided so as to sandwich the main body portion 93a, the breakable portion 96 provided at the distal end portion of the main body portion 93a, and the breakable portion 96 of the main body portion 93a. The first stress applying part 91 fixed to the inner surface and the second stress applying part 92 fixed to the other inner surface of the container main body are provided, and the breakable part 96 includes the first stress applying part 91 and the second stress applying part 91. It breaks due to the spread between the stress applying portions 92 and opens the main body portion 93a. Further, a tip portion 94 is formed by the two stress applying portions 91 and 92.

The discharge port 90 is a non-communication discharge port. As shown in FIGS. 15 and 16, the discharge port 90 does not communicate with the inside of the medicine chamber 21 when not broken. As shown in FIGS. 13 to 16, the discharge port 90 includes a main body portion 93a having a discharge passage 98 or a hollow portion, a first stress applying portion 91 and a second stress applying portion 91 that extend near one end portion of the main body portion 93a. A stress applying portion 92; and a breakable portion 96 that breaks when the first and second stress applying portions 91, 92 are spread and allows the main body portion 93a to communicate with the outside. The portion 91 is fixed to the inner surface of one sheet that forms the chemical chamber of the container body 2, and the second stress applying portion 92 is fixed to the inner surface of the other sheet that forms the chemical chamber, The breakable portion 96 is broken by the swelling of the fixing portions of the first stress applying portion 91 and the second stress applying portion 92 of the container body 2.
The first stress applying portion 91 extends from one sheet side portion near the front end portion of the main body portion 93a, and the second stress applying portion 92 is the other sheet side portion near the front end portion of the main body portion 93a. The breakable part 96 includes a first stress applying part 91 and a second stress of the container body 2 when the first stress applying part 91 and the second stress applying part 92 press the drug chamber. Due to the bulging of the fixing portion of the applying portion 92, it breaks to one sheet side and the other sheet side.

As shown in FIGS. 13 to 17, the discharge port 90 includes a main body portion 93a having a discharge passage 98 or a hollow portion, a breakable portion 96 provided in the main body portion 93a, a first stress applying portion 91, And a second stress applying portion 92.
The cylindrical body 93 for medical containers according to the embodiment includes a main body portion 93a, a breakable portion 96, a first stress applying portion 91, and a second stress applying portion 92. Further, a lid portion attaching portion 97 to which the seal member 95 is attached is formed at the base end portion of the cylindrical portion 93. Further, the proximal end portion of the cylindrical portion 93 has a certain length on the proximal end side from the breakable portion so that the tubular end portion 93 can be attached to the container body 2.
Further, the seal member 95 is a cylindrical portion whose base end is closed. The distal end portion of the seal member 95 has a shape that can be attached to the lid attaching portion 97 of the tubular portion 93. An elastic member 95a through which a needle tube (specifically, a discharge needle: not shown) or the like can be inserted is provided at the base end portion (discharge port of the discharge port) of the lid member 95.
The elastic member 95a is preferably the same as described above. The hollow part of the cylindrical part may contain a powder or solid medicine. In particular, it is preferably in a powder form.

  In the discharge port 90, the first stress applying portion 91 and the second stress applying portion 92 extend with the vicinity of the breakable portion of the main body portion 93a as the base end, as shown in FIGS. At the same time, the tip is a free end. The first stress applying portion 91 and the second stress applying portion 92 have a function of converting the force into stress for breaking the breakable portion 96 when a force for opening the both is applied. . Moreover, it is preferable that the first stress applying part 91 and the second stress applying part 92 are formed so as to face each other. The main body portions of the first stress applying portion 91 and the second stress applying portion 92 are preferably formed in a vertically long rectangular shape. With such a configuration, when the container body 2 is pressed and inflated, the first stress applying part 91 and the second stress applying part 92 reliably apply the breaking stress to the breakable part 96.

  Specifically, in the medical container tubular body 93 in the medical container of this embodiment, the first stress applying part 91 and the second stress applying part 92 are as shown in FIGS. A vertically long flat plate portion and side wall portions formed on both sides of the flat plate portion are provided. Furthermore, the first stress applying part 91 and the second stress applying part 92 are provided so as to extend in the axial direction of the main body part. And the 1st stress application part 91 and the 2nd stress application part 92 become what a side wall part opposes. The first stress applying part 91 and the second stress applying part 92 are provided so as to face each other and slightly apart. Moreover, it is preferable that the front-end | tip (other end) of the 1st stress provision part 91 and the 2nd stress provision part 92 is a free end like this Example. Furthermore, it is preferable that the first stress applying part 91 and the second stress applying part 92 include ribs provided on respective surfaces facing each other and disposed at positions where they do not contact each other.

  Moreover, it is preferable that the flat part 91a, 92a joined to the inner surface of the container main body 2 is formed in the outer surface of a flat plate part. The flat portions 91a and 92a are formed in a rectangular shape and have a flat joint surface. The flat portions 91a and 92a are formed from the vicinity of the proximal end portions of the first stress applying portion 91 and the second stress applying portion 92 to the distal end. The flat portions 91 a and 92 a that are joined to the inner surface of the container body 2 are at least partially formed of a material that can be fixed to the inner surface of the container body 2. Specifically, the flat portions 91a and 92a joined to the inner surface of the container body 2 are partly or entirely formed of the forming material of the container body 2 (particularly, the forming material forming the inner surface side of the container body 2). It is preferably formed of a compatible resin. With such a configuration, the first stress applying portion 91 and the second stress applying portion 92 can be reliably bonded to the inner surface of the container body 2. The compatible resin is preferably a material that is the same as or similar to the constituent material of the container body. In the embodiment of the present invention, the compatible resin layer is preferably produced by two-color molding. In addition, you may produce all the 1st stress provision parts or the 2nd stress provision part with resin compatible with the container main body of a chemical | medical agent container. The compatible resin layer is preferably made flat so as to be easily joined to the inner surface of the container body.

Further, the first stress applying part 91 and the second stress applying part 92 are formed slightly apart between the first stress applying part 91 and the second stress applying part 92. Thus, the first stress applying part 91 and the second stress applying part 92 are not so far apart. For this reason, even if the space between the first stress applying part 91 and the second stress applying part 92 is pressed when being fixed to the container body 2, the first stress applying part 91 and the second stress applying part are allowed. The amount of deformation is small, and the breakable portion 96 is not likely to break.
In the medical multi-chamber container 80, the whole or part of the flat surface portion 91a of the first stress applying portion 91 is joined to the inner surface of one sheet of the container main body 2, and similarly, the second stress applying portion. The whole or part of the flat portion 92 a of 92 is joined to the inner surface of the other sheet of the container body 2. For this reason, the first stress applying part and the second stress applying part follow the spread between the first stress applying part of the container main body and the fixing part of the second stress applying part when the drug chamber is pressed. It spreads, and a breakable portion, which will be described later, is opened and broken on one sheet side and the other sheet side.

Bonding between the flat surface portion 91a of the first stress applying portion 91 and the flat surface portion 92a of the second stress applying portion 92 and the inner surface of each sheet of the container main body 2 includes ultrasonic fusion, high frequency fusion, thermal fusion, and the like. Is preferably carried out by
Moreover, it is preferable that the 1st stress provision part 91 or the 2nd stress provision part 92 is the structure which can carry | support and spread from the exterior of the container main body 2. FIG.
The first stress applying part and the second stress applying part of the present invention are not limited to those having the above-described configuration, and can be joined to one sheet inner surface and the other sheet inner surface constituting the container body, Moreover, any configuration may be used as long as it is configured to apply stress to the breakable portion in conjunction with the swelling of the container body.

The breakable portion 96 is located in the vicinity of the distal end portion of the main body portion 93 a, located between the first stress applying portion 91 and the second stress applying portion 92 and extending to the proximal end side of the discharge port 90. And a first stress applying portion side portion 96b and a second stress applying portion side portion 96c that branch at the respective base end portions of the distal end side portion 96a and extend in the side surface direction of the main body portion 93a. With such a configuration, when the first stress applying portion 91 and the second stress applying portion 92 are spread, the breakable portion 96 is broken and the main body portion 93a is reliably opened.
In particular, the breakable portion 96 in this embodiment is provided so as to pass between the first stress applying portion 91 and the second stress applying portion 92 in the vicinity of the distal end portion of the main body portion 93a and extends to the proximal end side. The distal end side portion 96a, the first stress applying portion side portion 96b and the second stress provided so as to branch at the proximal end portion of the distal end side portion 96a and connect the proximal end portions of the distal end side portion 96a. The provision part side part 96c is provided. That is, in this embodiment, the first stress applying portion side portion 96b and the second stress applying portion side portion 96c of the breakable portion 96 are continuous without being interrupted, and each of the front end side portions 96a of the breakable portion 96 is provided. It connects between the base end parts. Only one of the first stress applying part side portion 96b and the second stress applying part side portion 96c of the breakable part 96 may be configured as described above.

  Further, as shown in FIGS. 13 and 15, the distal end side portion 96a passes through the vicinity of the middle between the first stress applying portion 91 and the second stress applying portion 92 in the vicinity of the distal end portion of the main body portion 93a. It is preferable to extend to the base end side so as to pass through the vicinity of the middle between the sheet side and the other sheet side. Specifically, as shown in FIGS. 13 and 15, the distal end side portion 96 a of this embodiment is formed in a U shape along the vicinity of one sheet side of the main body 93 a and the other sheet side. Yes. By comprising in this way, the main-body part 93a can be torn to the one sheet | seat side and the other sheet | seat side from a substantially middle.

  The breakable portion 96 is a fragile portion that is a breakable portion. Specifically, the breakable part is a thin part. Moreover, it is preferable that the breakable part 96 is produced by forming a groove part in the main body part 93a. The breakable part is produced by forming a groove part having a V-shaped cross section. Specifically, the angle of the groove is preferably 30 to 120 °, particularly 40 to 60 °, and the minimum thickness is preferably 0.05 to 0.3 mm, particularly 0.08 to 0.2 mm. By producing the groove forming portion at such an angle, when the container main body 2 is inflated, the stress concentrates on the center of the breakable portion, and it is surely broken. Further, the groove portion may have any shape as long as it is easily broken, and is not limited to the V shape as in the embodiment, and may be a semicircular shape, a semielliptical shape, or the like. Moreover, although the breakable part of the present invention can be broken by forming a thin part by forming a groove part, it is not limited to this. The breakable portion may be produced by, for example, forming a portion forming the breakable portion of the medicine storage portion with a material more fragile than the other portions. Specifically, it is preferable that a part forming the breakable part is made of an easily breakable material by multicolor molding, and the other part is made of a material that is not easily broken.

  Also in the medical multi-chamber container 80 of this embodiment, as in the medical multi-chamber container 1 described above, a space (third chamber 23) is defined by the weak seal portion 100 for blocking communication, the discharge port 90, and the closing portion 6a. Is formed. This space (third room) 23 is an empty room. However, it is preferable that a liquid that is harmless even when administered to a living body (for example, water or physiological saline) is added to the third chamber. By putting the liquid in the third chamber 23 in this way, the sterilization inside the third chamber is ensured. The amount of liquid placed in the third chamber 23 varies depending on the size of the third chamber, but is preferably about 0.1 to 0.5 ml. Moreover, it is preferable that the addition amount of the liquid per 1 ml capacity of the third chamber is about 0.02 to 0.1 ml. The weak seal portion 100 for inhibiting communication can be formed by heat-sealing the sheet material in a band shape (thermal fusion, high frequency fusion, ultrasonic fusion, etc.).

  And as shown in FIG. 17, the 2nd chemical | medical agent chamber 22 of the medical multi-chamber container 80 is pressed, the partition weak seal part 100 is peeled, and the 1st chemical | medical agent chamber 21 is expanded by pressing further. In conjunction with the bulge, the first stress applying portion 91 and the second stress applying portion 92 open in the direction of one sheet and the other sheet, and first, the distal end side portion 96a of the breakable portion 96 is broken, Next, the first stress applying part side portion 96b and the second stress applying part side portion 96c are broken. Thereby, the discharge port 90 is opened, the main body portion 93a communicates with the chemical liquid chamber 21, and the chemical liquid in the container main body 2 can be administered. Moreover, in the discharge port 90 of this embodiment, the first stress applying part 91 and the second stress applying part 92 are separated from the main body part 93a.

(Experiment)
As a sheet-like cylindrical body, a soft resin obtained by blending polypropylene with a styrene-ethylene-butylene-styrene block copolymer is molded into a cylindrical shape having a thickness of 330 μm [folded diameter (width 210 mm)] by inflation molding. Using.
And as shown in FIG. 1, it forms by heat-heat-sealing a heat seal part to the upper end and lower end of said sheet-like cylindrical body, Furthermore, it is higher than the center of a weak seal part and a lower end seal part in a center part. It formed by heat-sealing the weak seal part for communication inhibition so that it might extend. And it inserted in the chemical | medical agent container attachment part of an upper end seal part, and was fixed by heat sealing. Further, a cylindrical body of the discharge port is inserted into the discharge port mounting portion of the lower end seal portion and fixed by heat sealing, and the experimental medical multi-chamber container having substantially the same form as the medical multi-chamber container shown in FIG. Was made. In addition, the sealing member is not attached to the cylindrical body. The volume of the space defined by the weak seal portion for communicating with the discharge port in this experimental medical multi-chamber container was 10 ml.
Nine laboratory medical multi-chamber containers were prepared as described above.
Then, each of the experimental medical multi-chamber containers is divided into three groups, and the first group of multi-chamber containers is filled with 10 ⁷ cfu of indicator bacteria (Bacillus subtilis) and 1.0 ml of RO water. Then, a sealing member was attached to the tip of the cylindrical body of the discharge port to seal the cylindrical body. In addition, in the second group of multi-chamber containers, after adding 10 ⁷ cfu of indicator bacteria (Bacillus subtilis) and 0.1 ml of RO water to the space, a sealing member is attached to the tip of the cylindrical body of the discharge port. And the cylindrical body was sealed. Further, in the multi-chamber container of the third group, after adding only 10 ⁷ cfu of indicator bacteria (Bacillus subtilis) to the space, a sealing member is attached to the tip of the tubular body of the discharge port, The body was sealed.
A plurality of laboratory medical multi-chamber containers prepared as described above are sterilized by autoclave (115 ° C., pressurized pressure of about 2 atm) and left for 72 hours, and are then partitioned by the weak seal portion for preventing communication. When the number of viable bacteria was measured, no viable bacteria were detected in any of the laboratory medical multi-chamber containers in the first group and the second group. However, in the third group of experimental medical multi-chamber containers, the survival of viable bacteria with an average value of 10 ⁷ cfu was detected.

DESCRIPTION OF SYMBOLS 1 Medical multiple-chamber container 2 Container main body 3 Drug discharge port 4 Drug container 5 The other end side (upper end side) seal part 6 The one end side (lower end side) seal part 9 The weak seal part 10 for partitioning The weak seal part 21 for communication inhibition 1 drug room 22 second drug room

Claims (15)

A container main body made of a flexible material and separated into a first drug chamber and a second drug chamber by a partition weak seal portion from which an internal space can be peeled, and a lower end portion of the first drug chamber communicated with each other A medical multi-chamber container comprising a possible discharge port, a first medicine housed in the first medicine chamber, and a second medicine housed in the second medicine chamber, The multi-chamber container for use is provided with a weak seal portion for preventing communication between the first drug chamber and the discharge port, and further capable of being peeled off. A first portion extending to the partitioning weak seal portion side from the closing portion to which the port is attached, and a second portion extending in a direction that is continuous with the first portion and substantially perpendicular to the central axis of the discharge port A portion, continuous with the second portion, and extending toward the closing portion and on the closing portion A third portion that reaches, and is formed so as to surround an upper portion of the distal end portion of the discharge port. The discharge port is a cylindrical body having a main body portion and the distal end portion, and the distal end portion is the main body. The distance between the tip of the tip of the discharge port and the edge of the discharge port side in the second portion of the weak seal portion for blocking communication is 6 to 6 mm. A medical multi-chamber container characterized by being 15 mm. The medical multi-chamber container according to claim 1, wherein a distal end portion of the discharge port has a flat shape. 2. The medical multi-chamber container according to claim 1, wherein a distal end portion of the discharge port is tapered in a tapered shape toward the second partial direction of the communication inhibition weak seal portion. A container main body made of a flexible material and separated into a first drug chamber and a second drug chamber by a partition weak seal portion from which an internal space can be peeled, and a lower end portion of the first drug chamber communicated with each other A medical multi-chamber container comprising a possible discharge port, a first medicine housed in the first medicine chamber, and a second medicine housed in the second medicine chamber, The multi-chamber container for use is provided with a weak seal portion for preventing communication between the first drug chamber and the discharge port, and further capable of being peeled off. A first portion extending to the partitioning weak seal portion side from the closing portion to which the port is attached, and a second portion extending in a direction that is continuous with the first portion and substantially perpendicular to the central axis of the discharge port A portion, continuous with the second portion, and extending toward the closing portion and on the closing portion The discharge port is formed to surround the upper portion of the discharge port, and the discharge port has a cylindrical shape having substantially the same outer diameter. The medical multi-chamber container, wherein the distance from the discharge port side end edge in the second portion of the weak seal portion for communication inhibition is 15 to 30 mm. The closing portion includes a straight portion extending in a side portion direction of the container main body formed on both sides of the discharge port at an edge on the first drug chamber side, and the second portion of the weak seal portion for communication inhibition is provided. 5. The discharge port side edge of the portion is located on the partition weak seal portion side with respect to an imaginary line connecting the respective straight portions of the closed portions located on both sides of the discharge port. A multi-chamber container for medical use according to crab. An imaginary line connecting the respective straight portions of the blocking portions located on both sides of the discharge port is closer to the second portion of the weak seal portion for blocking communication than the tip of the tip portion of the discharge port. The medical multi-chamber container according to any one of claims 1 to 4. The medical multi-chamber container according to any one of claims 1 to 6, wherein a liquid is added to a space formed by the weak seal part for communication inhibition, the discharge port, and the closed part. The medical multi-chamber container according to any one of claims 1 to 6, wherein the partition weak seal portion and the communication blocking weak seal portion are formed by heat sealing. Liquid is added to the space formed by the weak seal portion for blocking communication, the discharge port, and the lower end side seal portion to which the discharge port is fixed, and the amount of the liquid added to the space The medical multi-chamber container according to any one of claims 1 to 8, wherein 0.02 to 0.1 ml per 1 ml of volume in the space. Liquid is added to the space formed by the weak seal portion for blocking communication, the discharge port, and the lower end side seal portion to which the discharge port is fixed, and the amount of the liquid added to the space The medical multi-chamber container according to any one of claims 1 to 8, wherein 0.001 to 0.1 ml per 1 ml of volume in the space. The medical multi-chamber container according to claim 9 or 10, wherein the medical multi-chamber container is sterilized by high-pressure steam. A container body made of a flexible material and separated into a first drug chamber and a second drug chamber by a partition weak seal portion that can be separated from the inner space, and fixed to a lower end side seal portion of the container body. A discharge port communicating with the lower end of the first drug chamber; a first drug stored in the first drug chamber; a second drug stored in the second drug chamber; A medical multi-chamber container comprising a weak seal portion for preventing communication and preventing communication between the first drug chamber and the discharge port, the weak seal portion for preventing communication, the discharge port, and the lower end A medical multi-chamber container, wherein 0.005 to 0.1 ml of liquid is added to 1 ml of volume in the space formed by the side seal portion. The medical multi-chamber container according to claim 12, wherein the medical multi-chamber container is sterilized by high-pressure steam. The medical multi-chamber container according to claim 12 or 13, wherein an amount of the liquid added to the space is 0.02 to 0.1 ml per 1 ml of volume in the space. The medical multi-chamber container according to claim 12 or 13, wherein an amount of the liquid added to the space is 0.01 to 0.05 ml per 1 ml of the volume in the space.

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