JP3839624B2 - Multi-chamber container - Google Patents

Description

【００７５】
表１に示すように、実施例１〜３の複室容器は、いずれも、比較例１、２に比べ、Ｔ₁とＴ₂の乖離がある程度大きく、また、Ｐ₁とＰ₂の乖離がある程度大きい。そのため、例えば保管中、搬送中等、複室容器の姿勢が水平な状態では、仕切り部が剥離し難く、液漏れを防止することができる一方、複室容器を起立姿勢とした状態では、より小さな圧力で簡単に仕切り部を剥離（開封）して第１の空間と第２の空間とを連通させ、液体を混合させることができる。
【００７６】
【発明の効果】
以上述べたように、本発明の複室容器によれば、例えば保管中、搬送中等の必要時以外に仕切り部が誤って剥離し、第１の空間と第２の空間とが連通することが防止されるので、薬液の安定性が保持され、安全性が高い。
【００７７】
そして、必要時には、簡単な操作で、第１の空間と第２の空間とを連通させることができ、例えばそれらの空間に収納されている異なる液体同士を混合することができる。
【００７８】
特に、複室容器の外部から両空間を連通させることができるため、迅速に液の調製を行なうことができる。また、このような液体の調製時に液体が外気に触れないため、細菌や異物の混入のおそれがなく、薬液の調製を安全に行うことができる。
【００７９】
以上のことから、本発明の複室容器は、病院等の医療機関において医師や看護婦が使用する場合は勿論のこと、例えば在宅医療において高齢者や体力が衰えた患者が使用する場合にも適している。
【図面の簡単な説明】
【図１】本発明の複室容器の実施形態を示す部分断面正面図である。
【図２】本発明の複室容器を水平に載置した状態を示す主要部の断面側面図である。
【図３】本発明の複室容器を懸垂した状態を示す主要部の断面側面図である。
【図４】本発明の複室容器を水平に載置し、押圧して第１の空間を加圧した状態を示す主要部の断面側面図である。
【図５】本発明の複室容器を懸垂し、押圧して第１の空間を加圧した状態を示す主要部の断面側面図である。
【図６】本発明の複室容器を懸垂し、押圧して仕切り部が剥離した状態を示す主要部の断面側面図である。
【図７】従来の複室容器を水平に載置し、押圧して第１の空間を加圧した状態を示す主要部の断面側面図である。
【図８】従来の複室容器を懸垂し、押圧して第１の空間を加圧した状態を示す主要部の断面側面図である。
【符号の説明】
１ 複室容器
２ バッグ
２２ シール部
２３ 孔
２４ シール部
２５ シート材
３ 第１の空間
４ 第２の空間
３０、４０ 液体
５ 仕切り部
６ 排出口
６１ 管体
６２ 外筒
６３ 弾性体
６４ キャップ
６５ フランジ部
１０ 従来のバッグ
１１ シート材
１２ 第１の空間
１３ 第２の空間
１４ 仕切り部[0001]
[Technical field to which the invention belongs]
The present invention relates to a multi-chamber container for storing a liquid such as an infusion solution or a peritoneal dialysis solution.
[0002]
[Prior art]
For example, in the case of infusion, when two or more kinds of liquids (chemical solutions) are mixed and used, if they are mixed from the beginning and stored in a bag, they may deteriorate or deteriorate over time.
[0003]
Therefore, the middle part of the bag made of the resin sheet material is fused in a band shape to form a partition portion, and the partition portion partitions the inside of the bag into two chambers (spaces). A multi-chamber container has been developed in which the liquid is contained in the two chambers by separating (opening) the partition portion when necessary (for example, immediately before infusion) and mixing the liquids in both chambers. Currently, as this type of multi-chamber container, there are infusion bags such as Otsuka Pharmaceutical Co., Ltd., Aminotripa No. 2, Nippon Hoechst Marion Lucel Co., Ltd., P Twin Twin No. 3, etc. These can be peeled off at the time of use, and in order to make a container that does not require a separation preventing member for the partition part, the separation strength of the partition part is usually 0.98 N / 20 mm width (0.10 kgf / 20 mm width) or more. In addition, the bag is wrapped in two in the partition part.
[0004]
When these bags are peeled off at the time of use, the bag is taken out from the packaging material, opened in a folded state by a partitioning part and placed on a desk, and one room is pressurized by hand, etc., but peeling during transportation is prevented. For the purpose, since the seal strength of the partition portion is set higher than the above-mentioned value, a large force is required for peeling (opening) of the partition portion, and the opening operability is poor.
[0005]
In particular, with regard to home medical care, which has become widespread in recent years, it is important for elderly people and patients with weak physical strength to perform the peeling (opening) operation of the bag partition, so that this operation can be performed easily. It is a problem.
[0006]
[Problems to be solved by the invention]
An object of the present invention is to provide a multi-chamber container that is less likely to peel off a partition part inadvertently during transportation or storage and cause liquid leakage, and can be peeled off and opened by a simple operation when necessary. There is.
[0007]
[Means for Solving the Problems]
The above problems are solved by the present invention described below.
[0008]
Separation of the partition portion is caused by sheet tension acting in a direction perpendicular to the inner peeling seal portion, in which the pressure in the container is converted into the tension of the sheet surface. The peel strength when the partition part peels does not change depending on how the container is placed.However, if the container shape changes depending on how the container is placed, the sheet tension necessary for peeling can be applied to the partition part even if the container pressure is small. As a result of diligent study, we used a flexible sheet material as much as possible, and when the container was suspended, the container shape of the partition part had a large radius of curvature. The invention has invented a multi-chamber container that is difficult to peel off when pressed and packaged for transportation or storage, and easily peels off when the upper chamber is suspended and pressurized. Specifically, the present invention is achieved by the following (1) to (5) .
[0009]
(1) It is composed of a sheet material having flexibility, and the interior is partitioned into a first space and a second space for storing liquid via a partition portion formed by fusing the sheet material. A multi-chamber container,
5% modulus value of the sheet material is 20 to 60 kgf / cm ² ,
The volume of the first space is not less than the volume of the second space and is 200 to 2000 ml,
In use, the first space is in a state of being suspended vertically so that the liquid is stored in the first space and the first space is above the second space (hereinafter referred to as “standing posture”). The space is used, and at least a part of the partition portion is peeled off to communicate the first space with the second space,
In the standing posture, the sheet material near the partition portion on the first space side is deformed by the liquid head pressure of the liquid, and the sheet materials are pulled in opposite directions to each other via the partition portion. The angle formed by these becomes an obtuse angle,
The maximum thickness of the portion corresponding to the first space in a state where the liquid is stored in the first space and horizontally placed (hereinafter referred to as “horizontal state”) is T ₁ , and the _first thickness in the standing posture is When the maximum thickness of the portion corresponding to one space is T ₂ , the condition of 1.2 ≦ T ₂ / T ₁ ≦ 3.0 is satisfied,
In the horizontal state, the pressure in the first space (pressure excluding the hydraulic head pressure) when the first space is pressurized and the partition portion starts to peel is P ₁ , and in the standing posture, the first space when the pressure of the first space when the partition portion of the space is pressurized starts to peel (pressure excluding the hydraulic head pressure) was set to _{P 2, 0.3 ≦ P 2 /} P 1 ≦ 0.8 A multi-chamber container characterized by satisfying the following conditions.
[0010]
(2) The multiple chamber according to (1), wherein at least a part of the partition portion is configured by a weak seal portion that can be peeled by pressing a portion corresponding to the first space of the multiple chamber container. container.
[0011]
(3) The multi-chamber container according to (1) or (2), wherein the partition portion has a seal strength of 0.15 to 4.0 kgf / 20 mm width.
[0014]
(4) The multi-chamber container according to any one of (1) to (3), wherein the constituent material of the sheet material is a soft resin that is softened by blending an elastomer with polypropylene.
[0015]
(5) The multi-chamber container according to any one of (1) to (3), wherein the constituent material of the sheet material includes polypropylene and a styrene-butadiene copolymer, and is a polymer blend of these.
[0017]
DETAILED DESCRIPTION OF THE INVENTION
Hereinafter, the multi-chamber container of the present invention will be described in detail based on a preferred embodiment shown in the accompanying drawings.
[0018]
FIG. 1 is a partial cross-sectional front view showing an embodiment of a multi-chamber container of the present invention, FIG. 2 is a cross-sectional side view showing a state where the multi-chamber container of the present invention is horizontally placed, and FIG. FIG. 4 is a cross-sectional side view showing a state in which the multi-chamber container is suspended, and FIG. 4 is a cross-sectional side view showing a state in which the multi-chamber container of the present invention is horizontally placed and pressed to pressurize the first space. FIG. 6 is a cross-sectional side view showing a state in which the multi-chamber container of the present invention is suspended and pressed to pressurize the first space, and FIG. It is a cross-sectional side view which shows the state which peeled. In the following description, the upper side in FIG. 1 will be referred to as a “base end” and the lower side as a “tip”.
[0019]
As shown in FIG. 1, the multi-chamber container 1 of the present invention includes a bag 2 made of a soft material having a first space 3 and a second space 4 for storing a liquid therein, a discharge port 6, have.
[0020]
The bag 2 is formed by forming a sheet material made of a flexible soft material into a tubular shape (tube shape) (for example, inflation molding), and fusing both ends (thermal fusion, high frequency fusion, etc.) or bonding. Sealed into a bag. The proximal end side seal portion 22 and the distal end side seal portion 24 of the bag 2 are each cut into a desired shape.
[0021]
A hole (hanging portion) 23 for suspending the multi-chamber container 1 on a hanger or the like is provided at a substantially central portion of the seal portion 22 on the proximal end side of the bag 2.
[0022]
A partition 5 is formed in the middle of the bag 2 in the vertical direction in FIG. 1, and the interior of the bag 2 is partitioned into a first space 3 and a second space 4 by the partition 5. ing. Both spaces 3 and 4 store liquids 30 and 40 having different compositions, respectively. In this case, the liquid 30 and the liquid 40 are likely to react with each other (deterioration or deterioration) with each other, such as a glucose infusion preparation and an amino acid infusion preparation.
[0023]
Until it is used, the liquid 30 and the liquid 40 are stored separately without mixing, and in use, the partition portion 5 is peeled off (opened) to allow the first space 3 and the second space 4 to communicate with each other. The liquid 30 and the liquid 40 are mixed. Thereby, alteration, deterioration, etc. of the liquids 30 and 40 can be prevented, and the intended medicinal effect can be obtained more reliably.
[0024]
In addition, by storing a liquid that requires pH adjustment, for example, a peritoneal dialysis solution and a pH adjusting agent that neutralizes the liquid separately, that is, in each of the first space 3 and the second space 4, Such liquid alteration, decomposition, deterioration, coloring, discoloration, generation of precipitates and the like can be prevented.
[0025]
In the present invention, the liquids 30 and 40 are not particularly limited, and may be any of, for example, physiological saline, electrolyte solution, Ringer's solution, high-calorie infusion solution, glucose solution, water for injection, peritoneal dialysis solution, and oral nutrient. May be.
[0026]
The partition part 5 is obtained by fusing (or adhering) the sheet material 25 of the bag 2 in a band shape. This partition part 5 is comprised by the weak seal part of the grade which peels by pressing (pressing) the part by the side of the 1st space 3 of the bag 2 by hand, and raising the internal pressure of the 1st space 3, for example. . Thereby, the interruption | blocking by the partition part 5 is cancelled | released by simple operation | work, without using a special instrument etc., and the liquid in both the spaces 3 and 4 can be mixed.
[0027]
In addition, it is not restricted to the case where all the partition parts 5 are comprised by the weak seal part, A part of partition part 5 may be comprised by the weak seal part. Further, for example, a difference in the peel strength may be provided by a method such as providing a difference in the width of the band of the partition portion 5, and a portion that is easily peeled and a portion that is difficult to peel may be provided.
[0028]
As the sheet material 25 of such a bag 2, a material having high flexibility and flexibility is used.
[0029]
The sheet material 11 used in the conventional bag 10 is relatively hard and has poor flexibility. Therefore, as shown in FIG. 7, when the pressing force is applied and the first space 12 is pressurized in a state where the bag 10 is horizontally placed (a typical posture when storing the bag 10). Since the deformation of the sheet material 11 is small, the tension of the sheet material 11 generated by pressurization is weak as a force (vector) for separating the partition portion 14 vertically.
[0030]
On the other hand, as shown in FIG. 8, when the bag 10 is in a vertical state (standing posture) and the upper side of the bag is pressed by hand to separate (open) the partition portion 14, the liquid in the first space 12 is removed. The hydraulic head pressure (higher hydraulic head pressure than when the bag 10 is in a horizontal state) acts on the sheet material 11 in the vicinity of the partition portion 14, but the sheet material 11 is relatively hard, and its deformation is small. Since the opening angle between the sheet materials 11 around the partition portion 14 does not increase so much, the pressure required to peel (open) the partition portion 14 is exclusively when the bag 10 is pressed (squeezed) by hand. Not much different from pressure.
[0031]
As described above, the conventional bag 10 constituted by the relatively hard sheet material 11 is set so that the partition portion 14 is peeled (opened) and liquid leakage does not occur when a pressing force is accidentally applied during storage or the like. When the partition 14 is peeled off during use, a large force is required and the operability is inferior.
[0032]
On the other hand, the sheet material 25 of the bag 2 in the present invention is rich in flexibility and flexibility. As shown in FIG. 4, in the state in which the bag 2 is placed horizontally (a typical posture when storing the bag 2), the angle between the sheet members 25 in the vicinity of the partition portion 5 is an acute angle as in the conventional bag. The tension of the sheet material 25 generated by the pressing is weak as a vertical vector for separating the partition portion 5. That is, the pressing force required to peel off the partition portion 5 is large.
[0033]
On the other hand, as shown in FIGS. 3 and 5, when the bag 2 is in a vertical state (standing posture) and the upper side of the bag 2 is pressed by hand to try to peel (open) the partition portion 5, The water head pressure of the liquid 30 in the space 3 (high head pressure compared to when the bag 2 is in a horizontal state) acts on the sheet material 25 near the partition portion 5, but the sheet material 25 is rich in flexibility. Therefore, even in a state before the pressing force by the hand is applied, the sheet material 25 in the vicinity of the distal end side of the first space 3, particularly in the vicinity of the partition portion 5, is deformed by the action of the water head pressure (see FIG. 3). The sheet members 25 are pulled in directions opposite to each other via the partition portion 5, and the angle formed by these becomes an obtuse angle.
[0034]
Then, as shown in FIG. 5, when a pressing force is applied to the bag 2 from this state to pressurize the interior of the first space 3, sheet tensions in opposite directions acting on the sheet members 25 in the vicinity of the partition portion 5. A and B increase and serve effectively as a vector for peeling. Next, the partition portion 5 is peeled off, the first space 3 and the second space 4 are communicated, and the liquid 30 in the first space 3 flows into the second space 4 and is mixed with the liquid 40. Is done.
[0035]
As described above, the bag 2 formed of the flexible sheet material 25 is difficult to peel (open) the partition portion 14 even when a pressing force is accidentally applied during storage or the like, and liquid leakage is prevented. Moreover, when mixing the liquid 30 and the liquid 40 in use, the partition part 5 can be peeled (opened) with a relatively small pressure, and the operability is excellent. Therefore, not only when doctors and nurses perform in medical institutions such as hospitals, but also for elderly people and patients whose physical strength has declined in home medical care, the separation (opening) operation of the partition part 5 of the bag 2 is easy and reliable. Can be done.
[0036]
Such sheet material 25 has such flexibility and flexibility as described below.
[0037]
As shown in FIG. 2, the maximum thickness of the portion corresponding to the first space 3 in a state where the bag 2 (multiple chamber container 1) in which the liquid 30 is stored in the first space 3 is horizontally placed is represented by T. _1, and as shown in FIG. 3, part liquid 30 to the first space 3 corresponding to the first space 3 in the state, appended vertically at housed bag 2 (multi-chamber container 1) a hole 23 When the maximum thickness of T ₂ is T ₂ , it satisfies 1.2 ≦ T ₂ / T ₁ ≦ 3.0, more preferably 1.4 ≦ T ₂ / T ₁ ≦ 3.0. It ’s like that.
[0038]
When T ₂ / T ₁ is less than the lower limit, the flexibility of the sheet material 25 becomes insufficient, and the effects as described above are not sufficiently exhibited. On the other hand, when T ₂ / T ₁ exceeds the upper limit, the strength of the sheet material 25 is insufficient, and breakage tends to occur.
[0039]
In addition, as shown in FIG. 4, in the state where the bag 2 (multiple chamber container 1) containing the liquid 30 is horizontally placed in the first space 3, a pressing force is applied to add the first space 3. pressure, the pressure of the first space 3 (pressure excluding the hydraulic head pressure) when the partition portion 5 starts to peel P _1, as shown in FIG. 5, the bag in which the liquid 30 is accommodated in the first space 3 2 (multi-chamber container 1) suspended vertically in the hole 23, the pressure in the first space 3 when the first space 3 was pressurized and the partition part 5 began to peel (the head pressure was removed). When the pressure is P ₂ , it satisfies 0.3 ≦ P ₂ / P ₁ ≦ 0.8, more preferably satisfies 0.4 ≦ P ₂ / P ₁ ≦ 0.7. Is.
[0040]
When P ₂ / P ₁ is less than the lower limit, the strength of the sheet material 25 is insufficient, and breakage tends to occur. Further, when P ₂ / P ₁ exceeds the upper limit, the flexibility of the sheet material 25 is insufficient, it is not sufficiently exhibited effects as described above.
[0041]
The reason why the pressures P ₁ and P ₂ in the first space 3 are the pressures excluding the water head pressure is as follows. If the liquid level of the liquid 30 in the first space 3 is higher than that of the partition portion, the hydraulic head pressure also increases accordingly. In this case, since it works favorably for the separation of the partition portion 5, the pressure excluding the hydraulic head pressure is used. The characteristics of the container were shown by eliminating the dependence on the water head pressure.
[0042]
In the multi-chamber container 1 of the present invention, the material of the sheet material 25 (polymer composition of constituent materials, molecular weight, additive such as plastic material), the thickness of the sheet material 25, the strength and elasticity of the sheet material 25, The above conditions can be satisfied by selecting a suitable combination of conditions such as the shape and dimensions in the vicinity of the partition portion 5.
[0043]
Elastic sheet member 25 is not particularly limited, 5% modulus value is preferably from 20~60kgf / cm ^2, and more preferably 20~35kgf / cm ^2. If the 5% modulus value is too small, the strength of the sheet material 25 is reduced, and the thickness of the sheet material 25 needs to be relatively thick. On the other hand, if the 5% modulus value is too large, the above-described effects may not be sufficiently exhibited.
[0044]
Further, in order to more effectively prevent deterioration and deterioration of the liquids 30 and 40, the sheet material 25 is preferably as low as possible in gas permeability (having gas barrier properties).
[0045]
Examples of materials (resin materials) that can be used for the sheet material 25 include polyolefins such as polyethylene (PE), polypropylene (PP), polybutadiene, and ethylene-vinyl acetate copolymer (EVA), olefin elastomers, and styrene. Examples thereof include various thermoplastic elastomers such as elastomers, and combinations of these arbitrarily (blend resins, polymer alloys, laminates, etc.). These resin materials are also preferable in that they have heat resistance and water resistance that can withstand high-pressure steam sterilization (autoclave sterilization).
[0046]
Particularly preferred as a constituent material of the sheet material 25 is a soft resin that is softened by blending an elastomer such as styrene-butadiene copolymer or styrene-ethylene-butylene-styrene block copolymer with polyethylene or polypropylene. it can. This material is preferable in that it has high strength and flexibility, heat resistance (particularly heat resistance during sterilization) and water resistance, and is particularly excellent in workability and can reduce manufacturing costs.
[0047]
Furthermore, in order to maintain the quality of the internal liquids 30 and 40, it is possible to further laminate a film such as an aluminum foil in order to provide the bag 2 with an oxygen barrier property and a light shielding property.
[0048]
In order to provide oxygen barrier properties, a thin film such as a vapor deposition film made of an oxide such as titanium oxide, aluminum oxide, or silicon oxide can be formed on the surface of the bag 2. Even in this case, the transparency of the bag 2 can be maintained, and internal visibility is ensured.
[0049]
The thickness of the sheet material 25 constituting the bag 2 is not particularly limited, and varies depending on other conditions such as the material of the sheet material 25, but is usually preferably about 0.2 to 0.5 mm. More preferably, it is about 25 to 0.35 mm.
[0050]
Moreover, although the capacity | capacitance of the bag 2 changes with kinds etc. of the liquids 30 and 40 accommodated in an inside, normally each capacity | capacitance (volume) of the 1st space 3 and the 2nd space 4 is about 100-5000 ml. It is preferable that it is about 200-2000 ml.
[0051]
Further, the magnitude relationship between the capacity of the first space 3 and the capacity of the second space 4 is not particularly limited, but the capacity of the first space 3 is preferably equal to or larger than the capacity of the second space 4. Thereby, it becomes easy to pressurize the 1st space 3 by hand, and mixing by the movement to the 2nd space 4 of the liquid 30 when the partition part 5 is opened is performed easily.
[0052]
The seal strength (peeling strength) of the weak seal portion of the partition portion 5 is not particularly limited, but is usually preferably 0.15 to 4.0 kgf / 20 mm width, and 0.3 to 2.5 kgf / 20 mm width. It is more preferable that When the seal strength is less than this range, the partition portion 5 is easily peeled off accidentally during transportation or storage, and when the seal strength exceeds this range, the operability when the partition portion 5 is peeled (opened). Decreases.
[0053]
The partition portion 5 can be formed by the following method and conditions, for example. That is, the partition part 5 has a mold temperature of preferably 90 to 140 ° C., more preferably 100 to 120 ° C., and a sealing pressure of preferably ^{2 to} 12 kgf / cm ² , more preferably 3.5 to 7.5 kgf / cm. ² , The heat sealing can be performed preferably in 1 to 10 seconds, more preferably in 2 to 5 seconds. In addition, the method and conditions mentioned here are examples, and are not limited thereto.
[0054]
A discharge port (mouth) 6 communicating with the second space 4 is provided at the front end of the bag 2. The discharge port 6 has at least a function of discharging a liquid, and includes a tubular (particularly cylindrical) tube body (inner tube) 61 and an outer tube 62 installed outside the tube body 61. ing.
[0055]
An elastic body (plug body) 63 made of an elastic material is installed at the distal ends of the tube body 61 and the outer cylinder 62, and a cap (elastic body support member) 64 is crowned thereon to attach the elastic body 63. The tube body 61 and the outer cylinder 62 are crimped to the tips.
[0056]
The base end portion of the cap 64 is fixed by being fitted or screwed to a flange portion 65 provided on the outer periphery in the middle of the outer cylinder 62.
[0057]
The elastic body 63 can pierce a needle tube (not shown) such as a bottle needle or a cannula needle. When necessary, the elastic body 63 is pierced through the needle tube so that the liquid 40 or the liquid 30 and the liquid 40 in the multi-chamber container 1 are inserted. The mixed liquid can be taken out, or a chemical solution or the like can be mixed and injected into the multi-chamber container 1. Further, the elastic body 63 has a self-occlusion property, and after the needle tube is extracted from the elastic body 63, the puncture hole is closed to prevent the leakage of the chemical solution.
[0058]
As a constituent material of the elastic body 63, a flexible polymer material is preferable. For example, polyethylene, polypropylene, ethylene-propylene copolymer, ethylene-vinyl acetate copolymer, cross-linked ethylene-vinyl acetate copolymer Such as polyolefin, polyester, polyvinyl chloride, polyurethane, polyamide, polyamide elastomer, polyester elastomer, and other thermoplastic resins (thermoplastic elastomer), natural rubber, isoprene rubber, silicone rubber, butadiene rubber, styrene-butadiene rubber, etc. Examples thereof include elastic materials such as rubber materials, or combinations of any two or more of these (blends, laminates, etc.).
[0059]
The cap 64 has a ring shape and is fixed to the distal end portion of the outer cylinder 62 by a method such as screwing, fitting, caulking, adhesion, or fusion. The constituent material of the cap 64 is not particularly limited, and examples thereof include various resin materials and metal materials.
[0060]
The outer cylinder 62 is fixed by being sandwiched and fused between the sheet materials 25 and 25 at the seal portion 24 at the tip of the bag 2. Thereby, the outer cylinder 62 can be fixed to the bag 2 easily and reliably, and the outer cylinder 62 and the sheet material 25 have high bondability and adhesiveness (sealing performance), so liquid leakage and the like are also ensured. Can be prevented. Moreover, there exists an advantage that manufacture and an assembly of the multi-chamber container 1 are easy.
[0061]
Examples of the constituent material of the tube body 61 and the outer cylinder 62 include polyethylene, polypropylene, polyvinyl chloride, polycarbonate, polymethyl methacrylate, polyester, polyamide, ABS resin, and the like.
[0062]
A plurality of such discharge ports (or mixed injection ports) may be provided. In addition, a similar discharge port (or mixed injection port) communicating with the first space 3 may be provided.
[0063]
As mentioned above, although the multi-chamber container of this invention was demonstrated based on embodiment of illustration, this invention is not limited to this.
[0064]
【Example】
Example 1
As a sheet material, a soft resin in which polypropylene and styrene-butadiene copolymer are blended at a weight ratio of 6: 4 (polymer blend) is molded into a cylindrical body by inflation molding, and heat-sealed and cut into a desired pattern And the discharge port was mounted | worn and the multi-chamber container of this invention of the shape shown in FIG. 1 was manufactured.
[0065]
Glucose solution: 1600 ml was sealed in the first space of the multi-chamber container, and electrolyte solution: 400 ml was sealed in the second space, and autoclave sterilization was performed. Table 1 shows the sheet material thickness, 5% modulus value, container length, container width, partition seal conditions, partition seal strength, and autoclave sterilization conditions.
[0066]
The maximum thicknesses T ₁ , T ₂ , pressures P ₁ , P ₂ are measured by the above-described method for the multi-chamber container in which the first space and the second space are filled with liquid, respectively. Thus, T ₂ / T ₁ and P ₂ / P ₁ were obtained. The results are shown in Table 1 below.
[0067]
The pressures P ₁ and P ₂ were measured using a hydraulic digital pressure sensor (AP-80A) manufactured by Keyence Corporation.
[0068]
(Examples 2 and 3)
The same procedure as in Example 1 was carried out except that the partition sealing conditions, autoclave sterilization conditions, and the like were changed as shown in Table 1, respectively.
[0069]
Example 4
As a sheet material, a soft resin in which polypropylene, an ethylene-butene copolymer, and a styrene-butadiene copolymer are blended (polymer blend) at a weight ratio of 5: 2: 3 is used. Containers were manufactured and evaluated. The conditions are shown in Table 1.
[0070]
(Comparative Example 1)
A commercially available infusion bag, Aminotripa No. 2 manufactured by Otsuka Pharmaceutical Co., Ltd. was prepared. In this infusion bag, sugar / electrolyte solution: 1200 ml is sealed in the first space, and amino acid solution: 600 ml is sealed in the second space.
[0071]
The maximum thicknesses T ₁ and T ₂ , pressures P ₁ and P ₂ were measured by the same method as described above, and T ₂ / T ₁ and P ₂ / P ₁ were further determined from these. The results are shown in Table 1 below.
[0072]
(Comparative Example 2)
A commercially available infusion bag made by Nippon Hoechst Marion Rucell Co., Ltd., PN Twin No. 3 was prepared. In this infusion bag, a sugar / electrolyte solution: 800 ml is sealed in the first space, and an amino acid solution: 400 ml is sealed in the second space.
[0073]
The maximum thicknesses T ₁ and T ₂ , pressures P ₁ and P ₂ were measured by the same method as described above, and T ₂ / T ₁ and P ₂ / P ₁ were further determined from these. The results are shown in Table 1 below.
[0074]
[Table 1]

[0075]
As shown in Table 1, in the multi-chamber containers of Examples 1 to 3, the difference between T ₁ and T ₂ is somewhat larger than that of Comparative Examples ₁ and ₂ , and the difference between P ₁ and P ₂ is large. Somewhat big. Therefore, for example, when the posture of the multi-chamber container is horizontal, such as during storage or transportation, the partition portion is difficult to peel off and liquid leakage can be prevented, but smaller when the multi-chamber container is in the standing posture. The partition can be easily peeled off (opened) by pressure to allow the first space and the second space to communicate with each other, thereby mixing the liquid.
[0076]
【The invention's effect】
As described above, according to the multi-chamber container of the present invention, for example, the partition part may be accidentally peeled except when necessary during storage, transportation, etc., and the first space and the second space communicate with each other. Therefore, the stability of the chemical solution is maintained and the safety is high.
[0077]
When necessary, the first space and the second space can be communicated with each other by a simple operation. For example, different liquids stored in these spaces can be mixed.
[0078]
In particular, since both spaces can be communicated from the outside of the multi-chamber container, the liquid can be quickly prepared. In addition, since the liquid does not come into contact with the outside air during the preparation of such a liquid, there is no possibility of contamination with bacteria and foreign substances, and the chemical liquid can be prepared safely.
[0079]
From the above, the multi-chamber container of the present invention is used not only when used by doctors and nurses in medical institutions such as hospitals, but also when used by elderly people or patients with weak physical strength in home medical care. Is suitable.
[Brief description of the drawings]
FIG. 1 is a partial sectional front view showing an embodiment of a multi-chamber container of the present invention.
FIG. 2 is a cross-sectional side view of the main part showing a state in which the multi-chamber container of the present invention is horizontally placed.
FIG. 3 is a cross-sectional side view of the main part showing a state in which the multi-chamber container of the present invention is suspended.
FIG. 4 is a cross-sectional side view of the main part showing a state in which the multi-chamber container of the present invention is horizontally placed and pressed to pressurize the first space.
FIG. 5 is a cross-sectional side view of the main part showing a state where the multi-chamber container of the present invention is suspended and pressed to pressurize the first space.
FIG. 6 is a cross-sectional side view of a main part showing a state where a multi-chamber container of the present invention is suspended and pressed to separate a partition part.
FIG. 7 is a cross-sectional side view of a main part showing a state in which a conventional multi-chamber container is horizontally placed and pressed to pressurize a first space.
FIG. 8 is a cross-sectional side view of a main part showing a state in which a conventional multi-chamber container is suspended and pressed to pressurize a first space.
[Explanation of symbols]
DESCRIPTION OF SYMBOLS 1 Multi-chamber container 2 Bag 22 Seal part 23 Hole 24 Seal part 25 Sheet material 3 1st space 4 2nd space 30, 40 Liquid 5 Partition part 6 Outlet 61 Tubing body 62 Outer cylinder 63 Elastic body 64 Cap 65 Flange Part 10 Conventional bag 11 Sheet material 12 First space 13 Second space 14 Partition part

Claims (5)

It is composed of a flexible sheet material, and the interior is divided into a first space for storing liquid via a partition portion formed by fusing the sheet material and a second space partitioned by the second space. A chamber container,
5% modulus value of the sheet material is 20 to 60 kgf / cm ² ,
The volume of the first space is not less than the volume of the second space and is 200 to 2000 ml ,
In use, the first space is in a state of being suspended vertically so that the liquid is stored in the first space and the first space is above the second space (hereinafter referred to as “standing posture”). The space is used, and at least a part of the partition portion is peeled off to communicate the first space with the second space,
In the standing posture, the sheet material near the partition portion on the first space side is deformed by the liquid head pressure of the liquid, and the sheet materials are pulled in opposite directions to each other via the partition portion. The angle formed by these becomes an obtuse angle,
The maximum thickness of the portion corresponding to the first space in a state where the liquid is stored in the first space and horizontally placed (hereinafter referred to as “horizontal state”) is T ₁ , and the _first thickness in the standing posture is When the maximum thickness of the portion corresponding to one space is T ₂ , the condition of 1.2 ≦ T ₂ / T ₁ ≦ 3.0 is satisfied,
In the horizontal state, the pressure in the first space (pressure excluding the hydraulic head pressure) when the first space is pressurized and the partition portion starts to peel is P ₁ , and in the standing posture, the first space when the pressure of the first space when the partition portion of the space is pressurized starts to peel (pressure excluding the hydraulic head pressure) was set to _{P 2, 0.3 ≦ P 2 /} P 1 ≦ 0.8 A multi-chamber container characterized by satisfying the following conditions.   2. The multi-chamber container according to claim 1, wherein at least a part of the partition portion is configured by a weak seal portion that can be peeled by pressing a portion corresponding to the first space of the multi-chamber container.   The multi-chamber container according to claim 1 or 2, wherein the partition portion has a seal strength of 0.15 to 4.0 kgf / 20 mm width.   The multi-chamber container according to any one of claims 1 to 3, wherein a constituent material of the sheet material is a soft resin softened by blending an elastomer with polypropylene.   The multi-chamber container according to any one of claims 1 to 3, wherein the constituent material of the sheet material includes polypropylene and a styrene-butadiene copolymer, which are obtained by polymer blending them.

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