JP5376825B2 - Method of injecting chemical solution container, chemical formulation and medical solution into medical infusion bag - Google Patents

Description

The present invention relates to a chemical solution container having a plurality of chambers, a chemical preparation containing a plurality of types of chemical solutions in the chemical solution container, and a method for injecting the chemical solution stored in the chemical solution container into the medical infusion bag . More specifically, in order to inject a liquid solution that easily causes a reaction into an infusion preparation to be supplied to the human body by infusion, for example, a high calorie infusion, an amino acid infusion, an electrolyte infusion, a saccharide infusion, or other medical infusion before use. The present invention relates to a chemical solution container having a plurality of suitable chambers, a chemical preparation containing a plurality of types of chemical solutions in the chemical solution container, and a method for injecting the first, second and third chemical solutions stored in the chemical solution container into the medical infusion bag. .

  Conventionally, infusion components supplied to the human body by infusion, for example, amino acid solution, glucose solution, etc., are altered when mixed, so each of the infusion containers separated by a detachable isolating means, especially into a plurality of individual chambers in the infusion bag, respectively. It has been devised to house and press the infusion bag from the outside at the time of use to separate and separate the separating means, and such techniques are disclosed in, for example, JP-A-62-176451, JP-A-8-182739. No. 5, No. 8-509631, and the like. In addition, when infusion is administered to a patient by intravenous drip, depending on the patient's pathology, a small amount of various medicinal solutions such as amino acid solution and glucose solution, for example, trace mineral (trace element), vitamin, analgesic, fat infusion, antibiotics It is necessary to mix substances, minerals, cardiotonics, etc. Usually, a work (mixed injection) for mixing a small amount of liquid medicine with an infusion preparation is performed in a clean booth in a hospital, and the liquid medicine to be mixed is injected into the infusion liquid in an infusion bag using a syringe. In this case, it is performed carefully so as not to cause bacterial infection of the drug solution. These mixed injection operations are complicated, and it is desired that mixed injection can be performed with a simple operation.

  On the other hand, in recent years, home medical care has been favored and tends to increase, and infusions are frequently administered to patients at home. Infusions are often 2 infusion bags with a daily dose of about 1 kg, and they are relatively heavy. When a medical solution is mixed with a medical solution for home medical care, it does not change after the mixed injection. In order to administer it to patients, it is necessary to frequently transport infusions from hospitals, increasing the burden of home care.

  Japanese Patent Laid-Open No. 10-24088 discloses a drug-filled container set for the purpose of providing an infusion container in which a drug-filled vial or the like is simply connected with few parts in a state where sterility is guaranteed. This drug enclosure container set is a resin container and has a plurality of chambers, and at least a part of a separating strip portion between the chambers is formed by a peel seal portion or a weak seal portion that can be opened from the outside. A chemical solution is stored in the chamber, a filling container is connected to the second chamber, the filling container stores the drug mixed with the chemical solution, and a lid or a film body that closes the opening of the filling container presses from the outside of the second chamber. Thus, it can be pushed into the filling container, and the second chamber and the filling container are communicated with each other by pushing the lid or film into the filling container. The plastic container sterilized by high-pressure steam and the vial containing the drug are connected in a sterile, dust-free chamber, and then only the second chamber is sterilized by electron irradiation, and the outer surface of the filled container once exposed to the outside in the second chamber And sterilized together.

  Japanese Utility Model Publication No. 6-42676 discloses an infusion bag for the purpose of easily and safely adding a drug in a vial to an infusion drug solution in the bag. This infusion bag has a mouth member capable of connecting a mouth portion of a vial sealed with a rubber stopper. The mouth member has a bottomed cylindrical part 3 with a lower outer peripheral surface fused to one opening end of the synthetic resin film, a lower end sealed with a sealing film, and a male screw on the upper outer periphery. The hollow needle 6 having a puncture blade at the tip is fixed and the lower end is a stick-shaped part 4 having a puncture blade and a male screw of a bottomed cylindrical part. Second part 5 having a small diameter part having a female screw to be screwed together and a small diameter part and a large diameter part which is integrally formed through the partition part and into which the mouth of the vial is fitted, and through which the hollow needle pierces the partition part. And a seal 10 for closing the open end of the large diameter portion of the second part. Instead of the tip being a puncture blade, a rubber stopper 63 fixed to the end of the rod-shaped part can be provided.

  When examining a chemical container that can be mixed and mixed with an infusion preparation with a small number of operations, it is necessary to consider what each chemical solution causes to be contaminated or promoted to decompose. In particular, vitamin agents are not only accelerated in quality deterioration due to light and temperature, but may contain insoluble precipitates or fine particles or may be decomposed when mixed with trace elements.

In sugar, electrolytes, and amino acid solutions for high-calorie infusion, there are many cases where vitamin B _{2 and} other vitamin preparations, and trace element preparations containing a plurality of trace elements such as an iron source are mixed. The chemical solution in which the vitamin preparation and the trace element preparation are mixed deteriorates in a short time, and in particular, precipitates derived from vitamin B ₂ and the iron supply source contained in the trace element preparation can be confirmed. Factors such as temperature, light, reducing substances, and oxygen are involved in the formation of this precipitate, but since it is generated in a very short time, it is difficult to fill the same container.

  The present invention can safely and easily perform the work of co-injecting a small amount of liquid medicine necessary for a patient into an infusion bag containing high-calorie infusion, amino acid infusion, electrolyte infusion, saccharide infusion, and other medicinal liquids in a hospital, Moreover, it aims at providing the chemical | medical solution container which enables mixed injection work in the home where home medical care is made. The present invention also provides a chemical container capable of separating and accommodating chemical liquids in a plurality of chambers that are selectively isolated by a partition means by eliminating an interaction that causes quality deterioration between different kinds of chemical liquids to be mixed. Then the purpose. Other objects of the present invention will be clarified in the following description.

The medicinal solution container of the present invention includes a first compartment that contains a medicinal solution containing vitamin B ₂ , a second compartment that contains a medicinal solution containing an iron supply source, and a communication mechanism capable of sending the medicinal solution from both compartments into the infusion container. Is provided. The chemical solution containing an iron source contains a zinc source, a copper source, a manganese source, or an iodine source. The first compartment is divided into a first chamber (A1), a second chamber, and a subchamber, a chemical solution containing vitamin B ₂ is stored in the first chamber, and vitamin A, vitamin D, vitamin E, or vitamins are stored in the second chamber. A chemical solution containing K is accommodated, vitamin B ₁₂ or folic acid is contained in the chemical solution in the first chamber or the second chamber, and the subchamber has a communication mechanism. As the communication mechanism, the communication mechanism described in Japanese Patent Application No. 2000-32487 can be used.

The first chamber and the sub chamber are partitioned by the first isolating means, and the second chamber and the sub chamber are partitioned by the second isolating means, and the first isolating means and the second isolating means are the first chamber. Or it opens by pressing the chemical | medical solution of a 2nd chamber from the outside. The first chamber is divided into a first chamber and a second chamber, the first chamber contains a chemical solution containing vitamin B ₁ , the second chamber contains a chemical solution containing vitamin C, and vitamin B ₂ is the first It is contained in the chemical solution stored in the small chamber or the second small chamber. Vitamin B ₆ , nicotinic acids, pantothenic acids, or biotin is contained in the chemical solution in either the first chamber or the second chamber.

  The communication mechanism includes a passage that connects the inside of the infusion container and any compartment or chamber of the chemical container, a closing body that closes the passage, and a means for moving the closing body or forming a through passage in the closing body to open the passage including.

  The medicinal solution container of the present invention includes a first compartment that contains a medicinal solution containing vitamins, a second compartment that contains a medicinal solution containing an iron supply source, and a communication mechanism capable of sending the medicinal solution from both compartments into the infusion container. . The first compartment and the second compartment are formed by partitioning a bag-like space formed by firmly adhering the peripheral portions of the flexible resin film to each other by a strong sealing portion. Arranged in the second section. Preferably, the first section is divided into a first chamber, a second chamber, and a sub chamber, and the second chamber and the sub chamber are partitioned by the second isolating means, and the first isolating means and the second isolating means. Is opened by pressing the chemical solution in the first chamber or the second chamber from the outside. The first separating means and the second separating means are formed by weakly bonding the resin film.

  The liquid chemical container of the present invention forms a bag-like space by firmly bonding two side edges, an upper edge, and a lower edge of a two-layered flexible resin film. It includes four chambers (E, V1, V2, V3) that are partitioned by seals (72, 73, 74). A communication mechanism capable of delivering the chemical solution in the room to the infusion container is disposed at the lower edge, and the three weak seals (75, 73, 74) are more strongly bonded to the one farther from the communication mechanism 52 and open to the farther one. Is configured so that a large pressing force is required.

  The chemical solution container of the present invention can be made of a thermoplastic resin such as glass, polyethylene, polypropylene, poly-4-methylpentene, or cycloolefin polymer (Cyclo Olefine Polymer (COP), trade name: ZEONOR, manufactured by ZEON Corporation). . As the chemical solution container of the present invention, a thermoplastic resin rich in moldability and flexibility is preferably used, but particularly fat-soluble vitamins (vitamin A, vitamin D, vitamin E and vitamin K) among the vitamin agents are adsorbed. It is preferable to use a difficult thermoplastic resin, and the cycloolefin polymer (trade name: ZEONOR, manufactured by Nippon Zeon Co., Ltd.) having excellent cord characteristics is particularly preferable. Further, it is preferable to form a multilayer film in which a cycloolefin polymer and polyethylene are laminated in two or three layers by a T-die extruder or an inflation molding machine, and use the resultant as a chemical container. Further, in place of polyethylene, a multilayer film of polypropylene or a resin having a mixed composition of polyethylene and polypropylene may be formed.

  As the communication mechanism of the present invention, a needle body having a sharp tip made of metal or thermoplastic resin, or a communication needle having a blunt tip to prevent a needle stick accident during mixed injection operation can be suitably used. Further, as a communication mechanism when each chamber of the chemical container partitioned by the isolating means is made of glass or a rigid or quasi-rigid thermoplastic resin, a plug movable by an operating rod described in Japanese Patent Application No. 2000-32487 The body may be used as a closure. Furthermore, a double cylinder-shaped needle body in which two ridges having different lengths are adjacent to each other or a small-diameter inner heel is provided inside the ridge may be used as the communication mechanism.

  When mixing each chemical solution into the infusion container using the chemical solution container of the present invention, the communication mechanism can be easily joined to the communication port on the infusion container side, and the chemical solution container equipped with the communication mechanism can be quickly used for the mixed injection operation. It is preferable to increase the rigidity of the low part. In particular, when each chamber for storing a chemical solution is formed of a flexible resin, a preferable mixed operability can be obtained by setting the rigidity of the low portion higher than that of the chemical solution storage chamber. Further, when the plurality of chambers are partitioned by the flexible resin film, the film is formed on the lower member made of a thermoplastic resin having a needle body on the lower surface, a welding rib on the upper surface, and a chemical passage inside. Is preferably adhered. When the rigidity of the low member is adjusted so as not to be easily deformed, the bonding accuracy and bonding speed of the flexible film are increased, and the mixed injection operability is improved.

When only one communication mechanism is provided in the chemical solution container of the present invention, a chemical solution containing a trace element is accommodated in a chamber adjacent to the communication mechanism, and vitamin A and vitamin which are difficult to change in combination with the trace element in the upper layer of the chamber. A chamber containing a drug solution containing D, vitamin E, and vitamin K is provided through a weakly bonded partition wall, and the upper layer of the chamber containing vitamin A, etc., is provided with vitamins other than vitamin A, vitamin D, vitamin E, and vitamin K. It is preferable to provide a chamber containing a water-soluble vitamin group including vitamin B2 through a weakly bonded partition wall. At this time, by adjusting the adhesive strength of the weakly bonded partition wall so that the lower layer side communicates with a lower pressing force than the upper layer, the mixed injection operation is started and the chamber containing the trace elements first becomes the infusion container. After the injection, the chemical solution containing vitamin A, vitamin D, vitamin E, and vitamin K is used to wash out trace elements, and finally, the chemical solution containing vitamin B _{2 and the} like that are easily mixed with trace elements is injected. It is preferable. The adjustment of the adhesive strength of the weakly bonded portion can be adjusted by the width of the partition wall and its shape, and can be controlled by adjusting the temperature, pressure, and pressurizing time at the time of sealing.

  The communication mechanism of the chemical solution container of the present invention is preferably provided with a sealing means that can be removed or opened by a communication mechanism such as a needle body before the mixed injection operation. Furthermore, in the chemical container partitioned by the isolating means of the present invention, the isolating means may be mechanically or artificially cut so that each chamber can be separated in a liquid-tight state. Thereby, for example, the chamber part containing the chemical solution containing the trace element and the chamber part containing the vitamin agent can be individually packaged in the drug container of the present invention after the sterilization process, It can be used as a chemical container when only vitamins should be mixed or only trace elements should be mixed. The chemical container of the present invention is preferably enclosed in an oxygen poorly permeable outer bag made of a colored light-shielding film or an aluminum laminate film together with an oxygen scavenger to form a final product.

Vitamin preparations to be mixed with high-calorie infusion include 13 essential vitamins: vitamin A, B ₁ , B ₆ , B ₁₂ , C, D, E, K, pantothenic acid, biotin, nicotinic acid and folic acid be able to. Each of the 13 types of vitamins has an optimum pH when adjusted to a chemical solution, and when mixed in the same chemical solution, the composition may change between vitamins, so it is separated into appropriate groups and filled in each chamber. It is preferable to do. In addition, the amount of the chemical solution containing the vitamin is preferably 1 to 5 ml, but each chamber is filled with an inert gas such as nitrogen gas and carbon dioxide gas together with the chemical solution to adjust the chemical solution container volume to have good operability. Is preferred. If the capacity of the chemical container of the chemical container is too small, such as 5 ml or less, the mixed injection operation becomes difficult, and if the capacity is 200 ml or more, it is difficult to mix with one hand and the cost of the container material is undesirably high.

  Examples of the iron supply source blended in the chemical solution containing trace elements include iron sulfate, ferrous chloride, ferric chloride and iron gluconate. Examples of the zinc supply source include zinc sulfate, zinc chloride, zinc gluconate, zinc lactate, and zinc acetate. Examples of the manganese supply source include manganese sulfate, and examples of the copper supply source include copper sulfate. Regarding combinations of preferable sources of the trace element preparation, ferric chloride (hexahydrate), manganese chloride (tetrahydrate), zinc sulfate (seven) described in Table 1 of Japanese Patent Application No. 2001-54370 are used. Hydrate), copper sulfate (pentahydrate) and potassium iodide are preferably contained. The trace element-containing preparation described in Japanese Patent Application No. 2000-394260 is suitably used as a chemical solution because it does not contain manganese as a trace element preparation mixed for patients with hepatic dysfunction.

  The medicinal solution container of the present invention is suitably filled and accommodated with a multivitamin and a trace element preparation, but in addition, can also contain various drugs marketed as injection solutions. Inorganic salt preparations that can change the infusion composition according to the patient's condition, amino acid preparations for injection containing arginine and glutamine that can increase the dosage of arginine and glutamine, and fat-containing injections such as soybean oil And anticoagulants such as sodium heparin injection can also be accommodated.

  Vitamin C blended as a vitamin preparation may be vitamin C itself, or a derivative or salt thereof. Specific examples include vitamin C (ascorbic acid), sodium ascorbate, ascorbyl palmitate, ascorbyl dipalmitate, ascorbic acid phosphate magnesium salt, and the like. As vitamin B1, any conventionally used one can be used. For example, thiamine may be used, and derivatives thereof, specifically, prosultiamine, actiamine, thiamine disulfide, fullsultiamine and the like. Or a salt thereof such as thiamine hydrochloride, thiamine nitrate and the like. As vitamin B1, any conventionally used one can be used. For example, thiamine may be used, and derivatives thereof, specifically, prosultiamine, actiamine, thiamine disulfide, fullsultiamine and the like. Or a salt thereof such as thiamine hydrochloride, thiamine nitrate and the like.

Vitamin A, vitamin D, vitamin E and vitamin K may be per se or may be used in the form of their derivatives. Specifically, vitamin A and its derivatives include vitamin A ₁ (retinol), vitamin A ₂ (3-dehydroretinol), vitamin A ₃ (subvitamin A), retinene (vitamin A aldehyde), vitamin A acid, Examples thereof include retinol palmitate and retinol acetate. Vitamin D and its derivatives include vitamin D ₂ (ergocalciferol), vitamin D ₃ (cholecalciferol), vitamin D ₄ , provitamin D ₂ (ergosterin), provitamin D ₃ (dehydrocholesterin), etc. Can do. Examples of vitamin E and derivatives thereof include α-tocopherol, tocopherol acetate, β-tocopherol, γ-tocopherol, and δ-tocopherol. Vitamin K and a derivative thereof vitamin K1 (phylloquinone, phytonadione), vitamin K ₂ (Farunokinon), vitamin K ₃ (menadione), vitamin K _4, vitamin K _5, vitamin K _6, and the like vitamins K ₇ .

FIGS. 1 to 6 are schematic plan views showing chemical liquid containers according to first to sixth embodiments of the chemical liquid container of the present invention. The same reference numerals are given to the same parts or components, and duplicated descriptions are omitted. To do. The chemical solution container 10 according to the first embodiment of the present invention shown in FIG. 1 includes a first compartment A that contains a chemical solution containing vitamin B ₂ , a second compartment B that contains a chemical solution containing an iron supply source, and both compartments. Communication mechanisms 52 and 53 are provided for delivering the chemical solution. The first compartment A and the second compartment B of the chemical solution container 10 are formed of a flexible resin film including two side edges 12, 12, an upper edge 14, a lower edge 18, and a connecting edge 16. The communication mechanisms 52 and 53 of the chemical solution container 10 are constituted by a hollow needle, a communication tool described later with reference to FIG. The outer surfaces of the communication mechanisms 52 and 53 are covered with the protective cover 53 and maintained in a sterile state until just before use. The chemical | medical solution containing the iron supply source in the 2nd division B contains a zinc supply source, a copper supply source, a manganese supply source, or an iodine supply source.

In the chemical solution container 20 of the second embodiment of FIG. 2, a portion corresponding to the first compartment A of FIG. 1 is partitioned into a first chamber A 1, a second chamber A 2, and a sub chamber 28 by the separating means 22. The first chamber A1 and the sub chamber 28 are partitioned by the first weak seal 24, and the second chamber A2 and the sub chamber 28 are partitioned by the second weak seal 25. The first weak seal 24 and the second seal 225 are separated by pressing the chemical solution in the first chamber A1 or the second chamber A2 from the outside, respectively, and the chemical solution in each chamber is not shown via the sub chamber 28 and the communication mechanism 52. It can be delivered into the container and mixed with the infusion solution. 2nd division B accommodates the chemical | medical solution containing an iron supply source. The chemical | medical solution of 2nd division B can contain a zinc supply source, a copper supply source, a manganese supply source, or an iodine supply source. The first chamber A1 of the chemical solution container 20 stores a chemical solution containing vitamin B ₂ . The second chamber A2 contains a chemical solution containing vitamin A, vitamin D, vitamin E, or vitamin K. Vitamin B ₁₂ or folic acid is contained in the first chamber or the second chamber of the chemical solution.

  In the chemical solution container 30 of the third embodiment of FIG. 3, a portion corresponding to the first chamber A <b> 1 of FIG. 2 is partitioned into a first small chamber A <b> 11 and a second small chamber A <b> 12 by the separating means 23. The first small chamber A11 and the sub chamber 28 are partitioned by the third weak seal 241 and the second small chamber A12 and the sub chamber 28 are partitioned by the fourth weak seal 242. The third weak seal 241 and the fourth weak seal 242 can be peeled by pressing the chemical solution in the first small chamber A11 or the second small chamber A12 from the outside, respectively, and the chemical solution in each chamber is separated from the sub chamber 28 and the communication mechanism 52. It can be sent into an infusion container (not shown) via the, and mixed with the infusion solution. 2nd division B accommodates the chemical | medical solution containing an iron supply source. The chemical solution in the second zone B contains a zinc source, a copper source, a manganese source, or an iodine source.

The first chamber A11 containing a chemical solution containing vitamin B _1, the second chamber A12 houses the drug solution containing the vitamin C. Vitamin B2 is contained in the chemical solution contained in the first chamber A11 or the second chamber A12. The second chamber A2 contains a chemical solution containing vitamin A, vitamin D, vitamin E, or vitamin K. The chemical | medical solution containing the iron supply source in the 2nd division B contains a zinc supply source, a copper supply source, a manganese supply source, or an iodine supply source.

  The chemical solution container 60 according to the fourth embodiment of the present invention shown in FIG. 4 includes two side edges 12, 12, an upper edge 14, a lower edge 18, and a connecting edge 16 of a flexible resin film stacked on each other. A bag-shaped space is formed by firmly bonding, and the bag-shaped space is divided into three chambers E, V1, V2, and V3 formed by three weak seals 72, 73, and 74. The chamber E accommodates a chemical solution containing an iron supply source and includes a communication mechanism 52. The outer surface of the communication mechanism 52 is covered with a protective cover 53 and maintained in a sterile state until just before use. The chamber V1 contains the same chemical solution as the first small chamber A11 in FIG. 3, the chamber V2 contains the same chemical solution as the second small chamber A12 in FIG. 3, and the chamber V3 has the same chemical solution as the second chamber A2. To accommodate.

  In the chemical container 60 of the fourth embodiment of the present invention shown in FIG. 4, the three weak seals 72, 73, 74 are strongly bonded to the one farther from the communication mechanism 52, and require a large pressing force to open the farther one. Be made to be. With such a configuration of the weak seals 72, 73, 74, when the chemical solution in the chemical solution container 60 is sent into the infusion container (not shown) via the communication mechanism 52, the communication mechanism is applied by applying pressure to the chemical solution container 60 from the outside. The chemicals are sequentially delivered from the chamber closer to 52. Therefore, the mixing amount of the chemical solutions in different chambers in the chemical solution container 60 is minimized, and the change due to the mixing is minimized.

  The chemical solution container 70 of the fifth embodiment of FIG. 5 firmly bonds two side edges 12, 12, an upper edge 14, a lower edge 18, and a connecting edge 16 of a flexible resin film stacked in two sheets. Thus, a bag-like space is formed, and the bag-like space has four chambers E, V1, V2, and V3 formed by partitioning the bag-like space with one strong seal 16 and two weak seals 73 and 74. The chamber E stores a chemical solution containing an iron supply source and includes a communication mechanism 54. The chamber V1 includes a communication mechanism 52. The ends of the communication mechanisms 52 and 54 on the chamber V1 side and the chamber E side are covered with weak seals 75 and 76, respectively. The chambers E, V1, V2, and V3 contain chemical solutions similar to the chambers E, V1, V2, and V3 of the chemical solution container 60 of the fourth embodiment shown in FIG. Further, the three weak seals 75, 73, and 74 are more strongly bonded to the one farther from the communication mechanism 52, and require a larger pressing force to open the farther one. The peel strength of the weak seal 75 that covers the end of the communication mechanism 52 is greater than that of the weak seal 76, so that the chemical solution in the chamber E can be delivered before the chemical solution in the other chambers.

  The chemical solution container 80 of the sixth embodiment of FIG. 6 is a partial modification of the chemical solution container 70 of the fifth embodiment of FIG. 5, is provided with a sub chamber 88 and is replaced with two communication mechanisms. A mechanism 52 is provided. The subchamber 88 is vacant or contains a suitable liquid or medicament. The sub chamber 88 and the chamber E are partitioned by a weak seal 76, and the sub chamber 88 and the chamber E are partitioned by a weak seal 76. The other structure and the chemical solution stored in each chamber can be the same as in the fifth embodiment of FIG.

  FIG. 7 is a schematic plan view showing an infusion bag (infusion container) 100 capable of injecting a drug from the drug solution container of the present invention, and FIG. 8 is a perspective view showing an injection port body 90 incorporated in the infusion bag of FIG. It is. The infusion bag 100 forms a bag-like space by firmly bonding two side edge portions 112, 112, an upper edge portion 114, and a lower edge portion 118 of a two-layered flexible resin film. It has two chambers 101 and 102 formed by partitioning the space with one weak seal 107. The chambers 101 and 102 contain an amino acid solution and a glucose solution, respectively, in order to avoid mixing changes of the infusion components as is well known. The upper edge 114 of the infusion bag includes an inlet main body 90 and suspension holes 104, 105, 106. The lower edge 128 of the infusion bag comprises a port 112 covered with a protective cap. The infusion solution in the infusion bag is pierced through the plug in the port 112 with a hollow needle, and is administered to the patient via the hollow needle and the tube.

  The inlet body 90 has four inlets 91 to 94. The inlets 91 and 92 include a stopper with a slit, and can receive a pair of communication mechanisms whose tips are not sharp. The inlets 93 and 94 are provided with plugs without slits and can receive a pair of sharp communication mechanisms such as hollow needles. The inlets 91 to 94 are covered with a protective cap (not shown) until just before use in order to prevent contamination.

  FIG. 9 is a schematic cross-sectional view of the state in which the communication mechanism 52 of the medicine container 10 is in a communication state. In the embodiment of FIG. 9, the stopper 151 arranged on the side of the medicine container 10 is pierced by the hollow communication tool 144, thereby passing through the passage 142 in the communication tool 144 and the inside of the drug container 10 and the infusion bag 100. A communication path that communicates with the first chamber 101 is formed. The communication tool 144 extends in the support 156 and has an end portion 141 in the drug container 10, and the passage 142 in the communication tool 144 communicates with the inside of the infusion bag at the end portion 141. The communication tool 144 is manually pressed from the outside of the flexible infusion bag toward the drug container 10 so that the sharp tip 145 pierces the plug 151 that closes the cylindrical mouth of the drug container 10, and the communication tool 144. The distal end opening 143 is positioned in the medicine container 10, and the inside of the medicine container 10 and the infusion bag 100 are brought into a liquid communication state through the opening 143 and the passage 142. The communication tool 144 includes a plurality of ribs 146 that engage with the support hole 114 at the outer peripheral portion thereof and maintain the position of the communication tool 144 before and after the plug body 151 is pierced.

  A procedure for assembling the drug container and the infusion bag shown in FIG. 9 will be described. First, the somewhat enlarged end portion 141 of the communication mechanism 52 is inserted into the inlet 91 of the inlet body 90 of the flexible infusion bag 100. Next, the sharp tip 145 of the communication tool 144 is advanced through the partition wall 140 and the plug 151, and the tip opening 143 adjacent to the tip 145 is communicated with the inside of the drug container 10, thereby the inside of the infusion bag 100 and the drug container. 10 is communicated through a tip opening 143 and a passage 142. The drug in the drug container 10 is caused to flow into the infusion bag 100 through this communication path, and a mixed solution is formed in the drug solution bag 100. Next, the drug solution bag 100 is engaged with an infusion stand (not shown) using the suspension holes 104 to 106, the stopper of the drug solution discharge port 112 is punctured with a hollow needle, and the tube communicated with the hollow needle and the hollow needle. The drug solution is instilled into the patient via the above.

  FIG. 10 is a schematic plan view showing a chemical solution container 170 according to a seventh embodiment of the present invention. This chemical solution container has substantially the same structure as the chemical solution container 70 of FIG. 5, and the communication mechanism is changed. The communication mechanism 52 of the chemical solution container 170 includes a disk-shaped portion 51, a plate-shaped protrusion 55, and a double hollow needle 121 as shown in side views viewed from an angle different from 90 degrees in FIGS. FIG. 13 is a side cross-sectional view showing the inner and outer hollow parts of the double hollow needle 121 eccentric, and FIG. 14 is a plan view seen from below the double hollow needle of FIG.

  The circumferential portion of the communication mechanism 52 is firmly bonded to the inner surface of the resin film forming the lower edge portion 28, and the edge 56 of the plate-like protrusion 55 is attached to the inner surface of the resin film forming the connecting edge portion 16. Bonded firmly.

  The medical solution container of the present invention performs a safe and easy operation in a hospital for co-injecting a small amount of medical solution necessary for a patient into an infusion bag containing high-calorie infusion, amino acid infusion, electrolyte infusion, saccharide infusion, or other medicinal solution. It is possible to perform co-infusion work at home where home medical care is performed. The chemical solution container of the present invention can separate and accommodate the chemical solution in a plurality of chambers that are selectively separated by the partition means by eliminating an interaction that causes quality deterioration between different types of chemical solutions to be mixed.

The schematic plan view which shows the chemical | medical solution container of 1st Example of this invention. The schematic plan view which shows the chemical | medical solution container of 2nd Example of this invention. The schematic plan view which shows the chemical | medical solution container of 3rd Example of this invention. The schematic plan view which shows the chemical | medical solution container of 4th Example of this invention. The schematic plan view which shows the chemical | medical solution container of 5th Example of this invention. The schematic plan view which shows the chemical | medical solution container of 6th Example of this invention. The schematic plan view which shows the infusion bag which can inject | pour a chemical | medical agent from the chemical | medical solution container of this invention. The perspective view which shows the injection inlet main body integrated in the infusion bag of FIG. It is sectional drawing which attaches the communication tool applicable to the chemical | medical agent container of this invention to the inlet main body of an infusion bag, and shows it. The schematic plan view which shows the chemical | medical solution container of 7th Example of this invention. The side view of the communication mechanism of FIG. FIG. 11 is a side view of the communication mechanism of FIG. 10, and is a side view rotated 90 degrees with respect to FIG. 11. FIG. 11 is a side sectional view of the double hollow needle of FIG. 10. It is the top view seen from the downward direction of the double hollow needle of FIG.

Explanation of symbols

10, 20, 30, 40: Chemical solution container, 12: Side edge wing, 14: Upper edge, 18: Lower edge, 23: Isolation means, 28: Sub chamber, 52: Communication mechanism, 53: Protective cover, 72-74: Weak seal, A: 1st division, B: 2nd division, A11: 1st small chamber, A12: 2nd small chamber, A2: 2nd small chamber

Claims (6)

A medical solution container 60, 70, 80 for injecting a medical solution into the medical infusion bag 100 before use,
In order to send the chemical solution from the chemical solution containers 60, 70, 80 to the medical infusion bag 100, the medical solution container 60, 70, 80 and the medical infusion bag 100 are communicated with each other, and a communication mechanism 52 is provided.
The chemical solution container includes a first chamber V1 that can communicate with the communication mechanism 52, a second chamber V2 that communicates with the communication mechanism 52 via the first chamber V1, and the second chamber V2. And a third chamber V3 communicating with the first chamber V1 through
Between the communication mechanism 52 and the first chamber V1, first weak seal portions 72 and 75 having the weakest adhesive strength are provided,
Between the first chamber V1 and the second chamber V2, a second weak seal portion 73 having stronger adhesive strength than the first weak seal portions 72 and 75 is provided,
Between the second chamber V2 and the third chamber V3, a third weak seal portion 74 having stronger adhesive strength than the second weak seal portion 73 is provided,
A chemical solution container, wherein the first, second, and third chambers V1, V2, and V3 contain first, second, and third chemical solutions, respectively. A chemical preparation containing a plurality of types of chemical solutions in the chemical solution container according to claim 1,
The first chemical solution contained in the first chamber V1 is a chemical solution containing a trace element;
The second chemical liquid stored in the second chamber V2 is a chemical liquid that hardly mixes with the trace element,
The drug solution formulation, wherein the third drug solution stored in the third chamber V3 is a drug solution that is easily mixed with the trace element. The chemical solution containing trace elements, a chemical solution containing iron sources, chemical formulation according to claim 2, wherein the formulation labile chemical solution, characterized in that it is a chemical liquid containing vitamin B _2.   The medicinal solution preparation according to claim 3, wherein the medicinal solution which is difficult to change is a medicinal solution containing fat-soluble vitamins.   The drug solution preparation according to claim 3 or 4, wherein the drug solution containing the iron supply source contains a zinc supply source, a copper supply source, a manganese supply source, or an iodine supply source. Before using the medical infusion bag, the first, second and third chemical liquids contained in the chemical liquid container according to claim 1 are injected into the medical infusion bag,
First, the first chamber V1 is pressed to open the first weak seal portions 72 and 75, and the first drug solution is injected into the medical infusion bag through the communication mechanism 52,
Next, the second chamber V2 is pressed to open the second weak seal portion 73, and the second chemical solution is used to wash out the first chemical solution remaining in the first chamber V1, while Injecting the second drug solution into the medical infusion bag via the communication mechanism 52;
Next, the third chamber V3 is pressed to open the third weak seal portion 74, and the third chamber V3, the first chamber V1, and the communication mechanism 52 are used to connect the third chamber V3. A method for injecting a chemical solution into a medical infusion bag, characterized by injecting the chemical solution into the medical infusion bag.

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