JP2006175212A - Medical liquid container and preparation-containing medical liquid container - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a medical liquid container and a preparation-containing medicament container, not causing sealing defect of a sealing part of the peripheral edge of a medicament housing chamber and alteration of a small quantity of a medicament housed. <P>SOLUTION: This medical liquid container 10 includes: a primary medicament housing chamber 11 housing a medicament; and at least one or more secondary liquid medicament-housing chambers 12 connected to the primary medicament housing chamber housing a smaller quantity of medical liquid stored than that of the medicament housed in the primary medicament housing chamber 11, wherein the interiors of the primary liquid medicament-housing chamber 11 and secondary liquid medicament-housing chamber 12 are partitioned from each other to communicate with each other. The secondary liquid medicament-housing chamber 12 has a bulged part 15 bulged such that the internal medicament-housing space before housing a second medicament is larger than the volume of the housed second medicament. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a medical drug container that contains a drug such as an infusion solution and a medical drug container containing a drug that contains the drug in the medical drug container.

  Some medical drugs are used alone, but a plurality of drugs are often administered to a patient in combination. In particular, in the case of a liquid injection administered by infusion, it is often prepared by mixing a drug, or a small amount of a secondary drug is mixed with the main drug. This work must be done aseptically. This aseptic dispensing operation is complicated and the risk of dispensing errors has been pointed out. Improvements have been made in safety and efficiency by improving this dispensing operation from the viewpoint of medical chemical containers.

  In containers used in the medical field, a plurality of contents are stored in a plurality of compartments in one container, and the contents are not mixed before use. A chemical container that can easily mix things is known. For example, immediately before infusion of an infusion drug, as a chemical container for preparing an infusion drug by mixing a plurality of kinds of drugs, a seal portion in which the inner wall surface of a bag-like container formed of a synthetic resin film is thermally welded There is known a multi-chamber chemical solution container in which a medicine is stored in a plurality of chambers in which a bag portion is partitioned by a seal portion. In such a multi-chamber chemical container, a breakable liquid-tight stopper member is sandwiched in a part of the partition formed by the seal part, and the liquid-tight stopper is broken so that the chambers communicate with each other. There is known one that can mix a chemical solution.

  Alternatively, a part or all of the partition part formed by the seal part is a peelable weak seal, and the peelable weak seal is peeled off by pressing or the like so that the chambers communicate with each other. A container that can mix a chemical solution that has been used is known. When these containers are infused using the contained medicines, the partitions that partition the chambers communicate with each other, and the inside of the container is made into a continuous chamber to mix each medicine. .

  Of these multi-chamber drug containers, for medical use, which has a main drug storage room and a sub drug storage room for storing a small amount of drug, in which there is a large difference in the volume between the chemical liquids stored in the respective chemical liquid storage rooms As a partitioning means that can also be used in a chemical container, it is easier to manufacture than using a separate member for the partition, using a weak seal part conventionally used in a medical chemical container for two rooms, Since communication is possible by pressing one chamber and increasing the internal pressure of the chemical solution, mixing of the chemical solution at the time of use is also easy. Containers made of sheet material are highly flexible, do not require a vent needle, and have excellent hygiene, safety, and workability, such as maintaining a constant drainage rate during infusion from start to finish. In addition, since the volume at the time of disposal is small and the volume at the time of disposal is reduced, it is preferred over conventional glass bottles and medical drug containers made entirely by blow molding.

  By the way, since the sheet material is flat in the drug storage chamber partitioned by the seal portion using the sheet material, the drug storage chamber before the drug is inevitably in a state of almost zero volume. A medical container made of a sheet material has a bulging shape for the first time because the sheet material is deformed by the pressure generated by the weight of the drug by containing the drug. In particular, in the case of a relatively small volume of secondary medicine, the container cannot be inflated simply because a small amount of medicine is added because the rigidity of the sheet material is stronger than the pressure generated by the weight of the medicine. Only spread over a large area like a membrane between sheets.

  When a small-volume medicine spreads over a large area in this way, when the secondary medicine storage chamber is sealed with a heat seal, the medicine itself touches the heat seal part, the seal becomes defective, or the medicine is altered. Cause problems. In addition, in order to accommodate a small amount of a secondary drug, a large-sized storage room is required, which makes the medical container excessively large and unusable.

As a medical container in the case where the content ratio between the chemical liquids stored in the respective chemical liquid storage chambers is large, for example, Patent Document 1 uses a weak seal that can be peeled on one partition portion of the storage container. A container is described in which a plurality of containers are joined via a portion and can be mixed at the time of use of the medicine.
However, in such a medical container made of a sheet material, when a small-capacity secondary drug chamber partitioned by a partition portion by a seal is formed, a large area must be secured as the secondary drug chamber. The entire container is very large and unusable.

  Further, in Patent Document 2, a cylindrical injection molding member is used, a relatively small secondary medicine container part is formed, and joining to the main medicine container part is the same as joining a cylindrical drainage port. Containers that can be joined by the above technique are described. However, in order to communicate the auxiliary drug storage chamber formed by the injection molded member with the main drug chamber, it is necessary to destroy a part of the injection molded member partitioning the two chambers and remove the partition. For this reason, it must be suppressed to such an extent that fine particles, fine particles and the like are hardly generated by the communication operation or do not cause an infusion failure. For this reason, the design, manufacture and production management of this injection-molded member are very strict and difficult.

  Furthermore, when there are two or more secondary medicines that cannot be mixed and stored in advance and must be mixed at the time of use, the secondary medicine storage container portion by this injection molded member is used as the secondary medicine. Must be joined to the main drug container portion, which is complicated mechanically and workably.

  In Patent Document 3, when a planar bag formed of a sheet is used, the secondary drug storage container portion becomes relatively large. Therefore, in order to suppress the overall size of the drug, bag-shaped secondary drug storage is performed. An example is described in which the container is stored in the main drug container. As described above, in order to store the secondary drug container in the main drug container, the foreign substances adhering to the surface of the secondary drug container are sufficiently removed, the main drug container is opened in a clean environment, and the secondary drug is stored. The container must be put in, and it becomes very complicated mechanically and workably.

  Furthermore, Patent Document 4 discloses a medical container that is formed so that a container that stores a relatively small volume of secondary medicine enters the suspension hole. An object of the present invention is to extremely reduce the risk of forgetting to add a small-capacity auxiliary drug without connecting the partition between the auxiliary drug storage chamber and the main drug storage chamber. That is, when the infusion container is suspended, the secondary medicine chamber entering the suspension hole becomes an obstacle, and attention is directed to the secondary medicine to prevent forgetting to mix the medicines. In order to identify whether or not the secondary medicine is mixed in this way, it is disclosed that the material forming the small-volume secondary medicine chamber preferably has flexibility.

Further, it is described that when the secondary medicine is in the secondary medicine chamber without being mixed, the mixed medicine chamber swells, so that it is easily visible from the outside. For these reasons, in the invention described in Patent Document 4, the material forming the secondary drug storage chamber is essentially flexible and swells when the secondary drug is stored, but the secondary drug is the main drug. It is described that it is a secondary medicine storage chamber that does not bulge when mixed with the medicine. In other words, the secondary drug storage container that is essentially flexible and does not bulge in the absence of a secondary drug requires a large area to store a small volume of secondary drug, and is therefore used for medical purposes. It becomes very big as a container.
JP 2002-165864 A JP 2003-159309 A JP 2003-62038 A JP 2000-5275 A

  As described above, in the invention described in Patent Document 1, when a container for storing a small-capacity secondary medicine is produced with a flat container that can be weakly sealed, a container with a large area is required. There was a problem that the size would increase. In addition, in the invention described in Patent Document 2, when the injection molded member is used as the secondary drug container, the part of the injection molded member is destroyed during mixing at the time of use to open the main drug container. Is possible. For this reason, injection molded members have to be designed and manufactured so that the generation of fine pieces, fine particles, etc. does not occur at the time of destruction, and production management has become very strict.

  Furthermore, in the invention described in Patent Document 3, in order to store the auxiliary drug container portion in the main drug container, the adhered foreign substances on the surface of the auxiliary drug container portion are sufficiently removed, and the main drug is obtained in a clean environment. The operation of opening the container and storing and fixing the auxiliary drug container portion must be performed. Such a process requires a mechanically complex device, which must be installed and operated in a clean environment. Furthermore, there has been a problem that management for preventing the mixing of foreign matters becomes very complicated.

  In the invention described in Patent Document 4, if a container that accommodates a small-capacity auxiliary drug is produced in a shape that can be weakly sealed, a large-area container is required, and the size of the entire drug becomes large. And it is also disclosed that the injection-molded member is used for a partition wall that divides the mixed drug container and the main drug container, or the mixed drug container itself. There is a problem that becomes complicated and difficult and becomes expensive.

  The present invention has been made in view of such a situation, and it is relatively easy to use as a medical container without causing poor sealing at the periphery of the chemical solution storage chamber or altering the small amount of medicine to be stored. An object of the present invention is to provide a compact medical drug container and a medical drug container containing a drug.

In order to achieve the above object, according to the present invention, a main drug solution storage chamber for storing a drug and a smaller amount of drug solution connected to the main drug solution storage chamber and stored in the main drug solution storage chamber are stored. A medical drug container in which the main drug solution storage chamber and the sub drug solution storage chamber are partitioned so as to be able to communicate with each other. Provided is a medical liquid container characterized by having a bulging portion that is bulged so that the internal drug containing space is larger than the volume of the drug to be stored before the container is stored.
It is preferable that the auxiliary chemical solution storage chamber is liquid-tightly sealed and partitioned so as to allow communication. At this time, it is preferable that the liquid tight seal is located outside the main drug solution storage chamber.
The main drug solution storage chamber is preferably formed of a flexible sheet-like member.

  The bulging portion may be composed of two sheet-like members and a separating member accommodated in the secondary chemical solution storage chamber that separates the two sheet-like members to form a space. Alternatively, the bulging portion may be formed by cold stretching or heat stretching of a sheet-like member. Alternatively, the auxiliary chemical solution storage chamber may be a blow molded body.

  The main drug solution storage chamber only needs to be composed of a plurality of storage chambers partitioned by a peelable liquid-tight seal. There is provided a medical medicinal solution container containing a medicine, wherein a medicinal product is accommodated in each of the main drug solution storage chamber and the auxiliary drug solution storage chamber of the medical drug solution container. The secondary drug solution storage chamber may be a drug-containing secondary drug solution storage chamber manufactured by a method of continuously forming a chamber by blow molding, storing a drug, and sealing the chamber.

  The main drug solution storage chamber preferably stores a drug containing at least one of sugar, electrolyte and amino acid. At this time, it is preferable that a medicine containing any one or more of water-soluble vitamins, fat-soluble vitamins and trace elements is stored in the auxiliary drug solution storage chamber.

  According to the present invention, by forming in advance a bulging portion larger than the volume of the medicine accommodated in the internal medicine accommodating space before the medicine is accommodated in the auxiliary medicine storage chamber, two flat sheet materials Compared to the case where a small amount of chemical solution is placed in the secondary chemical solution storage chamber composed of the above, the drug does not spread over a wide area like a membrane between the sheets, and the bulging part has a thickness. Stored. By inserting a small volume of medicine into such a bulging portion, when the secondary chemical solution storage chamber is sealed with a heat seal, it is prevented that the medicine itself touches the heat seal portion and the seal becomes defective. Moreover, it is prevented that a chemical | medical agent touches a heat seal and changes in quality, and a chemical | medical agent is accommodated in a bulging part in a favorable state. Furthermore, the area of the auxiliary drug solution storage container can be reduced, and the entire medical drug solution container can be made compact and easy to use.

Hereinafter, the present invention will be described in detail with reference to the drawings.
FIG. 1 is an external perspective view showing an example of a medical drug container of the present invention. The medical liquid container 10 has a main chemical liquid storage chamber 11 for storing the first chemical liquid, and a second chemical liquid that is connected to the main chemical liquid storage chamber 11 and is smaller than the first chemical liquid stored in the main chemical liquid storage chamber 11. And a secondary chemical solution storage chamber 12 for storing the chemical solution.

  The main drug solution storage chamber 11 forms a strong seal portion 13 in which the entire periphery of the peripheral portion is sealed so as not to be peeled off, and is entirely formed of a flexible sheet-like member such as a synthetic resin film. The resin used for the synthetic resin film is not particularly limited as long as it is a resin used in the field of medical containers. Specific examples include polyolefin resin, polyamide resin, polyester resin, (meth) acrylic resin, vinyl chloride resin, vinylidene chloride resin, polyethersulfone, and ethylene-vinyl alcohol copolymer. Among these, preferred are polyolefin resins which are excellent in transparency, flexibility and hygiene and are inexpensive.

  Examples of the polyolefin resin include high-density polyethylene, medium-density polyethylene, high-pressure low-density polyethylene, linear low-density polyethylene, ethylene-vinyl acetate copolymer and other polyethylene resins, ethylene-α olefin random copolymer, and the like. Olefin-based elastomers, polypropylene, ethylene-propylene random copolymers, polypropylene resins such as α-olefin-propylene random copolymers, cyclic polyolefin resins, and mixtures thereof. Such a resin may be partially crosslinked for the purpose of improving heat resistance.

  Further, the synthetic resin film may be a single-layer film in which one or two or more of the resins listed above are combined, or may be a multilayer film composed of two or more layers. Such a synthetic resin film may have a thickness of 50 to 1000 μm, preferably about 100 to 500 μm. The synthetic resin film may be a cast film formed by T-die molding or an inflation film formed by inflation molding.

A discharge port 18 is formed at one end of the main drug solution storage chamber 11. The discharge port 18 is an outlet for taking out the mixed chemical liquid in which the first chemical liquid and the second chemical liquid are mixed, and is connected from the medical chemical liquid container 10 by connecting a discharge means such as a dedicated adapter or a needle. Is taken out.
Moreover, it may be used as an injection port for injecting another chemical solution into the mixed chemical solution. In addition to the discharge port 18, one or two or more injection ports may be joined to one end or the other end of the main drug solution storage chamber. Further, the discharge port 18 may be joined to the auxiliary chemical solution storage chamber.

  FIG. 2 is a cross-sectional view of a main part showing a part of the main chemical solution storage chamber 11 and the auxiliary chemical solution storage chamber 12. The secondary chemical storage chamber 12 is connected to the end of the main chemical storage chamber 11 opposite to the side where the discharge port 18 is formed. Further, in this example, the auxiliary chemical solution storage chamber 12 and the main chemical solution storage chamber 11 are formed separately and then are fixed to each other at the connection portion 14 so as not to be peeled off. The secondary drug solution storage chamber 12 has a bulging portion 15 bulged so as to be larger than the volume of the second drug in which the internal drug storage space is stored before the second drug is stored. , Three-dimensionally formed.

  The bulging portion 15 may be formed three-dimensionally by cold stretching or heat stretching of a sheet-like member, for example, and may be formed by blow molding using a mold. The auxiliary chemical storage chamber 12 provided with such a bulging portion 15 can be formed of various synthetic resins. Specific examples include polyolefin resin, polyamide resin, polyester resin, (meth) acrylic resin, vinyl chloride resin, vinylidene chloride resin, polyethersulfone, and ethylene-vinyl alcohol copolymer. Among these, preferred are polyolefin resins which are excellent in transparency, flexibility and hygiene and are inexpensive.

  Examples of the polyolefin resin include high-density polyethylene, medium-density polyethylene, high-pressure low-density polyethylene, linear low-density polyethylene, ethylene-vinyl acetate copolymer and other polyethylene resins, ethylene-α olefin random copolymer, and the like. Olefin-based elastomers, polypropylene, ethylene-propylene random copolymers, polypropylene resins such as α-olefin-propylene random copolymers, cyclic polyolefin resins, and mixtures thereof. Such a resin may be partially crosslinked for the purpose of improving heat resistance. Furthermore, the secondary chemical solution storage chamber provided with such a bulging portion 15 may have a single-layer configuration made of one or more resins selected from the various synthetic resins listed above, or a multi-layer configuration.

  Especially for drugs that can be adsorbed by polyethylene resins and polypropylene resins that are commonly used for medical purposes, such as fat-soluble vitamins, it is possible to take a multilayer structure using a cyclic polyolefin as the innermost layer in contact with the drug. preferable.

  When drugs such as antibiotics that deteriorate due to oxygen in the outside air are stored in the secondary drug solution storage chamber, a multilayer made of a resin such as oxygen-vinyl alcohol copolymer having gas barrier properties such as oxygen and other resins It is preferable to take a configuration. Furthermore, in order to increase the adhesive strength between the resin layers in the multilayer structure, a compatible resin is mixed in one or both of the resins forming the adjacent layers, or a new common resin is added between the layers. A layer made of a compatible resin, for example, an adhesive resin such as ethylene-vinyl acetate copolymer, may be added.

  In addition, when a drug such as a vitamin preparation that deteriorates due to light such as ultraviolet rays is stored as an auxiliary drug solution, a layer that blocks light in a wavelength range that is harmful to the drug may be added. For example, a polyolefin resin containing iron oxide may be used for the outer layer of the secondary chemical solution storage chamber having a multilayer structure in order to shield ultraviolet rays.

  When the auxiliary chemical solution storage chamber has a multilayer structure, the multilayer structure may be formed by multilayer coextrusion molding. Alternatively, a desired multilayer structure can be obtained by bonding single layer or multilayer materials by a method such as thermal lamination or dry lamination.

  The second medicine (secondary medicine) accommodated in the auxiliary medicine storage chamber 12 is mixed with the first medicine (main medicine) accommodated in the main medicine storage chamber 11 immediately before administration of the medicine to the patient or the like. Is done. In order to facilitate mixing at the time of use, the inside of the auxiliary chemical solution storage chamber 12 and the main chemical solution storage chamber 11 can communicate with each other by pressing the bulging portion 15 of the auxiliary chemical solution storage chamber 12 or the main chemical solution storage chamber 11. It is preferable that a liquid-tight seal 16 is formed.

  The liquid-tight seal 16 is formed so as to partition the main chemical solution storage chamber 11 and the auxiliary chemical solution storage chamber 12 so as to communicate with each other, and there is no limitation on the form thereof. Are preferred. Further, for example, as shown in the example of FIG. 2, the secondary chemical solution storage chamber 12 is liquid-tightly sealed 16 so that the main chemical solution storage chamber 11 and the secondary chemical solution storage chamber 12 are partitioned so as to communicate with each other. preferable. In such a form, after the second drug is stored in the secondary chemical storage chamber 12 and the secondary chemical storage chamber 12 is sealed with the liquid-tight seal 16, the secondary chemical storage chamber 12, the main chemical storage chamber 11, Can be connected. In this case, since the 2nd chemical | medical agent in the auxiliary | assistant chemical | medical solution storage chamber 12 does not touch external air at the time of a connection, it is preferable from a hygiene side.

  As a specific form example in which the auxiliary chemical solution storage chamber 12 is liquid-tightly sealed 16, as shown in FIG. 2, in addition to the embodiment formed in the portion located outside the main chemical solution storage chamber 11, FIG. 3 and FIG. The form formed in the part located inside the main chemical | medical solution storage chamber 11 like (a) is also mentioned. In the example of FIG. 3, the liquid tight seal 16 is provided so as to coincide with the connection portion 14 to which the main chemical solution storage chamber 11 and the auxiliary chemical solution storage chamber 12 are fixed. In the example of FIG. 4A, the liquid-tight seal 16 is a portion other than the connection portion 14 to which the main chemical solution storage chamber 11 and the auxiliary chemical solution storage chamber 12 are fixed (in this example, the tip of the auxiliary chemical solution storage chamber 12). Part).

  2, 3, and 4 (a), the secondary chemical storage chamber 12, the main chemical storage chamber 11, and the second chemical in the secondary chemical storage chamber 12 are not exposed to the outside air. 2 and FIG. 3 are preferable from the viewpoint of easy peeling of the liquid-tight seal 16 when the medical chemical container is used. That is, in the case of the form of FIG. 2 and FIG. 3, the liquid-tight seal 16 can be easily peeled by selecting and pressing only one of the main chemical solution storage chamber 11 or the auxiliary chemical solution storage chamber 12. Can do.

On the other hand, in the embodiment of FIG. 4A, even if the main drug solution storage chamber 11 side is pressed, sufficient pressure is not applied to the liquid-tight seal 16 as shown in FIG. 4B. Therefore, in order to peel off the liquid-tight seal 16, it is necessary to press the secondary chemical solution storage chamber 12.
Therefore, the form of FIG. 2 and FIG. 3 is preferable from the viewpoint of easy peeling of the liquid-tight seal 16 when the medical drug container is used.

  Furthermore, from the viewpoint of ease of manufacture of the medical drug solution container, comparing the form of FIG. 2 with the form of FIG. 3, FIG. That is, in the case of the configuration of FIG. 3, the main chemical solution storage chamber 11 and the auxiliary chemical solution storage chamber 12 overlap each other, and the auxiliary chemical solution storage chamber 12 is liquid-tightly sealed 16 at the connecting portion 14 that is fixed. The connection portion 14 and the liquid-tight seal 16 having different heat seal strengths must be formed at the same location, which is technically difficult and causes thermal damage to the same location multiple times. Therefore, in the case of the form of FIG. 3, it tends to be difficult to form the liquid-tight seal 16 having a stable peel strength. In this regard, as shown in FIG. 2, such a problem does not occur when the liquid-tight seal 16 formed in the auxiliary chemical solution storage chamber 12 is located outside the main chemical solution storage chamber 11.

  Although there is no particular limitation on the formation of the liquid-tight seal that can be peeled and communicated by this pressure, for example, the area occupied by the strong welded portion of the welded portion described in Japanese Patent Application Laid-Open No. 2004-000476 is less than 25%. This can be achieved by performing welding. Alternatively, the partition forming portion of the blow mold has a sufficient interval between the opposing surfaces of the mold, which is wider than the interval of complete welding and narrower than the interval of no welding at all. Also, it is possible to keep the adhesion to such an extent that it can be opened. Alternatively, it can also be achieved by taking a mold shape so that the strongly welded portion is less than 25% as in the case of the seal shape.

  The connecting portion 14 for connecting the auxiliary chemical solution storage chamber 12 and the main chemical solution storage chamber 11 so as not to be peeled off is, for example, bonding by heat sealing, bonding via a cylindrical member, or Japanese Patent Laid-Open No. 2001-87350. This is realized by means such as joining via a partition member. In particular, when the end portion of the auxiliary chemical solution storage chamber 12 is inserted into the main chemical solution storage chamber 11 and bonded by heat sealing, the sealing temperature at which the outer surface of the auxiliary chemical solution storage chamber 12 and the inner surface of the main drug solution storage chamber 11 are bonded is set as the auxiliary chemical solution. The sub-chemical solution storage chamber 12 can be formed by a simple sealing process by selecting a plurality of layers of the sheet material constituting each chamber so that the temperature can be set lower than the temperature at which the inner surfaces of the storage chamber 12 are welded. And the main drug solution storage chamber 11 can be joined.

  Or conversely, when the outer surface of the main chemical solution storage chamber 11 and the inner surface of the sub chemical solution storage chamber 12 are joined by heat sealing, the sealing temperature at which the outer surface of the main chemical solution storage chamber 11 and the inner surface of the sub chemical solution storage chamber 12 are joined. Also, the sheet material constituting each chamber can be set as a multilayer so as to be set lower than the temperature at which the inner surfaces of the main drug solution storage chamber 11 are welded, and the resin of each layer can be selected by a simple sealing process. The chemical solution storage chamber 12 and the main chemical solution storage chamber 11 can be joined. In the example of the present invention described with reference to FIGS. 2 to 4, only the secondary chemical storage chamber 12 is provided with a liquid-tight seal that can be separated and communicated, but the same liquid-tight seal is applied to the main chemical storage chamber 11. May be. Further, it can be applied to both the auxiliary chemical solution storage chamber 12 and the main chemical solution storage chamber 11.

  With reference to FIGS. 5 and 6, description will be given of the operation of the medical chemical container containing a medicine accommodated in the medical chemical container having the above-described configuration. As shown in FIG. 5, for example, about 100 mL to 5 L of medicine is accommodated in the medical medicinal liquid container 10 containing medicine, and the first medicine (main medicine) 22 is stored in the main medicine storage chamber 11 and the auxiliary drug storage chamber. 12, the second medicine (sub-medicine) 23 is accommodated in the same amount as the first medicine 22 or in an amount smaller than that. The specific capacity of the auxiliary drug solution storage chamber 22 is not particularly limited. However, when the amount is small, it is 100 mL or less, and in some cases, the volume is 10 mL or less.

  At this time, by forming a bulging portion 15 having a volume larger than that of the second medicine 23 in the secondary drug solution storage chamber 12 in advance, a small amount is stored in the secondary drug solution storage chamber composed of two flat sheets. Compared with the case where a chemical solution is added, the drug does not spread over a wide area like a film between sheets, and is accommodated with a thickness at the bulging portion 15. By putting a small amount of the second medicine 23 in the bulging portion 15, the second medicine 23 itself touches the heat sealing portion when the auxiliary chemical solution storage chamber 12 is sealed by heat sealing, resulting in poor sealing. Is prevented. Further, the second medicine is prevented from touching the heat seal and denatured, and the second medicine 23 is accommodated in the bulging portion 15 in a good state.

  And when using such a medical chemical container 10 containing a medicine, as shown in FIG. 6, for example, the liquid-tight seal 16 is peeled by pressing and crushing the bulging portion 15 of the auxiliary chemical liquid storage chamber 12. The main chemical solution storage chamber 11 and the auxiliary chemical solution storage chamber 12 communicate with each other. As a result, the first drug (main drug) 22 stored in the main drug solution storage chamber 11 and the second drug (sub drug) 23 stored in the sub drug solution storage chamber 12 are mixed, and the mixed drug 25 becomes It is formed.

  Two or more secondary chemical storage chambers having such bulging portions may be formed for one main chemical storage chamber. As shown in FIG. 7, two auxiliary drug solution storage chambers 33 and 34 are formed on one end side of the main drug solution storage chamber 32 of the medical drug solution container 31. In the auxiliary chemical solution storage chambers 33 and 34, bulging portions 35 and 36 for storing a small amount of chemical solution with high quality are formed, respectively.

In this way, by connecting two or more auxiliary chemical solution storage chambers 33 and 34 to one main chemical solution storage chamber 32, various combinations of mixed chemical solutions can be formed at the time of use.
Moreover, it is preferable that the two auxiliary chemical storage chambers 33 and 34 shown in FIG. 7 are molded and integrated at the same time. The joining of the plurality of integrated secondary chemical storage chambers 33 and 34 and the main chemical storage chamber 32 is completed at once, and the number of junctions does not increase even if the number of secondary chemical storage chambers increases. The production of the container is easy and preferable.

  In addition, in the medical chemical container containing a drug as described above, the main drug solution storage chamber is pressed during use to apply pressure to the main drug solution, and the liquid-tight seal that partitions the main drug solution storage chamber and the auxiliary drug solution storage chamber by this pressure. The main chemical solution and the auxiliary chemical solution may be mixed at the time of use. In particular, when two or more secondary chemical storage chambers are joined, it is easier to press the main chemical storage chamber and peel off all the liquid-tight seals at once.

  FIG. 8 shows another embodiment in which the configuration of the bulging portion of the auxiliary chemical solution storage chamber is changed. The auxiliary chemical solution storage chamber 43 connected to the main chemical solution storage chamber 42 of the medical drug solution container 41 of this embodiment stores the separating member 45 between the two sheet-like members 44 and forms the bulging portion 46. This is an example.

  In addition to the cylindrical shape shown in FIG. 8, the spacing member 45 is a constant shape before the medicine is accommodated by separating two sheet-like members 44 such as a spherical shape, a cylindrical shape, a cubic shape, and a rectangular parallelepiped shape. The shape is not limited as long as the space is formed. The two sheet-like members may be a sheet-like member obtained by bending one sheet-like member or a sheet-like member made of an inflation tube. In addition, the spacing member 45 is made of polyolefin resin such as polyethylene resin, polypropylene resin, cyclic polyolefin resin, polyamito resin, polyester resin, (meth) acrylic resin, vinyl chloride resin, vinylidene chloride resin, polyethersulfone, ethylene-vinyl. What is necessary is just to be formed with the alcohol copolymer and those mixtures.

Furthermore, as a form of the medical drug solution container, the main drug solution storage chamber may be divided into a plurality of chambers by a fluid-tight seal capable of communicating. For example, as shown in FIG. 9, the first and second main drug solution storage chambers 52 and 53 are partitioned by a peelable liquid-tight seal 51, and the second main drug solution storage chamber 53 is connected at the connection portion 59. It may be a medical chemical solution container 58 including three auxiliary chemical solution storage chambers 54, 55, and 56 connected thereto. In such a medical drug solution container 58, two types of main drug solutions and three types of auxiliary drug solutions can be mixed at the time of use. Further, an injection port for mixed medicine can be attached to the second main drug solution storage chamber 53.
In the medical drug solution container 58 of this example, liquid-tight seals 57a, 57b, and 57c are provided only in the auxiliary drug solution storage chambers 54, 55, and 56, respectively, and the liquid-tight seals 57a, 57b, and 57c are provided. Is located outside the second main drug solution storage chamber 53. Therefore, after the secondary chemical solution storage chambers 54, 55, 56 are sealed with the liquid-tight seals 57a, 57b, 57c, the secondary chemical solution storage chamber 54 can be connected to the second main chemical solution storage chamber 53. The inside of the first main drug solution storage chamber 52 and the second main drug solution storage chamber 53 are divided by a single operation of pressing the second main drug solution storage chamber 53 directly connected to 55 and 56. The liquid-tight seal 51 and the liquid-tight seals 57a, 57b, and 57c that separate the second main chemical solution storage chamber 53 and the sub chemical solution storage chambers 54, 55, and 56 can be peeled simultaneously. Can do. Therefore, according to such a medical drug solution container 58, a complicated operation of sequentially peeling all the liquid-tight seals 51, 57a, 57b, 57c is unnecessary, and preparation of a drug is easy. Troubles such as forgetting to peel off any of the three liquid-tight seals 57a, 57b, 57c can be avoided.

  The medical drug container of the present invention can be used as a container for transcentral parenteral nutrition kit preparation, transperipheral parenteral nutrition kit preparation used for transcentral parenteral nutrition, component nutrients used for enteral nutrition, and the like. it can. The medicinal-solution containing medical solution of the present invention is one in which a drug is accommodated in each of the main drug solution storage chamber and the auxiliary drug solution storage chamber of the medical drug solution container of the present invention. The main drug contained in the main drug solution storage chamber is not particularly limited, but includes, for example, a solution such as distilled water, an electrolyte infusion such as physiological saline, a saccharide infusion such as a glucose solution, and an amino acid preparation. Examples thereof include fat transfusions such as amino acid transfusions and fat emulsions.

  In addition, the main drug when the main drug solution storage chamber is composed of a plurality of chambers is not particularly limited. For example, a nutritional infusion solution containing any one or more of sugar, electrolyte, amino acid, fat emulsion and the like Examples thereof include blood substitute infusion solutions in which various electrolytes are combined, dialysis solutions in which sugars and electrolytes are combined, and the like. In addition, the secondary drug stored in the secondary chemical storage chamber is not particularly limited, for example, vitamins such as water-soluble vitamins, fat-soluble vitamins, trace metals such as copper, iron, manganese, zinc, Iodine, calcium chloride for correction, insulin, antibiotics, anticancer agents, peptic ulcer agents, agents for liver damage, cardiotonic agents, analgesics, antipyretic analgesics, anesthetics, fat emulsions, antihypertensive agents, vasodilators , Hormone agents, heparin and the like. In addition, the medicine accommodated may be not only a liquid agent but also a solid agent and a powder agent.

  In particular, when a liquid medicine is stored in the secondary chemical storage chamber, a secondary chemical storage chamber containing a medicine manufactured by a method of continuously forming the chamber by blow molding, storing the medicine, and sealing the chamber is used. It is preferable because the medicine can be aseptically stored in the secondary chemical solution storage chamber without opening the secondary chemical solution storage chamber.

  As an example of the medicinal solution medical container with a medicine of the present invention, for example, a high-calorie infusion used as a starting liquid or a maintenance liquid as a trans-central parenteral nutrition kit preparation for transcentral parenteral nutrition. As a preferred embodiment of the high calorie infusion, the main drug solution storage chamber stores a drug containing one or more of sugar, electrolytes and amino acids, and the auxiliary drug solution storage chamber stores water-soluble vitamins, fat-soluble vitamins and trace amounts. A drug containing any one or more of the elements is contained.

It is a perspective view which shows an example of the medical chemical | medical solution container of this invention. It is principal part sectional drawing of the medical chemical | medical solution container shown in FIG. It is principal part sectional drawing of the medical chemical | medical solution container of another example of this invention. (A) It is principal part sectional drawing of the medical chemical | medical solution container of further another example of this invention, (b) It is explanatory drawing which shows a mode when the main chemical | medical solution storage chamber of this medical chemical | medical solution container is pressed. It is explanatory drawing which shows the effect | action of the medical chemical liquid container with a medicine of this invention. It is explanatory drawing which shows the effect | action of the medical chemical liquid container with a medicine of this invention. It is a perspective view which shows other embodiment of the medical chemical | medical solution container of this invention. It is a perspective view which shows other embodiment of the medical chemical | medical solution container of this invention. It is a perspective view which shows other embodiment of the medical chemical | medical solution container of this invention.

Explanation of symbols

10 .... Medical solution container, 11 .... Main drug solution storage room, 12 .... Sub-drug solution storage room, 15 .... Expansion part

Claims (12)

A main drug solution storage chamber for storing a drug; and at least one auxiliary drug solution storage chamber that is connected to the main drug solution storage chamber and stores a smaller amount of the drug solution than the drug solution stored in the main drug solution storage chamber. , A medical drug container in which the main drug solution storage chamber and the auxiliary drug solution storage chamber are partitioned so as to communicate with each other;
The secondary drug solution storage chamber includes a bulging portion that is bulged so as to be larger than the volume of the drug in which the internal drug storage space is stored before the drug is stored. container.   2. The medical drug solution container according to claim 1, wherein the secondary drug solution storage chamber is liquid-tightly sealed and partitioned so as to allow communication.   The medical liquid container according to claim 2, wherein the liquid tight seal is located outside the main drug solution storage chamber.   The medical drug solution container according to any one of claims 1 to 3, wherein the main drug solution storage chamber is formed of a flexible sheet-like member.   The bulge portion includes two sheet-like members and a separation member accommodated in the auxiliary chemical solution storage chamber that forms a space by separating the two sheet-like members from each other. Item 5. A medical drug solution container according to any one of Items 1 to 4.   The medical liquid container according to any one of claims 1 to 4, wherein the bulging portion is formed by cold stretching or heat stretching of a sheet-like member.   The medical chemical container according to any one of claims 1 to 4, wherein the auxiliary chemical storage chamber is a blow molded body.   The medical drug container according to any one of claims 1 to 7, wherein the main drug solution storage chamber includes a plurality of storage chambers partitioned by a peelable liquid-tight seal.   9. A medical medicinal liquid container containing a medicine, wherein the medicinal liquid container of the medical medicinal liquid container according to claim 1 is stored in each of the main chemical liquid storage chamber and the auxiliary chemical liquid storage chamber.   The said secondary chemical | medical solution storage chamber consists of a secondary chemical | medical solution storage chamber containing the medicine manufactured by the method of performing the shaping | molding of the chamber by blow molding, accommodation of a chemical | medical agent, and sealing of a chamber continuously. Drug-filled medical chemical container.   The medicinal liquid container for medicine according to claim 9 or 10, wherein a medicine containing any one or more of sugar, electrolyte and amino acid is accommodated in the main drug solution storage chamber. The medicinal solution containing medicine according to any one of claims 9 to 11, wherein a medicine containing any one or more of water-soluble vitamins, fat-soluble vitamins and trace elements is accommodated in the auxiliary drug solution storage chamber. container.

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