JP4335334B2 - Drug infusion container - Google Patents

Description

[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a drug mixed infusion container used for instillation injection and the like. More specifically, a liquid for dilution or dissolution (referred to as “liquid drug” in the present invention) and another drug (in the present invention, mixed or dissolved in a liquid drug) "Other drugs" are sealed and housed in a sealed state, and these drugs are kept separated during transportation and storage, and these can be easily operated when used as an infusion container for infusion. The present invention relates to a drug-mixed infusion container that can easily dissolve or mix both drugs.
[0002]
[Prior art]
In the medical field, instillation is widely used, and infusion used for infusion may be infused by mixing two or more kinds of drugs immediately before use. For example, when instilling a powdered drug or freeze-dried drug in a container such as a vial, these are dissolved in a liquid drug and used for infusion as an infusion. In such cases, the mixing operation is usually performed in the examination room. Or, since it is carried out in an environment such as a hospital room, there is a concern about the possibility of contamination by foreign substances and invasion of germs.
[0003]
In order to avoid such a risk, various drug-mixed infusion containers having sanitary and epidemiological properties have been developed. These drug-mixed infusion containers are those in which a vial drug container and a portable liquid drug container are sealed in a system that is shielded from the outside air, and when used, this seal is broken in the sealed system. Communicating and mixing two drugs. Such infusion containers have been proposed in JP-A-5-123377, JP-A-5-192377, JP-A-7-255820, and the like.
[0004]
However, in these infusion containers, the risk of invasion of various germs has been avoided, but these infusion containers use conventional vial containers, which increases the number of parts and complicates the container assembly process. There is a problem that the storage amount in the boxing due to bulkiness is small, and the container body must be disassembled at the time of disposal and separated into rubber, plastic, glass and the like.
[0005]
[Problems to be solved by the invention]
The present invention has been made in view of such problems, and an object of the present invention is to provide a composite infusion container that can simplify an assembling process and is excellent in hygiene prevention, storage, and easy disposal.
[0006]
[Means for Solving the Problems]
The present invention
[1] A flexible container 1 containing a liquid medicine inside and sealed by a mouth member 2 whose end face is closed with a cover film 6, and another medicine used by mixing with the liquid medicine The flexible container 7 having the mouth member 8 whose end face is closed with the cover film 11 and the communication jig 9 is connected and joined between the two film surfaces, and the communication jig 9 is a flexible container. is inserted into the 7 is sandwiched by the bottom of the vessel, the liquid medicine and other drugs dissolved or mixed in the mouth member 10 having a stopper 12, a hole 13 adjusted drug is passable passageway communicating Michiharu A drug-mixing infusion container characterized by having a sharp tip on the opposite side of the mouth member 10 at the bottom of the device in the flexible container;
The above objective was achieved by developing
[0007]
DETAILED DESCRIPTION OF THE INVENTION
Hereinafter, the contents of the present invention will be described in detail with reference to the drawings.
Examples of the liquid drug include physiological saline, glucose solution, distilled water for injection, and other various electrolyte-containing solutions. Other drugs include powder drugs, freeze-dried drugs, and liquid drugs used for instillation injections.
An example of the drug-mixed infusion container of the present invention is shown in FIG.
The flexible container 1 in Fig. 1 is a container of flexible for accommodating the liquid medicament, made of a material having a heat resistance for transparency and retort sterilization for the contents confirmation. Preferable materials include a single polyolefin film, a laminated film of two or more types of polyolefin, a laminated film of polyolefin and other synthetic resin, and the like.
Method of manufacturing a flexible container 1 need not be particularly limited, for example, by cutting the tubular film obtained by a general inflation molding advantageously be used to seal the top and bottom in brass tick molding.
[0008]
The bottom of the flexible container 1 neck member (2) for filling and removal and polyolefin as a main material is bonded to the sealing portion 3 of the tubular film. In this case, sealing by heat sealing is advantageous in terms of cost and performance. Upper peripheral edge portion 4 of the flexible container 1 is also bonded by heat-sealing. In this case, the peripheral edge 4 may be provided with a suspending hole 5 for suspending from the pedestal during drip injection.
After the flexible container 1 is filled from the mouth member 2 a liquid drug, an end surface of the mouth member 2 is sealed by heat-sealing the cover film 6 in which the polyolefin as a main material.
[0009]
Container for housing the other agent 7 is required to be a flexible container. Same as the flexible container 1 can be used as the material used. Further, when it is necessary to prevent the alteration of the drug, a material having a barrier property against oxygen and water vapor may be used. Specific examples of the barrier material include a laminate material in which the innermost layer is a polyolefin layer and a barrier layer is disposed thereon. If necessary, a protective layer such as polyolefin may be provided on the barrier layer.
Preferred barrier layer materials include ethylene-vinyl alcohol copolymer, polyamide, polyvinylidene chloride, polyester, aluminum foil or resin film deposited with silicon oxide, aluminum oxide or aluminum, etc. Properties of other drugs These barrier materials are selected according to the above or combined and used.
[0010]
To produce the flexible container 7 for other agents, general multilayer inflation molding to be used in the film molding of plastic, multi-layer T-die molding, the use of a film obtained by lamination molding, etc. Can do.
On top of the flexible container 7, thereby clamping the same mouth member 8 and the mouth member 2 used in the flexible container 1. The upper end surface of the mouth member 8 to plugging the cover film 11 in which the polyolefin as a main material for example by heat sealing. The bottom of the flexible container 7 to sandwich the drug loading and unloading mouth member 10 having a communication Michiharu device 9 shaped with a pointed tip in which the polyolefin rigid main material as shown in FIG.
Form of the mouth member 10 having a該連Michiharu tool 9 is preferably molded by injection molding or the like communicating Michiharu member 9 and the mouth member 10 integrally, or combinations supported after forming separately, separately It may be integrated after being molded. The flexible container 7 is sealed with a rubber stopper 12 after filling from the mouth member 10 other agents.
[0011]
該連Michiharu member 9 is a hollow needle is preferred, for example when broke cover film 6 and 11, the liquid agent can be introduced into the flexible container 7 from the flexible container 1, and other drugs dissolved or mixed with other agents prepared was passable to the mouth member 10 of a flexible container 7 passages, for example, holes 13, if any, with the shape of acicular, pointed rods, plate-like, etc. Any shape can be used as long as the cover film can be broken.
The tip of the communicating Michiharu device 9, as can be reliably penetrate the cover film 6 and 11, is inserted supported by the hollow portion of the mouth member 8.
[0012]
Since it can be handled in separate form because it is sealed by a respective flexible container 1 and the flexible container 7 cover film as described above, appropriate sterilization conditions in accordance with the drug each content Can be selected. That is, radiation when such flexible container 1 containing the liquid drug to retort sterilization at a high temperature heat sterilization, while the other flexible container 7 containing the drug is the danger of deterioration by heat after sterilization by such sterilization may be integrated by welding connecting the mouth member 2 and 8 of them in such a clean room.
The flexible container 1 and the flexible container 7 as the surface of both the cover film 6 and 11 overlap, connecting by welding the peripheral edge portions of the mouth member 2 and the mouth member 8 by holding the cover film It is integrated. Examples of the welding method include butt welding, hot plate welding, impulse welding, high frequency welding, ultrasonic welding, and the like, but high frequency welding is particularly preferable from the viewpoint of productivity.
[0013]
Agent such as a drug mixed infusion container is filled may extent to protect storage, transport by cardboard between the mouth member 2 and the mouth member 10 in order to ensure the safety of the sealing portion of the like, It can be safely packed, transported and stored.
Details of the communication method between the two flexible containers are shown in FIG.
After removing the protective material such as corrugated cardboard, the flexible container 7 is compressed in the longitudinal direction so that the tip of the communication jig 9 guided by the mouth member 8 penetrates and breaks the cover films 6 and 11, thereby liquid. The flexible drug container 1 and the flexible container 7 communicate with each other, and both drugs are mixed. In some cases, the flexible container 1 and the flexible container 7 can be crushed alternately to achieve more uniform mixing of the drugs.
Is well mixed or dissolved was prepared after completion medicament is to through the hollow needle or the like through the rubber stopper that plugging the mouth member 10 is used, such as an infusion.
[0014]
【The invention's effect】
The composite infusion container of the present invention has a small number of parts, is easy to manufacture, has a structure with good productivity, and reliably maintains each drug until it is used even after drug filling. However, it can be mixed while maintaining sterility by a simple operation when used. Furthermore, it is a plastic mixed infusion container which is plastic as a whole and is easy to dispose of, has a sanitary and epidemiological property that can be mixed in a sealed drug mixed infusion container, and is excellent in storage before use and disposal after use.
[Brief description of the drawings]
FIG. 1 is a front sectional view of a drug infusion container of the present invention.
FIG. 2 is a schematic view showing a state when the drug-mixed infusion container of the present invention is in communication.
[Explanation of symbols]
1 flexible container 2 mouth member 3 heat-sealed portion 4 periphery 5 hanging hole 6 cover film 7 flexible container 8 neck member 9 stations Michiharu instrument 10 neck member 11 cover film 12 rubber plug 13 Hole provided in the communication jig

Claims (1)

A liquid medicine is accommodated therein, and a flexible container 1 sealed with a mouth member 2 whose end face is closed with a cover film 6 and other medicines to be used by mixing with the liquid medicine are accommodated. The opening member 8 whose end face is closed with the cover film 11 and the flexible container 7 having the communication jig 9 are connected and joined between the two film surfaces, and the communication jig 9 is placed in the flexible container 7. The hole 13 which is a passage through which the liquid medicine and other chemicals are dissolved or mixed in the mouth member 10 which is inserted and clamped at the lower part of the container 12 and has the stopper 12 and through which the adjusted medicine can pass can be used as a communication jig. A drug-mixing infusion container characterized by having a tip at the bottom in a flexible container and having a sharp tip opposite to the mouth member 10.

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