JP2003215004A - スライスされる組織標本の製造方法および装置 - Google Patents
スライスされる組織標本の製造方法および装置Info
- Publication number
- JP2003215004A JP2003215004A JP2002366530A JP2002366530A JP2003215004A JP 2003215004 A JP2003215004 A JP 2003215004A JP 2002366530 A JP2002366530 A JP 2002366530A JP 2002366530 A JP2002366530 A JP 2002366530A JP 2003215004 A JP2003215004 A JP 2003215004A
- Authority
- JP
- Japan
- Prior art keywords
- cassette
- tissue
- tissue specimen
- cassette according
- foam
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims abstract description 33
- 238000004519 manufacturing process Methods 0.000 title abstract description 7
- 239000012188 paraffin wax Substances 0.000 claims abstract description 35
- 238000012545 processing Methods 0.000 claims description 30
- 239000006260 foam Substances 0.000 claims description 16
- 229920000936 Agarose Polymers 0.000 claims description 11
- 239000000463 material Substances 0.000 claims description 8
- 238000005520 cutting process Methods 0.000 claims description 7
- 238000002844 melting Methods 0.000 claims description 5
- 230000008018 melting Effects 0.000 claims description 5
- KXGFMDJXCMQABM-UHFFFAOYSA-N 2-methoxy-6-methylphenol Chemical compound [CH]OC1=CC=CC([CH])=C1O KXGFMDJXCMQABM-UHFFFAOYSA-N 0.000 claims description 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 4
- 239000005011 phenolic resin Substances 0.000 claims description 4
- 229920001568 phenolic resin Polymers 0.000 claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 3
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 claims description 3
- 238000005553 drilling Methods 0.000 claims description 3
- 238000004080 punching Methods 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 239000008096 xylene Substances 0.000 claims description 3
- 238000000465 moulding Methods 0.000 claims description 2
- 238000010562 histological examination Methods 0.000 claims 3
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 230000001934 delay Effects 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 description 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- 239000000020 Nitrocellulose Substances 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 229920001220 nitrocellulos Polymers 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000003313 weakening effect Effects 0.000 description 2
- BLKPFVWYBFDTPX-UHFFFAOYSA-N 2-(6,6-dimethyl-4-bicyclo[3.1.1]hept-3-enyl)acetaldehyde Chemical compound C1C2C(C)(C)C1CC=C2CC=O BLKPFVWYBFDTPX-UHFFFAOYSA-N 0.000 description 1
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 description 1
- 101100321669 Fagopyrum esculentum FA02 gene Proteins 0.000 description 1
- 240000008607 Opuntia megacantha Species 0.000 description 1
- 235000002840 Opuntia megacantha Nutrition 0.000 description 1
- 235000006538 Opuntia tuna Nutrition 0.000 description 1
- 101100219325 Phaseolus vulgaris BA13 gene Proteins 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- KRVSOGSZCMJSLX-UHFFFAOYSA-L chromic acid Substances O[Cr](O)(=O)=O KRVSOGSZCMJSLX-UHFFFAOYSA-L 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- PKRPQASGRXWUOJ-UHFFFAOYSA-L dipotassium;dichloride Chemical compound [Cl-].[Cl-].[K+].[K+] PKRPQASGRXWUOJ-UHFFFAOYSA-L 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000000834 fixative Substances 0.000 description 1
- AWJWCTOOIBYHON-UHFFFAOYSA-N furo[3,4-b]pyrazine-5,7-dione Chemical compound C1=CN=C2C(=O)OC(=O)C2=N1 AWJWCTOOIBYHON-UHFFFAOYSA-N 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000005470 impregnation Methods 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 229960002523 mercuric chloride Drugs 0.000 description 1
- LWJROJCJINYWOX-UHFFFAOYSA-L mercury dichloride Chemical compound Cl[Hg]Cl LWJROJCJINYWOX-UHFFFAOYSA-L 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 239000012285 osmium tetroxide Substances 0.000 description 1
- 229910000489 osmium tetroxide Inorganic materials 0.000 description 1
- OXNIZHLAWKMVMX-UHFFFAOYSA-N picric acid Chemical compound OC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-N 0.000 description 1
- 238000012805 post-processing Methods 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- -1 that is Polymers 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/36—Embedding or analogous mounting of samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N1/31—Apparatus therefor
- G01N2001/315—Basket-type carriers for tissues
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/36—Embedding or analogous mounting of samples
- G01N2001/366—Moulds; Demoulding
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/807—Apparatus included in process claim, e.g. physical support structures
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/2525—Stabilizing or preserving
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10029658 | 2001-12-20 | ||
| US10/029,658 US7005110B2 (en) | 2001-12-20 | 2001-12-20 | Method and apparatus for preparing tissue samples for sectioning |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003215004A true JP2003215004A (ja) | 2003-07-30 |
| JP2003215004A5 JP2003215004A5 (enExample) | 2006-02-09 |
Family
ID=21850182
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002366530A Pending JP2003215004A (ja) | 2001-12-20 | 2002-12-18 | スライスされる組織標本の製造方法および装置 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7005110B2 (enExample) |
| EP (1) | EP1321757B1 (enExample) |
| JP (1) | JP2003215004A (enExample) |
| AT (1) | ATE327502T1 (enExample) |
| AU (1) | AU2002330521B2 (enExample) |
| CA (1) | CA2413902A1 (enExample) |
| DE (1) | DE60211637T2 (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009507231A (ja) * | 2005-09-06 | 2009-02-19 | レイカ バイオシステムズ メルボルン ピーティーワイ リミテッド | 組織標本の処理方法及び処理装置 |
| JP2011503519A (ja) * | 2006-12-12 | 2011-01-27 | バイオパス・オートメーション・エル・エル・シー | 切片化可能な弾性発泡材料を備えた生検支持体 |
| JP2011525633A (ja) * | 2008-06-18 | 2011-09-22 | ライカ・バイオシステムズ・メルボルン・プロプライエタリー・リミテッド | 組織の取扱いおよび包埋のための装置ならびに方法における改良 |
| JP2015531876A (ja) * | 2012-09-12 | 2015-11-05 | バイオパス・オートメーション・エル・エル・シー | ミクロトームで切り出し可能なゲル状支持構造体及び方法 |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100518940C (zh) | 2002-09-26 | 2009-07-29 | 比欧帕斯自动化公司 | 操作组织样品的盒子、嵌入组件和方法 |
| US7179424B2 (en) | 2002-09-26 | 2007-02-20 | Biopath Automation, L.L.C. | Cassette for handling and holding tissue samples during processing, embedding and microtome procedures, and methods therefor |
| JP4105164B2 (ja) | 2002-09-26 | 2008-06-25 | バイオパス・オートメーション・エル・エル・シー | 組織標本のハンドリングおよび包埋を自動化する機器および方法 |
| US7541161B2 (en) * | 2002-10-31 | 2009-06-02 | University Of Massachusetts | Method and apparatus for preparing cells for microtome sectioning and archiving nucleic acids and proteins |
| US7648678B2 (en) | 2002-12-20 | 2010-01-19 | Dako Denmark A/S | Method and system for pretreatment of tissue slides |
| KR200327028Y1 (ko) | 2003-06-17 | 2003-09-19 | 장시창 | 인체조직검사기구 |
| US7521021B2 (en) | 2003-11-26 | 2009-04-21 | Leica Biosvstems St. Louis Llc | System for in situ processing of a tissue specimen |
| US8518348B2 (en) | 2003-11-26 | 2013-08-27 | Leica Biosystems Richmond, Inc. | Histological specimen retaining device |
| US20070116612A1 (en) * | 2005-11-02 | 2007-05-24 | Biopath Automation, L.L.C. | Prefix tissue cassette |
| US7975586B2 (en) | 2006-02-06 | 2011-07-12 | Leica Biosystems Richmond, Inc. | Microtome and method of reversibly altering a microtome |
| WO2008074073A1 (en) * | 2006-12-18 | 2008-06-26 | Leica Biosystems Melbourne Pty Ltd | Device and method for tissue handling and embedding |
| US7906076B2 (en) * | 2007-07-02 | 2011-03-15 | University Of Massachusetts | Method and apparatus for biopsy sample processing |
| US8118962B2 (en) * | 2007-12-27 | 2012-02-21 | Cytyc Corporation | Method and apparatus for spacing cellular matter in a cell block |
| CA2749135C (en) | 2009-01-22 | 2017-04-18 | Biopath Automation, L.L.C. | Microtome sectionable biopsy support for orienting tissue samples |
| WO2012018860A2 (en) | 2010-08-02 | 2012-02-09 | Microscopy Innovations, Llc | Methods and devices for preparing microscopy samples |
| WO2013192607A1 (en) | 2012-06-22 | 2013-12-27 | Leica Biosystems Nussloch Gmbh | Tissue sample container and methods |
| CA2876682A1 (en) | 2012-06-22 | 2013-12-27 | Leica Biosystems Nussloch Gmbh | Biopsy tissue sample transport device and method of using thereof |
| US9052256B2 (en) | 2013-03-15 | 2015-06-09 | Leica Biosystems Nussloch Gmbh | Method for processing and embedding tissue |
| CA2845832C (en) | 2013-03-15 | 2020-09-22 | Leica Biosystems Nussloch Gmbh | Tissue cassette with biasing element |
| US9097629B2 (en) | 2013-03-15 | 2015-08-04 | Leica Biosystems Nussloch Gmbh | Tissue cassette with retractable member |
| WO2017136401A1 (en) * | 2016-02-01 | 2017-08-10 | Bioventures, Llc | Dual-purpose biopsy collection container and tissue processing cassette |
| WO2019102504A1 (en) * | 2017-11-23 | 2019-05-31 | Sergio Cometto | Disposable process chamber for processing biologic material |
| DE102018121948B4 (de) | 2018-09-08 | 2021-12-23 | JOMESA Meßsysteme GmbH | Verfahren und Mittel zur Fixierung von Partikeln auf einem Substrat |
| DE102018122173A1 (de) * | 2018-09-11 | 2020-03-12 | Thomas Märsch | Verfahren zum Herstellen eines eine Gewebeprobe enthaltenden Blocks und Gewebeblock |
| TWI798731B (zh) * | 2021-06-28 | 2023-04-11 | 華邦電子股份有限公司 | 承載系統 |
| DE102021118984A1 (de) * | 2021-07-22 | 2023-01-26 | Thomas Märsch | Ausgießform für Biopsien und Verfahren zum Herstellen eines Gewebeblocks mittels einer solchen Ausgießform |
| IT202100029357A1 (it) * | 2021-11-19 | 2023-05-19 | Expertmed S R L | Attrezzatura e metodo per la processazione di campioni biologici |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3411185A (en) | 1966-06-06 | 1968-11-19 | John E.P. Pickett | Composite histologic tissue receptacle |
| US3674396A (en) * | 1970-09-21 | 1972-07-04 | Miles Lab | Biological specimen processing and embedding apparatus |
| US3982862A (en) * | 1975-04-03 | 1976-09-28 | Pickett John E P | Two-part composite device for histologic tissue processing and embedding |
| GB1582988A (en) * | 1977-11-15 | 1981-01-21 | Mardon Illingworth | Security container |
| US4557903A (en) * | 1983-09-16 | 1985-12-10 | Pelam, Inc. | Apparatus for preparing and embedding tissue samples for histological examination |
| EP0142575A1 (de) | 1983-11-22 | 1985-05-29 | Freiherr von Gise, Hardo, Dr. med. | Inkubationskapsel für die Einbettung biologischer Präparate in Paraffin zur Verwendung in automatisch arbeitenden Inkubations- und Aufblockeinrichtungen |
| GB2189596B (en) * | 1986-04-16 | 1990-08-01 | Pa Consulting Services | Methods of and apparatus for preparing tissue specimens |
| FI83668C (fi) * | 1989-09-08 | 1991-08-12 | Johan Eric Walter Ahlqvist | Foerfarande och medel foer behandling av cytologiska preparat. |
| US5080869A (en) * | 1990-08-14 | 1992-01-14 | Mccormick James B | Apparatus and method for preparing tissue samples for histological examination |
| US5269671A (en) * | 1992-02-11 | 1993-12-14 | Mccormick James B | Apparatus for embedding tissue samples |
| US5354370A (en) * | 1992-04-15 | 1994-10-11 | Hacker Industries, Inc. | Tissue processor |
| US5424040A (en) * | 1992-11-09 | 1995-06-13 | Bjornsson; Bjorn L. | Tissue specimen collection kit |
| DE4333118A1 (de) * | 1993-09-29 | 1995-03-30 | Leica Instr Gmbh | Kassette zur Behandlung von Proben für histologische Untersuchungen, insbesondere zur Schnittpräparation |
| US5432056A (en) * | 1993-11-15 | 1995-07-11 | Ventana Medical Systems, Inc. | Bisulfite-based tissue fixative |
| US5427742A (en) * | 1994-04-26 | 1995-06-27 | Holland; Wayne | Tissue processing cassette |
| US5665398A (en) * | 1995-11-20 | 1997-09-09 | Mccormick; James B. | Apparatus for embedding tissue samples |
| US6017476A (en) * | 1996-09-19 | 2000-01-25 | Renshaw; Anthony A. | Method for embedding and sectioning specimen |
| GB9701930D0 (en) * | 1997-01-30 | 1997-03-19 | Life Sciences Int Europe | Tissue processing apparatus and method |
| US5928934A (en) * | 1998-04-14 | 1999-07-27 | Mccormick; James B. | Apparatus and method for preparing small tissue samples for histological examination |
| US6372512B1 (en) * | 1998-09-16 | 2002-04-16 | Resolution Sciences Corporation | Combined en bloc staining and embedding process |
| JP4303849B2 (ja) * | 1999-10-19 | 2009-07-29 | サクラファインテックジャパン株式会社 | 検体処理容器並びに検体処理容器を構成する容器本体および蓋体 |
| US6395234B1 (en) * | 2000-02-08 | 2002-05-28 | Triangle Biomedical Sciences, Inc. | Sample cassette having utility for histological processing of tissue samples |
-
2001
- 2001-12-20 US US10/029,658 patent/US7005110B2/en not_active Expired - Lifetime
-
2002
- 2002-12-10 CA CA002413902A patent/CA2413902A1/en not_active Abandoned
- 2002-12-11 AU AU2002330521A patent/AU2002330521B2/en not_active Ceased
- 2002-12-17 AT AT02028076T patent/ATE327502T1/de not_active IP Right Cessation
- 2002-12-17 EP EP02028076A patent/EP1321757B1/en not_active Expired - Lifetime
- 2002-12-17 DE DE60211637T patent/DE60211637T2/de not_active Expired - Lifetime
- 2002-12-18 JP JP2002366530A patent/JP2003215004A/ja active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009507231A (ja) * | 2005-09-06 | 2009-02-19 | レイカ バイオシステムズ メルボルン ピーティーワイ リミテッド | 組織標本の処理方法及び処理装置 |
| US9234823B2 (en) | 2005-09-06 | 2016-01-12 | Leica Biosystems Melbourne Pty Ltd | Method and apparatus for handling tissue samples |
| JP2011503519A (ja) * | 2006-12-12 | 2011-01-27 | バイオパス・オートメーション・エル・エル・シー | 切片化可能な弾性発泡材料を備えた生検支持体 |
| JP2011525633A (ja) * | 2008-06-18 | 2011-09-22 | ライカ・バイオシステムズ・メルボルン・プロプライエタリー・リミテッド | 組織の取扱いおよび包埋のための装置ならびに方法における改良 |
| JP2015531876A (ja) * | 2012-09-12 | 2015-11-05 | バイオパス・オートメーション・エル・エル・シー | ミクロトームで切り出し可能なゲル状支持構造体及び方法 |
| US10794804B2 (en) | 2012-09-12 | 2020-10-06 | Biopath Automation, Llc | Microtome sectionable gel support structure and methods |
| US12270739B2 (en) | 2012-09-12 | 2025-04-08 | Biopath Automation, Llc | Microtome sectionable gel support structure and methods |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1321757A3 (en) | 2004-06-02 |
| US20030119200A1 (en) | 2003-06-26 |
| EP1321757A2 (en) | 2003-06-25 |
| DE60211637D1 (de) | 2006-06-29 |
| AU2002330521A1 (en) | 2003-08-28 |
| US7005110B2 (en) | 2006-02-28 |
| CA2413902A1 (en) | 2003-06-20 |
| EP1321757B1 (en) | 2006-05-24 |
| ATE327502T1 (de) | 2006-06-15 |
| AU2002330521B2 (en) | 2007-06-07 |
| DE60211637T2 (de) | 2007-04-26 |
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