JP2003210187A5 - - Google Patents
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- Publication number
- JP2003210187A5 JP2003210187A5 JP2002380069A JP2002380069A JP2003210187A5 JP 2003210187 A5 JP2003210187 A5 JP 2003210187A5 JP 2002380069 A JP2002380069 A JP 2002380069A JP 2002380069 A JP2002380069 A JP 2002380069A JP 2003210187 A5 JP2003210187 A5 JP 2003210187A5
- Authority
- JP
- Japan
- Prior art keywords
- hnl
- recombinant
- hydroxynitrile
- hydroxynitrile lyase
- prunus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108030003190 (S)-hydroxynitrile lyases Proteins 0.000 description 5
- 101000988658 Arabidopsis thaliana Alpha-hydroxynitrile lyase Proteins 0.000 description 5
- 235000011437 Amygdalus communis Nutrition 0.000 description 3
- 244000144725 Amygdalus communis Species 0.000 description 3
- 244000043261 Hevea brasiliensis Species 0.000 description 3
- 241000235058 Komagataella pastoris Species 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 241000588724 Escherichia coli Species 0.000 description 2
- 235000008994 Laurocerasus officinalis Nutrition 0.000 description 2
- 244000061600 Laurocerasus officinalis Species 0.000 description 2
- 240000003183 Manihot esculenta Species 0.000 description 2
- 235000016735 Manihot esculenta subsp esculenta Nutrition 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 2
- HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 description 2
- 108010031620 mandelonitrile lyase Proteins 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 235000003840 Amygdalus nana Nutrition 0.000 description 1
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- 108090000856 Lyases Proteins 0.000 description 1
- 102000004317 Lyases Human genes 0.000 description 1
- 235000011432 Prunus Nutrition 0.000 description 1
- 241000220299 Prunus Species 0.000 description 1
- 240000008296 Prunus serotina Species 0.000 description 1
- 235000014441 Prunus serotina Nutrition 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000000633 chiral stationary phase gas chromatography Methods 0.000 description 1
- 239000007979 citrate buffer Substances 0.000 description 1
- MSMGXWFHBSCQFB-UHFFFAOYSA-N ethyl cyanoformate Chemical compound CCOC(=O)C#N MSMGXWFHBSCQFB-UHFFFAOYSA-N 0.000 description 1
- NNICRUQPODTGRU-UHFFFAOYSA-N mandelonitrile Chemical compound N#CC(O)C1=CC=CC=C1 NNICRUQPODTGRU-UHFFFAOYSA-N 0.000 description 1
- QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 description 1
- 229910000160 potassium phosphate Inorganic materials 0.000 description 1
- 239000008057 potassium phosphate buffer Substances 0.000 description 1
- 235000011009 potassium phosphates Nutrition 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 235000014774 prunus Nutrition 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT2044/2001 | 2001-12-28 | ||
| AT0204401A AT410792B (de) | 2001-12-28 | 2001-12-28 | Verfahren zur herstellung von geschützten, enantiomeren-angereicherten cyanhydrinen durch in-situ-derivatisierung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003210187A JP2003210187A (ja) | 2003-07-29 |
| JP2003210187A5 true JP2003210187A5 (https=) | 2006-02-16 |
Family
ID=3689713
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002380069A Pending JP2003210187A (ja) | 2001-12-28 | 2002-12-27 | その場で誘導体化することによってエナンチオマー豊富な保護されたシアノヒドリンを製造する方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6909011B2 (https=) |
| EP (1) | EP1323829B1 (https=) |
| JP (1) | JP2003210187A (https=) |
| AT (2) | AT410792B (https=) |
| CA (1) | CA2415190A1 (https=) |
| DE (1) | DE50206986D1 (https=) |
| ES (1) | ES2262750T3 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT410792B (de) * | 2001-12-28 | 2003-07-25 | Dsm Fine Chem Austria Gmbh | Verfahren zur herstellung von geschützten, enantiomeren-angereicherten cyanhydrinen durch in-situ-derivatisierung |
| DE10219934A1 (de) * | 2002-05-03 | 2003-11-20 | Basf Ag | Neue Proteine mit (R)-Hydroxynitril Lyase-Aktivität |
| AT500910B1 (de) * | 2004-01-30 | 2006-11-15 | Dsm Fine Chem Austria Gmbh | Verfahren zur herstellung von beta-hydroxynitroverbindungen |
| HUE025528T2 (en) | 2008-04-23 | 2016-05-30 | Gilead Sciences Inc | 1'-substituted carba-nucleoside analogs for antiviral treatment |
| MX2011008409A (es) * | 2009-02-10 | 2011-10-21 | Gilead Sciences Inc | Análogos de carba-nucléosido para tratamiento antiviral. |
| MX2012003126A (es) | 2009-09-21 | 2012-06-19 | Gilead Sciences Inc | Procesos e intermedios para la preparacion de analogos de 1'-carbonucleosidos sustituidos. |
| AU2011282241B2 (en) | 2010-07-19 | 2015-07-30 | Gilead Sciences, Inc. | Methods for the preparation of diasteromerically pure phosphoramidate prodrugs |
| ES2524356T3 (es) | 2010-07-22 | 2014-12-05 | Gilead Sciences, Inc. | Métodos y compuestos para tratar infecciones provocadas por virus Paramyxoviridae |
| TWI687432B (zh) | 2014-10-29 | 2020-03-11 | 美商基利科學股份有限公司 | 絲狀病毒科病毒感染之治療 |
| DK3785717T3 (da) | 2015-09-16 | 2022-03-21 | Gilead Sciences Inc | Fremgangsmåder til behandling af coronaviridae-infektioner |
| US10682368B2 (en) | 2017-03-14 | 2020-06-16 | Gilead Sciences, Inc. | Methods of treating feline coronavirus infections |
| CA3059777C (en) | 2017-05-01 | 2023-02-21 | Gilead Sciences, Inc. | Crystalline forms of (s)-2-ethylbutyl 2-(((s)-(((2r,3s,4r,5r)-5-(4-aminopyrrolo[2,1-f] [1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy) phosphoryl)amino)propanoate |
| WO2019014247A1 (en) | 2017-07-11 | 2019-01-17 | Gilead Sciences, Inc. | COMPOSITIONS COMPRISING POLYMERASE RNA INHIBITOR AND CYCLODEXTRIN FOR THE TREATMENT OF VIRAL INFECTIONS |
| JP2023512656A (ja) | 2020-01-27 | 2023-03-28 | ギリアード サイエンシーズ， インコーポレイテッド | ＳＡＲＳ ＣｏＶ－２感染を治療するための方法 |
| KR20220153619A (ko) | 2020-03-12 | 2022-11-18 | 길리애드 사이언시즈, 인코포레이티드 | 1'-시아노 뉴클레오사이드의 제조 방법 |
| CA3172483A1 (en) | 2020-04-06 | 2021-10-14 | Scott Ellis | Inhalation formulations of 1'-cyano substituted carbanucleoside analogs |
| TW202203941A (zh) | 2020-05-29 | 2022-02-01 | 美商基利科學股份有限公司 | 瑞德西韋之治療方法 |
| PE20230618A1 (es) | 2020-06-24 | 2023-04-14 | Gilead Sciences Inc | Analogos de nucleosido de 1'-ciano y usos de los mismos |
| IL300453A (en) | 2020-08-27 | 2023-04-01 | Gilead Sciences Inc | COMPOSITIONS AND METHODS FOR THE TREATMENT OF VIRAL INFECTIONS |
| KR20240154647A (ko) | 2022-03-02 | 2024-10-25 | 길리애드 사이언시즈, 인코포레이티드 | 바이러스성 감염 치료를 위한 화합물 및 방법 |
| US12357577B1 (en) | 2024-02-02 | 2025-07-15 | Gilead Sciences, Inc. | Pharmaceutical formulations and uses thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4414218A (en) * | 1982-03-03 | 1983-11-08 | The Dow Chemical Company | Cyano-(substituted and unsubstituted pyridinyl) methyl and aryl esters of carbonic acid |
| US5329023A (en) * | 1987-12-24 | 1994-07-12 | Duphar International Research B.V. | Method of preparing optically active alcohols which consist substantially or entirely of one enantiomer |
| AT396252B (de) * | 1991-10-31 | 1993-07-26 | Chemie Linz Gmbh | Enzymatisches verfahren zur enantioselektiven herstellung optisch aktiver cyanhydrine |
| EP0547655A1 (en) * | 1991-12-11 | 1993-06-23 | Duphar International Research B.V | Method of preparing optically active cyanohydrins |
| US5241087A (en) * | 1992-03-09 | 1993-08-31 | Bend Research, Inc. | Enantiomeric enrichment of cyanohydrins |
| AT406959B (de) * | 1997-01-13 | 2000-11-27 | Chemie Linz Gmbh | Enantioselektives verfahren zur herstellung von (s)-cyanhydrinen |
| AT406960B (de) * | 1997-03-18 | 2000-11-27 | Chemie Linz Gmbh | Verfahren zur selektiven mikrobiellen hydroxylierung von aldehyden und ketonen |
| AT406961B (de) * | 1997-12-29 | 2000-11-27 | Dsm Fine Chem Austria Gmbh | Enzymatisches verfahren zur herstellung von (s)-cyanhydrinen |
| AT411064B (de) * | 2001-12-27 | 2003-09-25 | Dsm Fine Chem Austria Gmbh | Verfahren zur herstellung von enantiomerenangereicherten cyanhydrinen unter verwendung von acetalen oder ketalen als substrate |
| AT410792B (de) * | 2001-12-28 | 2003-07-25 | Dsm Fine Chem Austria Gmbh | Verfahren zur herstellung von geschützten, enantiomeren-angereicherten cyanhydrinen durch in-situ-derivatisierung |
-
2001
- 2001-12-28 AT AT0204401A patent/AT410792B/de not_active IP Right Cessation
-
2002
- 2002-11-29 AT AT02026849T patent/ATE328105T1/de not_active IP Right Cessation
- 2002-11-29 ES ES02026849T patent/ES2262750T3/es not_active Expired - Lifetime
- 2002-11-29 DE DE50206986T patent/DE50206986D1/de not_active Expired - Fee Related
- 2002-11-29 EP EP02026849A patent/EP1323829B1/de not_active Expired - Lifetime
- 2002-12-23 US US10/325,923 patent/US6909011B2/en not_active Expired - Fee Related
- 2002-12-27 JP JP2002380069A patent/JP2003210187A/ja active Pending
- 2002-12-27 CA CA002415190A patent/CA2415190A1/en not_active Abandoned
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