DE50206986D1 - Verfahren zur Herstellung von geschützten, enantiomeren-angereicherten Cyanhydrinen durch in-situ-Derivatisierung - Google Patents
Verfahren zur Herstellung von geschützten, enantiomeren-angereicherten Cyanhydrinen durch in-situ-DerivatisierungInfo
- Publication number
- DE50206986D1 DE50206986D1 DE50206986T DE50206986T DE50206986D1 DE 50206986 D1 DE50206986 D1 DE 50206986D1 DE 50206986 T DE50206986 T DE 50206986T DE 50206986 T DE50206986 T DE 50206986T DE 50206986 D1 DE50206986 D1 DE 50206986D1
- Authority
- DE
- Germany
- Prior art keywords
- protected
- preparation
- enantiomerically enriched
- optionally substituted
- cyanohydrins
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000001212 derivatisation Methods 0.000 title 1
- 238000011065 in-situ storage Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 150000002576 ketones Chemical class 0.000 abstract 4
- 108030003190 (S)-hydroxynitrile lyases Proteins 0.000 abstract 2
- 150000001299 aldehydes Chemical class 0.000 abstract 2
- -1 cyanoformate ester Chemical class 0.000 abstract 2
- 239000000839 emulsion Substances 0.000 abstract 2
- 125000004474 heteroalkylene group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/002—Nitriles (-CN)
- C12P13/004—Cyanohydrins
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0204401A AT410792B (de) | 2001-12-28 | 2001-12-28 | Verfahren zur herstellung von geschützten, enantiomeren-angereicherten cyanhydrinen durch in-situ-derivatisierung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE50206986D1 true DE50206986D1 (de) | 2006-07-06 |
Family
ID=3689713
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE50206986T Expired - Fee Related DE50206986D1 (de) | 2001-12-28 | 2002-11-29 | Verfahren zur Herstellung von geschützten, enantiomeren-angereicherten Cyanhydrinen durch in-situ-Derivatisierung |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6909011B2 (https=) |
| EP (1) | EP1323829B1 (https=) |
| JP (1) | JP2003210187A (https=) |
| AT (2) | AT410792B (https=) |
| CA (1) | CA2415190A1 (https=) |
| DE (1) | DE50206986D1 (https=) |
| ES (1) | ES2262750T3 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT410792B (de) * | 2001-12-28 | 2003-07-25 | Dsm Fine Chem Austria Gmbh | Verfahren zur herstellung von geschützten, enantiomeren-angereicherten cyanhydrinen durch in-situ-derivatisierung |
| DE10219934A1 (de) * | 2002-05-03 | 2003-11-20 | Basf Ag | Neue Proteine mit (R)-Hydroxynitril Lyase-Aktivität |
| AT500910B1 (de) * | 2004-01-30 | 2006-11-15 | Dsm Fine Chem Austria Gmbh | Verfahren zur herstellung von beta-hydroxynitroverbindungen |
| HUE025528T2 (en) | 2008-04-23 | 2016-05-30 | Gilead Sciences Inc | 1'-substituted carba-nucleoside analogs for antiviral treatment |
| MX2011008409A (es) * | 2009-02-10 | 2011-10-21 | Gilead Sciences Inc | Análogos de carba-nucléosido para tratamiento antiviral. |
| MX2012003126A (es) | 2009-09-21 | 2012-06-19 | Gilead Sciences Inc | Procesos e intermedios para la preparacion de analogos de 1'-carbonucleosidos sustituidos. |
| AU2011282241B2 (en) | 2010-07-19 | 2015-07-30 | Gilead Sciences, Inc. | Methods for the preparation of diasteromerically pure phosphoramidate prodrugs |
| ES2524356T3 (es) | 2010-07-22 | 2014-12-05 | Gilead Sciences, Inc. | Métodos y compuestos para tratar infecciones provocadas por virus Paramyxoviridae |
| TWI687432B (zh) | 2014-10-29 | 2020-03-11 | 美商基利科學股份有限公司 | 絲狀病毒科病毒感染之治療 |
| DK3785717T3 (da) | 2015-09-16 | 2022-03-21 | Gilead Sciences Inc | Fremgangsmåder til behandling af coronaviridae-infektioner |
| US10682368B2 (en) | 2017-03-14 | 2020-06-16 | Gilead Sciences, Inc. | Methods of treating feline coronavirus infections |
| CA3059777C (en) | 2017-05-01 | 2023-02-21 | Gilead Sciences, Inc. | Crystalline forms of (s)-2-ethylbutyl 2-(((s)-(((2r,3s,4r,5r)-5-(4-aminopyrrolo[2,1-f] [1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy) phosphoryl)amino)propanoate |
| WO2019014247A1 (en) | 2017-07-11 | 2019-01-17 | Gilead Sciences, Inc. | COMPOSITIONS COMPRISING POLYMERASE RNA INHIBITOR AND CYCLODEXTRIN FOR THE TREATMENT OF VIRAL INFECTIONS |
| JP2023512656A (ja) | 2020-01-27 | 2023-03-28 | ギリアード サイエンシーズ， インコーポレイテッド | ＳＡＲＳ ＣｏＶ－２感染を治療するための方法 |
| KR20220153619A (ko) | 2020-03-12 | 2022-11-18 | 길리애드 사이언시즈, 인코포레이티드 | 1'-시아노 뉴클레오사이드의 제조 방법 |
| CA3172483A1 (en) | 2020-04-06 | 2021-10-14 | Scott Ellis | Inhalation formulations of 1'-cyano substituted carbanucleoside analogs |
| TW202203941A (zh) | 2020-05-29 | 2022-02-01 | 美商基利科學股份有限公司 | 瑞德西韋之治療方法 |
| PE20230618A1 (es) | 2020-06-24 | 2023-04-14 | Gilead Sciences Inc | Analogos de nucleosido de 1'-ciano y usos de los mismos |
| IL300453A (en) | 2020-08-27 | 2023-04-01 | Gilead Sciences Inc | COMPOSITIONS AND METHODS FOR THE TREATMENT OF VIRAL INFECTIONS |
| KR20240154647A (ko) | 2022-03-02 | 2024-10-25 | 길리애드 사이언시즈, 인코포레이티드 | 바이러스성 감염 치료를 위한 화합물 및 방법 |
| US12357577B1 (en) | 2024-02-02 | 2025-07-15 | Gilead Sciences, Inc. | Pharmaceutical formulations and uses thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4414218A (en) * | 1982-03-03 | 1983-11-08 | The Dow Chemical Company | Cyano-(substituted and unsubstituted pyridinyl) methyl and aryl esters of carbonic acid |
| US5329023A (en) * | 1987-12-24 | 1994-07-12 | Duphar International Research B.V. | Method of preparing optically active alcohols which consist substantially or entirely of one enantiomer |
| AT396252B (de) * | 1991-10-31 | 1993-07-26 | Chemie Linz Gmbh | Enzymatisches verfahren zur enantioselektiven herstellung optisch aktiver cyanhydrine |
| EP0547655A1 (en) * | 1991-12-11 | 1993-06-23 | Duphar International Research B.V | Method of preparing optically active cyanohydrins |
| US5241087A (en) * | 1992-03-09 | 1993-08-31 | Bend Research, Inc. | Enantiomeric enrichment of cyanohydrins |
| AT406959B (de) * | 1997-01-13 | 2000-11-27 | Chemie Linz Gmbh | Enantioselektives verfahren zur herstellung von (s)-cyanhydrinen |
| AT406960B (de) * | 1997-03-18 | 2000-11-27 | Chemie Linz Gmbh | Verfahren zur selektiven mikrobiellen hydroxylierung von aldehyden und ketonen |
| AT406961B (de) * | 1997-12-29 | 2000-11-27 | Dsm Fine Chem Austria Gmbh | Enzymatisches verfahren zur herstellung von (s)-cyanhydrinen |
| AT411064B (de) * | 2001-12-27 | 2003-09-25 | Dsm Fine Chem Austria Gmbh | Verfahren zur herstellung von enantiomerenangereicherten cyanhydrinen unter verwendung von acetalen oder ketalen als substrate |
| AT410792B (de) * | 2001-12-28 | 2003-07-25 | Dsm Fine Chem Austria Gmbh | Verfahren zur herstellung von geschützten, enantiomeren-angereicherten cyanhydrinen durch in-situ-derivatisierung |
-
2001
- 2001-12-28 AT AT0204401A patent/AT410792B/de not_active IP Right Cessation
-
2002
- 2002-11-29 AT AT02026849T patent/ATE328105T1/de not_active IP Right Cessation
- 2002-11-29 ES ES02026849T patent/ES2262750T3/es not_active Expired - Lifetime
- 2002-11-29 DE DE50206986T patent/DE50206986D1/de not_active Expired - Fee Related
- 2002-11-29 EP EP02026849A patent/EP1323829B1/de not_active Expired - Lifetime
- 2002-12-23 US US10/325,923 patent/US6909011B2/en not_active Expired - Fee Related
- 2002-12-27 JP JP2002380069A patent/JP2003210187A/ja active Pending
- 2002-12-27 CA CA002415190A patent/CA2415190A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AT410792B (de) | 2003-07-25 |
| CA2415190A1 (en) | 2003-06-28 |
| EP1323829A2 (de) | 2003-07-02 |
| EP1323829A3 (de) | 2003-12-10 |
| JP2003210187A (ja) | 2003-07-29 |
| ATE328105T1 (de) | 2006-06-15 |
| US6909011B2 (en) | 2005-06-21 |
| US20030129714A1 (en) | 2003-07-10 |
| ATA20442001A (de) | 2002-12-15 |
| ES2262750T3 (es) | 2006-12-01 |
| EP1323829B1 (de) | 2006-05-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |