JP2003155246A - Abirritant composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an abirritant agent by using components having abirritant action. SOLUTION: The abirritant agent includes at least one of vegetable oil selected from the group consisting of Elettaria cardamomum, Sophora flavescens, Peucedanum japonicum, Curcuma zedoaria, Matricaria chamomilla, Paullinia cupana, Pueraria mirifeda, Panax notoginseng, Fagopyrum tataricum, seeds of Myristica fragrans, Piper nigrum, Zingiber officinale and seeds of Prunus percica. The abirritant composition includes the abirritant agent. The content of plant extract is 0.001-30 wt.% in the abirritant composition.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a stimulant alleviating agent for alleviating irritation of skin, hair and mucous membranes caused by various components.

[0002]

2. Description of the Related Art Surfactants are widely used as a cleansing component in external preparations for skin such as cosmetics and as an emulsifier for creams and the like. However, for surfactants, skin, hair,
It has the drawback of having irritation to the mucous membranes. In order to alleviate this irritation, development of amino acid-based mild surfactants has been underway (Japanese Patent Publication No. 50125/1975 and Japanese Patent Laid-Open No. 60189/1990), but it is still insufficient. Further, antibacterial agents and antiseptics used in cosmetics and the like are widely used for maintaining the quality of products, but on the other hand, they have skin irritation.

In addition to these, alcohols, thickeners, pigments,
A lot of stimulative components such as fragrances, oils and fats, and plant extracts are contained in external preparations for skin such as cosmetics. As a skin and mucous membrane irritation reducing agent therefor, trehalose monofatty acid ester (JP-A-10-45560) and the like, and as an alcohol irritation reducing agent, glucose derivatives such as phenylethyl-α-glucoside and phenylethyl-β-glucoside (special Kaihei 8-283121) and the like are known.

In recent years, the number of people with allergic diseases such as atopic dermatitis and those who perceive so-called sensitive skin has increased with changes in the environment. Since these people have hypersensitive skin, redness caused by cosmetics, etc. Many people feel irritation such as itchiness, and cosmetic products with lower irritation are required.

Therefore, it is required to newly provide an excellent ingredient for alleviating such irritation.

[0006]

SUMMARY OF THE INVENTION It is an object of the present invention to provide a stimulant alleviating agent and a hypoallergenic composition which are effective for alleviating the irritation of the skin, hair, mucous membranes and the like due to various components.

[0007]

Means for Solving the Problems The present inventor has conducted research to solve the above problems, and as a result, cardamom, clara, buttonbowhu, gadget, chamomile, guarana, pueraria, seven ginseng ginseng, tartary buckwheat, The present invention has been completed by finding that extracts of nutmeg, pepper, ginger, and peach kernel have a stimulating effect.

That is, the present invention is as follows: Cardamom, Clara, Button Bow-fu, Gautu,
1. A stimulant containing at least one plant extract selected from the group consisting of chamomile, guarana, pueraria, ginseng ginseng, tartary buckwheat, nutmeg, pepper, ginger, and peach kernel. 2. A hypoallergenic composition containing the irritation reducing agent. Cardamom, Clara, Button Bow-fu, Gautu,
3. A skin cell irritation / prevention composition comprising at least one plant extract selected from the group consisting of chamomile, guarana, pueraria, field ginseng, tartary buckwheat, nutmeg, pepper, ginger, and peach kernel. Cardamom, Clara, Button Bow-fu, Gautu,
4. A skin barrier-forming composition comprising at least one plant extract selected from the group consisting of chamomile, guarana, pueraria, seven fields of ginseng, tartary buckwheat, nutmeg, pepper, ginger, and peach kernel. The content of the plant extract is 0.001 to 30% by weight, 2
4. The composition according to any one of 4 above.

[0009]

BEST MODE FOR CARRYING OUT THE INVENTION Embodiments of the present invention will be described in more detail below.

[0010] Cardamom (Elettaria cardamomum) is a plant belonging to the genus Oyster genus of the ginger family, and is also known as shozuku. Besides spices, it is also used as an aphrodisiac and stomach medicine.

[0011] Clara (Sophora flavescens) is a plant belonging to the genus Enju of the legume family, and is also known as Kusaenju. Used for jaundice, melena, and stomach medicine.

[0012] Peucedanum japonicum is a plant belonging to the genus Kawalaboufu, belonging to the family Apiaceae, and has antitussive, sedative, diuretic,
It is used tough.

Gajutsu (Curcuma zedoaria) is a plant belonging to the genus Turmeric of the ginger family and is used as a stomach and expectorant.

[0014] Chamomile (Matricaria chamomilla) is a plant belonging to the genus Chrysanthemum of the Asteraceae family, and is also called as "camilure". Effective against sweating and deworming.

[0015] Guarana (Paullinia cupana) is a plant of the genus Guarana of the Sucrose family and is used as tea and soft drinks.

[0016] Pueraria mirifeda is a plant of the family Leguminosae, and is a tropical plant native to northern Thailand.
The main component is isoflavone derivative.

Panax notoginseng is a plant belonging to the genus Totiban ginseng in the family Araliaceae, and is also called another name, Radix Notoginseng. Used for hemostasis, analgesia, anti-inflammatory, etc.

[0018] Tartary buckwheat (Fagopyrum tataricum) is a plant of the genus Buckwheat genus, and is also called as Niga buckwheat. Seeds are used for food. It contains rutin and is used for stomach pain, dyspepsia, diarrhea, etc.

Nutmeg is a seed of a nutmeg plant, Myristica fragrans, excluding the callus,
Widely used as a spice.

Pepper (Piper nigrum) is a plant belonging to the genus Pepper of the family Pepperidae and is used as a spice, as well as for digestive digestion, stomach pain, abdominal pain and the like.

Ginger (Zingiber officinale) is a plant of the genus Ginger of the ginger family and is used for food, healthy stomach,
Used for promoting metabolic function.

Peachus is a plant of the genus Prunus of the family Rosaceae.
percica) seeds, used for gynecological, postpartum abdominal pain and bruises in Chinese medicine.

The plant extract used in the present invention is prepared according to a conventional method.
Plant leaves, stems, dried fruits or whole grass, after roasting if necessary, for example with water or an aqueous organic solvent, after filtering the extract obtained by extraction at room temperature or 50 ~ 100 ℃, It can be used as it is or as a powder after concentration and drying. However, this is an example of extraction, and the present invention is not limited to this.

Although the compounding amount of the plant extract of the present invention is not necessarily limited, it is 0.001 to 30 with respect to the total amount of the preparation such as cosmetics.
Weight% is preferable, and one or more kinds may be used in combination. The stimulant of the present invention includes, for example, skin cleansers, hair cleansers, lotions, skin creams, emulsions, rinses, conditioners, kitchen detergents, laundry detergents, toothpaste cosmetics, pharmaceuticals, quasi drugs, etc. It can be used in compositions applied to humans and can be incorporated into compositions for sensitive skin. Further, if necessary, within a range that does not impair the effects of the present invention, oil, pigment, fragrance,
It can be used in combination with antiseptics, bactericides, moisturizers, thickeners, antioxidants, surfactants, powder components, water, plant extracts and various other additives.

According to the irritation reducing agent of the present invention, irritation caused by raw materials for cosmetics such as surfactants, antibacterial agents and preservatives, pharmaceuticals, detergents, etc. can be alleviated. In addition, by blending the plant extract of the present invention, it is possible to protect skin cells from various stimuli and serve as a skin barrier against various stimuli to protect the skin.

[0026]

The present invention will be described in more detail with reference to examples, but the present invention is not limited to these examples. A surfactant was used as an index of irritation in the test of stimulus alleviation.

(Preparation of plant extract)
EX high speed solvent extractor ASE-200 is used at 100 ℃, 1500ps
What was subjected to hot water extraction with i for 10 minutes and freeze-dried was used in the following test.

(Evaluation of Irritation Relief Effect) The plant extract was evaluated for its stimulant relieving effect by the following method. The cultured human epidermal keratinocytes are allowed to act with 0.005% sodium lauryl sulfate aqueous solution or 0.005% sodium lauryl sulfate aqueous solution to which each concentration of plant extract is added,
Cell viability was measured by the MTT reduction method. The MTT reduction method is MTT [3- (4,5-dimethylthiazol -2-yl) -2,5-dipheny
l tetrazolium bromide] is reduced to a blue product by succinate dehydrogenase in mitochondria, etc., but this product is dissolved and colored, and then the absorbance is measured and used as an index of viable cell amount. Is. The stimulation relaxation rate was calculated by the following formula and evaluated. Stimulus relaxation rate (%) = (A−A0) / (A1−A0) × 100

Here, A1 is the untreated cell viability, A0 is the cell viability when the sodium lauryl sulfate aqueous solution is acting, and A is the cell viability when the plant extract is added and the sodium lauryl sulfate aqueous solution is acting. Table 1 shows the relationship between the added concentration (%) of the plant extract and the stimulation relaxation rate (%).

[0030]

[Table 1]

As shown in Table 1, the addition amount of any of cardamom, clara, buttonbowhu, zedoary, chamomile, guarana, pueraria, field ginseng, tartary buckwheat, nutmeg, pepper, ginger, and peach kernel extract It can be seen that the irritation relaxation rate increases with the increase of, and the irritation of the surfactant is alleviated.

As described above, according to the present invention, the extracts of cardamom, clara, buttonbowfew, zedoary, chamomile, guarana, pueraria, seven ginseng, tartary buckwheat, nutmeg, pepper, ginger, and peach kernel are in the skin. It is clear that it has an action of significantly relieving irritation to hair, mucous membranes and the like, and is useful as a stimulant alleviating agent and a hypoallergenic composition containing the same.

[0033]

INDUSTRIAL APPLICABILITY The present invention provides an excellent stimulant relieving agent, and a low-irritant cosmetic, external skin preparation, medicine, detergent, etc. containing the same.

─────────────────────────────────────────────────── ─── Continuation of front page (51) Int.Cl. ⁷ Identification code FI theme code (reference) A61K 35/78 A61K 35/78 T 7/00 7/00 K 7/48 7/48 A61P 17/00 A61P 17/00 C11D 3/382 C11D 3/382

Claims (5)

[Claims] 1. A stimulus containing at least one plant extract selected from the group consisting of cardamom, clara, buttonfish, guajutu, chamomile, guarana, pueraria, field seven ginseng, tartary buckwheat, nutmeg, pepper, ginger, and peach kernel. Emollient. 2. A hypoallergenic composition comprising the stimulant alleviating agent according to claim 1. 3. A card extract containing at least one plant selected from the group consisting of cardamom, clara, buttonfish, guajutu, chamomile, guarana, pueraria, seven ginseng, tartary buckwheat, nutmeg, pepper, ginger, and peach kernel. A skin cell stimulation protection composition. 4. A card extract containing at least one plant selected from the group consisting of cardamom, clara, buttonfish, guajutu, chamomile, guarana, pueraria, field seven ginseng, tartary buckwheat, nutmeg, pepper, ginger, and peach kernel. Skin barrier forming composition. 5. The composition according to claim 2, wherein the content of the plant extract is 0.001 to 30% by weight.