JP2001192338A - Agent for promoting recovery from adverse effect of stress and skin preparation which contain the same and is useful for external use - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a skin preparation which is useful for external use, promotes the recovery of skin from the adverse effects of stresses and improves sensitive skins such as atopic dermatitis and anaphylaxia. SOLUTION: This skin preparation for external use, such as a cosmetic, containing an agent which is used for promoting the recovery of skin from the adverse effects of stresses and comprises the essences of the following origin plants of Chinese galenicals. (The origin plants of Chinese galenicals); Mucunae cauli in the family leguminosae, Commiphora molmol in the family Burseraceae, aloe in the family Liliaceae, spikenard in the family Valerianaceae, SANGONA in the family Umbelliferae, Visci herba in Loranthaceae, Ephedra sinica in the family Ephedraceae, Zingiber officinale in the family Zingiberaceae, Purataria lobata in the family leguminosa, Pulsatilla cernua in the family Ranunculaceae, Dictamnus albus in the family Rutaceae, Notopterygii rhizoma in the family Umbelliferae.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an agent for promoting recovery from the adverse effects of stress and an external preparation for skin such as cosmetics containing the agent.

[0002]

2. Description of the Related Art The present age is a time of stress overload, and more or less living in the present age lives under the influence of the applied stress. In recent years, the effects of such stress on the human body have been investigated in detail, and it has become clear that unexpectedly large effects are expected. It is said that many criminal cases that have a shocking impact on society in recent years are caused by such stress. Such effects are not limited to such cases. For example, in recent years, the number of people suffering from atopic dermatitis has rapidly increased, or in cosmetics users, hypersensitivity that causes skin troubles when ordinary cosmetics are used. It has been suggested that the background of the rapid increase in the number of people with sensitive skin is the effect of such stresses, as well as the deterioration of the environment. In view of such a situation, there is a demand for the development of cosmetics for people with atopic dermatitis and people with sensitive skin, which are increasing rapidly. Few substances are known to have the effect of promoting recovery from the adverse effects of stress on the skin. Furthermore,
No attempt has been made to use a skin external preparation to promote recovery from the effects of such stress and to improve sensitive skin such as atopic dermatitis and hypersensitivity.

[0003] On the other hand, leguminous cornweed, lanternaceae spruce, lily family aloe, oleraceae sagebush, seriaceae coral coral, mistletoeaceae scorpionum, leguminous flower, gingerbush, ginsengaceae, citrusaceae. Hakusen and Umbelliferae are known as the base plants of Chinese herbal medicines that have a releasing effect, a water-removing effect, a freshening effect, a blood-removing effect, a phlebotomy effect, a physical effect or a supplemental effect. However, it has not been known that the essence of these plants is excellent in promoting the recovery from the adverse effects of stress.

[0004]

DISCLOSURE OF THE INVENTION The present invention has been made under such circumstances, and an external preparation for skin promotes recovery from the effects of such stress, and provides atopic dermatitis and hypersensitivity. It is an object of the present invention to provide means for improving sensitive skin such as.

[0005]

In view of such circumstances, the present inventors have promoted recovery from the effects of such stress by using a skin external preparation, and improved sensitive skin such as atopic dermatitis and hypersensitivity. As a result of intensive research efforts in search of means to do this, legumes corn cane, citrus family syringa, lily family Aloe, ominaerid family paniculaceae, seriaceae coral, mistletoe family prunus, ephedra family ginseng, ginger family ginger, legume Family kudzu, buttercup family okinagusa, citrus family hakusen and sapaceae family kyoukatsu have found that the essence of recovery from adverse effects of stress has an accelerating effect, by including these in a skin external preparation,
They have found that such means can be provided, and have completed the invention. That is, the present invention relates to the following technology. (1) An agent for promoting recovery from the adverse effects of stress consisting of the essence of the base plant of Chinese herbal medicine shown below. (Basic plants of Chinese herbal medicine) Leguminosae corn beetle, Orchidaceae spruce, Lily family aloe, Oleander family Paniculaceae, Aceraceae coral, Sadoniaceae
(2) Recovery from the adverse effects of stress according to (1), wherein the stress is overcrowding stress, wherein the stress is an overcrowding stress. Accelerator. (3) An external preparation for skin, comprising one or more selected from the agents for promoting recovery from the adverse effects of stress described in (1) or (2). (4) The external preparation for skin according to (3), which is a cosmetic. (5) The external preparation for skin according to (3) or (4), which is used for a person with atopic dermatitis and / or hypersensitivity.

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION (1) The agent for promoting recovery from the adverse effects of stress according to the present invention includes the agent for promoting recovery from the adverse effects of stress according to the present invention. Persimmon, Apiaceae corona,
It consists of the essences of the mistletoe family, Papaveraceae, Gynaceae, Ginseng, Ginseng, Ginseng, Leguminosae crap, Ranunculaceae, Okinagusa, Rutaceae, Hakusen, and Aceraceae. Here, the essence referred to in the present invention is a plant itself, a processed product obtained by drying, shredding, pulverizing, etc. a plant, an extract obtained by adding a solvent to a plant or its processed product, and a solvent derived from the extract. From the solvent from which the solvent has been removed, and a purified product obtained by purifying the extract or the solvent-removed product using a purification means such as liquid-liquid extraction or column chromatography. Among these essences, particularly preferred is an extract or a solvent-removed product thereof. In order to prepare such an extract, a 1 to 20-fold amount of a solvent is added to a plant or a processed product thereof, and immersed for several days at room temperature or several hours at a temperature near the boiling point. Thereafter, if necessary, the solvent may be removed by filtration of insolubles or concentration under reduced pressure. As the solvent used for such extraction, a polar solvent is preferable, and examples thereof include water, alcohols such as ethanol and 1,3-butanediol, esters such as ethyl acetate and methyl formate, and halogenated carbons such as chloroform and methylene chloride. One or more selected from hydrogens, ethers such as diethyl ether and tetrahydrofuran, ketones such as acetone and methyl ethyl ketone, and acetonitriles are preferred. Of these, particularly preferred are alcohols and / or water, and among the alcohols, ethanol and 1,3-butanediol are particularly preferred. Further, as the site of use, a portion used in Chinese medicine is particularly preferred, and seeds or flowers and buds in the case of leguminous corn cane, resin in the case of the periphoraceae, and the above-ground part of the plant in the case of the aloe family aloe. The above-ground part of the plant in the case of Paniculaceae, the underground part of the plant in the case of Cormorantidae coral, the above-ground part of the plant in the case of Mistletoe sect. Particularly preferred is the underground stem for ginger, the underground part for legumes, the above-ground part of the plant for Ranunculaceae, the bark for Rutaceae, and the underground part for Ceramiaceae. The thus obtained agent for promoting recovery from the adverse effects of stress of the present invention, when administered under a stress load, promotes the recovery of the living body from the effects of this stress and is administered to an already stressed living body. This has the effect of promoting recovery from the effects already received and preventing the effects from accumulating and exacerbating. The preferred content of the agent for promoting recovery from the adverse effects of these stresses in the skin external preparation of the present invention is preferably 0.01 to 20% by weight, more preferably 0.05 to 10% by weight.

(2) External preparation for skin of the present invention The external preparation for skin of the present invention contains one or more selected from the above-mentioned agents for promoting recovery from the adverse effects of stress. It has an effect of promoting the recovery of the skin from the adverse effects of stress. Such an effect is, for example, when animals are bred under stress such as overcrowding, and then the skin is damaged by stripping or the like. When skin is administered, the recovery of skin function after stripping becomes faster,
That is, it appears as an improvement in skin function 3 to 4 days after stripping. This is because the agent to prevent the adverse effects of stress,
This is different from the phenomenon that appears to prevent a decrease in skin function immediately after stripping. This index value can be obtained from the calculation of the total amount of the dissipated moisture after stripping as shown in Example 1. Here, in the present invention, the skin external preparation is a general term for a substance or a composition which is externally administered to the skin, and specifically, a skin external medicine, a cosmetic,
Washing agents, bath agents, skin external disinfectants, skin external disinfectants and the like can be exemplified. Among these, external skin medicines, cosmetics, cleaning agents, bath agents are preferred, and cosmetics are particularly preferably applied. You. The adverse effects of such stress on the skin include, for example, invasion of damaging substances, elevation of various proinflammatory factors and runaway of the immune system, and disturbance of the endocrine system due to a decrease in skin barrier function. Since the external preparation for skin of the present invention has an effect of promoting recovery from the effects of stress when stress is applied, it is administered before or during the time when stress is continuously applied. Is particularly preferred. In the present invention, such an effect of the skin external preparation of the present invention is tentatively referred to as a recovery effect from the adverse effect of stress. The external preparation for skin of the present invention can contain optional components usually used in external preparations for skin, in addition to the above-mentioned essential component, that is, the agent for recovering from the adverse effect of stress. Such components include, for example, hydrocarbons such as squalane, petrolatum, microcrystalline wax, jojoba oil, carnauba wax, esters such as octyldodecyl oleate, triglycerides such as olive oil, tallow, coconut oil, and stearin. Acid, oleic acid, fatty acids such as ritinoleic acid, oleyl alcohol,
Higher alcohols such as stearyl alcohol and octyldodecanol; anionic surfactants such as sulfosuccinates and sodium polyoxyethylene alkyl sulfate; amphoteric surfactants such as alkyl betaine salts; and cationic surfactants such as dialkylammonium salts. Sorbitan fatty acid esters, fatty acid monoglycerides, their non-ionic surfactants such as polyoxyethylene adducts, polyoxyethylene alkyl ethers, polyoxyethylene fatty acid esters, and polyethylene glycol, glycerin, and 1,3-butanediol. It may contain a polyhydric alcohol, a thickening / gelling agent, an antioxidant, an ultraviolet absorber, a coloring agent, a preservative, a powder and the like. Of these, particularly preferred are polyhydric alcohols. This is because, for example, when the external preparation for skin of the present invention is used during the application of stress, the skin barrier function may be reduced due to the stress previously applied. This is because the polyhydric alcohol can enhance the water retention ability of the skin and complement the skin barrier function. The preferred content of the polyhydric alcohol in the skin external preparation of the present invention is 3 to 15% by weight, more preferably 4 to 10% by weight, as a percentage by weight of the total amount of the polyhydric alcohol relative to the total amount of the cosmetic. In addition, in the skin external preparation of the present invention, a component that suppresses inflammation, for example, a nonsteroidal anti-inflammatory drug such as indomethacin or bufexamak, an anti-inflammatory crude drug such as burdock root extract or birch extract and / or an extract thereof is used. It is also preferable to contain it, because it can suppress the adverse effect of the stress that has already appeared and provide an additive or synergistic effect. The external preparation for skin of the present invention can be produced by treating the above essential component and optional component according to a conventional method.

[0008]

EXAMPLES The present invention will be described in more detail with reference to the following examples, but it goes without saying that the present invention is not limited only to these examples.

<Example 1> Flowers and buds of Leguminosae radishes, resin of Peridotaceae, Asteraceae, above-ground parts of Aloe, Lilyaceae, above-ground parts of Salicaceae, Underground parts of Cormorantidae coral, and of mistletoeae Above ground,
5 l methanol was added to 1 kg of each of the above-ground parts of the ephedra family, the ginger rhizome, the underground parts of the legume spruce, the underground parts of Ranunculaceae, the bark of Rutaceae, and the underground parts of Keratinaceae, and heated for 2 hours. The mixture was refluxed, filtered, and concentrated under reduced pressure to obtain the accelerators 1 to 12 for recovering from the adverse effects of stress of the present invention.

[0010]

[Table 1]

Example 2 An animal experiment was set up to examine the relationship between overcrowding stress and skin function and the effect of the load stress reducing agent of the present invention on it. That is, S of 12 weeks old
kh-1 mice (male) were bred in a normal group with 5 mice per cage (95.2 cm 2 per mouse), and in an overcrowded stress group with 21 mice per cage (22.7 cm per mouse).
Reared in 2). The breeding period was one week. During this time, the sample administration group applied 0.1 ml of the sample to the back every day. As a sample, 2 mg of the essence of Example 1 dissolved in 100 μl of a 50% ethanol aqueous solution was administered and used. The normal group was bred by a normal breeding method during this stress load period. Thereafter, the back was shaved and stripped, and the amount of water dissipated from the skin was measured using a dissipative water meter. Measurements were taken 1, 2, 3 and 4 days after stripping. From this numerical value, the value of Σ (the amount of water dissipated on the first day in the administration group—the amount of water dissipated on the n-th day in the administration group) is Σ
The value obtained by dividing by the value of (dissipated water amount on the first day in the control group−dissipated water amount on the nth day in the control group) was determined and used as a recovery promoting value. Table 2 shows the results. The unit of the amount of water dissipated is g / m2 / h. From these results, it can be seen that any of the agents for promoting recovery from the adverse effects of stress of the present invention are excellent in promoting the recovery of the living body from the adverse effects of stress.

[0012]

[Table 2]

Example 3 A lotion was prepared according to the following formulation. That is, the prescription component was heated and stirred at 80 ° C., and then stirred and cooled to obtain a lotion. Glycerin 5 parts by weight Sulfated sodium trehalose 0.1 part by weight 1,2-pentanediol 5 parts by weight Ethanol 5 parts by weight Recovery agent from adverse effects of stress 1 0.001 parts by weight Polyoxyethylene (60) hydrogenated castor oil 0. 1 part by weight Water 84.799 parts by weight

<Embodiment 4> Using the lotion of Embodiment 3,
A use test was conducted for 2 weeks using 10 people per group of atopic dermatitis. In the use test, it was agreed that the test should be stopped immediately when an unfavorable reaction such as skin trouble occurs. Before and after the test, the amount of dissipated water was measured. The control group used the lotion of Control Example 1 in which the agent 1 for recovering from the adverse effect of stress was replaced with water. In the control group, six dropouts were observed, and the amount of water loss was 7% on average. However, in the group administered with Example 3, the number of dropouts was 0, and the loss of water loss was on average. 36% was observed, and improvement of atopic dermatitis due to the effect of promoting the recovery from the adverse effects of stress of the cosmetic of the present invention was observed.

Example 5 A lotion was prepared according to the following formulation. That is, the prescription component was heated and stirred at 80 ° C., and then stirred and cooled to obtain a lotion. Glycerin 5 parts by weight Sulfated sodium trehalose 0.1 part by weight 1,2-pentanediol 5 parts by weight Ethanol 5 parts by weight Reducing agent from adverse effects of stress 8 0.001 parts by weight Polyoxyethylene (60) hydrogenated castor oil 0. 1 part by weight Water 84.799 parts by weight

Example 6 Using the lotion of Example 5,
A two-week usage test was performed using four groups of hypersensitive individuals. In the use test, it was agreed that the test should be stopped immediately when an unfavorable reaction such as skin trouble occurs. Before and after the test, the amount of dissipated water was measured. The control group is a recovery agent from adverse effects of stress 8
Was replaced with water, and the lotion of Comparative Example 2 was used. In the control group, two dropouts were observed, and the amount of water loss was 4% on average. However, in the group administered with Example 5, the number of dropouts was 0, and the loss of water loss was on average. 48% was observed, and improvement of atopic dermatitis due to the effect of the cosmetic of the present invention for promoting recovery from the adverse effects of stress was observed.

Example 7 A cream (cosmetic) was prepared according to the following formulation. That is, the components (a), (b) and (c) are heated to 80 ° C., (b) is gradually added to (a) to emulsify, (c) is neutralized by further adding (c), and the particles are aligned with a homogenizer. Obtained. These showed an excellent effect of improving sensitive skin as in Example 5. Liquid paraffin 10 parts by weight Solid paraffin 5 parts by weight Microcrystalline wax 5 parts by weight Olive oil 20 parts by weight Sorbitan sesquistearate 1.5 parts by weight Glycerin monooleate 1 part by weight Stearic acid 0.3 parts by weight Polyoxyethylene (20) 1.7 parts by weight of behenyl ether 0.1 part by weight of butyl paraben 4 parts by weight of a recovery agent from the adverse effect of stress 4 0.2 parts by weight b 31 parts by weight of water 0.3 parts by weight of carboxyvinyl polymer 5 parts by weight of propylene glycol 0.2 parts by weight of methyl paraben Parts c Potassium hydroxide 0.2 parts by weight Water 18.5 parts by weight

Example 8 A cream (cosmetic) was prepared according to the following formulation. That is, the components (a), (b) and (c) are heated to 80 ° C., (b) is gradually added to (a) to emulsify, (c) is neutralized by further adding (c), and the particles are aligned with a homogenizer. Obtained. These showed an excellent effect of improving sensitive skin as in Example 5. Liquid paraffin 10 parts by weight Solid paraffin 5 parts by weight Microcrystalline wax 5 parts by weight Olive oil 20 parts by weight Sorbitan sesquistearate 1.5 parts by weight Glycerin monooleate 1 part by weight Stearic acid 0.3 parts by weight Polyoxyethylene (20) 1.7 parts by weight of behenyl ether 0.1 parts by weight of butyl paraben 9 0.5 parts by weight of a stress-reducing agent 9 0.5 parts by weight of water b 31 parts by weight of carboxyvinyl polymer 0.3 parts by weight of propylene glycol 5 parts by weight of methyl paraben 0.2 parts by weight Parts c Potassium hydroxide 0.2 parts by weight Water 18.2 parts by weight

[0019]

According to the present invention, a skin external preparation can provide a means for accelerating recovery from the effects of stress and improving sensitive skin such as atopic dermatitis and hypersensitivity.

 ──────────────────────────────────────────────────続 き Continued on the front page (72) Mitsuo Kawai Inventor 560 Kashio-cho, Totsuka-ku, Yokohama-shi, Kanagawa Prefecture F-term in the Totsuka Laboratories, Totsuka Laboratory Co., Ltd. 4C083 AA111 AA112 AA122 AB032 AC012 AC022 AC102 AC112 AC122 AC182 AC242 AC422 AC432 AC442 AC482 AD092 AD212 CC02 CC04 CC05 DD23 DD31 EE12 EE13 EE50 FF01 FF05 4C088 AB04 AB12 AB23 AB32 AB40 AB59 AB62 AB81 AB85 AC02 AC03 AC04 AC06 AC10 AC12 BA07 BA09 BA10 CA03 CA11 MA63 ZA89 ZB13

Claims (5)

[Claims] 1. An agent for promoting recovery from the adverse effects of stress, comprising the essence of the base plant of Chinese herbal medicine shown below. (Basic plants of Chinese herbal medicine) Leguminosae corn beetle, Orchidaceae spruce, Lily family aloe, Oleander family Paniculaceae, Aceraceae coral, Sadoniaceae
Ephedra family, Ginger family ginger, Legume family spruce, Ranunculaceae family Okinagusa, Rutaceae family Hakusen, Apiaceae family Kyoukatsu 2. The agent according to claim 1, wherein the stress is overcrowding stress. 3. An external preparation for skin, comprising one or more selected from the agents for promoting recovery from the adverse effects of stress according to claim 1 or 2. 4. The external preparation for skin according to claim 3, which is a cosmetic. 5. The external preparation for skin according to claim 3, which is used for a person with atopic dermatitis and / or hypersensitivity.