JP2003121444A5 - - Google Patents
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- Publication number
- JP2003121444A5 JP2003121444A5 JP2001314357A JP2001314357A JP2003121444A5 JP 2003121444 A5 JP2003121444 A5 JP 2003121444A5 JP 2001314357 A JP2001314357 A JP 2001314357A JP 2001314357 A JP2001314357 A JP 2001314357A JP 2003121444 A5 JP2003121444 A5 JP 2003121444A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- glycoprotein
- nicked
- monoclonal antibody
- gpi
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102100030802 Beta-2-glycoprotein 1 Human genes 0.000 claims description 28
- 108010023562 beta 2-Glycoprotein I Proteins 0.000 claims description 28
- 210000001124 body fluid Anatomy 0.000 claims description 8
- 239000010839 body fluid Substances 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 5
- 206010008118 cerebral infarction Diseases 0.000 claims description 2
- 208000026106 cerebrovascular disease Diseases 0.000 claims description 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 14
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 14
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 125000000539 amino acid group Chemical group 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 5
- 239000007983 Tris buffer Substances 0.000 description 3
- 210000004408 hybridoma Anatomy 0.000 description 3
- 230000001900 immune effect Effects 0.000 description 3
- 210000002381 plasma Anatomy 0.000 description 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 3
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 2
- 102100034613 Annexin A2 Human genes 0.000 description 2
- 108090000668 Annexin A2 Proteins 0.000 description 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
- 108090000288 Glycoproteins Proteins 0.000 description 2
- 102000003886 Glycoproteins Human genes 0.000 description 2
- 101001033280 Homo sapiens Cytokine receptor common subunit beta Proteins 0.000 description 2
- 229920001213 Polysorbate 20 Polymers 0.000 description 2
- 230000004520 agglutination Effects 0.000 description 2
- 229940098773 bovine serum albumin Drugs 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 102000055647 human CSF2RB Human genes 0.000 description 2
- 230000003100 immobilizing effect Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 2
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 2
- 238000010517 secondary reaction Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 101000793425 Homo sapiens Beta-2-glycoprotein 1 Proteins 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000002981 blocking agent Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 230000002414 glycolytic effect Effects 0.000 description 1
- 238000010324 immunological assay Methods 0.000 description 1
- 230000009871 nonspecific binding Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001314357A JP4070443B2 (ja) | 2001-10-11 | 2001-10-11 | 脳梗塞を検出する方法 |
| AT02775332T ATE499608T1 (de) | 2001-10-11 | 2002-10-11 | Verfahren zur diagnose eines hirninfarkts |
| US10/492,479 US20040248200A1 (en) | 2001-10-11 | 2002-10-11 | Method of diagnosing cerebral infarction |
| PCT/JP2002/010610 WO2003034066A1 (en) | 2001-10-11 | 2002-10-11 | Method of diagnosing cerebral infarction |
| DE60239281T DE60239281D1 (de) | 2001-10-11 | 2002-10-11 | Verfahren zur diagnose eines hirninfarkts |
| EP02775332A EP1443326B1 (en) | 2001-10-11 | 2002-10-11 | Method of diagnosing cerebral infarction |
| US12/197,730 US20090004750A1 (en) | 2001-10-11 | 2008-08-25 | Method of Diagnosing Cerebral Infarction |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001314357A JP4070443B2 (ja) | 2001-10-11 | 2001-10-11 | 脳梗塞を検出する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003121444A JP2003121444A (ja) | 2003-04-23 |
| JP2003121444A5 true JP2003121444A5 (enExample) | 2005-06-02 |
| JP4070443B2 JP4070443B2 (ja) | 2008-04-02 |
Family
ID=19132685
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001314357A Expired - Fee Related JP4070443B2 (ja) | 2001-10-11 | 2001-10-11 | 脳梗塞を検出する方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20040248200A1 (enExample) |
| EP (1) | EP1443326B1 (enExample) |
| JP (1) | JP4070443B2 (enExample) |
| AT (1) | ATE499608T1 (enExample) |
| DE (1) | DE60239281D1 (enExample) |
| WO (1) | WO2003034066A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1853631T3 (en) * | 2005-01-24 | 2016-03-29 | Univ Texas | Fc-FUSION CONSTRUCTIONS BINDING TO PHOSPHATIDYLSERINE AND THERAPEUTIC APPLICATION THEREOF |
| JP6312302B2 (ja) * | 2014-01-06 | 2018-04-18 | 公益財団法人ヒューマンサイエンス振興財団 | 脳梗塞の診断マーカー |
| CN117568445B (zh) * | 2024-01-18 | 2024-04-09 | 西南交通大学 | 一种tat、pic复合质控品的制备方法及其应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2172247A1 (en) * | 1993-09-29 | 1995-04-06 | Eiji Matsuura | Method of assaying oxidized lipoprotein and application thereof |
| JP2000028607A (ja) * | 1998-07-10 | 2000-01-28 | Iatron Lab Inc | 新規なモノクローナル抗体及びニックβ２グリコプロテインＩの免疫学的分析方法 |
-
2001
- 2001-10-11 JP JP2001314357A patent/JP4070443B2/ja not_active Expired - Fee Related
-
2002
- 2002-10-11 DE DE60239281T patent/DE60239281D1/de not_active Expired - Lifetime
- 2002-10-11 US US10/492,479 patent/US20040248200A1/en not_active Abandoned
- 2002-10-11 AT AT02775332T patent/ATE499608T1/de not_active IP Right Cessation
- 2002-10-11 EP EP02775332A patent/EP1443326B1/en not_active Expired - Lifetime
- 2002-10-11 WO PCT/JP2002/010610 patent/WO2003034066A1/ja not_active Ceased
-
2008
- 2008-08-25 US US12/197,730 patent/US20090004750A1/en not_active Abandoned
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