JP2002543215A - Ａ−ｄｎａ型およびｂ−ｄｎａ型立体配座幾何学形状を有するオリゴヌクレオチド - Google Patents

Ａ−ｄｎａ型およびｂ−ｄｎａ型立体配座幾何学形状を有するオリゴヌクレオチド

Info

Publication number
JP2002543215A
JP2002543215A JP2000615638A JP2000615638A JP2002543215A JP 2002543215 A JP2002543215 A JP 2002543215A JP 2000615638 A JP2000615638 A JP 2000615638A JP 2000615638 A JP2000615638 A JP 2000615638A JP 2002543215 A JP2002543215 A JP 2002543215A
Authority
JP
Japan
Prior art keywords
nucleotides
ribonucleotide
oligonucleotide
bond
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000615638A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002543215A5 (https=
Inventor
マノハラン，ムティア
モーハン，ベンカトラマン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ionis Pharmaceuticals Inc
Original Assignee
Isis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Pharmaceuticals Inc filed Critical Isis Pharmaceuticals Inc
Publication of JP2002543215A publication Critical patent/JP2002543215A/ja
Publication of JP2002543215A5 publication Critical patent/JP2002543215A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2000615638A 1999-05-03 2000-05-03 Ａ−ｄｎａ型およびｂ−ｄｎａ型立体配座幾何学形状を有するオリゴヌクレオチド Pending JP2002543215A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/303,586 1999-05-03
US09/303,586 US6369209B1 (en) 1999-05-03 1999-05-03 Oligonucleotides having A-DNA form and B-DNA form conformational geometry
PCT/US2000/011913 WO2000066609A1 (en) 1999-05-03 2000-05-03 Oligonucleotides having a-dna form and b-dna form conformational geometry

Publications (2)

Publication Number Publication Date
JP2002543215A true JP2002543215A (ja) 2002-12-17
JP2002543215A5 JP2002543215A5 (https=) 2007-06-28

Family

ID=23172770

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000615638A Pending JP2002543215A (ja) 1999-05-03 2000-05-03 Ａ−ｄｎａ型およびｂ−ｄｎａ型立体配座幾何学形状を有するオリゴヌクレオチド

Country Status (6)

Country Link
US (2) US6369209B1 (https=)
EP (2) EP1180113A4 (https=)
JP (1) JP2002543215A (https=)
AU (1) AU762212C (https=)
CA (1) CA2373225A1 (https=)
WO (1) WO2000066609A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013520395A (ja) * 2009-02-22 2013-06-06 ケムジーンズ コーポレーション 治療、診断、ｇ‐テトラド形成オリゴヌクレオシド及びアプタマーといった生物学的応用のための新規修飾を取り入れたアラ‐２’‐ｏ‐メチル‐ヌクレオシド、当該ホスホラミダイト及びオリゴヌクレオチドの合成

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7119184B2 (en) * 1991-08-12 2006-10-10 Isis Pharmaceuticals, Inc. Oligonucleotides having A-DNA form and B-DNA form conformational geometry
US6271358B1 (en) * 1998-07-27 2001-08-07 Isis Pharmaceuticals, Inc. RNA targeted 2′-modified oligonucleotides that are conformationally preorganized
NZ527602A (en) * 2001-02-19 2005-02-25 Genvartec Pty Ltd A method of identifying differences between nucleic acid molecules
EP1436614A4 (en) * 2001-09-13 2005-03-16 Genvartec Pty Ltd METHOD FOR DETECTING A CHANGED INFORMATION IN A NUCLEIC ACID ELEMENT BY TREATMENT WITH AN OXIDIZING AGENT OR A REACTIVE SUBSTANCE AS A RESULT OF CONTACT WITH ENVIRONMENTAL OR CHEMICAL CONDITIONS
US20040009602A1 (en) * 2002-05-13 2004-01-15 The Government Of The U.S.A. As Represented By The Secretary Of The Dept. Of Health & Human Services DNA modifying molecules and methods of use thereof
US20040198640A1 (en) * 2003-04-02 2004-10-07 Dharmacon, Inc. Stabilized polynucleotides for use in RNA interference
US20050074801A1 (en) * 2003-09-09 2005-04-07 Monia Brett P. Chimeric oligomeric compounds comprising alternating regions of northern and southern conformational geometry
US20090280567A1 (en) * 2004-02-06 2009-11-12 Dharmacon, Inc. Stabilized sirnas as transfection controls and silencing reagents
EP2123759B1 (en) * 2004-02-06 2014-01-15 Thermo Fisher Scientific Biosciences Inc. Stabilized RNAS as transfection controls and silencing reagents
WO2005089268A2 (en) * 2004-03-15 2005-09-29 Isis Pharmaceuticals, Inc. Compositions and methods for optimizing cleavage of rna by rnase h
KR101147147B1 (ko) * 2004-04-01 2012-05-25 머크 샤프 앤드 돔 코포레이션 Ｒｎａ 간섭의 오프 타겟 효과 감소를 위한 변형된폴리뉴클레오타이드
US20050244869A1 (en) * 2004-04-05 2005-11-03 Brown-Driver Vickie L Modulation of transthyretin expression
JP2008512097A (ja) * 2004-09-07 2008-04-24 アーケミックス コーポレイション アプタマー医薬品化学
CA2857881A1 (en) 2004-11-12 2006-12-28 Asuragen, Inc. Methods and compositions involving mirna and mirna inhibitor molecules
US7935811B2 (en) * 2004-11-22 2011-05-03 Dharmacon, Inc. Apparatus and system having dry gene silencing compositions
US7923207B2 (en) 2004-11-22 2011-04-12 Dharmacon, Inc. Apparatus and system having dry gene silencing pools
US20060166234A1 (en) * 2004-11-22 2006-07-27 Barbara Robertson Apparatus and system having dry control gene silencing compositions
US7875352B2 (en) * 2004-12-03 2011-01-25 Japan Science And Technology Agency Stabilized inorganic nanoparticle, stabilized inorganic nanoparticle material, method for producing stabilized inorganic nanoparticle, and method for using stabilized inorganic nanoparticle
US20060223777A1 (en) * 2005-03-29 2006-10-05 Dharmacon, Inc. Highly functional short hairpin RNA
EP3342415B1 (en) 2006-08-08 2022-01-26 Rheinische Friedrich-Wilhelms-Universität Bonn Structure and use of 5' phosphate oligonucleotides
WO2008036841A2 (en) * 2006-09-22 2008-03-27 Dharmacon, Inc. Tripartite oligonucleotide complexes and methods for gene silencing by rna interference
US8188060B2 (en) 2008-02-11 2012-05-29 Dharmacon, Inc. Duplex oligonucleotides with enhanced functionality in gene regulation
EP2297323A1 (en) 2008-05-21 2011-03-23 Hartmann, Gunther 5' triphosphate oligonucleotide with blunt end and uses thereof
WO2010017509A1 (en) * 2008-08-07 2010-02-11 Isis Pharmaceuticals, Inc. Modulation of transthyretin expression for the treatment of cns related disorders
RU2572826C2 (ru) 2008-12-02 2016-01-20 Чиралджен, Лтд. Способ синтеза модифицированных по атому фосфора нуклеиновых кислот
CA2767253A1 (en) 2009-07-06 2011-01-13 Ontorii, Inc. Novel nucleic acid prodrugs and methods of use thereof
US20130079382A1 (en) 2009-10-12 2013-03-28 Larry J. Smith Methods and Compositions for Modulating Gene Expression Using Oligonucleotide Based Drugs Administered in vivo or in vitro
RS56011B1 (sr) 2010-04-29 2017-09-29 Ionis Pharmaceuticals Inc Modulacija ekspresije transtiretina
JP5868324B2 (ja) 2010-09-24 2016-02-24 株式会社Wave Life Sciences Japan 不斉補助基
EP2508530A1 (en) 2011-03-28 2012-10-10 Rheinische Friedrich-Wilhelms-Universität Bonn Purification of triphosphorylated oligonucleotides using capture tags
AU2012284265B2 (en) 2011-07-19 2017-08-17 Wave Life Sciences Ltd. Methods for the synthesis of functionalized nucleic acids
JP6453212B2 (ja) 2012-07-13 2019-01-16 ウェイブ ライフ サイエンシズ リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． キラル制御
CN104684923B (zh) 2012-07-13 2018-09-28 株式会社新日本科学 手性核酸佐剂
SG11201500239VA (en) 2012-07-13 2015-03-30 Wave Life Sciences Japan Asymmetric auxiliary group
EP2712870A1 (en) 2012-09-27 2014-04-02 Rheinische Friedrich-Wilhelms-Universität Bonn Novel RIG-I ligands and methods for producing them
WO2015108047A1 (ja) 2014-01-15 2015-07-23 株式会社新日本科学 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤
JPWO2015108046A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤
WO2015108048A1 (ja) 2014-01-15 2015-07-23 株式会社新日本科学 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
ES2917473T3 (es) 2014-01-16 2022-07-08 Wave Life Sciences Ltd Diseño quiral
CN108424432B (zh) * 2017-07-13 2021-04-23 上海兆维科技发展有限公司 一种3’-氧-甲氧乙基核苷的制备方法
US10426424B2 (en) 2017-11-21 2019-10-01 General Electric Company System and method for generating and performing imaging protocol simulations
WO2019217459A1 (en) 2018-05-07 2019-11-14 Alnylam Pharmaceuticals, Inc. Extrahepatic delivery
CN116606336B (zh) * 2022-04-02 2025-09-12 思合基因(北京)生物科技有限公司 高稳定性和亲和力的2′-o-取代核苷及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06128284A (ja) * 1991-06-20 1994-05-10 Europ Lab Fuer Molekularbiolog Elmb 合成触媒オリゴヌクレオチド構造、核酸の目標配列の切断方法、抗ウイルス治療用薬剤ならびにその製造方法、診断試薬及びその製造方法
WO1998029124A1 (en) * 1996-12-31 1998-07-09 Isis Pharmaceuticals, Inc. Oligonucleotide compositions and methods for the modulation of the expression of b7 protein

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3687808A (en) 1969-08-14 1972-08-29 Univ Leland Stanford Junior Synthetic polynucleotides
NZ209840A (en) 1983-10-17 1988-11-29 Kaji Akira A method of inhibiting viral propagation by hybridising dna with the viral rna thus blocking its action
US5194428A (en) 1986-05-23 1993-03-16 Worcester Foundation For Experimental Biology Inhibition of influenza virus replication by oligonucleotide phosphorothioates
US4806463A (en) 1986-05-23 1989-02-21 Worcester Foundation For Experimental Biology Inhibition of HTLV-III by exogenous oligonucleotides
US5216141A (en) 1988-06-06 1993-06-01 Benner Steven A Oligonucleotide analogs containing sulfur linkages
US5004810A (en) 1988-09-30 1991-04-02 Schering Corporation Antiviral oligomers
US5298416A (en) 1989-01-18 1994-03-29 British Technology Group Ltd. Attenuated polioviruses
US5457189A (en) 1989-12-04 1995-10-10 Isis Pharmaceuticals Antisense oligonucleotide inhibition of papillomavirus
US5212295A (en) 1990-01-11 1993-05-18 Isis Pharmaceuticals Monomers for preparation of oligonucleotides having chiral phosphorus linkages
US5620963A (en) 1991-10-15 1997-04-15 Isis Pharmaceuticals, Inc. Oligonucleotides for modulating protein kinase C having phosphorothioate linkages of high chiral purity
US5514788A (en) 1993-05-17 1996-05-07 Isis Pharmaceuticals, Inc. Oligonucleotide modulation of cell adhesion
US5591623A (en) 1990-08-14 1997-01-07 Isis Pharmaceuticals, Inc. Oligonucleotide modulation of cell adhesion
US5248670A (en) 1990-02-26 1993-09-28 Isis Pharmaceuticals, Inc. Antisense oligonucleotides for inhibiting herpesviruses
US5514577A (en) 1990-02-26 1996-05-07 Isis Pharmaceuticals, Inc. Oligonucleotide therapies for modulating the effects of herpes viruses
US5166195A (en) 1990-05-11 1992-11-24 Isis Pharmaceuticals, Inc. Antisense inhibitors of the human immunodeficiency virus phosphorothioate oligonucleotides
JPH0813274B2 (ja) 1990-08-13 1996-02-14 アイシス・ファーマシューティカルス・インコーポレーテッド 遺伝子発現を検出及び変調する糖修飾されたオリゴヌクレオチド
KR970005274B1 (ko) 1990-08-14 1997-04-15 아이시스 파마슈티칼스, 인코포레이티드 안티센스 올리고뉴클레오티드에 의한 a형 인플루엔자 바이러스, 안 아아보스트레인(ann arbor strain) h2n2의 억제
US5442049A (en) 1992-11-19 1995-08-15 Isis Pharmaceuticals, Inc. Oligonucleotides for modulating the effects of cytomegalovirus infections
CA2089666C (en) 1990-08-16 2003-01-07 Kevin P. Anderson Oligonucleotides for modulating the effects of cytomegalovirus infections
US5242906A (en) 1991-04-22 1993-09-07 University Of North Carolina At Chapel Hill Antisense oligonucleotides against Epstein-Barr virus
WO1994008003A1 (en) 1991-06-14 1994-04-14 Isis Pharmaceuticals, Inc. ANTISENSE OLIGONUCLEOTIDE INHIBITION OF THE ras GENE
US5582986A (en) 1991-06-14 1996-12-10 Isis Pharmaceuticals, Inc. Antisense oligonucleotide inhibition of the ras gene
AU672175B2 (en) 1991-06-14 1996-09-26 Isis Pharmaceuticals, Inc. Antisense oligonucleotide inhibition of the ras gene
US5607923A (en) 1991-10-15 1997-03-04 Isis Pharmaceuticals, Inc. Oligonucleotides for modulating cytomegalovirus having phosphorothioate linkages of high chiral purity
US5661134A (en) 1991-10-15 1997-08-26 Isis Pharmaceuticals, Inc. Oligonucleotides for modulating Ha-ras or Ki-ras having phosphorothioate linkages of high chiral purity
US5681747A (en) 1992-03-16 1997-10-28 Isis Pharmaceuticals, Inc. Nucleic acid sequences encoding protein kinase C and antisense inhibition of expression thereof
IL107150A0 (en) 1992-09-29 1993-12-28 Isis Pharmaceuticals Inc Oligonucleotides having a conserved g4 core sequence
US5877309A (en) 1997-08-13 1999-03-02 Isis Pharmaceuticals, Inc. Antisense oligonucleotides against JNK

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06128284A (ja) * 1991-06-20 1994-05-10 Europ Lab Fuer Molekularbiolog Elmb 合成触媒オリゴヌクレオチド構造、核酸の目標配列の切断方法、抗ウイルス治療用薬剤ならびにその製造方法、診断試薬及びその製造方法
WO1998029124A1 (en) * 1996-12-31 1998-07-09 Isis Pharmaceuticals, Inc. Oligonucleotide compositions and methods for the modulation of the expression of b7 protein

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013520395A (ja) * 2009-02-22 2013-06-06 ケムジーンズ コーポレーション 治療、診断、ｇ‐テトラド形成オリゴヌクレオシド及びアプタマーといった生物学的応用のための新規修飾を取り入れたアラ‐２’‐ｏ‐メチル‐ヌクレオシド、当該ホスホラミダイト及びオリゴヌクレオチドの合成

Also Published As

Publication number Publication date
US6369209B1 (en) 2002-04-09
AU4691000A (en) 2000-11-17
EP1743901A3 (en) 2009-01-28
AU762212C (en) 2004-02-12
WO2000066609A1 (en) 2000-11-09
EP1743901A2 (en) 2007-01-17
EP1180113A1 (en) 2002-02-20
AU762212B2 (en) 2003-06-19
US6737520B2 (en) 2004-05-18
CA2373225A1 (en) 2000-11-09
EP1180113A4 (en) 2002-09-18
US20030105311A1 (en) 2003-06-05

Similar Documents

Publication Publication Date Title
AU762212C (en) Oligonucleotides having A-DNA form and B-DNA form conformational geometry
EP1100809B1 (en) Rna targeted 2'-modified oligonucleotides that are conformationally preorganized
EP1222309B1 (en) Human rnase h and oligonucleotide compositions thereof
US6043352A (en) 2'-O-Dimethylaminoethyloxyethyl-modified oligonucleotides
JP5763539B2 (ja) ５’及び２’ビス置換ヌクレオシド及びそれから製造されるオリゴマー化合物
EP1097162B1 (en) Oligonucleotides having site specific chiral phosphorothioate internucleoside linkages
JP5006485B2 (ja) Ｒｎａを切断するオリゴリボヌクレオチドおよびリボヌクレアーゼ
US7321029B2 (en) 2′-arabino-fluorooligonucleotide N3′→P5′ phosphoramidates: their synthesis and use
US7119184B2 (en) Oligonucleotides having A-DNA form and B-DNA form conformational geometry
JP2003520200A (ja) ２’−ｏ−アセトアミド修飾モノマーおよびオリゴマー
AU2003228477B2 (en) Oligomeric compounds having modified phosphate groups
CN105121452A (zh) 三环核苷和由其制备的寡聚化合物
WO2000004189A1 (en) Modified oligonucleotides
US6673912B1 (en) 2′-O-aminoethyloxyethyl-modified oligonucleotides

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20070507

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20070507

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20101125

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20110427