JP2002542169A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2002542169A5 JP2002542169A5 JP2000611685A JP2000611685A JP2002542169A5 JP 2002542169 A5 JP2002542169 A5 JP 2002542169A5 JP 2000611685 A JP2000611685 A JP 2000611685A JP 2000611685 A JP2000611685 A JP 2000611685A JP 2002542169 A5 JP2002542169 A5 JP 2002542169A5
- Authority
- JP
- Japan
- Prior art keywords
- immunogenic composition
- toxin
- fragment
- recombinant
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12868699P | 1999-04-09 | 1999-04-09 | |
| US60/128,686 | 1999-04-09 | ||
| US18620100P | 2000-03-01 | 2000-03-01 | |
| US60/186,201 | 2000-03-01 | ||
| US19011100P | 2000-03-20 | 2000-03-20 | |
| US60/190,111 | 2000-03-20 | ||
| PCT/US2000/009525 WO2000061762A1 (en) | 1999-04-09 | 2000-04-10 | RECOMBINANT TOXIN A/TOXIN B VACCINE AGAINST $i(CLOSTRIDIUM DIFFICILE) |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009298925A Division JP5566684B2 (ja) | 1999-04-09 | 2009-12-28 | Ｃｌｏｓｔｒｉｄｉｕｍｄｉｆｆｉｃｉｌｅに対する、組換え毒素Ａ／毒素Ｂワクチン |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002542169A JP2002542169A (ja) | 2002-12-10 |
| JP2002542169A5 true JP2002542169A5 (enExample) | 2006-08-31 |
Family
ID=27383767
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000611685A Pending JP2002542169A (ja) | 1999-04-09 | 2000-04-10 | Ｃｌｏｓｔｒｉｄｉｕｍｄｉｆｆｉｃｉｌｅに対する、組換え毒素Ａ／毒素Ｂワクチン |
| JP2009298925A Expired - Fee Related JP5566684B2 (ja) | 1999-04-09 | 2009-12-28 | Ｃｌｏｓｔｒｉｄｉｕｍｄｉｆｆｉｃｉｌｅに対する、組換え毒素Ａ／毒素Ｂワクチン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009298925A Expired - Fee Related JP5566684B2 (ja) | 1999-04-09 | 2009-12-28 | Ｃｌｏｓｔｒｉｄｉｕｍｄｉｆｆｉｃｉｌｅに対する、組換え毒素Ａ／毒素Ｂワクチン |
Country Status (5)
| Country | Link |
|---|---|
| EP (2) | EP2502998A3 (enExample) |
| JP (2) | JP2002542169A (enExample) |
| AU (1) | AU781175B2 (enExample) |
| CA (1) | CA2365915C (enExample) |
| WO (1) | WO2000061762A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0205206D0 (en) * | 2002-03-06 | 2002-04-17 | Oxoid Ltd | Synthetic peptides |
| US6912151B2 (en) | 2002-06-28 | 2005-06-28 | Synopsys, Inc. | Negative differential resistance (NDR) based memory device with reduced body effects |
| US20110243991A1 (en) * | 2008-12-03 | 2011-10-06 | Boehringer Ingelheim Vetmedica Gmbh | Process for production of vaccines |
| CN103957931B (zh) | 2010-09-03 | 2017-10-24 | 瓦尔内瓦奥地利有限责任公司 | 艰难梭状芽胞杆菌毒素a和毒素b蛋白的分离多肽及其用途 |
| GB201016742D0 (en) | 2010-10-05 | 2010-11-17 | Health Prot Agency | Clostridium difficile antigens |
| CN103619871B (zh) | 2011-04-22 | 2016-12-14 | 惠氏有限责任公司 | 涉及突变体难辨梭菌毒素的组合物及其方法 |
| CN107098977A (zh) * | 2011-05-27 | 2017-08-29 | 葛兰素史密丝克莱恩生物有限公司 | 免疫原性组合物 |
| AU2016203241B2 (en) * | 2011-05-27 | 2018-05-10 | Glaxosmithkline Biologicals S.A. | Immunogenic composition |
| KR20140101835A (ko) | 2011-12-08 | 2014-08-20 | 노파르티스 아게 | 클로스트리듐 디피실레 톡신-기반 백신 |
| GB201206070D0 (en) * | 2012-04-04 | 2012-05-16 | Health Prot Agency | Clostridium difficile antigens |
| BR122016023101B1 (pt) | 2012-10-21 | 2022-03-22 | Pfizer Inc | Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile |
| ES2939307T3 (es) | 2012-12-05 | 2023-04-20 | Glaxosmithkline Biologicals Sa | Composición inmunogénica |
| JP2016501550A (ja) | 2012-12-27 | 2016-01-21 | グリコヴァキシン アーゲー | Ｃｒｍ１９７に関する方法及び組成物 |
| WO2015197737A1 (en) | 2014-06-25 | 2015-12-30 | Glaxosmithkline Biologicals S.A. | Clostridium difficile immunogenic composition |
| US10533036B2 (en) | 2015-02-19 | 2020-01-14 | Immune Biosolutions Inc | Clostridium difficile toxins a and/or B antigen and epitope antibody, and pharmaceutical uses thereof |
| BR112020024514A2 (pt) | 2018-06-19 | 2021-03-02 | Glaxosmithkline Biologicals S.A. | composição imunogênica |
| JP2022513077A (ja) * | 2018-11-16 | 2022-02-07 | マトリバックス，インコーポレーテッド | クロストリジウム・ディフィシル多成分ワクチン |
| WO2021255690A2 (en) | 2020-06-19 | 2021-12-23 | Pfizer Inc. | Immunogenic compositions against clostridioides (clostridium) difficile and methods thereof |
| CN112442472B (zh) * | 2020-11-30 | 2023-05-26 | 四川大学华西医院 | 抗艰难梭菌的重组乳酸乳球菌、活载体疫苗及其制备方法 |
| GB202205833D0 (en) | 2022-04-21 | 2022-06-08 | Glaxosmithkline Biologicals Sa | Bacteriophage |
| WO2024160901A1 (en) | 2023-02-02 | 2024-08-08 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4530833A (en) | 1982-09-13 | 1985-07-23 | Wilkins Tracy D | Toxins and antibodies of C. difficile |
| US4879218A (en) | 1982-09-13 | 1989-11-07 | Virginia Tech Intellectual Properties, Inc. | Antibody for C.difficile |
| US4533630A (en) | 1982-09-13 | 1985-08-06 | Wilkins Tracy D | Toxins and antibodies of C. difficile |
| US4863852A (en) | 1985-07-03 | 1989-09-05 | Virginia Tech Intellectual Properties, Inc. | Method of detecting, isolating and purifying clostridium difficile toxin A and its receptors |
| GB8517071D0 (en) * | 1985-07-05 | 1985-08-14 | Hoffmann La Roche | Gram-positive expression control sequence |
| US5736139A (en) | 1989-10-31 | 1998-04-07 | Ochidian Pharmaceuticals, Inc. | Treatment of Clostridium difficile induced disease |
| US5098826A (en) | 1990-03-09 | 1992-03-24 | Virginia Tech Intellectual Properties, Inc. | Detection, isolation and purification of Clostridium difficile toxin A with toxin receptors |
| EP0604580A1 (en) * | 1991-09-19 | 1994-07-06 | Genentech, Inc. | EXPRESSION IN E. COLI OF ANTIBODY FRAGMENTS HAVING AT LEAST A CYSTEINE PRESENT AS A FREE THIOL, USE FOR THE PRODUCTION OF BIFUNCTIONAL F(ab') 2? ANTIBODIES |
| AU709586B2 (en) * | 1994-10-24 | 1999-09-02 | Ophidian Pharmaceuticals, Inc. | Vaccine and antitoxin for treatment and prevention of C. difficile disease |
| NZ312502A (en) * | 1995-07-07 | 1999-03-29 | Oravax Inc | Clostridium difficile toxins as mucosal adjuvants |
| US5919463A (en) | 1995-07-07 | 1999-07-06 | Oravax, Inc. | Clostridium difficle toxins as mucosal adjuvants |
| JPH09323999A (ja) * | 1996-06-03 | 1997-12-16 | Unitika Ltd | 人工タンパク質ポリマー |
| WO1998059053A1 (en) * | 1997-06-20 | 1998-12-30 | Queen Mary & Westfield College | Immonogenic fragments of toxin a of clostridium difficile |
| CN103957931B (zh) * | 2010-09-03 | 2017-10-24 | 瓦尔内瓦奥地利有限责任公司 | 艰难梭状芽胞杆菌毒素a和毒素b蛋白的分离多肽及其用途 |
-
2000
- 2000-04-10 JP JP2000611685A patent/JP2002542169A/ja active Pending
- 2000-04-10 EP EP12155470A patent/EP2502998A3/en not_active Withdrawn
- 2000-04-10 CA CA2365915A patent/CA2365915C/en not_active Expired - Fee Related
- 2000-04-10 AU AU49732/00A patent/AU781175B2/en not_active Ceased
- 2000-04-10 WO PCT/US2000/009525 patent/WO2000061762A1/en not_active Ceased
- 2000-04-10 EP EP00931926A patent/EP1169456B1/en not_active Expired - Lifetime
-
2009
- 2009-12-28 JP JP2009298925A patent/JP5566684B2/ja not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2002542169A5 (enExample) | ||
| KR100500782B1 (ko) | 융합단백질로서의 이종성 항원유전자 발현 시스템 | |
| JP5566684B2 (ja) | Ｃｌｏｓｔｒｉｄｉｕｍｄｉｆｆｉｃｉｌｅに対する、組換え毒素Ａ／毒素Ｂワクチン | |
| JP3267333B2 (ja) | 融合タンパク質 | |
| Sanchez et al. | Recombinant system for overexpression of cholera toxin B subunit in Vibrio cholerae as a basis for vaccine development. | |
| US9346860B2 (en) | Expression system | |
| JP2764022B2 (ja) | 免疫グロブリン結合性タンパク質及びその製造方法 | |
| EP3099800B1 (en) | Expression and purification of crm197 and related proteins | |
| US4985243A (en) | Composition and method for protecting against diseases caused by microorganisms | |
| Belev et al. | A fully modular vector system for the optimization of gene expression in Escherichia coli | |
| CA1338705C (en) | Vaccines obtained from antigenic gene products of recombinant genes | |
| EA006232B1 (ru) | Стрептококковые антигены | |
| JPH0376580A (ja) | 大腸菌発現ベクターとそれを利用した抗ウイルス性タンパク質の製造方法 | |
| Abomoelak et al. | Humoral and cellular immune responses in mice immunized with recombinant Mycobacterium bovis Bacillus Calmette-Guerin producing a pertussis toxin-tetanus toxin hybrid protein | |
| JP2023154063A (ja) | 肺炎球菌表面タンパク質Ａ（ＰｓｐＡ）の発現 | |
| HUT64596A (en) | Recombinant vaccine against swine pleuropneumonie | |
| US6777202B2 (en) | Recombinant expression of S-layer proteins | |
| CN100427506C (zh) | 从融合多肽制备感兴趣的多肽的方法 | |
| FI104496B (fi) | Yliekspressiojärjestelmät kolera B-alayksikön ekspressiota varten vieraiden promoottoreiden ja johtopeptidien avulla | |
| JPH08512210A (ja) | ペプチドの合成及び精製のための方法 | |
| US20040086524A1 (en) | Vaccines and agents for inducing immunity in fish against rickettsial diseases, and associated preventative therapy | |
| JP7161729B2 (ja) | 多価ワクチン | |
| JP2903414B2 (ja) | 抗酸菌分泌発現ベクター及び抗酸菌 | |
| KR102280493B1 (ko) | GnRH가 삽입된 STF2 재조합 단백질 및 이의 용도 | |
| WO1996026282A1 (en) | Expression of gene products from genetically manipulated strains of bordetella |