CA2365915C - Recombinant toxin a/toxin b vaccine against clostridium difficile - Google Patents
Recombinant toxin a/toxin b vaccine against clostridium difficile Download PDFInfo
- Publication number
- CA2365915C CA2365915C CA2365915A CA2365915A CA2365915C CA 2365915 C CA2365915 C CA 2365915C CA 2365915 A CA2365915 A CA 2365915A CA 2365915 A CA2365915 A CA 2365915A CA 2365915 C CA2365915 C CA 2365915C
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- Prior art keywords
- asn
- toxin
- gly
- ile
- protein
- Prior art date
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| PCT/US2000/009525 WO2000061762A1 (en) | 1999-04-09 | 2000-04-10 | RECOMBINANT TOXIN A/TOXIN B VACCINE AGAINST $i(CLOSTRIDIUM DIFFICILE) |
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| US6912151B2 (en) | 2002-06-28 | 2005-06-28 | Synopsys, Inc. | Negative differential resistance (NDR) based memory device with reduced body effects |
| MX2011005758A (es) * | 2008-12-03 | 2011-06-28 | Boehringer Ingelheim Vetmed | Procedimiento para la produccion de vacunas. |
| HUE033342T2 (en) | 2010-09-03 | 2017-11-28 | Valneva Austria Gmbh | Isolated polypeptide of the toxin a and toxin b proteins of c. difficile and uses thereof |
| GB201016742D0 (en) | 2010-10-05 | 2010-11-17 | Health Prot Agency | Clostridium difficile antigens |
| HUE047085T2 (hu) | 2011-04-22 | 2020-04-28 | Wyeth Llc | Clostridium difficile mutáns toxinjához kapcsolódó készítmények és eljárásai |
| AU2016203241B2 (en) * | 2011-05-27 | 2018-05-10 | Glaxosmithkline Biologicals S.A. | Immunogenic composition |
| DK2714910T3 (en) * | 2011-05-27 | 2018-02-05 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
| CA2858519A1 (en) | 2011-12-08 | 2013-06-13 | Novartis Ag | Clostridium difficile toxin-based vaccine |
| GB201206070D0 (en) | 2012-04-04 | 2012-05-16 | Health Prot Agency | Clostridium difficile antigens |
| BR122016023101B1 (pt) | 2012-10-21 | 2022-03-22 | Pfizer Inc | Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile |
| DK2928489T3 (en) | 2012-12-05 | 2019-04-23 | Glaxosmithkline Biologicals Sa | IMMUNOGENE COMPOSITION |
| US10287330B2 (en) | 2012-12-27 | 2019-05-14 | Glaxosmithkline Biologicals S.A. | Methods and compositions relating to CRM197 |
| LT3160500T (lt) * | 2014-06-25 | 2019-10-25 | Glaxosmithkline Biologicals Sa | Clostridium difficile imunogeninė kompozicija |
| CA2976976C (en) | 2015-02-19 | 2023-02-28 | Immune Biosolutions Inc. | Clostridium difficile toxins a and/or b antigen and epitope antibody, and pharmaceutical uses thereof |
| CA3102353A1 (en) | 2018-06-19 | 2019-12-26 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
| CN113329766A (zh) * | 2018-11-16 | 2021-08-31 | 马特里瓦克斯公司 | 艰难梭菌多组分疫苗 |
| CN112442472B (zh) * | 2020-11-30 | 2023-05-26 | 四川大学华西医院 | 抗艰难梭菌的重组乳酸乳球菌、活载体疫苗及其制备方法 |
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| US4530833A (en) | 1982-09-13 | 1985-07-23 | Wilkins Tracy D | Toxins and antibodies of C. difficile |
| US4533630A (en) | 1982-09-13 | 1985-08-06 | Wilkins Tracy D | Toxins and antibodies of C. difficile |
| US4879218A (en) | 1982-09-13 | 1989-11-07 | Virginia Tech Intellectual Properties, Inc. | Antibody for C.difficile |
| US4863852A (en) | 1985-07-03 | 1989-09-05 | Virginia Tech Intellectual Properties, Inc. | Method of detecting, isolating and purifying clostridium difficile toxin A and its receptors |
| GB8517071D0 (en) * | 1985-07-05 | 1985-08-14 | Hoffmann La Roche | Gram-positive expression control sequence |
| US5736139A (en) | 1989-10-31 | 1998-04-07 | Ochidian Pharmaceuticals, Inc. | Treatment of Clostridium difficile induced disease |
| US5098826A (en) | 1990-03-09 | 1992-03-24 | Virginia Tech Intellectual Properties, Inc. | Detection, isolation and purification of Clostridium difficile toxin A with toxin receptors |
| EP0604580A1 (en) * | 1991-09-19 | 1994-07-06 | Genentech, Inc. | EXPRESSION IN E. COLI OF ANTIBODY FRAGMENTS HAVING AT LEAST A CYSTEINE PRESENT AS A FREE THIOL, USE FOR THE PRODUCTION OF BIFUNCTIONAL F(ab') 2? ANTIBODIES |
| CZ296806B6 (cs) * | 1994-10-24 | 2006-06-14 | Allergan, Inc. | Rozpustný fúzní protein a zpusob výroby rozpustného rekombinantního botulinového toxinu |
| ATE195878T1 (de) * | 1995-07-07 | 2000-09-15 | Oravax Inc | Toxine und toxoide von clostridium difficile als schleimhautadjuvans |
| US5919463A (en) | 1995-07-07 | 1999-07-06 | Oravax, Inc. | Clostridium difficle toxins as mucosal adjuvants |
| JPH09323999A (ja) * | 1996-06-03 | 1997-12-16 | Unitika Ltd | 人工タンパク質ポリマー |
| WO1998059053A1 (en) * | 1997-06-20 | 1998-12-30 | Queen Mary & Westfield College | Immonogenic fragments of toxin a of clostridium difficile |
| HUE033342T2 (en) * | 2010-09-03 | 2017-11-28 | Valneva Austria Gmbh | Isolated polypeptide of the toxin a and toxin b proteins of c. difficile and uses thereof |
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2000
- 2000-04-10 JP JP2000611685A patent/JP2002542169A/ja active Pending
- 2000-04-10 WO PCT/US2000/009525 patent/WO2000061762A1/en not_active Ceased
- 2000-04-10 AU AU49732/00A patent/AU781175B2/en not_active Ceased
- 2000-04-10 EP EP12155470A patent/EP2502998A3/en not_active Withdrawn
- 2000-04-10 EP EP00931926A patent/EP1169456B1/en not_active Expired - Lifetime
- 2000-04-10 CA CA2365915A patent/CA2365915C/en not_active Expired - Fee Related
-
2009
- 2009-12-28 JP JP2009298925A patent/JP5566684B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002542169A (ja) | 2002-12-10 |
| AU781175B2 (en) | 2005-05-12 |
| EP2502998A3 (en) | 2013-02-27 |
| EP1169456A1 (en) | 2002-01-09 |
| JP5566684B2 (ja) | 2014-08-06 |
| WO2000061762A1 (en) | 2000-10-19 |
| CA2365915A1 (en) | 2000-10-19 |
| JP2010083898A (ja) | 2010-04-15 |
| AU4973200A (en) | 2000-11-14 |
| EP1169456B1 (en) | 2012-07-11 |
| EP2502998A2 (en) | 2012-09-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20180410 |