JP2002539245A5 - - Google Patents
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- Publication number
- JP2002539245A5 JP2002539245A5 JP2000606206A JP2000606206A JP2002539245A5 JP 2002539245 A5 JP2002539245 A5 JP 2002539245A5 JP 2000606206 A JP2000606206 A JP 2000606206A JP 2000606206 A JP2000606206 A JP 2000606206A JP 2002539245 A5 JP2002539245 A5 JP 2002539245A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- acetylhomotaurinate
- agent
- gaba
- nmda
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 description 93
- 238000000034 method Methods 0.000 description 52
- 239000003795 chemical substances by application Substances 0.000 description 35
- 208000024891 symptom Diseases 0.000 description 21
- 208000019901 Anxiety disease Diseases 0.000 description 19
- 239000003814 drug Substances 0.000 description 18
- 230000005062 synaptic transmission Effects 0.000 description 17
- 231100000252 nontoxic Toxicity 0.000 description 16
- 230000003000 nontoxic effect Effects 0.000 description 16
- 230000003252 repetitive effect Effects 0.000 description 16
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 15
- 229910052791 calcium Inorganic materials 0.000 description 15
- 239000011575 calcium Substances 0.000 description 15
- 230000000694 effects Effects 0.000 description 15
- 229940079593 drug Drugs 0.000 description 14
- 239000002253 acid Substances 0.000 description 12
- 230000005540 biological transmission Effects 0.000 description 11
- 239000003703 n methyl dextro aspartic acid receptor blocking agent Substances 0.000 description 11
- 208000028173 post-traumatic stress disease Diseases 0.000 description 11
- 150000003839 salts Chemical class 0.000 description 11
- 239000003483 4 aminobutyric acid A receptor stimulating agent Substances 0.000 description 10
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 10
- 229930195712 glutamate Natural products 0.000 description 10
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 9
- 229910052749 magnesium Inorganic materials 0.000 description 9
- 239000011777 magnesium Substances 0.000 description 9
- 230000007423 decrease Effects 0.000 description 8
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 7
- 229940099433 NMDA receptor antagonist Drugs 0.000 description 7
- BUVGWDNTAWHSKI-UHFFFAOYSA-L acamprosate calcium Chemical compound [Ca+2].CC(=O)NCCCS([O-])(=O)=O.CC(=O)NCCCS([O-])(=O)=O BUVGWDNTAWHSKI-UHFFFAOYSA-L 0.000 description 7
- 229910052744 lithium Inorganic materials 0.000 description 7
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 description 6
- 239000003825 glutamate receptor antagonist Substances 0.000 description 6
- 239000013543 active substance Substances 0.000 description 5
- 229910001425 magnesium ion Inorganic materials 0.000 description 5
- 230000003285 pharmacodynamic effect Effects 0.000 description 5
- 229940002612 prodrug Drugs 0.000 description 5
- 239000000651 prodrug Substances 0.000 description 5
- 229940122459 Glutamate antagonist Drugs 0.000 description 4
- 210000004227 basal ganglia Anatomy 0.000 description 4
- 230000006399 behavior Effects 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 210000004556 brain Anatomy 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 150000002148 esters Chemical class 0.000 description 4
- 210000003715 limbic system Anatomy 0.000 description 4
- 230000008447 perception Effects 0.000 description 4
- 210000001035 gastrointestinal tract Anatomy 0.000 description 3
- 150000002500 ions Chemical class 0.000 description 3
- BUGYDGFZZOZRHP-UHFFFAOYSA-N memantine Chemical group C1C(C2)CC3(C)CC1(C)CC2(N)C3 BUGYDGFZZOZRHP-UHFFFAOYSA-N 0.000 description 3
- 230000002195 synergetic effect Effects 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 208000012661 Dyskinesia Diseases 0.000 description 2
- 208000015592 Involuntary movements Diseases 0.000 description 2
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 description 2
- AFCGFAGUEYAMAO-UHFFFAOYSA-N acamprosate Chemical compound CC(=O)NCCCS(O)(=O)=O AFCGFAGUEYAMAO-UHFFFAOYSA-N 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 229960003692 gamma aminobutyric acid Drugs 0.000 description 2
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 159000000003 magnesium salts Chemical group 0.000 description 2
- 229960004640 memantine Drugs 0.000 description 2
- 230000017311 musculoskeletal movement, spinal reflex action Effects 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 239000000018 receptor agonist Substances 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- SNKZJIOFVMKAOJ-UHFFFAOYSA-N 3-Aminopropanesulfonate Chemical compound NCCCS(O)(=O)=O SNKZJIOFVMKAOJ-UHFFFAOYSA-N 0.000 description 1
- 108091006146 Channels Proteins 0.000 description 1
- 108090000862 Ion Channels Proteins 0.000 description 1
- 102000004310 Ion Channels Human genes 0.000 description 1
- 102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 description 1
- 108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 description 1
- HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 description 1
- 125000003047 N-acetyl group Chemical group 0.000 description 1
- 229940127523 NMDA Receptor Antagonists Drugs 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 229960004047 acamprosate Drugs 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- -1 elixirs Substances 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 230000036963 noncompetitive effect Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/273,036 | 1999-03-19 | ||
| US09/273,036 US6391922B1 (en) | 1998-01-13 | 1999-03-19 | Treatment of posttraumatic stress disorder, obsessive-compulsive disorder and related neuropsychiatric disorders |
| PCT/US2000/007119 WO2000056301A2 (en) | 1999-03-19 | 2000-03-17 | Treatment of posttraumatic stress disorder, obsessive-compulsive disorder and related neuropsychiatric disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002539245A JP2002539245A (ja) | 2002-11-19 |
| JP2002539245A5 true JP2002539245A5 (https=) | 2007-03-15 |
| JP4633262B2 JP4633262B2 (ja) | 2011-02-16 |
Family
ID=23042279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000606206A Expired - Lifetime JP4633262B2 (ja) | 1999-03-19 | 2000-03-17 | 心的外傷後ストレス障害、強迫性障害および関連する神経精神医学的障害の処置 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US6391922B1 (https=) |
| EP (1) | EP1162960A2 (https=) |
| JP (1) | JP4633262B2 (https=) |
| AU (1) | AU3895000A (https=) |
| CA (1) | CA2367015A1 (https=) |
| WO (1) | WO2000056301A2 (https=) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6391922B1 (en) * | 1998-01-13 | 2002-05-21 | Synchroneuron, Llc | Treatment of posttraumatic stress disorder, obsessive-compulsive disorder and related neuropsychiatric disorders |
| US20020022657A1 (en) * | 1998-02-11 | 2002-02-21 | Francine Gervais | Methods for modulating neuronal cell death |
| EP1852113A3 (en) * | 2000-12-07 | 2008-03-12 | Neuromolecular Inc. | Methods for treating neuropsychiatric disorders with NMDA receptors antagonists |
| AU2002311784B2 (en) * | 2001-03-29 | 2007-11-22 | Michael Davis | Acute pharmacologic augmentation of psychotherapy with enhancers of learning or conditioning |
| US6462084B1 (en) * | 2001-05-14 | 2002-10-08 | Brookhaven Science Associates, Llc | Treatment for obsessive-compulsive disorder (OCD) and OCD-related disorders using GVG |
| US20030045541A1 (en) * | 2001-07-23 | 2003-03-06 | Christopher Bruckner | GABA-Receptor modulators with NMDA-Antagonistic activity |
| US20040034106A1 (en) * | 2001-11-06 | 2004-02-19 | Read Holly Ann | Treatment of anxiety disorders |
| EP1471909A4 (en) * | 2002-01-16 | 2007-07-25 | Endo Pharmaceuticals Inc | PHARMACEUTICAL COMPOSITION AND METHOD FOR THE TREATMENT OF DISEASES OF THE CENTRAL NERVOUS SYSTEM |
| JPWO2004093910A1 (ja) * | 2003-04-22 | 2006-07-13 | アステラス製薬株式会社 | ＰＰＡＲδアゴニストによる脳神経変性疾患治療剤 |
| US7396535B2 (en) * | 2003-04-25 | 2008-07-08 | Ackerman Alan H | Therapy for obsessive compulsive head banging |
| US7390496B2 (en) * | 2003-04-25 | 2008-06-24 | Allergan, Inc. | Therapeutic treatments for repetitive hand washing |
| US7422753B2 (en) * | 2003-04-25 | 2008-09-09 | Allergan, Inc. | Methods for treating trichotillomania |
| US7393537B2 (en) * | 2003-04-25 | 2008-07-01 | Allergan, Inc. | Botulinum toxin for treatment of obsessive compulsive finger biting disorder |
| WO2005056574A2 (en) * | 2003-12-09 | 2005-06-23 | Yeda Research And Development Co. Ltd. | Method and vaccine comprising copolymer 1 for treatment of psychiatric disorders |
| US8609112B2 (en) | 2003-10-29 | 2013-12-17 | Allergan, Inc. | Botulinum toxin treatments of depression |
| US8617572B2 (en) | 2003-10-29 | 2013-12-31 | Allergan, Inc. | Botulinum toxin treatments of depression |
| US8734810B2 (en) | 2003-10-29 | 2014-05-27 | Allergan, Inc. | Botulinum toxin treatments of neurological and neuropsychiatric disorders |
| US8609113B2 (en) | 2003-10-29 | 2013-12-17 | Allergan, Inc. | Botulinum toxin treatments of depression |
| US7619007B2 (en) | 2004-11-23 | 2009-11-17 | Adamas Pharmaceuticals, Inc. | Method and composition for administering an NMDA receptor antagonist to a subject |
| EP1831173B1 (en) * | 2004-12-17 | 2011-01-26 | Janssen Pharmaceutica NV | Tetrahydroisoquinoline compounds for treatment of cns disorders |
| US20060167068A1 (en) * | 2005-01-26 | 2006-07-27 | Seth Feuerstein | Method of treating self-injurious behavior with glutamate modulating agents |
| US8778979B2 (en) * | 2005-04-05 | 2014-07-15 | Yale University | Glutamate agents in the treatment of mental disorders |
| JP5666087B2 (ja) | 2005-04-06 | 2015-02-12 | アダマス・ファーマシューティカルズ・インコーポレーテッド | Ｃｎｓ関連疾患の治療のための方法及び組成物 |
| US20060252830A1 (en) * | 2005-05-06 | 2006-11-09 | Brandon Stephen F | Method for the treatment of magnesium and potassium deficiencies |
| US20060252831A1 (en) * | 2005-05-06 | 2006-11-09 | Christopher Offen | Method for the treatment of magnesium and potassium deficiencies |
| EP1928445A1 (en) * | 2005-09-16 | 2008-06-11 | Cereuscience AB | Method and means of preventing and treating sleep disordered breathing |
| EP1968561B8 (en) * | 2005-12-22 | 2010-10-20 | Kiacta Sàrl | Treatment of diabetic nephropathy |
| WO2008078176A1 (en) * | 2006-12-22 | 2008-07-03 | Bellus Health (International) Limited | Methods, compounds, and compositions for treating metabolic disorders and diabetes |
| US20080171750A1 (en) * | 2007-01-11 | 2008-07-17 | Braincells, Inc. | Modulation Of Neurogenesis With Use of Modafinil |
| US20090104160A1 (en) * | 2007-02-01 | 2009-04-23 | Moraga Biotechnology Corporation | Mobilization of Stem Cells After Trauma and Methods Therefor |
| JP2010534676A (ja) * | 2007-07-23 | 2010-11-11 | シノシア・セラピューティクス | 心的外傷後ストレス障害の治療 |
| US20090082464A1 (en) * | 2007-09-07 | 2009-03-26 | Bernd Jandeleit | Externally masked neopentyl sulfonyl ester cyclization release prodrugs of acamprosate, compositions thereof, and methods of use |
| EP2217564A1 (en) * | 2007-09-07 | 2010-08-18 | XenoPort, Inc. | Complex pantoic acid ester neopentyl sulfonyl ester cyclization release prodrugs of acamprosate, compositions thereof, and methods of use |
| US20090099253A1 (en) * | 2007-10-15 | 2009-04-16 | Xenoport, Inc. | Internally Masked Neopentyl Sulfonyl Ester Cyclization Release Prodrugs of Acamprosate, Compositions Thereof, and Methods of Use |
| US20090156886A1 (en) * | 2007-12-12 | 2009-06-18 | Synapse Research Company | Method and apparatus for providing automatic eye focused therapy |
| EP2135607A1 (en) | 2008-06-18 | 2009-12-23 | Pharnext | Combination of pilocarpin and methimazol for treating Charcot-MarieTooth disease and related disorders |
| CA2781830C (en) | 2009-02-12 | 2018-03-27 | Indiana University Research & Technology Corporation | Materials and methods for treating developmental disorders including comorbid and idiopathic autism |
| US9125907B2 (en) | 2009-09-30 | 2015-09-08 | Christopher Shaari | Use of botulinum neurotoxin to treat substance addictions |
| US9387206B2 (en) | 2009-11-03 | 2016-07-12 | Pharnext | Therapeutic approaches for treating Alzheimer's disease |
| EP2322163A1 (en) | 2009-11-03 | 2011-05-18 | Pharnext | New therapeutics approaches for treating alzheimer disease |
| MX346203B (es) | 2010-09-28 | 2017-03-09 | Depomed Inc | Formas de dosificacion retentivas gastricas para liberacion prolongada de acamprosato en el tracto gastrointestinal superior. |
| EP3034079B1 (en) | 2010-11-15 | 2018-01-10 | Agenebio, Inc. | Pyridazine derivatives, compositions and methods for treating cognitive impairment |
| US9248111B2 (en) | 2011-03-01 | 2016-02-02 | Pharnext | Therapeutic approaches for treating parkinson's disease |
| TR201809351T4 (tr) * | 2011-03-01 | 2018-07-23 | Pharnext | Nörolojik bozuklukların baklofen ve akamprosat tabanlı terapisi. |
| EP2705842A1 (en) * | 2012-09-05 | 2014-03-12 | Pharnext | Therapeutic approaches for treating parkinson's disease |
| US10010515B2 (en) | 2011-03-01 | 2018-07-03 | Pharnext | Therapeutic approaches for treating Parkinson's disease |
| US9241933B2 (en) | 2011-03-01 | 2016-01-26 | Pharnext | Compositions for treating amyotrophic lateral sclerosis |
| CN104487064B (zh) * | 2012-03-01 | 2018-01-26 | 法耐斯特公司 | 用于治疗肌萎缩性侧索硬化症的新组合物 |
| US20130143867A1 (en) * | 2011-12-02 | 2013-06-06 | Sychroneuron Inc. | Acamprosate formulations, methods of using the same, and combinations comprising the same |
| JP6722453B2 (ja) * | 2012-08-23 | 2020-07-15 | スチュアート エル ウェグ | 抗不安薬組成物、製剤および使用方法 |
| WO2014197744A1 (en) | 2013-06-05 | 2014-12-11 | Synchroneuron, Inc. | Acamprosate formulations, methods of using the same, and combinations comprising the same |
| EP3083569B1 (en) | 2013-12-20 | 2022-01-26 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
| US9717903B1 (en) * | 2015-03-17 | 2017-08-01 | Gary Barrett | Electronic process to restore, improve and/or strengthen the libido; method to mend the sex drive in males and females |
| US10431109B2 (en) * | 2015-06-03 | 2019-10-01 | Cambia Health Solutions, Inc. | Systems and methods for somatization identification and treatment |
| JP6987384B2 (ja) | 2015-06-19 | 2021-12-22 | エージンバイオ， インコーポレイテッド | ベンゾジアゼピン誘導体、組成物、および認知障害を処置するための方法 |
| US20180170941A1 (en) | 2016-12-19 | 2018-06-21 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
| US11505555B2 (en) | 2016-12-19 | 2022-11-22 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
| RU2019143572A (ru) | 2017-05-25 | 2021-06-25 | Глитек Ллс. | Композиции для лечения посттравматического стрессового расстройства |
| US10682086B2 (en) * | 2017-09-12 | 2020-06-16 | AebeZe Labs | Delivery of a digital therapeutic method and system |
| US11157700B2 (en) * | 2017-09-12 | 2021-10-26 | AebeZe Labs | Mood map for assessing a dynamic emotional or mental state (dEMS) of a user |
| US11414425B2 (en) | 2018-06-19 | 2022-08-16 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
| US11694786B1 (en) * | 2019-01-04 | 2023-07-04 | Yasmine Van Wilt | Recommendation methods, systems and devices |
| PH12022551856A1 (en) | 2020-01-22 | 2024-01-03 | Seelos Therapeutics Inc | Reducing side effects of nmda antagonists |
| WO2025106574A1 (en) | 2023-11-14 | 2025-05-22 | Aardwolf Therapeutics, Inc. | Flumazenil for treating post-traumatic stress disorder and anxiety |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2457281A1 (fr) | 1979-05-23 | 1980-12-19 | Meram Lab | Nouveaux derives de l'acide 3-aminopropanesulfonique ayant une activite membranaire renforcee |
| US4745126A (en) | 1987-03-12 | 1988-05-17 | Eli Lilly And Company | Method of treating anxiety with tetrahydrobenz[c,d]indole-6-carboxamides |
| US4985256A (en) | 1988-04-27 | 1991-01-15 | Bionix Corporation | Methods for diagnosing, monitoring and controlling the onset and progression of certain dementias and impeding memory loss or improving impairment of memory |
| US4962128A (en) | 1989-11-02 | 1990-10-09 | Pfizer Inc. | Method of treating anxiety-related disorders using sertraline |
| US5028612A (en) | 1990-03-22 | 1991-07-02 | Hillel Glover | Method for treating emotional numbness |
| US5086072A (en) | 1990-06-18 | 1992-02-04 | The United States Of America As Represented By The Department Of Health And Human Services | Treatment of mood disorders with functional antagonists of the glycine/nmda receptor complex |
| US5145866A (en) | 1991-04-22 | 1992-09-08 | Hoechst-Roussel Pharmaceuticals Incorporated | Method of treating anxiety with the aid of r(+)-3-amino-1-hydroxy-pyrrolidin-2-one |
| US5602150A (en) | 1992-10-02 | 1997-02-11 | Research Foundation For Mental Hygiene, Inc. | Treatment of central nervous system disorders associated with psychotic behavior and dementia with a combination of neuroleptic drugs and taurine, or derivatives thereof, to prevent the development of tardive dyskinesia |
| US5356902A (en) | 1992-11-06 | 1994-10-18 | Eli Lilly And Company | Decahydroisoquinoline compounds as excitatory amino acid receptor antagonists |
| US5475019A (en) | 1993-02-08 | 1995-12-12 | East Carolina University | Method of treating anxiety-related disorders with 2-aminocycloaliphatic amide compounds |
| US5475007A (en) | 1993-05-28 | 1995-12-12 | The Regents Of The University Of California | 1,2,3,4-tetrahydroquinoline-2,3,4-trione-3 or 4-oximes and the use thereof |
| US5665757A (en) | 1994-07-13 | 1997-09-09 | Robert W. Dunn | Method for treating anxiety |
| US5597922A (en) | 1994-07-29 | 1997-01-28 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon | Glycine receptor antagonist pharmacophore |
| US6562862B1 (en) | 1994-10-20 | 2003-05-13 | Eli Lilly And Company | Methods of inhibiting physiological conditions associated with an excess of neuropeptide Y |
| US5574028A (en) | 1994-10-31 | 1996-11-12 | Eli Lilly And Company | Method for treating anxiety |
| US5484794A (en) | 1994-11-09 | 1996-01-16 | Eli Lilly And Company | Method for treating anxiety |
| US5726193A (en) | 1994-10-31 | 1998-03-10 | Eli Lilly And Company | Method for treating anxiety |
| US5488056A (en) | 1994-10-31 | 1996-01-30 | Eli Lilly And Company | Method for treating anxiety |
| US5476933A (en) | 1994-11-16 | 1995-12-19 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon | Azepine synthesis via a diels-alder reaction |
| US5654303A (en) | 1995-06-07 | 1997-08-05 | Warner-Lambert Company | Alkyl amine derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists |
| US5614508A (en) | 1995-06-07 | 1997-03-25 | Warner-Lambert Company | Amino acid derivatives of substituted quinoxaline 2,3-dione derivatives as glutamate receptor antagonists |
| US5763457A (en) | 1995-11-13 | 1998-06-09 | Eli Lilly And Company | Method for treating anxiety |
| US5852037A (en) | 1995-11-13 | 1998-12-22 | Eli Lilly And Company | Method for treating anxiety |
| US5681578A (en) | 1996-01-22 | 1997-10-28 | Sahley; Billie J. | Composition for relieving stress anxiety, grief, and depression |
| US5776969A (en) | 1997-02-27 | 1998-07-07 | Eli Lilly And Company | Treatment of sleep disorders |
| US5866585A (en) | 1997-05-22 | 1999-02-02 | Synchroneuron, Llc | Methods of treating tardive dyskinesia using NMDA receptor antagonists |
| US5883083A (en) | 1997-06-09 | 1999-03-16 | Harlmen, Inc. | Dietary supplement for alleviating behavioral problems in canines and reducing seizures in canines and felines |
| US6294583B1 (en) | 1998-01-13 | 2001-09-25 | Synchroneuron, Llc | Methods of treating tardive dyskinesia and other movement disorders |
| WO1999036064A2 (en) | 1998-01-13 | 1999-07-22 | Synchroneuron, Llc | Methods of treating tardive dyskinesia and other movement disorders |
| US6391922B1 (en) * | 1998-01-13 | 2002-05-21 | Synchroneuron, Llc | Treatment of posttraumatic stress disorder, obsessive-compulsive disorder and related neuropsychiatric disorders |
-
1999
- 1999-03-19 US US09/273,036 patent/US6391922B1/en not_active Expired - Lifetime
-
2000
- 2000-03-17 JP JP2000606206A patent/JP4633262B2/ja not_active Expired - Lifetime
- 2000-03-17 AU AU38950/00A patent/AU3895000A/en not_active Abandoned
- 2000-03-17 WO PCT/US2000/007119 patent/WO2000056301A2/en not_active Ceased
- 2000-03-17 EP EP00918076A patent/EP1162960A2/en not_active Withdrawn
- 2000-03-17 CA CA002367015A patent/CA2367015A1/en not_active Abandoned
-
2002
- 2002-03-01 US US10/087,357 patent/US6689816B2/en not_active Expired - Lifetime
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