JP2002537284A5 - - Google Patents
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- Publication number
- JP2002537284A5 JP2002537284A5 JP2000599730A JP2000599730A JP2002537284A5 JP 2002537284 A5 JP2002537284 A5 JP 2002537284A5 JP 2000599730 A JP2000599730 A JP 2000599730A JP 2000599730 A JP2000599730 A JP 2000599730A JP 2002537284 A5 JP2002537284 A5 JP 2002537284A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkoxy
- hydroxy
- aryl
- carbonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 description 77
- 125000003545 alkoxy group Chemical group 0.000 description 27
- 150000001875 compounds Chemical class 0.000 description 11
- 125000001072 heteroaryl group Chemical group 0.000 description 11
- 125000003118 aryl group Chemical group 0.000 description 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 10
- 125000001624 naphthyl group Chemical group 0.000 description 9
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 description 6
- 229910052757 nitrogen Inorganic materials 0.000 description 5
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 4
- 125000004356 hydroxy functional group Chemical group O* 0.000 description 4
- 125000004923 naphthylmethyl group Chemical group C1(=CC=CC2=CC=CC=C12)C* 0.000 description 4
- 125000004433 nitrogen atom Chemical group N* 0.000 description 4
- 150000003839 salts Chemical group 0.000 description 4
- -1 4-hydroxy-3 -Methoxy-benzyl Chemical group 0.000 description 3
- 125000004448 alkyl carbonyl group Chemical group 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- 229940071127 thioglycolate Drugs 0.000 description 3
- CWERGRDVMFNCDR-UHFFFAOYSA-M thioglycolate(1-) Chemical compound [O-]C(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-M 0.000 description 3
- WLAMNBDJUVNPJU-BYPYZUCNSA-N (S)-2-methylbutyric acid Chemical compound CC[C@H](C)C(O)=O WLAMNBDJUVNPJU-BYPYZUCNSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 235000008206 alpha-amino acids Nutrition 0.000 description 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 125000004093 cyano group Chemical group *C#N 0.000 description 2
- 125000001041 indolyl group Chemical group 0.000 description 2
- 210000000440 neutrophil Anatomy 0.000 description 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 description 1
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 description 1
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 description 1
- 125000004398 2-methyl-2-butyl group Chemical group CC(C)(CC)* 0.000 description 1
- 0 C[C@@]1[C@](C*)[C@]2[C@@](*)C(*)C(*)CC2CC1 Chemical compound C[C@@]1[C@](C*)[C@]2[C@@](*)C(*)C(*)CC2CC1 0.000 description 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 description 1
- 125000003282 alkyl amino group Chemical group 0.000 description 1
- 125000005213 alkyl heteroaryl group Chemical group 0.000 description 1
- 125000003275 alpha amino acid group Chemical group 0.000 description 1
- 150000001370 alpha-amino acid derivatives Chemical class 0.000 description 1
- 150000001414 amino alcohols Chemical class 0.000 description 1
- 230000001548 androgenic effect Effects 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940124599 anti-inflammatory drug Drugs 0.000 description 1
- 125000005129 aryl carbonyl group Chemical group 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 125000005223 heteroarylcarbonyl group Chemical group 0.000 description 1
- 125000005842 heteroatom Chemical group 0.000 description 1
- 230000002519 immonomodulatory effect Effects 0.000 description 1
- 229940124622 immune-modulator drug Drugs 0.000 description 1
- 230000001506 immunosuppresive effect Effects 0.000 description 1
- 229940124589 immunosuppressive drug Drugs 0.000 description 1
- 150000003951 lactams Chemical class 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 210000003200 peritoneal cavity Anatomy 0.000 description 1
- 206010034674 peritonitis Diseases 0.000 description 1
- 125000005936 piperidyl group Chemical class 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 125000004076 pyridyl group Chemical group 0.000 description 1
- 125000005493 quinolyl group Chemical group 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9903546.1 | 1999-02-16 | ||
| GB9903546A GB9903546D0 (en) | 1999-02-16 | 1999-02-16 | Organic compounds |
| GB9927880A GB9927880D0 (en) | 1999-11-25 | 1999-11-25 | Organic compounds |
| GB9927880.6 | 1999-11-25 | ||
| PCT/EP2000/001191 WO2000048989A1 (en) | 1999-02-16 | 2000-02-14 | Mevinolin derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002537284A JP2002537284A (ja) | 2002-11-05 |
| JP2002537284A5 true JP2002537284A5 (enExample) | 2006-01-05 |
| JP4167806B2 JP4167806B2 (ja) | 2008-10-22 |
Family
ID=26315146
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000599730A Expired - Fee Related JP4167806B2 (ja) | 1999-02-16 | 2000-02-14 | メビノリン誘導体 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US20020037895A1 (enExample) |
| EP (1) | EP1154988B1 (enExample) |
| JP (1) | JP4167806B2 (enExample) |
| CN (1) | CN1229335C (enExample) |
| AR (1) | AR022588A1 (enExample) |
| AT (1) | ATE273272T1 (enExample) |
| AU (1) | AU763357B2 (enExample) |
| BR (1) | BR0008292A (enExample) |
| CA (1) | CA2361841C (enExample) |
| CO (1) | CO5140104A1 (enExample) |
| DE (1) | DE60012888T2 (enExample) |
| DK (1) | DK1154988T3 (enExample) |
| ES (1) | ES2226802T3 (enExample) |
| PE (1) | PE20001495A1 (enExample) |
| PT (1) | PT1154988E (enExample) |
| SI (1) | SI1154988T1 (enExample) |
| WO (1) | WO2000048989A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2758037B2 (ja) * | 1989-08-04 | 1998-05-25 | 株式会社アマダ | タレットパンチプレスの金型インデックス装置 |
| US6110922A (en) | 1998-12-29 | 2000-08-29 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds |
| US6867203B2 (en) | 1998-12-29 | 2005-03-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds |
| US6878700B1 (en) | 1998-12-29 | 2005-04-12 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds |
| NZ523445A (en) | 2000-06-29 | 2004-10-29 | Abbott Lab | Aryl phenylheterocyclyl sulfide derivatives and their use as cell adhesion-inhibiting anti-inflammatory and immune-suppressive agents |
| US20020156122A1 (en) * | 2000-09-19 | 2002-10-24 | Novlmmune S.A. | Statins (HMG-CoA reductase inhibitors) as a novel type of immunomodulator, immunosuppressor and anti-inflammatory agent |
| GB0217152D0 (en) * | 2002-07-24 | 2002-09-04 | Novartis Ag | Organic compounds |
| AU2003282510A1 (en) | 2002-10-11 | 2004-05-04 | Bristol-Myers Squibb Company | Hexahydro-benzimidazolone compounds useful as anti-inflammatory agents |
| ATE551339T1 (de) | 2003-11-05 | 2012-04-15 | Sarcode Bioscience Inc | Modulatoren der zellulären adhäsion |
| US7884116B2 (en) * | 2003-12-26 | 2011-02-08 | Nippon Shinyaku Co., Ltd. | Octahydronaphthalene derivative and medicine |
| JP2008507592A (ja) * | 2004-06-09 | 2008-03-13 | ジェネンテック・インコーポレーテッド | 環状肉芽腫又はサルコイドの治療法 |
| EP2583678A3 (en) | 2004-06-24 | 2013-11-13 | Novartis Vaccines and Diagnostics, Inc. | Small molecule immunopotentiators and assays for their detection |
| TW200616634A (en) | 2004-10-01 | 2006-06-01 | Bristol Myers Squibb Co | Crystalline forms and process for preparing spiro-hydantoin compounds |
| US7186727B2 (en) | 2004-12-14 | 2007-03-06 | Bristol-Myers Squibb Company | Pyridyl-substituted spiro-hydantoin compounds and use thereof |
| ES2830024T3 (es) | 2007-10-19 | 2021-06-02 | Novartis Ag | Composiciones y métodos para el tratamiento del edema macular |
| CN102617533B (zh) * | 2011-02-01 | 2014-08-27 | 北京北大维信生物科技有限公司 | 一种从红曲中分离的化合物、其制备方法及用途 |
| WO2016161085A1 (en) | 2015-04-01 | 2016-10-06 | Cedars-Sinai Medical Center | Anti-methanogenic lovastatin analogs or derivatives and uses thereof |
| WO2017038650A1 (ja) * | 2015-08-28 | 2017-03-09 | 積水メディカル株式会社 | ベンジル化合物 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4678806A (en) | 1986-09-02 | 1987-07-07 | Merck & Co., Inc. | Prodrugs of antihypercholesterolemic compounds |
| US4820850A (en) | 1987-07-10 | 1989-04-11 | Merck & Co., Inc. | Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof |
| US5021451A (en) * | 1988-11-14 | 1991-06-04 | Hoffman-La Roche Inc. | Method for inhibiting hyperproliferative diseases |
| EP0415488B1 (en) * | 1989-08-31 | 1994-04-20 | Merck & Co. Inc. | 7-Substituted HMG-COA reductase inhibitors |
| NZ250609A (en) * | 1992-12-28 | 1995-07-26 | Sankyo Co | Hexahydronaphthalene esters and ring closed lactones; preparation and medicaments |
| US5393893A (en) | 1993-11-08 | 1995-02-28 | Apotex, Inc. | Process for producing simvastatin and analogs thereof |
| AU720853B2 (en) * | 1995-11-02 | 2000-06-15 | Warner-Lambert Company | Method and pharmaceutical composition for regulating lipid concentration |
| US5763653A (en) | 1997-03-13 | 1998-06-09 | Ranbaxy Laboratories, Ltd. | Key intermediates in the manufacture of simvastatin |
| US5763646A (en) | 1997-03-13 | 1998-06-09 | Ranbaxy Laboratories, Ltd. | Process for manufacturing simvastatin from lovastatin or mevinolinic acid |
| ES2197465T3 (es) | 1997-01-28 | 2004-01-01 | Plus Chemicals B.V. | Proceso para la produccion de estatinas semisinteticas a traves de nuevos intermedios. |
| PT1007033E (pt) * | 1997-08-28 | 2008-07-22 | Novartis Ag | Antagonistas do antigénio-1 da função de linfócitos |
-
2000
- 2000-02-09 CO CO00008363A patent/CO5140104A1/es unknown
- 2000-02-14 ES ES00916832T patent/ES2226802T3/es not_active Expired - Lifetime
- 2000-02-14 AR ARP000100626A patent/AR022588A1/es unknown
- 2000-02-14 PE PE2000000114A patent/PE20001495A1/es not_active Application Discontinuation
- 2000-02-14 SI SI200030511T patent/SI1154988T1/xx unknown
- 2000-02-14 EP EP00916832A patent/EP1154988B1/en not_active Expired - Lifetime
- 2000-02-14 DE DE60012888T patent/DE60012888T2/de not_active Expired - Fee Related
- 2000-02-14 CN CNB008038171A patent/CN1229335C/zh not_active Expired - Fee Related
- 2000-02-14 PT PT00916832T patent/PT1154988E/pt unknown
- 2000-02-14 JP JP2000599730A patent/JP4167806B2/ja not_active Expired - Fee Related
- 2000-02-14 DK DK00916832T patent/DK1154988T3/da active
- 2000-02-14 AT AT00916832T patent/ATE273272T1/de not_active IP Right Cessation
- 2000-02-14 AU AU38040/00A patent/AU763357B2/en not_active Ceased
- 2000-02-14 BR BR0008292-9A patent/BR0008292A/pt not_active Application Discontinuation
- 2000-02-14 WO PCT/EP2000/001191 patent/WO2000048989A1/en not_active Ceased
- 2000-02-14 CA CA002361841A patent/CA2361841C/en not_active Expired - Fee Related
-
2001
- 2001-08-13 US US09/928,593 patent/US20020037895A1/en not_active Abandoned
-
2002
- 2002-07-11 US US10/192,888 patent/US6818638B2/en not_active Expired - Fee Related
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