AR043210A1 - Compuestos de triazol utiles en terapia - Google Patents

Compuestos de triazol utiles en terapia

Info

Publication number
AR043210A1
AR043210A1 ARP040100495A ARP040100495A AR043210A1 AR 043210 A1 AR043210 A1 AR 043210A1 AR P040100495 A ARP040100495 A AR P040100495A AR P040100495 A ARP040100495 A AR P040100495A AR 043210 A1 AR043210 A1 AR 043210A1
Authority
AR
Argentina
Prior art keywords
alkyl
independently represent
optionally substituted
ring
halogen
Prior art date
Application number
ARP040100495A
Other languages
English (en)
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of AR043210A1 publication Critical patent/AR043210A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Abstract

Un compuesto de fórmula (1) o un derivado farmacéuticamente aceptable del mismo, donde V representa -(CH2)d(O)e-, -CO- o -CH(alquilo C1-6)-; W es -O-, -S(O)a- o -N(R1)-, R1 representa H, alquilo C1-6, -(CH2)bCOR2, CO(CH2)bNR2R3, SO2R2, (CH2)cOR2, (CH2)cNR2R3 o (CH2)bhet1; het1 representa un heterociclo saturado o insaturado de 3 a 8 átomos que contiene uno o más heteroátomos seleccionados entre O, N o S, opcionalmente sustituido con alquilo C1-6; X e Y representan independientemente H, alquilo C1-6, halógeno, OH, CF3, OCF3, OR4; Z representa -(CH2)f(O)g-, -CO- o -CH(alquilo C1-6)-; El anillo A representa un heterociclo saturado que contiene N de 4-7 miembros, opcionalmente sustituido con OH y en el que opcionalmente al menos un N de anillo está sustituido con O; El anillo B representa fenilo o un heterociclo insaturado que contiene N de 4-7 miembros, opcionalmente sustituido con OH, halógeno, CN, CONH2, CF3, OCF3 y en el que opcionalmente al menos un N de anillo está sustituido con O; R2 y R3 representan independientemente H, alquilo C1-6 [opcionalmente sustituido con OH, halógeno, N(alquilo C1-6)2 o alquiloxi C1-6], alquiloxi C1-6, N(alquilo C1-6)2 o [cicloalquilo C3-8]; o R2 y R3, junto con el átomo de N al que están unidos, representan independientemente un heterociclo de 3 a 8 átomos, opcionalmente sustituido con alquilo C1-6; R4 representa alquilo C1-6 lineal o ramificado, a y c representan independientemente 0, 1 o 2; b, e y g representan independientemente 0 o 1; y d y f representan independientemente 1 o 2; son útiles en el tratamiento de la dismenorrea. Procedimientos para la preparación del compuesto, intermediarios y formulación farmacéutica.
ARP040100495A 2003-02-19 2004-02-18 Compuestos de triazol utiles en terapia AR043210A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0303852.8A GB0303852D0 (en) 2003-02-19 2003-02-19 Triazole compounds useful in therapy

Publications (1)

Publication Number Publication Date
AR043210A1 true AR043210A1 (es) 2005-07-20

Family

ID=9953327

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040100495A AR043210A1 (es) 2003-02-19 2004-02-18 Compuestos de triazol utiles en terapia

Country Status (11)

Country Link
CN (1) CN1751047A (es)
AR (1) AR043210A1 (es)
CL (1) CL2004000293A1 (es)
GB (1) GB0303852D0 (es)
GT (1) GT200400020A (es)
NL (1) NL1025527C2 (es)
PA (1) PA8596101A1 (es)
PE (1) PE20050222A1 (es)
TW (1) TW200500367A (es)
UY (1) UY28201A1 (es)
WO (1) WO2004074291A1 (es)

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US8420633B2 (en) * 2010-03-31 2013-04-16 Hoffmann-La Roche Inc. Aryl-cyclohexyl-tetraazabenzo[e]azulenes
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US8492376B2 (en) * 2010-04-21 2013-07-23 Hoffmann-La Roche Inc. Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes
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EA036630B1 (ru) 2012-09-25 2020-12-02 Ф. Хоффманн-Ля Рош Аг Бициклические производные
AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
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Also Published As

Publication number Publication date
CN1751047A (zh) 2006-03-22
NL1025527C2 (nl) 2005-03-14
WO2004074291A1 (en) 2004-09-02
GT200400020A (es) 2004-09-21
NL1025527A1 (nl) 2004-08-23
UY28201A1 (es) 2004-09-30
PE20050222A1 (es) 2005-04-13
PA8596101A1 (es) 2005-08-04
CL2004000293A1 (es) 2005-01-07
GB0303852D0 (en) 2003-03-26
TW200500367A (en) 2005-01-01

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