AR043210A1 - USEFUL TRIAZOL COMPOUNDS IN THERAPY - Google Patents
USEFUL TRIAZOL COMPOUNDS IN THERAPYInfo
- Publication number
- AR043210A1 AR043210A1 ARP040100495A ARP040100495A AR043210A1 AR 043210 A1 AR043210 A1 AR 043210A1 AR P040100495 A ARP040100495 A AR P040100495A AR P040100495 A ARP040100495 A AR P040100495A AR 043210 A1 AR043210 A1 AR 043210A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- independently represent
- optionally substituted
- ring
- halogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un compuesto de fórmula (1) o un derivado farmacéuticamente aceptable del mismo, donde V representa -(CH2)d(O)e-, -CO- o -CH(alquilo C1-6)-; W es -O-, -S(O)a- o -N(R1)-, R1 representa H, alquilo C1-6, -(CH2)bCOR2, CO(CH2)bNR2R3, SO2R2, (CH2)cOR2, (CH2)cNR2R3 o (CH2)bhet1; het1 representa un heterociclo saturado o insaturado de 3 a 8 átomos que contiene uno o más heteroátomos seleccionados entre O, N o S, opcionalmente sustituido con alquilo C1-6; X e Y representan independientemente H, alquilo C1-6, halógeno, OH, CF3, OCF3, OR4; Z representa -(CH2)f(O)g-, -CO- o -CH(alquilo C1-6)-; El anillo A representa un heterociclo saturado que contiene N de 4-7 miembros, opcionalmente sustituido con OH y en el que opcionalmente al menos un N de anillo está sustituido con O; El anillo B representa fenilo o un heterociclo insaturado que contiene N de 4-7 miembros, opcionalmente sustituido con OH, halógeno, CN, CONH2, CF3, OCF3 y en el que opcionalmente al menos un N de anillo está sustituido con O; R2 y R3 representan independientemente H, alquilo C1-6 [opcionalmente sustituido con OH, halógeno, N(alquilo C1-6)2 o alquiloxi C1-6], alquiloxi C1-6, N(alquilo C1-6)2 o [cicloalquilo C3-8]; o R2 y R3, junto con el átomo de N al que están unidos, representan independientemente un heterociclo de 3 a 8 átomos, opcionalmente sustituido con alquilo C1-6; R4 representa alquilo C1-6 lineal o ramificado, a y c representan independientemente 0, 1 o 2; b, e y g representan independientemente 0 o 1; y d y f representan independientemente 1 o 2; son útiles en el tratamiento de la dismenorrea. Procedimientos para la preparación del compuesto, intermediarios y formulación farmacéutica.A compound of formula (1) or a pharmaceutically acceptable derivative thereof, wherein V represents - (CH2) d (O) e-, -CO- or -CH (C1-6 alkyl) -; W is -O-, -S (O) a- or -N (R1) -, R1 represents H, C1-6 alkyl, - (CH2) bCOR2, CO (CH2) bNR2R3, SO2R2, (CH2) cOR2, ( CH2) cNR2R3 or (CH2) bhet1; het1 represents a saturated or unsaturated heterocycle of 3 to 8 atoms containing one or more heteroatoms selected from O, N or S, optionally substituted with C1-6 alkyl; X and Y independently represent H, C1-6 alkyl, halogen, OH, CF3, OCF3, OR4; Z represents - (CH2) f (O) g-, -CO- or -CH (C1-6 alkyl) -; Ring A represents a saturated heterocycle containing 4-7 membered N, optionally substituted with OH and wherein optionally at least one ring N is substituted with O; Ring B represents phenyl or an unsaturated heterocycle containing 4-7 membered N, optionally substituted with OH, halogen, CN, CONH2, CF3, OCF3 and in which optionally at least one ring N is substituted with O; R2 and R3 independently represent H, C1-6 alkyl [optionally substituted with OH, halogen, N (C1-6 alkyl) 2 or C1-6 alkyloxy], C1-6 alkyloxy, N (C1-6 alkyl) 2 or [cycloalkyl C3-8]; or R2 and R3, together with the N atom to which they are attached, independently represent a heterocycle of 3 to 8 atoms, optionally substituted with C1-6 alkyl; R4 represents linear or branched C1-6 alkyl, a and c independently represent 0, 1 or 2; b, e and g independently represent 0 or 1; and d and f independently represent 1 or 2; They are useful in the treatment of dysmenorrhea. Procedures for the preparation of the compound, intermediates and pharmaceutical formulation.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0303852.8A GB0303852D0 (en) | 2003-02-19 | 2003-02-19 | Triazole compounds useful in therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR043210A1 true AR043210A1 (en) | 2005-07-20 |
Family
ID=9953327
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040100495A AR043210A1 (en) | 2003-02-19 | 2004-02-18 | USEFUL TRIAZOL COMPOUNDS IN THERAPY |
Country Status (11)
| Country | Link |
|---|---|
| CN (1) | CN1751047A (en) |
| AR (1) | AR043210A1 (en) |
| CL (1) | CL2004000293A1 (en) |
| GB (1) | GB0303852D0 (en) |
| GT (1) | GT200400020A (en) |
| NL (1) | NL1025527C2 (en) |
| PA (1) | PA8596101A1 (en) |
| PE (1) | PE20050222A1 (en) |
| TW (1) | TW200500367A (en) |
| UY (1) | UY28201A1 (en) |
| WO (1) | WO2004074291A1 (en) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0325021D0 (en) * | 2003-10-27 | 2003-12-03 | Pfizer Ltd | Therapeutic combinations |
| US7745630B2 (en) | 2003-12-22 | 2010-06-29 | Justin Stephen Bryans | Triazolyl piperidine arginine vasopressin receptor modulators |
| DE102004001871A1 (en) * | 2004-01-14 | 2005-09-01 | Bayer Healthcare Ag | Tricyclic benzazepine derivatives and their use |
| MX2007002248A (en) * | 2004-08-25 | 2008-10-02 | Pfizer | Triazolobenzodiazepines and their use as vasopressin antagonists. |
| EP1877399A1 (en) * | 2005-04-26 | 2008-01-16 | Pfizer Limited | Triazole derivatives as vasopressin antagonists |
| MX2011004575A (en) | 2008-11-13 | 2011-06-01 | Hoffmann La Roche | Spiro-5,6-dihydro-4h-2,3,5,10b-tetraaza-benzo[e]azulenes. |
| JP5384659B2 (en) * | 2008-11-18 | 2014-01-08 | エフ．ホフマン−ラ ロシュ アーゲー | Alkylcyclohexyl ether of dihydrotetraazabenzoazulene |
| MY150837A (en) | 2008-11-28 | 2014-02-28 | Hoffmann La Roche | Arylcyclohexylethers of dihydrotetraazabenzoazulenes for use as vasopressin via receptor antagonists |
| EP2414361A1 (en) | 2009-03-31 | 2012-02-08 | ArQule, Inc. | Substituted heterocyclic compounds |
| JP2013510834A (en) * | 2009-11-16 | 2013-03-28 | メリテク | [1,5] -diazocine derivatives |
| US8420633B2 (en) | 2010-03-31 | 2013-04-16 | Hoffmann-La Roche Inc. | Aryl-cyclohexyl-tetraazabenzo[e]azulenes |
| US8461151B2 (en) | 2010-04-13 | 2013-06-11 | Hoffmann-La Roche Inc. | Aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes |
| US8492376B2 (en) * | 2010-04-21 | 2013-07-23 | Hoffmann-La Roche Inc. | Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes |
| US8481528B2 (en) * | 2010-04-26 | 2013-07-09 | Hoffmann-La Roche Inc. | Heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes |
| US8513238B2 (en) * | 2010-05-10 | 2013-08-20 | Hoffmann-La Roche Inc. | Heteroaryl-cyclohexyl-tetraazabenzo[E]azulenes |
| US9006450B2 (en) * | 2010-07-01 | 2015-04-14 | Boehringer Ingelheim International Gmbh | Compounds, pharmaceutical compositions and uses thereof |
| TW201242956A (en) | 2010-10-07 | 2012-11-01 | Takeda Pharmaceutical | Heterocyclic compounds |
| RU2011122942A (en) | 2011-06-08 | 2012-12-20 | Общество С Ограниченной Ответственностью "Асинэкс Медхим" | NEW KINAZ INHIBITORS |
| US8828989B2 (en) * | 2011-09-26 | 2014-09-09 | Hoffmann-La Roche Inc. | Oxy-cyclohexyl-4H,6H-5-oxa-2,3,10b-triaza-benzo[E]azulenes as V1A antagonists |
| BR112014007851A2 (en) | 2011-10-05 | 2017-04-18 | Hoffmann La Roche | cyclohexyl-4h, 6h-oxa-2,3,10b-triaza-benzo [e] azulenes as v1a antagonists |
| HUE030526T2 (en) | 2012-06-13 | 2017-05-29 | Hoffmann La Roche | New diazaspirocycloalkane and azaspirocycloalkane |
| CN102766674A (en) * | 2012-07-25 | 2012-11-07 | 辉源生物科技（上海）有限公司 | Establishment of screening platform for cynomolgus monkey antidiuretic hormone receptor V1A antagonist |
| SG11201500572YA (en) | 2012-09-25 | 2015-02-27 | Hoffmann La Roche | New bicyclic derivatives |
| AR095079A1 (en) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | DERIVATIVES OF OCTAHIDRO-PIRROLO [3,4-C] -PIRROL AND PIRIDINA-FENILO |
| EA201690179A1 (en) | 2013-08-19 | 2016-06-30 | Ф. Хоффманн-Ля Рош Аг | V1A RECEPTOR ANTAGONISTS FOR TREATMENT OF DISORDERS ASSOCIATED WITH SHEEP PHASE SHIFT |
| EA201691044A1 (en) | 2013-11-26 | 2016-09-30 | Ф. Хоффманн-Ля Рош Аг | NEW OCTAGIDRO-CYCLOBUT [1,2-C; 3,4-C '] DIPIRROL-2-IL |
| PL3077396T3 (en) | 2013-12-05 | 2021-10-04 | F. Hoffmann-La Roche Ag | Synthesis of trans-8-chloro-5-methyl-1 -[4-(pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4h-2,3,5,10b-tetraaza-benzo[e]azulene and crytalline forms thereof |
| UA119347C2 (en) | 2014-03-26 | 2019-06-10 | Ф. Хоффманн-Ля Рош Аг | Condensed [1,4]diazepine compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors |
| LT3122750T (en) | 2014-03-26 | 2019-11-11 | Hoffmann La Roche | Bicyclic compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors |
| MA41898A (en) | 2015-04-10 | 2018-02-13 | Hoffmann La Roche | BICYCLIC QUINAZOLINONE DERIVATIVES |
| CN108026077B (en) | 2015-09-04 | 2021-11-05 | 豪夫迈·罗氏有限公司 | Phenoxymethyl derivatives |
| CR20180143A (en) | 2015-09-24 | 2018-05-03 | Hoffmann La Roche | NEW BICYCLE COMPOUNDS AS DUAL INHIBITORS OF ATX / CA |
| KR20180054635A (en) | 2015-09-24 | 2018-05-24 | 에프. 호프만-라 로슈 아게 | As an autotaxin (ATX) inhibitor, |
| RU2724899C2 (en) | 2015-09-24 | 2020-06-26 | Ф. Хоффманн-Ля Рош Аг | New bicyclic compounds as dual inhibitors of atx/ca |
| MA42918A (en) | 2015-09-24 | 2018-08-01 | Hoffmann La Roche | BICYCLIC COMPOUNDS USED AS ATX INHIBITORS |
| KR20190129924A (en) | 2017-03-16 | 2019-11-20 | 에프. 호프만-라 로슈 아게 | Heterocyclic Compounds Useful as Dual Autotaxin (ATX) / Carbon Anhydrase (CA) Inhibitors |
| EP3596060B1 (en) | 2017-03-16 | 2023-09-20 | F. Hoffmann-La Roche AG | New bicyclic compounds as atx inhibitors |
| US11186577B2 (en) * | 2017-06-05 | 2021-11-30 | Blackthorn Therapeutics, Inc. | Vasopressin receptor antagonists and products and methods related thereto |
| TW201938171A (en) | 2017-12-15 | 2019-10-01 | 匈牙利商羅特格登公司 | Tricyclic compounds as vasopressin V1a receptor antagonists |
| HU231206B1 (en) * | 2017-12-15 | 2021-10-28 | Richter Gedeon Nyrt. | Triazolobenzazepines |
| CN111170983B (en) * | 2019-12-26 | 2021-07-09 | 中国农业大学 | Benzylthio acetamide compound and preparation method and application thereof |
| TWI804119B (en) * | 2020-12-21 | 2023-06-01 | 大陸商上海濟煜醫藥科技有限公司 | Derivative of triazole fused three rings, manufacturing method and use thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8823475D0 (en) * | 1988-10-06 | 1988-11-16 | Merck Sharp & Dohme | Chemical compounds |
| US5438035A (en) * | 1994-06-24 | 1995-08-01 | American Cyanamid Company | Methods for controlling undesirable plant species with benzodiazepine compounds |
| US5753648A (en) * | 1995-01-17 | 1998-05-19 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
| EP1021444B1 (en) * | 1996-11-01 | 2003-09-24 | Wyeth | 3-CARBOXAMIDE DERIVATIVES OF 5H-PYRROLO[2,1-c][1,4]-BENZODIAZEPINES |
| AU772397B2 (en) * | 1999-01-19 | 2004-04-29 | Ortho-Mcneil Pharmaceutical, Inc. | Tricyclic benzodiazepines as vasopressin receptor antagonists |
| US7109193B2 (en) * | 2001-04-12 | 2006-09-19 | Wyeth | Tricyclic diazepines tocolytic oxytocin receptor antagonists |
-
2003
- 2003-02-19 GB GBGB0303852.8A patent/GB0303852D0/en not_active Ceased
-
2004
- 2004-02-09 WO PCT/IB2004/000432 patent/WO2004074291A1/en active IP Right Grant
- 2004-02-09 CN CNA2004800047089A patent/CN1751047A/en active Pending
- 2004-02-17 PE PE2004000165A patent/PE20050222A1/en not_active Application Discontinuation
- 2004-02-18 CL CL200400293A patent/CL2004000293A1/en unknown
- 2004-02-18 TW TW093103978A patent/TW200500367A/en unknown
- 2004-02-18 GT GT200400020A patent/GT200400020A/en unknown
- 2004-02-18 AR ARP040100495A patent/AR043210A1/en not_active Application Discontinuation
- 2004-02-18 PA PA20048596101A patent/PA8596101A1/en unknown
- 2004-02-19 UY UY28201A patent/UY28201A1/en unknown
- 2004-02-19 NL NL1025527A patent/NL1025527C2/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PE20050222A1 (en) | 2005-04-13 |
| GT200400020A (en) | 2004-09-21 |
| PA8596101A1 (en) | 2005-08-04 |
| WO2004074291A1 (en) | 2004-09-02 |
| CL2004000293A1 (en) | 2005-01-07 |
| NL1025527C2 (en) | 2005-03-14 |
| CN1751047A (en) | 2006-03-22 |
| UY28201A1 (en) | 2004-09-30 |
| GB0303852D0 (en) | 2003-03-26 |
| NL1025527A1 (en) | 2004-08-23 |
| TW200500367A (en) | 2005-01-01 |
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| Date | Code | Title | Description |
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| FA | Abandonment or withdrawal |