JP2002536387A - 持続的放出生体接着膣投与剤 - Google Patents
持続的放出生体接着膣投与剤Info
- Publication number
- JP2002536387A JP2002536387A JP2000598098A JP2000598098A JP2002536387A JP 2002536387 A JP2002536387 A JP 2002536387A JP 2000598098 A JP2000598098 A JP 2000598098A JP 2000598098 A JP2000598098 A JP 2000598098A JP 2002536387 A JP2002536387 A JP 2002536387A
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- acrylic acid
- pph
- therapeutic agent
- agarose
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- MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 description 1
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/250,123 | 1999-02-12 | ||
| US09/250,123 US6159491A (en) | 1999-02-12 | 1999-02-12 | Prolonged release bioadhesive vaginal gel dosage form |
| PCT/US2000/003237 WO2000047144A1 (en) | 1999-02-12 | 2000-02-08 | Prolonged release bioadhesive vaginal gel dosage form |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002536387A true JP2002536387A (ja) | 2002-10-29 |
| JP2002536387A5 JP2002536387A5 (enExample) | 2007-04-05 |
Family
ID=22946381
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000598098A Pending JP2002536387A (ja) | 1999-02-12 | 2000-02-08 | 持続的放出生体接着膣投与剤 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6159491A (enExample) |
| EP (1) | EP1150630A4 (enExample) |
| JP (1) | JP2002536387A (enExample) |
| KR (1) | KR20010102088A (enExample) |
| CN (1) | CN1222279C (enExample) |
| AU (1) | AU762677B2 (enExample) |
| BR (1) | BR0008137A (enExample) |
| CA (1) | CA2362561A1 (enExample) |
| HK (1) | HK1045934B (enExample) |
| MX (1) | MXPA01008093A (enExample) |
| WO (1) | WO2000047144A1 (enExample) |
| ZA (1) | ZA200106640B (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008513771A (ja) * | 2004-09-22 | 2008-05-01 | ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ | クロマトグラフィーマトリックスの製造方法 |
| JP2008517043A (ja) * | 2004-10-20 | 2008-05-22 | インターファーム ディベロップメント エスエー | 放出プログラム化によるバイオ接着剤組成 |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040234606A1 (en) * | 1997-09-12 | 2004-11-25 | Levine Howard L. | Localized vaginal delivery without detrimental blood levels |
| US7022683B1 (en) | 1998-05-13 | 2006-04-04 | Carrington Laboratories, Inc. | Pharmacological compositions comprising pectins having high molecular weights and low degrees of methoxylation |
| US6544555B2 (en) | 2000-02-24 | 2003-04-08 | Advancis Pharmaceutical Corp. | Antibiotic product, use and formulation thereof |
| US6565882B2 (en) | 2000-02-24 | 2003-05-20 | Advancis Pharmaceutical Corp | Antibiotic composition with inhibitor |
| US6835717B2 (en) * | 2000-03-08 | 2004-12-28 | The Johns Hopkins University School Of Medicine | β-cyclodextrin compositions, and use to prevent transmission of sexually transmitted diseases |
| WO2002020663A2 (en) | 2000-09-06 | 2002-03-14 | Ap Pharma, Inc. | Degradable polyacetal polymers |
| GB2366794A (en) * | 2000-09-13 | 2002-03-20 | Procter & Gamble | Process for making a foam component |
| US6541014B2 (en) | 2000-10-13 | 2003-04-01 | Advancis Pharmaceutical Corp. | Antiviral product, use and formulation thereof |
| US20020068078A1 (en) | 2000-10-13 | 2002-06-06 | Rudnic Edward M. | Antifungal product, use and formulation thereof |
| EP1343492B1 (en) * | 2000-11-22 | 2006-02-01 | Rxkinetix, Inc. | Treatment of mucositis |
| US20020197314A1 (en) * | 2001-02-23 | 2002-12-26 | Rudnic Edward M. | Anti-fungal composition |
| US6777000B2 (en) | 2001-02-28 | 2004-08-17 | Carrington Laboratories, Inc. | In-situ gel formation of pectin |
| US7494669B2 (en) | 2001-02-28 | 2009-02-24 | Carrington Laboratories, Inc. | Delivery of physiological agents with in-situ gels comprising anionic polysaccharides |
| US6590059B2 (en) | 2001-05-11 | 2003-07-08 | Ap Pharma, Inc. | Bioerodible polyorthoesters from dioxolane-based diketene acetals |
| US20080182841A1 (en) * | 2001-10-29 | 2008-07-31 | Levine Howard L | Vaginally administered anti-dysrhythmic agents for treating pelvic pain |
| US8425892B2 (en) * | 2001-10-29 | 2013-04-23 | Columbia Laboratories, Inc. | Extended, controlled-release pharmaceutical compositions using charged polymers |
| US7709026B2 (en) * | 2001-10-29 | 2010-05-04 | Columbia Laboratories, Inc. | Low concentration of peroxide for treating or preventing vaginal infections |
| US6524606B1 (en) | 2001-11-16 | 2003-02-25 | Ap Pharma, Inc. | Bioerodible polyorthoesters containing amine groups |
| AR039540A1 (es) * | 2002-05-13 | 2005-02-23 | Tibotec Pharm Ltd | Compuestos microbicidas con contenido de pirimidina o triazina |
| AU2003286796A1 (en) * | 2002-10-31 | 2004-06-07 | Umd, Inc. | Therapeutic compositions for drug delivery to and through covering epithelia |
| JP4898431B2 (ja) * | 2003-04-29 | 2012-03-14 | ザ ジェネラル ホスピタル コーポレイション | 複数薬物の持続放出のための方法およびデバイス |
| RU2236851C1 (ru) * | 2003-06-16 | 2004-09-27 | Красноярская государственная медицинская академия | Способ местного лечения бактериального вагиноза |
| ES2237298B1 (es) | 2003-07-16 | 2006-11-01 | Italfarmaco, S.A. | Formulaciones mucoadhesivas semisolidas. |
| CA2533358C (en) | 2003-07-21 | 2014-03-11 | Advancis Pharmaceutical Corporation | Antibiotic product, use and formulation thereof |
| WO2005009365A2 (en) | 2003-07-21 | 2005-02-03 | Advancis Pharmaceutical Corporation | Antibiotic product, use and formulation thereof |
| WO2005009368A2 (en) | 2003-07-21 | 2005-02-03 | Advancis Pharmaceutical Corporation | Antibiotic product, use and formulation thereof |
| ITMI20031640A1 (it) | 2003-08-08 | 2005-02-09 | Mipharm S P A | Base per gel bioadesivi. |
| JP2007502296A (ja) | 2003-08-11 | 2007-02-08 | アドバンシス ファーマスーティカル コーポレイション | ロバストペレット |
| US8062672B2 (en) | 2003-08-12 | 2011-11-22 | Shionogi Inc. | Antibiotic product, use and formulation thereof |
| AU2004270170B2 (en) | 2003-08-29 | 2011-01-27 | Shionogi, Inc. | Antibiotic product, use and formulation thereof |
| WO2005027877A1 (en) | 2003-09-15 | 2005-03-31 | Advancis Pharmaceutical Corporation | Antibiotic product, use and formulation thereof |
| US20050202038A1 (en) * | 2004-03-10 | 2005-09-15 | Green Roger E. | Composition and method for minimizing residual fecal matter in the perianal area |
| US7276486B2 (en) * | 2004-03-15 | 2007-10-02 | Kimberly-Clark Worldwide, Inc. | Compositions for vaginal treatment |
| WO2006014427A1 (en) | 2004-07-02 | 2006-02-09 | Advancis Pharmaceutical Corporation | Tablet for pulsed delivery |
| AU2012200105B2 (en) * | 2004-10-20 | 2014-11-20 | Care & Pharma Perspectives Sa | Bioadhesive composition with programmed release |
| US20060106117A1 (en) * | 2004-11-12 | 2006-05-18 | Kimberly-Clark Worldwide, Inc. | Compound and method for prevention and/or treatment of vaginal infections |
| US7619008B2 (en) * | 2004-11-12 | 2009-11-17 | Kimberly-Clark Worldwide, Inc. | Xylitol for treatment of vaginal infections |
| US20060292102A1 (en) * | 2004-12-10 | 2006-12-28 | Roman Stephen B | Thixotropic personal lubricant |
| CN1302764C (zh) * | 2005-01-10 | 2007-03-07 | 凌沛学 | 一种妇科用药阴道凝胶片 |
| US20060223765A1 (en) * | 2005-03-30 | 2006-10-05 | Kimberly-Clark Worldwide, Inc. | Method for inhibiting and/or treating vaginal infection |
| US7786176B2 (en) * | 2005-07-29 | 2010-08-31 | Kimberly-Clark Worldwide, Inc. | Vaginal treatment composition containing xylitol |
| AU2006320538B2 (en) * | 2005-11-30 | 2013-07-04 | Endo Pharmaceuticals Inc. | Treatment of xerostomia with a sulfur-containing antioxidant |
| US8778924B2 (en) | 2006-12-04 | 2014-07-15 | Shionogi Inc. | Modified release amoxicillin products |
| US8357394B2 (en) | 2005-12-08 | 2013-01-22 | Shionogi Inc. | Compositions and methods for improved efficacy of penicillin-type antibiotics |
| US8399012B2 (en) | 2006-04-17 | 2013-03-19 | Kimberly-Clark Worldwide, Inc. | Degradable therapeutic delivery device |
| US8299052B2 (en) | 2006-05-05 | 2012-10-30 | Shionogi Inc. | Pharmaceutical compositions and methods for improved bacterial eradication |
| US9314524B2 (en) * | 2007-12-31 | 2016-04-19 | Calla Therapeutics Llc | Topical formulations of Flucytosine |
| US11058699B2 (en) * | 2008-07-01 | 2021-07-13 | Wisconsin Alumni Research Foundation | Method and compositions for inhibition of double stranded DNA viruses |
| ES2344673B1 (es) | 2008-08-07 | 2011-05-03 | Italfarmaco, S.A. | Uso de estriol en la preparacion de una formulacion farmaceutica parael tratamiento de atrofia vaginal en mujeres con riesgo de potologiatumoral. |
| ES2344675B1 (es) | 2008-12-19 | 2011-04-28 | Italfarmaco, S.A. | Uso de estriol en la preparacion de una formulacion farrmaceutica para el tratamiento de atrofia vaginal en mujeres con riesgo de patologiacardiovascular. |
| MX2013012745A (es) * | 2011-05-02 | 2014-12-05 | Aptalis Pharmatech Inc | Composiciones en forma de comprmido de disolución rápida para administración vaginal. |
| US9301921B2 (en) * | 2012-04-05 | 2016-04-05 | Gavis Pharmaceuticals, Llc | Laxative gel composition |
| US10835598B2 (en) * | 2014-08-18 | 2020-11-17 | Orgenesis Inc. | Prophylactic protection against viral infections, particularly HIV |
| US9642794B2 (en) * | 2014-08-18 | 2017-05-09 | Tamir Biotechnology, Inc. | Antiviral pharmaceutical for topical administration |
| EP3442501A1 (en) | 2016-04-15 | 2019-02-20 | Fairhaven Health, LLC | Compositions and methods for maintaining or enhancing homeostasis or function of female lower reproductive tract |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4226848A (en) * | 1979-03-05 | 1980-10-07 | Teijin Limited | Method and preparation for administration to the mucosa of the oral or nasal cavity |
| US4983393A (en) * | 1987-07-21 | 1991-01-08 | Maximed Corporation | Intra-vaginal device and method for sustained drug release |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3865108A (en) * | 1971-05-17 | 1975-02-11 | Ortho Pharma Corp | Expandable drug delivery device |
| US4983392A (en) * | 1983-11-14 | 1991-01-08 | Bio-Mimetics, Inc. | Bioadhesive compositions and methods of treatment therewith |
| US5225196A (en) * | 1983-11-14 | 1993-07-06 | Columbia Laboratories, Inc. | Bioadhesive compositions and methods of treatment therewith |
| US4795436A (en) * | 1983-11-14 | 1989-01-03 | Bio-Mimetics, Inc. | Bioadhesive composition and method of treatment therewith |
| EP0501523B1 (en) * | 1983-11-14 | 1997-04-09 | Columbia Laboratories, Inc. | Bioadhesive compositions |
| US4707362A (en) * | 1985-02-15 | 1987-11-17 | Biotek, Inc. | Sustained release composition |
| PL149493B1 (en) * | 1985-04-12 | 1990-02-28 | Method of obtaining a tablet capable to buoy over surface of gastric juice | |
| IT1183574B (it) * | 1985-05-08 | 1987-10-22 | Eurand Spa | Metodo per ottenere una sospensione estemporanea omogenea di microcapsule |
| GB8520664D0 (en) * | 1985-08-17 | 1985-09-25 | Euro Celtique Sa | Suppository |
| US4708834A (en) * | 1986-05-01 | 1987-11-24 | Pharmacaps, Inc. | Preparation of gelatin-encapsulated controlled release composition |
| US5624675A (en) * | 1989-06-06 | 1997-04-29 | Kelly; Patrick D. | Genital lubricants containing zinc salts to reduce risk of HIV infection |
| FI920856A0 (fi) * | 1989-08-28 | 1992-02-26 | Pharmaceutical Delivery System | Bioeroderbar polymerer foer kontrollerad frigoerelse av terapeutiska aemnen. |
| EP0431719B1 (en) * | 1989-10-31 | 1994-11-09 | Columbia Laboratories, Inc. | Vaginal tissue moisturizing composition |
| IT1243390B (it) * | 1990-11-22 | 1994-06-10 | Vectorpharma Int | Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione. |
| IT1250421B (it) * | 1991-05-30 | 1995-04-07 | Recordati Chem Pharm | Composizione farmaceutica a rilascio controllato con proprieta' bio-adesive. |
| US5318780A (en) * | 1991-10-30 | 1994-06-07 | Mediventures Inc. | Medical uses of in situ formed gels |
| US5472711A (en) * | 1992-07-30 | 1995-12-05 | Edward Mendell Co., Inc. | Agglomerated hydrophilic complexes with multi-phasic release characteristics |
| FI933979A0 (fi) * | 1992-09-10 | 1993-09-10 | Mcneil Ppc Inc | Bioeroderbar anordning foer dosering av aktiva ingredienser |
| US5330761A (en) * | 1993-01-29 | 1994-07-19 | Edward Mendell Co. Inc. | Bioadhesive tablet for non-systemic use products |
| US5455046A (en) * | 1993-09-09 | 1995-10-03 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems for insoluble drugs |
| FR2710265B1 (fr) * | 1993-09-22 | 1995-10-20 | Adir | Composition pharmaceutique bioadhésive pour la libération contrôlée de principes actifs. |
| GB9414699D0 (en) * | 1994-07-21 | 1994-09-07 | Slagel David | Aqueous foamable composition |
| US5667492A (en) * | 1994-10-07 | 1997-09-16 | Columbia Laboratories, Inc. | Use and composition of an anti-sexually transmitted diseases formulation |
| US5612052A (en) * | 1995-04-13 | 1997-03-18 | Poly-Med, Inc. | Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof |
| US5783212A (en) * | 1996-02-02 | 1998-07-21 | Temple University--of the Commonwealth System of Higher Education | Controlled release drug delivery system |
| US5817343A (en) * | 1996-05-14 | 1998-10-06 | Alkermes, Inc. | Method for fabricating polymer-based controlled-release devices |
| AU5782500A (en) * | 1999-07-06 | 2001-01-22 | Procter & Gamble Company, The | Pre-formed, self-adhesive sheet devices suitable for topical application |
-
1999
- 1999-02-12 US US09/250,123 patent/US6159491A/en not_active Expired - Fee Related
-
2000
- 2000-02-08 KR KR1020017010221A patent/KR20010102088A/ko not_active Ceased
- 2000-02-08 MX MXPA01008093A patent/MXPA01008093A/es not_active IP Right Cessation
- 2000-02-08 WO PCT/US2000/003237 patent/WO2000047144A1/en not_active Ceased
- 2000-02-08 CN CNB008059098A patent/CN1222279C/zh not_active Expired - Fee Related
- 2000-02-08 JP JP2000598098A patent/JP2002536387A/ja active Pending
- 2000-02-08 HK HK02107566.7A patent/HK1045934B/zh not_active IP Right Cessation
- 2000-02-08 EP EP00911730A patent/EP1150630A4/en not_active Withdrawn
- 2000-02-08 AU AU33581/00A patent/AU762677B2/en not_active Ceased
- 2000-02-08 BR BR0008137-0A patent/BR0008137A/pt not_active IP Right Cessation
- 2000-02-08 CA CA002362561A patent/CA2362561A1/en not_active Abandoned
-
2001
- 2001-08-13 ZA ZA200106640A patent/ZA200106640B/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4226848A (en) * | 1979-03-05 | 1980-10-07 | Teijin Limited | Method and preparation for administration to the mucosa of the oral or nasal cavity |
| US4983393A (en) * | 1987-07-21 | 1991-01-08 | Maximed Corporation | Intra-vaginal device and method for sustained drug release |
| US5069906A (en) * | 1987-07-21 | 1991-12-03 | Maximed Corporation | Intra-vaginal device and method |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008513771A (ja) * | 2004-09-22 | 2008-05-01 | ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ | クロマトグラフィーマトリックスの製造方法 |
| JP2008517043A (ja) * | 2004-10-20 | 2008-05-22 | インターファーム ディベロップメント エスエー | 放出プログラム化によるバイオ接着剤組成 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1222279C (zh) | 2005-10-12 |
| WO2000047144A1 (en) | 2000-08-17 |
| EP1150630A4 (en) | 2002-06-05 |
| HK1045934A1 (en) | 2002-12-20 |
| US6159491A (en) | 2000-12-12 |
| HK1045934B (zh) | 2006-07-14 |
| AU762677B2 (en) | 2003-07-03 |
| KR20010102088A (ko) | 2001-11-15 |
| CN1346252A (zh) | 2002-04-24 |
| AU3358100A (en) | 2000-08-29 |
| BR0008137A (pt) | 2003-06-10 |
| CA2362561A1 (en) | 2000-08-17 |
| MXPA01008093A (es) | 2003-07-21 |
| ZA200106640B (en) | 2002-10-14 |
| EP1150630A1 (en) | 2001-11-07 |
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