JP2002536369A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2002536369A5 JP2002536369A5 JP2000597284A JP2000597284A JP2002536369A5 JP 2002536369 A5 JP2002536369 A5 JP 2002536369A5 JP 2000597284 A JP2000597284 A JP 2000597284A JP 2000597284 A JP2000597284 A JP 2000597284A JP 2002536369 A5 JP2002536369 A5 JP 2002536369A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- phenyl
- substituted
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 20
- 125000001424 substituent group Chemical group 0.000 description 15
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 description 13
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 10
- 150000003839 salts Chemical class 0.000 description 10
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 9
- 150000001875 compounds Chemical class 0.000 description 9
- 125000001624 naphthyl group Chemical group 0.000 description 9
- 125000003118 aryl group Chemical group 0.000 description 8
- 229910052739 hydrogen Inorganic materials 0.000 description 7
- 239000001257 hydrogen Substances 0.000 description 7
- -1 hydroxy, amino Chemical group 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 5
- 229920001577 copolymer Chemical group 0.000 description 5
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 5
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 description 4
- 125000005842 heteroatom Chemical group 0.000 description 4
- 229910052757 nitrogen Inorganic materials 0.000 description 4
- 125000004433 nitrogen atom Chemical group N* 0.000 description 4
- 125000006763 (C3-C9) cycloalkyl group Chemical group 0.000 description 3
- 125000000623 heterocyclic group Chemical group 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 description 2
- PKORYTIUMAOPED-UHFFFAOYSA-N 1,2,3,4-tetrahydroquinazoline Chemical group C1=CC=C2NCNCC2=C1 PKORYTIUMAOPED-UHFFFAOYSA-N 0.000 description 2
- 229910052736 halogen Inorganic materials 0.000 description 2
- 150000002367 halogens Chemical class 0.000 description 2
- 125000001072 heteroaryl group Chemical group 0.000 description 2
- 150000002431 hydrogen Chemical class 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 125000004076 pyridyl group Chemical group 0.000 description 2
- 229910052717 sulfur Inorganic materials 0.000 description 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 description 1
- WUAQCTPWWDBLQC-UHFFFAOYSA-N 1,2,3,4-tetrahydroquinazolin-4-ol Chemical compound C1=CC=C2C(O)NCNC2=C1 WUAQCTPWWDBLQC-UHFFFAOYSA-N 0.000 description 1
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 206010003210 Arteriosclerosis Diseases 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 208000037260 Atherosclerotic Plaque Diseases 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 206010052337 Diastolic dysfunction Diseases 0.000 description 1
- 206010048554 Endothelial dysfunction Diseases 0.000 description 1
- 208000010228 Erectile Dysfunction Diseases 0.000 description 1
- 208000011514 Familial renal glucosuria Diseases 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 102000007637 Soluble Guanylyl Cyclase Human genes 0.000 description 1
- 108010007205 Soluble Guanylyl Cyclase Proteins 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 125000004103 aminoalkyl group Chemical group 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- 125000002619 bicyclic group Chemical group 0.000 description 1
- 208000020832 chronic kidney disease Diseases 0.000 description 1
- 208000022831 chronic renal failure syndrome Diseases 0.000 description 1
- 230000007882 cirrhosis Effects 0.000 description 1
- 208000019425 cirrhosis of liver Diseases 0.000 description 1
- 230000008694 endothelial dysfunction Effects 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 208000030603 inherited susceptibility to asthma Diseases 0.000 description 1
- 230000028252 learning or memory Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 125000002950 monocyclic group Chemical group 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 208000002815 pulmonary hypertension Diseases 0.000 description 1
- 208000007278 renal glycosuria Diseases 0.000 description 1
- 208000037803 restenosis Diseases 0.000 description 1
- 125000005505 thiomorpholino group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19904710.3 | 1999-02-05 | ||
| DE19904710A DE19904710A1 (de) | 1999-02-05 | 1999-02-05 | Substituierte 4-Amino-2-aryl-tetrahydrochinazoline, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| PCT/EP2000/000468 WO2000046214A1 (en) | 1999-02-05 | 2000-01-22 | Substituted 4-amino-2-aryltetrahydroquinazolines, their preparation, their use and pharmaceutical compositions comprising them |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002536369A JP2002536369A (ja) | 2002-10-29 |
| JP2002536369A5 true JP2002536369A5 (https=) | 2007-03-08 |
| JP4700194B2 JP4700194B2 (ja) | 2011-06-15 |
Family
ID=7896548
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000597284A Expired - Fee Related JP4700194B2 (ja) | 1999-02-05 | 2000-01-22 | 置換４−アミノ−２−アリールテトラヒドロキナゾリン、その製造、その使用およびそれを含む医薬組成物 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US6660746B1 (https=) |
| EP (1) | EP1150963B1 (https=) |
| JP (1) | JP4700194B2 (https=) |
| AT (1) | ATE255565T1 (https=) |
| AU (1) | AU2292900A (https=) |
| CA (1) | CA2362363C (https=) |
| DE (2) | DE19904710A1 (https=) |
| DK (1) | DK1150963T3 (https=) |
| ES (1) | ES2211503T3 (https=) |
| PT (1) | PT1150963E (https=) |
| WO (1) | WO2000046214A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19904710A1 (de) * | 1999-02-05 | 2000-08-10 | Aventis Pharma Gmbh | Substituierte 4-Amino-2-aryl-tetrahydrochinazoline, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| SV2002000205A (es) * | 1999-11-01 | 2002-06-07 | Lilly Co Eli | Compuestos farmaceuticos ref. x-01095 |
| EP1571146A4 (en) * | 2002-12-10 | 2010-09-01 | Ono Pharmaceutical Co | NITROGENIC HETEROCYCLIC COMPOUNDS AND THEIR MEDICAL USE |
| JP4895806B2 (ja) * | 2003-04-09 | 2012-03-14 | エクセリクシス， インク． | Ｔｉｅ−２モジュレータと使用方法 |
| CN1894222A (zh) * | 2003-08-05 | 2007-01-10 | 沃泰克斯药物股份有限公司 | 作为电压门控离子通道抑制剂的稠合嘧啶化合物 |
| JP2008510726A (ja) * | 2004-08-20 | 2008-04-10 | エントレメッド インコーポレイテッド | プロテイナーゼ活性化受容体アンタゴニストを含む組成物および方法 |
| TW200621257A (en) | 2004-10-20 | 2006-07-01 | Astellas Pharma Inc | Pyrimidine derivative fused with nonaromatic ring |
| AU2009322836B2 (en) * | 2008-11-25 | 2013-04-04 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase activators |
| US9284301B2 (en) | 2010-03-25 | 2016-03-15 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase activators |
| KR20140019004A (ko) | 2010-05-27 | 2014-02-13 | 머크 샤프 앤드 돔 코포레이션 | 가용성 구아닐레이트 시클라제 활성화제 |
| CN113880859B (zh) * | 2021-11-16 | 2022-06-21 | 江西科技师范大学 | 2-芳基-4-芳甲胺基嘧啶类化合物及其应用 |
| UY40657A (es) | 2023-03-01 | 2024-09-13 | Novartis Ag | Derivados de hidroquinazolina para el tratamiento de una enfermedad o un trastorno |
| WO2025129076A1 (en) * | 2023-12-15 | 2025-06-19 | Eikon Therapeutics, Inc. | Pyridopyrimidine and quinazoline derivatives as usp1 inhibitors, compositions comprising them and methods of using the same |
| WO2026047575A1 (en) * | 2024-08-29 | 2026-03-05 | Novartis Ag | Hydroquinazoline derivatives for the treatment of a disease or disorder |
| WO2026047577A1 (en) * | 2024-08-29 | 2026-03-05 | Novartis Ag | Hydroquinazoline derivatives and treatment of a disease or disorder using the same |
| WO2026047576A1 (en) * | 2024-08-29 | 2026-03-05 | Novartis Ag | Hydroquinazoline derivatives for the treatment of a disease or disorder |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3346452A (en) * | 1963-08-19 | 1967-10-10 | Ciba Geigy Corp | 5, 6-lower alkylene-pyrimidines |
| US4306065A (en) * | 1979-12-19 | 1981-12-15 | A. H. Robins Company, Incorporated | 2-Aryl-4-substituted quinazolines |
| DE3315424A1 (de) * | 1983-04-28 | 1984-12-20 | Cassella Ag, 6000 Frankfurt | Substituierte piperazin-1-yl-essigsaeure-amide, verfahren zu ihrer herstellung und ihre verwendung |
| DE3922735A1 (de) * | 1989-07-11 | 1991-01-24 | Hoechst Ag | Aminopyrimidin-derivate, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung als fungizide |
| DE4029654A1 (de) | 1990-09-19 | 1992-04-02 | Hoechst Ag | 2-phenyl-pyrimidine, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung als fungizide |
| JP2657760B2 (ja) * | 1992-07-15 | 1997-09-24 | 小野薬品工業株式会社 | ４−アミノキナゾリン誘導体およびそれを含有する医薬品 |
| JP2928079B2 (ja) | 1994-02-14 | 1999-07-28 | 永信薬品工業股▲ふん▼有限公司 | １−（置換ベンジル）−３−（置換アリール）縮合ピラゾール類、その製造法及びその用途 |
| JPH07228573A (ja) * | 1994-02-16 | 1995-08-29 | Dainippon Pharmaceut Co Ltd | ２−フェニルシクロアルカノピリミジン誘導体 |
| IL117659A (en) * | 1995-04-13 | 2000-12-06 | Dainippon Pharmaceutical Co | Substituted 2-phenyl pyrimidino amino acetamide derivative process for preparing the same and a pharmaceutical composition containing same |
| WO1997047601A1 (en) | 1996-06-11 | 1997-12-18 | Yoshitomi Pharmaceutical Industries, Ltd. | Fused heterocyclic compounds and medicinal uses thereof |
| JPH1087492A (ja) * | 1996-06-25 | 1998-04-07 | Ono Pharmaceut Co Ltd | 一酸化窒素産生阻害剤 |
| JPH10130150A (ja) * | 1996-09-05 | 1998-05-19 | Dainippon Pharmaceut Co Ltd | 酢酸アミド誘導体からなる医薬 |
| US6166027A (en) | 1996-10-14 | 2000-12-26 | Bayer Aktiengesellschaft | Heterocyclylmethyl-substituted pyrazole derivatives and their use for treating cardiovascular diseases |
| DE19642255A1 (de) | 1996-10-14 | 1998-04-16 | Bayer Ag | Verwendung von 1-Benzyl-3-(substituierten-hetaryl) -kondensierten Pyrazol-Derivaten |
| US6245760B1 (en) * | 1997-05-28 | 2001-06-12 | Aventis Pharmaceuticals Products, Inc | Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases |
| DE19836697A1 (de) | 1998-08-13 | 2000-02-17 | Hoechst Marion Roussel De Gmbh | Substituierte 4-Amino-2-aryl-pyrimidine, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| DE19853278A1 (de) | 1998-11-19 | 2000-05-25 | Aventis Pharma Gmbh | Substituierte 4-Amino-2-aryl-cyclopenta[d]pyrimidine, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| DE19904710A1 (de) * | 1999-02-05 | 2000-08-10 | Aventis Pharma Gmbh | Substituierte 4-Amino-2-aryl-tetrahydrochinazoline, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| DE19906037A1 (de) | 1999-02-12 | 2000-08-31 | Trw Automotive Electron & Comp | Schalter, insbesondere Kfz-Bremslichtschalter |
-
1999
- 1999-02-05 DE DE19904710A patent/DE19904710A1/de not_active Withdrawn
-
2000
- 2000-01-22 WO PCT/EP2000/000468 patent/WO2000046214A1/en not_active Ceased
- 2000-01-22 DK DK00901586T patent/DK1150963T3/da active
- 2000-01-22 CA CA002362363A patent/CA2362363C/en not_active Expired - Fee Related
- 2000-01-22 ES ES00901586T patent/ES2211503T3/es not_active Expired - Lifetime
- 2000-01-22 DE DE2000606936 patent/DE60006936T2/de not_active Expired - Lifetime
- 2000-01-22 AT AT00901586T patent/ATE255565T1/de active
- 2000-01-22 AU AU22929/00A patent/AU2292900A/en not_active Abandoned
- 2000-01-22 JP JP2000597284A patent/JP4700194B2/ja not_active Expired - Fee Related
- 2000-01-22 PT PT00901586T patent/PT1150963E/pt unknown
- 2000-01-22 EP EP00901586A patent/EP1150963B1/en not_active Expired - Lifetime
- 2000-02-04 US US09/497,723 patent/US6660746B1/en not_active Expired - Lifetime
-
2003
- 2003-10-01 US US10/674,350 patent/US7045526B2/en not_active Expired - Lifetime
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2002530385A5 (https=) | ||
| JP2002536369A5 (https=) | ||
| JP2002522536A5 (https=) | ||
| RU2329263C2 (ru) | Производные имида индолилмалеиновой кислоты как ингибиторы протеинкиназы с | |
| JP2001527066A5 (https=) | ||
| RU2000119774A (ru) | Производные индола как ингибиторы фактора ха | |
| RU2004132844A (ru) | Производные бензамида, полехные в качестве ингибиторов деацетилазы гистонов | |
| JP2006513265A5 (https=) | ||
| US20020052373A1 (en) | Combination treatment for dementia or cognitive deficits associated with alzheimer's disease and parkinson's disease | |
| JP2006143737A5 (https=) | ||
| CA2396590A1 (en) | 2-amino-nicotinamide derivatives and their use as vegf-receptor tyrosine kinase inhibitors | |
| JP2021510376A5 (https=) | ||
| JP2005504111A5 (https=) | ||
| JP2007517807A5 (https=) | ||
| CA2545427A1 (en) | Selective kinase inhibitors | |
| JP2005528325A5 (https=) | ||
| RU95118133A (ru) | Гетероциклические соединения, способы их получения и фармацевтическая композиция | |
| WO2002016356A3 (en) | Quinuclidine-substituted aryl moieties for treatment of disease (nicotinic acetylcholine receptor ligands) | |
| RU2002111866A (ru) | Производные N-замещенного индол-3-глиоксиламида - противоопухолевое лекарственное средство и средство, подавляющее ангиогенез (варианты), фармацевтическая композиция и противоопухолевое лекарственное средство (варианты) | |
| PE20071177A1 (es) | Derivados de 3,5-piridina como inhibidores de renina | |
| ATE324890T1 (de) | Zusammensetzung enthaltend einen angiotensin-ii- rezeptor-antagonist und einen diuretikum und deren verwendung zur behandlung von bluthochdruck | |
| RU2001135802A (ru) | Антагонисты рецептора брадикинина | |
| EP1780201A3 (en) | Phenylalanine enamide derivatives possessing a cyclobutene group, for use as integrin inhibitors | |
| JP2016536362A5 (https=) | ||
| CA2439268A1 (en) | Combination comprising a signal transduction inhibitor and an epothilone derivative |