PT1150963E - 4-amino-2-ariltetra-hidroquinazolinas substituidas sua preparacao sua utilizacao e composicoes farmaceuticas que as contem - Google Patents
4-amino-2-ariltetra-hidroquinazolinas substituidas sua preparacao sua utilizacao e composicoes farmaceuticas que as contemInfo
- Publication number
- PT1150963E PT1150963E PT00901586T PT00901586T PT1150963E PT 1150963 E PT1150963 E PT 1150963E PT 00901586 T PT00901586 T PT 00901586T PT 00901586 T PT00901586 T PT 00901586T PT 1150963 E PT1150963 E PT 1150963E
- Authority
- PT
- Portugal
- Prior art keywords
- sup
- formula
- compounds
- prophylaxis
- therapy
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 6
- ZOOGRGPOEVQQDX-KHLHZJAASA-N cyclic guanosine monophosphate Chemical compound C([C@H]1O2)O[P@](O)(=O)O[C@@H]1[C@H](O)[C@H]2N1C(N=C(NC2=O)N)=C2N=C1 ZOOGRGPOEVQQDX-KHLHZJAASA-N 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 238000011321 prophylaxis Methods 0.000 abstract 3
- 238000002560 therapeutic procedure Methods 0.000 abstract 3
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 206010002383 Angina Pectoris Diseases 0.000 abstract 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Hospice & Palliative Care (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19904710A DE19904710A1 (de) | 1999-02-05 | 1999-02-05 | Substituierte 4-Amino-2-aryl-tetrahydrochinazoline, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1150963E true PT1150963E (pt) | 2004-04-30 |
Family
ID=7896548
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT00901586T PT1150963E (pt) | 1999-02-05 | 2000-01-22 | 4-amino-2-ariltetra-hidroquinazolinas substituidas sua preparacao sua utilizacao e composicoes farmaceuticas que as contem |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US6660746B1 (https=) |
| EP (1) | EP1150963B1 (https=) |
| JP (1) | JP4700194B2 (https=) |
| AT (1) | ATE255565T1 (https=) |
| AU (1) | AU2292900A (https=) |
| CA (1) | CA2362363C (https=) |
| DE (2) | DE19904710A1 (https=) |
| DK (1) | DK1150963T3 (https=) |
| ES (1) | ES2211503T3 (https=) |
| PT (1) | PT1150963E (https=) |
| WO (1) | WO2000046214A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19904710A1 (de) * | 1999-02-05 | 2000-08-10 | Aventis Pharma Gmbh | Substituierte 4-Amino-2-aryl-tetrahydrochinazoline, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| EP1230225A2 (en) * | 1999-11-01 | 2002-08-14 | Eli Lilly And Company | Pharmaceutically active 4-substituted pyrimidine derivatives |
| WO2004052862A1 (ja) * | 2002-12-10 | 2004-06-24 | Ono Pharmaceutical Co., Ltd. | 含窒素複素環化合物およびその医薬用途 |
| EP1610774A4 (en) * | 2003-04-09 | 2008-07-16 | Exelixis Inc | TIE-2 MODULATORS AND METHODS OF USE |
| ZA200601859B (en) * | 2003-08-05 | 2008-03-26 | Vertex Pharma | Condensed pyrimidine compounds as inhibitors of voltagegated ion channels |
| US20060063930A1 (en) * | 2004-08-20 | 2006-03-23 | Agoston Gregory E | Compositions and methods comprising proteinase activated receptor antagonists |
| TW200621257A (en) * | 2004-10-20 | 2006-07-01 | Astellas Pharma Inc | Pyrimidine derivative fused with nonaromatic ring |
| AU2009322836B2 (en) * | 2008-11-25 | 2013-04-04 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase activators |
| US9284301B2 (en) | 2010-03-25 | 2016-03-15 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase activators |
| UA107112C2 (uk) | 2010-05-27 | 2014-11-25 | Мерк Шарп Енд Доме Корп. | Активатори розчинної гуанілатциклази |
| CN113880859B (zh) * | 2021-11-16 | 2022-06-21 | 江西科技师范大学 | 2-芳基-4-芳甲胺基嘧啶类化合物及其应用 |
| TW202435887A (zh) * | 2023-03-01 | 2024-09-16 | 瑞士商諾華公司 | 用於治療疾病或障礙的氫喹唑啉衍生物 |
| WO2025129076A1 (en) * | 2023-12-15 | 2025-06-19 | Eikon Therapeutics, Inc. | Pyridopyrimidine and quinazoline derivatives as usp1 inhibitors, compositions comprising them and methods of using the same |
| WO2026047575A1 (en) * | 2024-08-29 | 2026-03-05 | Novartis Ag | Hydroquinazoline derivatives for the treatment of a disease or disorder |
| WO2026047577A1 (en) * | 2024-08-29 | 2026-03-05 | Novartis Ag | Hydroquinazoline derivatives and treatment of a disease or disorder using the same |
| WO2026047576A1 (en) * | 2024-08-29 | 2026-03-05 | Novartis Ag | Hydroquinazoline derivatives for the treatment of a disease or disorder |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3346452A (en) * | 1963-08-19 | 1967-10-10 | Ciba Geigy Corp | 5, 6-lower alkylene-pyrimidines |
| US4306065A (en) * | 1979-12-19 | 1981-12-15 | A. H. Robins Company, Incorporated | 2-Aryl-4-substituted quinazolines |
| DE3315424A1 (de) * | 1983-04-28 | 1984-12-20 | Cassella Ag, 6000 Frankfurt | Substituierte piperazin-1-yl-essigsaeure-amide, verfahren zu ihrer herstellung und ihre verwendung |
| DE3922735A1 (de) * | 1989-07-11 | 1991-01-24 | Hoechst Ag | Aminopyrimidin-derivate, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung als fungizide |
| DE4029654A1 (de) | 1990-09-19 | 1992-04-02 | Hoechst Ag | 2-phenyl-pyrimidine, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung als fungizide |
| JP2657760B2 (ja) | 1992-07-15 | 1997-09-24 | 小野薬品工業株式会社 | ４−アミノキナゾリン誘導体およびそれを含有する医薬品 |
| JP2928079B2 (ja) | 1994-02-14 | 1999-07-28 | 永信薬品工業股▲ふん▼有限公司 | １−（置換ベンジル）−３−（置換アリール）縮合ピラゾール類、その製造法及びその用途 |
| JPH07228573A (ja) * | 1994-02-16 | 1995-08-29 | Dainippon Pharmaceut Co Ltd | ２−フェニルシクロアルカノピリミジン誘導体 |
| IL117659A (en) * | 1995-04-13 | 2000-12-06 | Dainippon Pharmaceutical Co | Substituted 2-phenyl pyrimidino amino acetamide derivative process for preparing the same and a pharmaceutical composition containing same |
| JP3531169B2 (ja) | 1996-06-11 | 2004-05-24 | 三菱ウェルファーマ株式会社 | 縮合ヘテロ環化合物およびその医薬用途 |
| JPH1087492A (ja) * | 1996-06-25 | 1998-04-07 | Ono Pharmaceut Co Ltd | 一酸化窒素産生阻害剤 |
| JPH10130150A (ja) * | 1996-09-05 | 1998-05-19 | Dainippon Pharmaceut Co Ltd | 酢酸アミド誘導体からなる医薬 |
| DE19642255A1 (de) | 1996-10-14 | 1998-04-16 | Bayer Ag | Verwendung von 1-Benzyl-3-(substituierten-hetaryl) -kondensierten Pyrazol-Derivaten |
| IL129416A0 (en) | 1996-10-14 | 2000-02-17 | Bayer Ag | New heterocyclylmethyl-substituted pyrazol derivatives |
| US6245760B1 (en) * | 1997-05-28 | 2001-06-12 | Aventis Pharmaceuticals Products, Inc | Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases |
| DE19836697A1 (de) | 1998-08-13 | 2000-02-17 | Hoechst Marion Roussel De Gmbh | Substituierte 4-Amino-2-aryl-pyrimidine, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| DE19853278A1 (de) | 1998-11-19 | 2000-05-25 | Aventis Pharma Gmbh | Substituierte 4-Amino-2-aryl-cyclopenta[d]pyrimidine, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| DE19904710A1 (de) * | 1999-02-05 | 2000-08-10 | Aventis Pharma Gmbh | Substituierte 4-Amino-2-aryl-tetrahydrochinazoline, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| DE19906037A1 (de) | 1999-02-12 | 2000-08-31 | Trw Automotive Electron & Comp | Schalter, insbesondere Kfz-Bremslichtschalter |
-
1999
- 1999-02-05 DE DE19904710A patent/DE19904710A1/de not_active Withdrawn
-
2000
- 2000-01-22 AU AU22929/00A patent/AU2292900A/en not_active Abandoned
- 2000-01-22 CA CA002362363A patent/CA2362363C/en not_active Expired - Fee Related
- 2000-01-22 ES ES00901586T patent/ES2211503T3/es not_active Expired - Lifetime
- 2000-01-22 DK DK00901586T patent/DK1150963T3/da active
- 2000-01-22 WO PCT/EP2000/000468 patent/WO2000046214A1/en not_active Ceased
- 2000-01-22 PT PT00901586T patent/PT1150963E/pt unknown
- 2000-01-22 JP JP2000597284A patent/JP4700194B2/ja not_active Expired - Fee Related
- 2000-01-22 EP EP00901586A patent/EP1150963B1/en not_active Expired - Lifetime
- 2000-01-22 AT AT00901586T patent/ATE255565T1/de active
- 2000-01-22 DE DE2000606936 patent/DE60006936T2/de not_active Expired - Lifetime
- 2000-02-04 US US09/497,723 patent/US6660746B1/en not_active Expired - Lifetime
-
2003
- 2003-10-01 US US10/674,350 patent/US7045526B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ATE255565T1 (de) | 2003-12-15 |
| DK1150963T3 (da) | 2004-04-05 |
| EP1150963A1 (en) | 2001-11-07 |
| WO2000046214A1 (en) | 2000-08-10 |
| US20040063690A1 (en) | 2004-04-01 |
| US6660746B1 (en) | 2003-12-09 |
| US7045526B2 (en) | 2006-05-16 |
| DE19904710A1 (de) | 2000-08-10 |
| JP4700194B2 (ja) | 2011-06-15 |
| AU2292900A (en) | 2000-08-25 |
| DE60006936D1 (de) | 2004-01-15 |
| EP1150963B1 (en) | 2003-12-03 |
| CA2362363C (en) | 2009-09-15 |
| CA2362363A1 (en) | 2000-08-10 |
| JP2002536369A (ja) | 2002-10-29 |
| ES2211503T3 (es) | 2004-07-16 |
| DE60006936T2 (de) | 2004-11-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT1150963E (pt) | 4-amino-2-ariltetra-hidroquinazolinas substituidas sua preparacao sua utilizacao e composicoes farmaceuticas que as contem | |
| PT1131302E (pt) | 4-amino-2-aril-ciclopenta[d]pirimidinas substituidas, sua preparacao, sua utilizacao e preparacoes farmaceuticas que as contem | |
| ATE360622T1 (de) | Substituierte 2-aryl-4-amino-chinazoline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel | |
| CA2340405A1 (en) | Substituted 4-amino-2-aryl-pyrimidines, their production and use and pharmaceutical preparations containing same | |
| BR9911942B1 (pt) | "n-arilamidas de ácido sulfonilaminocarboxílico como ativadores da ciclasse de guanilato e composições farmacêuticas contendo as mesmas" | |
| EP1614678A3 (en) | Sulfur substituted sulfonylaminocarboxylic acid N-heteroarylamides, their preparation, their use and pharmaceutical preparations comprising them | |
| IL166493A0 (en) | Acylamino-substituted heteroaromatic compounds andtheir use as pharmaceuticals | |
| IS4695A (is) | (Metýlsúlfónýl)fenýl-2-(5H)-fúranón sem sýklóoxýgenasa-2 tálmar | |
| BR9808998A (pt) | Imidazóis substituìdos úteis no tratamento de doenças inflamatórias | |
| EA200201271A1 (ru) | Ингибиторы 11-бета-гидроксистероиддегидрогеназы типа 1 | |
| BR0312464A (pt) | Inibidores de tirosina quinases | |
| MY141885A (en) | Acylated arylcycloalkylamines and their use as pharmaceuticals | |
| UY27548A1 (es) | Sales de ácido succínico de 5,7,14-triazatetraciclo (10.3.1.02.11.04,9) exadeca-2 (11),3,5,7,9-pentaeno y composiciones farmacéuticas | |
| DE68906609D1 (de) | Dopamin-vorlaeufer. | |
| PT1023267E (pt) | Compostos de piridilo e composicoes farmaceuticas que os contem | |
| CL2010000387A1 (es) | Composicion farmaceutica que comprende sal de acido lactico de un derivado de quinolina en un 50% a 80% en relacion al peso total y al menos dos ingredientes mas; procedimiento de preparacion; kit farmaceutico; util en el tratamiento del cancer (dividisional de la solicitud 3324-06). | |
| RU94038256A (ru) | Производные пиразолопиримидина, способ их получения, фармацевтические композиции на их основе | |
| BR9603179A (pt) | Guanididas de ácido cinâmico substituìdas, processo para sua preparação, sua aplicação como medicamento ou diagnóstico, bem como medicamento que as contém | |
| MXPA05011267A (es) | Derivados de la triaza-y tetraaza-antracenodiona, su preparacion y su uso como productos farmaceuticos. | |
| DK1115697T3 (da) | Umættede hydroximsyrederivater som PARP-inhibitorer | |
| CA2320822A1 (en) | Substituted isoindolones and their use as cyclic gmp modulators in medicaments | |
| ITMI931723A1 (it) | Derivati della beta-mercapto-propanammide utili nel trattamento delle malattie cardiovascolari | |
| MX2008000044A (es) | Amidas sustituidas con heteroarilo que comprenden un grupo enlazador saturado, y su uso como agentes farmaceuticos. | |
| DE60325959D1 (de) | Aminosäureanaloga | |
| MA29372B1 (fr) | Nouveaux composes derives du 5-thioxylose et leur utilisation therapeutique |