JP2002533456A5 - - Google Patents
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- JP2002533456A5 JP2002533456A5 JP2000591031A JP2000591031A JP2002533456A5 JP 2002533456 A5 JP2002533456 A5 JP 2002533456A5 JP 2000591031 A JP2000591031 A JP 2000591031A JP 2000591031 A JP2000591031 A JP 2000591031A JP 2002533456 A5 JP2002533456 A5 JP 2002533456A5
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- cancer
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- 239000000203 mixture Substances 0.000 description 48
- 150000001875 compounds Chemical class 0.000 description 31
- 238000000034 method Methods 0.000 description 14
- 125000000623 heterocyclic group Chemical group 0.000 description 9
- 108090000695 Cytokines Proteins 0.000 description 8
- 102000004127 Cytokines Human genes 0.000 description 8
- 206010028980 Neoplasm Diseases 0.000 description 7
- 201000011510 cancer Diseases 0.000 description 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 7
- 208000019664 bone resorption disease Diseases 0.000 description 6
- 229940011871 estrogen Drugs 0.000 description 6
- 239000000262 estrogen Substances 0.000 description 6
- 210000001035 gastrointestinal tract Anatomy 0.000 description 6
- 210000002307 prostate Anatomy 0.000 description 6
- 108090001005 Interleukin-6 Proteins 0.000 description 5
- 238000010276 construction Methods 0.000 description 5
- 201000009273 Endometriosis Diseases 0.000 description 4
- 108010041356 Estrogen Receptor beta Proteins 0.000 description 4
- 102100038595 Estrogen receptor Human genes 0.000 description 4
- 101710196141 Estrogen receptor Proteins 0.000 description 4
- 102100029951 Estrogen receptor beta Human genes 0.000 description 4
- 208000034578 Multiple myelomas Diseases 0.000 description 4
- 208000001132 Osteoporosis Diseases 0.000 description 4
- 206010035226 Plasma cell myeloma Diseases 0.000 description 4
- 206010060862 Prostate cancer Diseases 0.000 description 4
- 206010003246 arthritis Diseases 0.000 description 4
- 125000003118 aryl group Chemical group 0.000 description 4
- 210000000988 bone and bone Anatomy 0.000 description 4
- 210000000038 chest Anatomy 0.000 description 4
- 210000000918 epididymis Anatomy 0.000 description 4
- 201000010063 epididymitis Diseases 0.000 description 4
- 210000001508 eye Anatomy 0.000 description 4
- 210000002216 heart Anatomy 0.000 description 4
- 210000001320 hippocampus Anatomy 0.000 description 4
- 210000003016 hypothalamus Anatomy 0.000 description 4
- 210000000987 immune system Anatomy 0.000 description 4
- 230000002401 inhibitory effect Effects 0.000 description 4
- 210000003734 kidney Anatomy 0.000 description 4
- 210000004072 lung Anatomy 0.000 description 4
- 210000001672 ovary Anatomy 0.000 description 4
- 239000008194 pharmaceutical composition Substances 0.000 description 4
- 230000001817 pituitary effect Effects 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 210000001550 testis Anatomy 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 210000003932 urinary bladder Anatomy 0.000 description 4
- 210000004291 uterus Anatomy 0.000 description 4
- 125000003710 aryl alkyl group Chemical group 0.000 description 3
- 229910052736 halogen Inorganic materials 0.000 description 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 3
- 125000001424 substituent group Chemical group 0.000 description 3
- 208000002874 Acne Vulgaris Diseases 0.000 description 2
- 208000024827 Alzheimer disease Diseases 0.000 description 2
- 208000000044 Amnesia Diseases 0.000 description 2
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 description 2
- 208000006386 Bone Resorption Diseases 0.000 description 2
- 206010005949 Bone cancer Diseases 0.000 description 2
- 206010065687 Bone loss Diseases 0.000 description 2
- 208000018084 Bone neoplasm Diseases 0.000 description 2
- 206010006187 Breast cancer Diseases 0.000 description 2
- 208000026310 Breast neoplasm Diseases 0.000 description 2
- 208000024172 Cardiovascular disease Diseases 0.000 description 2
- 208000002177 Cataract Diseases 0.000 description 2
- 206010008342 Cervix carcinoma Diseases 0.000 description 2
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 description 2
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 2
- 206010020112 Hirsutism Diseases 0.000 description 2
- 208000033830 Hot Flashes Diseases 0.000 description 2
- 206010060800 Hot flush Diseases 0.000 description 2
- 208000035150 Hypercholesterolemia Diseases 0.000 description 2
- 201000002980 Hyperparathyroidism Diseases 0.000 description 2
- 206010025323 Lymphomas Diseases 0.000 description 2
- 208000026139 Memory disease Diseases 0.000 description 2
- 206010027951 Mood swings Diseases 0.000 description 2
- 208000008589 Obesity Diseases 0.000 description 2
- 208000010191 Osteitis Deformans Diseases 0.000 description 2
- 208000003076 Osteolysis Diseases 0.000 description 2
- 208000027868 Paget disease Diseases 0.000 description 2
- 208000004403 Prostatic Hyperplasia Diseases 0.000 description 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 2
- 208000006265 Renal cell carcinoma Diseases 0.000 description 2
- 206010046543 Urinary incontinence Diseases 0.000 description 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 206010000496 acne Diseases 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 230000024279 bone resorption Effects 0.000 description 2
- 210000000481 breast Anatomy 0.000 description 2
- 210000003169 central nervous system Anatomy 0.000 description 2
- 201000010881 cervical cancer Diseases 0.000 description 2
- 210000001072 colon Anatomy 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 230000002500 effect on skin Effects 0.000 description 2
- 230000002357 endometrial effect Effects 0.000 description 2
- 239000003256 environmental substance Substances 0.000 description 2
- 230000014509 gene expression Effects 0.000 description 2
- 125000005843 halogen group Chemical group 0.000 description 2
- 150000002367 halogens Chemical class 0.000 description 2
- 125000005343 heterocyclic alkyl group Chemical group 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 239000007943 implant Substances 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 208000029791 lytic metastatic bone lesion Diseases 0.000 description 2
- 208000027202 mammary Paget disease Diseases 0.000 description 2
- 230000006984 memory degeneration Effects 0.000 description 2
- 208000023060 memory loss Diseases 0.000 description 2
- 230000009245 menopause Effects 0.000 description 2
- 230000001394 metastastic effect Effects 0.000 description 2
- 206010061289 metastatic neoplasm Diseases 0.000 description 2
- 235000020824 obesity Nutrition 0.000 description 2
- 230000000399 orthopedic effect Effects 0.000 description 2
- 201000001514 prostate carcinoma Diseases 0.000 description 2
- 201000004240 prostatic hypertrophy Diseases 0.000 description 2
- 230000001850 reproductive effect Effects 0.000 description 2
- 206010039073 rheumatoid arthritis Diseases 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 230000021595 spermatogenesis Effects 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 2
- 230000009441 vascular protection Effects 0.000 description 2
- 125000004203 4-hydroxyphenyl group Chemical group [H]OC1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 125000004199 4-trifluoromethylphenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C(F)(F)F 0.000 description 1
- 0 CCN(CC)CCOc(cc1)ccc1C(c(c(OC1=*)c2)ccc2O)=C1c1ccccc1 Chemical compound CCN(CC)CCOc(cc1)ccc1C(c(c(OC1=*)c2)ccc2O)=C1c1ccccc1 0.000 description 1
- KKFMLXDEDGNDHG-UHFFFAOYSA-N Oc(cc1)cc(OC2)c1C(c(cc1)ccc1OCCN1CCCCC1)=C(c(cc1)ccc1Cl)C2=O Chemical compound Oc(cc1)cc(OC2)c1C(c(cc1)ccc1OCCN1CCCCC1)=C(c(cc1)ccc1Cl)C2=O KKFMLXDEDGNDHG-UHFFFAOYSA-N 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 125000001246 bromo group Chemical group Br* 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 125000001309 chloro group Chemical group Cl* 0.000 description 1
- 125000001153 fluoro group Chemical group F* 0.000 description 1
- 125000001072 heteroaryl group Chemical group 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 125000003037 imidazol-2-yl group Chemical group [H]N1C([*])=NC([H])=C1[H] 0.000 description 1
- 125000004282 imidazolidin-2-yl group Chemical group [H]N1C([H])([H])C([H])([H])N([H])C1([H])* 0.000 description 1
- 125000002346 iodo group Chemical group I* 0.000 description 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 description 1
- 230000001473 noxious effect Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 description 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 125000004076 pyridyl group Chemical group 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11447298P | 1998-12-30 | 1998-12-30 | |
| US60/114,472 | 1998-12-30 | ||
| PCT/US1999/031290 WO2000039120A2 (en) | 1998-12-30 | 1999-12-30 | Compounds and methods for modulation of estrogen receptors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002533456A JP2002533456A (ja) | 2002-10-08 |
| JP2002533456A5 true JP2002533456A5 (https=) | 2006-11-30 |
Family
ID=22355427
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000591031A Pending JP2002533456A (ja) | 1998-12-30 | 1999-12-30 | エストロゲン受容体のモジュレートを行うための化合物および方法 |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP1140889B1 (https=) |
| JP (1) | JP2002533456A (https=) |
| KR (1) | KR100615757B1 (https=) |
| CN (2) | CN100339374C (https=) |
| AT (1) | ATE248157T1 (https=) |
| AU (1) | AU765159B2 (https=) |
| CA (1) | CA2356986A1 (https=) |
| DE (1) | DE69910830T2 (https=) |
| DK (1) | DK1140889T3 (https=) |
| ES (1) | ES2207982T3 (https=) |
| HK (1) | HK1041258B (https=) |
| IL (2) | IL144003A0 (https=) |
| PT (1) | PT1140889E (https=) |
| WO (1) | WO2000039120A2 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6822563B2 (en) | 1997-09-22 | 2004-11-23 | Donnelly Corporation | Vehicle imaging system with accessory control |
| US5877897A (en) | 1993-02-26 | 1999-03-02 | Donnelly Corporation | Automatic rearview mirror, vehicle lighting control and vehicle interior monitoring system using a photosensor array |
| US7655894B2 (en) | 1996-03-25 | 2010-02-02 | Donnelly Corporation | Vehicular image sensing system |
| US6331562B1 (en) | 1998-12-30 | 2001-12-18 | Signal Pharmaceuticals, Inc. | Compounds and methods for modulation of estrogen receptors |
| US6291456B1 (en) | 1998-12-30 | 2001-09-18 | Signal Pharmaceuticals, Inc. | Compounds and methods for modulation of estrogen receptors |
| US6593322B1 (en) * | 1999-03-17 | 2003-07-15 | Signal Pharmaceuticals, Inc. | Compounds and methods for modulation of estrogen receptors |
| AU766648B2 (en) | 1999-03-17 | 2003-10-23 | Axys Pharmaceuticals, Inc. | Compounds and methods for modulation of estrogen receptors |
| PT1246814E (pt) * | 1999-12-30 | 2005-07-29 | Signal Pharm Llc | Compostos e metodos para a modulacao de receptores de estrgenio |
| EP1177787A3 (en) * | 2000-07-28 | 2003-09-10 | Pfizer Products Inc. | Use of an estrogen agonist/antagonist for treating cataracts |
| EP1281710A1 (en) * | 2001-08-03 | 2003-02-05 | CHIESI FARMACEUTICI S.p.A. | 2H-1-benzopyran derivatives, processes for their preparation and pharmaceutical compositions thereof |
| SK287086B6 (sk) * | 2001-01-24 | 2009-11-05 | Chiesi Farmaceutici S.P.A. | 2H-1-Benzopyránové deriváty, farmaceutické prostriedky s ich obsahom a ich použitie |
| ES2236056T3 (es) * | 2001-01-24 | 2005-07-16 | Chiesi Farmaceutici S.P.A. | Derivados de 2h-1-benzopirano, procedimientos para su preparacion y composiciones farmaceuticas de los mismos. |
| KR100715927B1 (ko) * | 2001-04-10 | 2007-05-08 | 다카라 바이오 가부시키가이샤 | 치료제 |
| US7148252B2 (en) * | 2001-10-03 | 2006-12-12 | Signal Pharmaceuticals, Llc | Use of benzopyranones for treating or preventing a primary brain cancer or a brain metastasis |
| UA83620C2 (ru) | 2001-12-05 | 2008-08-11 | Уайт | Замещенные бензоксазолы и их аналоги как эстрогенные агенты |
| EP1497277A1 (en) * | 2002-04-19 | 2005-01-19 | Signal Pharmaceuticals, Inc. | Benzopyranone compounds, compositions thereof, and methods of treatment therewith |
| AU2003225228A1 (en) | 2002-05-03 | 2003-11-17 | Donnelly Corporation | Object detection system for vehicle |
| US7091235B2 (en) | 2002-10-15 | 2006-08-15 | Signal Pharmaceuticals, Llc | Benzopyranone compounds, compositions thereof, and methods for treating or preventing cancer |
| FR2849653B1 (fr) * | 2003-01-08 | 2006-08-25 | B F B Etudes Et Rech S Experim | Derives de la coumarine ayant une affinite pour les recepteurs aux estrogenes, procede pour leur preparation et compositions pharmaceutiques en contenant |
| CA2538874A1 (en) * | 2003-09-15 | 2005-03-31 | Signal Pharmaceuticals, Llc | Benzopyranone compounds, compositions thereof, and methods of treatment therewith |
| US7526103B2 (en) | 2004-04-15 | 2009-04-28 | Donnelly Corporation | Imaging system for vehicle |
| CA2595477A1 (en) * | 2005-01-21 | 2006-07-27 | Janssen Pharmaceutica N.V. | Novel heterocyclic benzo[c]chromene derivatives useful as modulators of the estrogen receptors |
| EP1899316A1 (en) * | 2005-06-24 | 2008-03-19 | Signal Pharmaceuticals LLC | Benzopyranone compounds for treating cancer |
| AR059339A1 (es) * | 2006-02-09 | 2008-03-26 | Chugai Pharmaceutical Co Ltd | Derivados de la cumarina para trastornos proliferativos de celulas, composicion farmaceutica y agente terapeutico que los contiene |
| EP1860104A1 (en) * | 2006-05-22 | 2007-11-28 | Aptanomics | Anti-proliferative compounds deriving from a 3-aryl-coumarine or 3-aryl-quinolin-2-one and uses thereof |
| CN101200460B (zh) * | 2007-11-19 | 2010-06-16 | 北京珅奥基医药科技有限公司 | 二氢苯并吡喃酮类化合物及其用途 |
| CN105541810B (zh) * | 2016-03-04 | 2019-05-17 | 南京工业大学 | 一种香豆素类nedd8激活酶抑制剂及其制备方法与应用 |
| CN105801544A (zh) * | 2016-04-18 | 2016-07-27 | 中国药科大学 | 3-芳基-4-芳香胺-香豆素衍生物及其制备方法和医药用途 |
| CN105801543B (zh) * | 2016-04-18 | 2019-08-02 | 中国药科大学 | 4-芳香胺-香豆素衍生物及其制备方法和医药用途 |
| CN112426420B (zh) * | 2020-12-01 | 2021-12-28 | 浙江大学 | 香豆素-二硫代氨基甲酸酯衍生物在制备抗肿瘤药物中的应用 |
| CN112645922B (zh) * | 2020-12-24 | 2022-01-07 | 中国人民解放军空军军医大学 | 香豆素类化合物、制备方法及应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2857401A (en) * | 1956-12-20 | 1958-10-21 | Searle & Co | Acetylated coumarin derivatives |
| DE4323409A1 (de) * | 1993-07-13 | 1995-01-19 | Boehringer Mannheim Gmbh | Verwendung von Cumarinen und Carbostyrilen als PLA¶2¶-Inhibitoren, neue Cumarine und Carbostyrile, Verfahren zu ihrer Herstellung und Arzneimittel |
| HUP9801829A3 (en) * | 1995-02-06 | 1999-10-28 | Lilly Co Eli | Use of benzotiophene derivatives for producing pharmaceutical compositions for inhibiting effects of il-6 |
| CA2270111A1 (en) * | 1996-10-28 | 1998-05-07 | Lise Brown Christiansen | Novel (-)-enantiomers of cis-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes |
| AU744403B2 (en) * | 1996-10-28 | 2002-02-21 | Novo Nordisk A/S | Novel trans-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes |
| CA2270113A1 (en) * | 1996-10-28 | 1998-05-07 | Poul Jacobsen | Novel cis-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes |
| IL129627A0 (en) * | 1996-10-28 | 2000-02-29 | Novo Nordisk As | Novel CIS-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes |
| ZA979644B (en) * | 1996-10-28 | 1998-04-28 | Novo Nordisk As | Heterocyclic compounds, compositions and uses. |
| WO1998018776A1 (en) * | 1996-10-28 | 1998-05-07 | Novo Nordisk A/S | Novel cis-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes |
-
1999
- 1999-12-30 EP EP99968578A patent/EP1140889B1/en not_active Expired - Lifetime
- 1999-12-30 AT AT99968578T patent/ATE248157T1/de not_active IP Right Cessation
- 1999-12-30 PT PT99968578T patent/PT1140889E/pt unknown
- 1999-12-30 CN CNB2004100422993A patent/CN100339374C/zh not_active Expired - Fee Related
- 1999-12-30 WO PCT/US1999/031290 patent/WO2000039120A2/en not_active Ceased
- 1999-12-30 DE DE69910830T patent/DE69910830T2/de not_active Expired - Fee Related
- 1999-12-30 AU AU25970/00A patent/AU765159B2/en not_active Ceased
- 1999-12-30 KR KR1020017008410A patent/KR100615757B1/ko not_active Expired - Fee Related
- 1999-12-30 JP JP2000591031A patent/JP2002533456A/ja active Pending
- 1999-12-30 DK DK99968578T patent/DK1140889T3/da active
- 1999-12-30 IL IL14400399A patent/IL144003A0/xx active IP Right Grant
- 1999-12-30 CN CNB998163740A patent/CN1155589C/zh not_active Expired - Fee Related
- 1999-12-30 HK HK02101413.5A patent/HK1041258B/en not_active IP Right Cessation
- 1999-12-30 CA CA002356986A patent/CA2356986A1/en not_active Abandoned
- 1999-12-30 ES ES99968578T patent/ES2207982T3/es not_active Expired - Lifetime
-
2001
- 2001-06-26 IL IL144003A patent/IL144003A/en not_active IP Right Cessation
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