JP2002531091A5 - - Google Patents

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Publication number
JP2002531091A5
JP2002531091A5 JP2000585406A JP2000585406A JP2002531091A5 JP 2002531091 A5 JP2002531091 A5 JP 2002531091A5 JP 2000585406 A JP2000585406 A JP 2000585406A JP 2000585406 A JP2000585406 A JP 2000585406A JP 2002531091 A5 JP2002531091 A5 JP 2002531091A5
Authority
JP
Japan
Prior art keywords
leu
pth1r
receptor
val
pth3r
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000585406A
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English (en)
Japanese (ja)
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JP2002531091A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US1999/028207 external-priority patent/WO2000032775A1/en
Publication of JP2002531091A publication Critical patent/JP2002531091A/ja
Publication of JP2002531091A5 publication Critical patent/JP2002531091A5/ja
Pending legal-status Critical Current

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JP2000585406A 1998-11-30 1999-11-30 Pth1rおよびpth3rレセプター Pending JP2002531091A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11046798P 1998-11-30 1998-11-30
US60/110,467 1998-11-30
PCT/US1999/028207 WO2000032775A1 (en) 1998-11-30 1999-11-30 Pth1r and pth3r receptors

Publications (2)

Publication Number Publication Date
JP2002531091A JP2002531091A (ja) 2002-09-24
JP2002531091A5 true JP2002531091A5 (enExample) 2006-11-24

Family

ID=22333168

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000585406A Pending JP2002531091A (ja) 1998-11-30 1999-11-30 Pth1rおよびpth3rレセプター

Country Status (5)

Country Link
US (3) US6541220B1 (enExample)
EP (1) EP1135489A1 (enExample)
JP (1) JP2002531091A (enExample)
AU (2) AU4217299A (enExample)
WO (2) WO2000032771A1 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000023594A1 (en) * 1998-10-22 2000-04-27 The General Hospital Corporation BIOACTIVE PEPTIDES AND PEPTIDE DERIVATIVES OF PARATHYROID HORMONE (PTH) AND PARATHYROID HORMONE-RELATED PEPTIDE (PTHrP)
US6417333B1 (en) * 1998-11-25 2002-07-09 The General Hospital Corporation Modified human parathyroid hormone
US6537965B1 (en) * 1998-11-25 2003-03-25 The General Hospital Corporation Amino-terminal modified parathyroid hormone (PTH) analogs
WO2000032771A1 (en) * 1998-11-30 2000-06-08 The General Hospital Corporation Pth1r and pth3r receptors, methods and uses thereof
US7057012B1 (en) * 1998-12-31 2006-06-06 The General Hospital Corporation PTH functional domain conjugate peptides, derivatives thereof and novel tethered ligand-receptor molecules
ATE308609T1 (de) 1998-12-31 2005-11-15 Gen Hospital Corp Pth rezeptor und testverfahren unter verwendung desselben
EP1147133B1 (en) * 1998-12-31 2008-08-06 The General Hospital Corporation Peptides consisting of two PTH functional domains fused by a linker molecule, and derivatives thereof
WO2001023521A2 (en) * 1999-09-29 2001-04-05 The General Hospital Corporation Polypeptide derivatives of parathyroid hormone (pth)
US6756480B2 (en) * 2000-04-27 2004-06-29 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
KR100491737B1 (ko) * 2001-07-20 2005-05-27 주식회사 한국아이템개발 공기 정화 기능의 모기 퇴치기
US7572765B2 (en) 2001-07-23 2009-08-11 The General Hospital Corporation Conformationally constrained parathyroid hormone (PTH) analogs
AU2002951372A0 (en) * 2002-09-13 2002-09-26 St Vincent's Institute Of Medical Research Parathyroid hormone-like polypeptides
WO2004093902A1 (en) * 2003-03-19 2004-11-04 The General Hospital Corporation CONFORMATIONALLY CONSTRAINED PARATHYROID HORMONES WITH α-HELIX STABILIZERS
EP1653985A4 (en) * 2003-07-17 2009-08-05 Gen Hospital Corp FORCED PARATHORMON (PTH) ANALOGUE
US20060068426A1 (en) * 2004-08-20 2006-03-30 Tam James P Cyclic peptides and antibodies thereof
JP2009545320A (ja) * 2006-08-04 2009-12-24 ザ ジェネラル ホスピタル コーポレイション 副甲状腺ホルモン(pth)のポリペプチド誘導体
EP1961765A1 (en) * 2006-12-08 2008-08-27 Zealand Pharma A/S Truncated PTH peptides with a cyclic conformation
CN104072606B (zh) 2007-08-01 2017-09-22 总医院有限公司 利用g蛋白偶联受体和相关组合物的筛选方法
US20110256557A1 (en) * 2008-10-31 2011-10-20 Discoverybiomed, Inc. Identifying parathyroid hormone agonists and antagonists
JP5941040B2 (ja) 2010-05-13 2016-06-29 ザ ジェネラル ホスピタル コーポレイション 副甲状腺ホルモン類似体およびその使用
WO2018026748A1 (en) * 2016-08-01 2018-02-08 Xoma (Us) Llc Parathyroid hormone receptor 1 (pth1r) antibodies and uses thereof
JP2021516222A (ja) 2018-03-16 2021-07-01 ザ ジェネラル ホスピタル コーポレイション 副甲状腺ホルモンポリペプチドコンジュゲートおよびその使用方法
WO2022235929A1 (en) * 2021-05-05 2022-11-10 Radius Pharmaceuticals, Inc. Animal model having homologous recombination of mouse pth1 receptor
CN114874325B (zh) * 2022-06-01 2023-02-14 南京医科大学 抗人pth1r胞外区阻断型单域抗体及其应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4423037A (en) 1982-05-13 1983-12-27 The General Hospital Corporation Inhibitors of peptide hormone action
US5010010A (en) 1986-10-22 1991-04-23 Selmer-Sande, A.S. Production of human parathyroid hormone from microorganisms
US5462856A (en) 1990-07-19 1995-10-31 Bunsen Rush Laboratories, Inc. Methods for identifying chemicals that act as agonists or antagonists for receptors and other proteins involved in signal transduction via pathways that utilize G-proteins
JP3464796B2 (ja) * 1991-04-05 2003-11-10 ザ ジェネラル ホスピタル コーポレーション 副甲状腺ホルモンのレセプターとそれをコードしているdna
US5208041A (en) 1991-05-23 1993-05-04 Allelix Biopharmaceuticals Inc. Essentially pure human parathyroid hormone
AU3322593A (en) 1991-12-17 1993-07-19 Procter & Gamble Pharmaceuticals, Inc. Methods for the treatment of osteoporosis using bisphosphonates and parathyroid hormone
US5814603A (en) 1992-06-12 1998-09-29 Affymax Technologies N.V. Compounds with PTH activity
US5589452A (en) 1992-07-14 1996-12-31 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
US5496801A (en) 1993-12-23 1996-03-05 Allelix Biopharmaceuticals Inc. Parathyroid hormone formulation
WO2000023594A1 (en) * 1998-10-22 2000-04-27 The General Hospital Corporation BIOACTIVE PEPTIDES AND PEPTIDE DERIVATIVES OF PARATHYROID HORMONE (PTH) AND PARATHYROID HORMONE-RELATED PEPTIDE (PTHrP)
US6537965B1 (en) * 1998-11-25 2003-03-25 The General Hospital Corporation Amino-terminal modified parathyroid hormone (PTH) analogs
US6417333B1 (en) * 1998-11-25 2002-07-09 The General Hospital Corporation Modified human parathyroid hormone
WO2000032771A1 (en) * 1998-11-30 2000-06-08 The General Hospital Corporation Pth1r and pth3r receptors, methods and uses thereof
ES2316354T3 (es) 1999-09-29 2009-04-16 The General Hospital Corporation Derivados polipeptidos de la hormona paratiroidea (pth).

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