JP2002531051A - 血液透析及び腹膜透析患者における鉄デリバリーのための方法及び医薬組成物 - Google Patents
血液透析及び腹膜透析患者における鉄デリバリーのための方法及び医薬組成物Info
- Publication number
- JP2002531051A JP2002531051A JP53014898A JP53014898A JP2002531051A JP 2002531051 A JP2002531051 A JP 2002531051A JP 53014898 A JP53014898 A JP 53014898A JP 53014898 A JP53014898 A JP 53014898A JP 2002531051 A JP2002531051 A JP 2002531051A
- Authority
- JP
- Japan
- Prior art keywords
- iron
- dialysis
- patients
- ferric
- dialysis solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1654—Dialysates therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/28—Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
- A61M1/287—Dialysates therefor
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- External Artificial Organs (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.透析プロセスの間の、透析溶液から血液区画への分子の移動により血液学 的パラメーターを変更する方法。 2.赤血球細胞生産が、透析溶液から血液区画への分子の透析により調節され る、請求項1に記載の方法。 3.鉄が、透析プロセスの間、透析溶液から血液区画へ移される、請求項2に 記載の方法。 4.透析溶液から血液区画への鉄の移動が、透析溶液への、可溶性の、非コロ イド状の第2鉄化合物の添加により達成される、請求項3に記載の方法。 5.前記第2鉄が、10,000ダルトン未満の分子量をもつ、請求項4に記載の方 法。 6.前記第2鉄化合物が、ピロリン酸第2鉄である、請求項5に記載の方法。 7.透析を含む、いずれかの非経口経路によりピロリン酸第2鉄を投与する方 法。 8.透析が、血液透析又は腹膜透析としてさらに定義される、請求項1に記載 の方法。 9.前記注入工程が、100mg/時までの速度で、哺乳類の循環内に、鉄をデリ バリーする、請求項3に記載の方法。 10.哺乳類において血液学的パラメーターを調節する可溶性の、非コロイド状 化合物を含む透析溶液から本質的に成る医薬組成物。 11.可溶性の、非コロイド状の第2鉄化合物を含有する透析溶液から本質的に 成る医薬組成物。 12.前記第2鉄化合物が、10,000ダルトン未満の分子重量をもつ、請求項10に 記載の組成物。 13.前記第2鉄化合物が、ピロリン酸第2鉄である、請求項12に記載の組成物 。 14.請求項7に記載の、非経口投与のために好適なピロリン酸第2鉄の滅菌溶 液から本質的に成る、医薬組成物。 15.透析の間、透析溶液中で可溶性である、非コロイド状の第2鉄化合物の注 入により透析患者に鉄を投与する方法。 16.透析の間、透析溶液中で可溶性である、非コロイド状の第2鉄化合物を投 与することにより哺乳類において生物学的に利用可能な鉄の量を増加させる方法 。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/775,595 US6689275B1 (en) | 1996-12-31 | 1996-12-31 | Method and pharmaceutical composition for replacing iron losses in dialysis patients |
US5531597P | 1997-08-07 | 1997-08-07 | |
US60/055,315 | 1997-08-07 | ||
US08/775,595 | 1997-08-07 | ||
PCT/US1997/023719 WO1998029434A1 (en) | 1996-12-31 | 1997-12-30 | Method and pharmaceutical composition for iron delivery in hemodialysis and peritoneal dialysis patients |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007004535A Division JP4753379B2 (ja) | 1996-12-31 | 2007-01-12 | 血液透析及び腹膜透析患者における鉄デリバリーのための方法及び医薬組成物 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2002531051A true JP2002531051A (ja) | 2002-09-17 |
JP2002531051A5 JP2002531051A5 (ja) | 2005-07-14 |
JP3955639B2 JP3955639B2 (ja) | 2007-08-08 |
Family
ID=26734087
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP53014898A Expired - Lifetime JP3955639B2 (ja) | 1996-12-31 | 1997-12-30 | 血液透析及び腹膜透析患者における鉄デリバリーのための方法及び医薬組成物 |
JP2007004535A Expired - Lifetime JP4753379B2 (ja) | 1996-12-31 | 2007-01-12 | 血液透析及び腹膜透析患者における鉄デリバリーのための方法及び医薬組成物 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007004535A Expired - Lifetime JP4753379B2 (ja) | 1996-12-31 | 2007-01-12 | 血液透析及び腹膜透析患者における鉄デリバリーのための方法及び医薬組成物 |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP0951470B1 (ja) |
JP (2) | JP3955639B2 (ja) |
AT (1) | ATE311180T1 (ja) |
AU (1) | AU736053B2 (ja) |
BR (1) | BR9713653B1 (ja) |
CA (1) | CA2276442C (ja) |
DE (1) | DE69734781T2 (ja) |
DK (1) | DK0951470T3 (ja) |
EA (1) | EA002479B1 (ja) |
ES (1) | ES2255115T3 (ja) |
HK (1) | HK1023350A1 (ja) |
NO (1) | NO317873B1 (ja) |
NZ (1) | NZ336319A (ja) |
PL (1) | PL191377B1 (ja) |
SI (1) | SI20151A (ja) |
TR (1) | TR199901518T2 (ja) |
WO (1) | WO1998029434A1 (ja) |
YU (1) | YU31299A (ja) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007524629A (ja) * | 2003-06-24 | 2007-08-30 | アドバンスド レナル テクノロジーズ | 透析のための緩衝組成物 |
JP2009510402A (ja) * | 2005-09-24 | 2009-03-12 | ベックマン コールター, インコーポレイテッド | エリスロポエチン治療に対する反応性の決定法 |
JP2009108027A (ja) * | 2007-07-20 | 2009-05-21 | Rockwell Medical Technologies Inc | ピロリン酸クエン酸第二鉄キレート組成物の調製及び使用の方法 |
JP2011500578A (ja) * | 2007-10-11 | 2011-01-06 | バクスター・インターナショナル・インコーポレイテッド | ピロホスフェートを含む滅菌透析溶液 |
JP4838139B2 (ja) * | 2003-10-28 | 2011-12-14 | エモリー ユニバーシティー | 透析液並びに透析液に関連した方法及びシステム |
KR20160004257A (ko) * | 2013-02-01 | 2016-01-12 | 차락 엘엘씨 | 가용성 제이철 피로인산염으로 철 결핍을 치료하는 방법 |
JP2016535783A (ja) * | 2013-11-05 | 2016-11-17 | ロックウェル メディカル,インコーポレイテッド | 反応性が低下した患者のエリトロポエチン刺激剤の用量を減少させる方法 |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5906978A (en) * | 1996-08-14 | 1999-05-25 | Hemocleanse, Inc. | Method for iron delivery to a patient by transfer from dialysate |
WO2001021233A1 (en) | 1999-09-22 | 2001-03-29 | Advanced Renal Technologies | High citrate dialysate and uses thereof |
DE19951471A1 (de) * | 1999-10-26 | 2001-05-03 | Forssmann Wolf Georg | Verwendung von Urodilatin zur Behandlung chronischer Niereninsuffizienz mit Nierenrestfunktionen |
US8187467B2 (en) | 2003-12-30 | 2012-05-29 | Ajay Gupta | Parenteral administration of pyrophosphate for prevention or treatment of phosphate or pyrophosphate depletion |
SE0400523D0 (sv) | 2004-03-01 | 2004-03-01 | Gambro Lundia Ab | A medical solution, a method for producing said medical solution and use thereof |
SE0402507D0 (sv) | 2004-10-14 | 2004-10-14 | Gambro Lundia Ab | Medicinsk lösning, förfarande för framställning och användning därav |
CN102858351A (zh) * | 2010-04-23 | 2013-01-02 | 巴克斯特国际公司 | 减少或防止腹膜透析治疗期间血管钙化的方法和组合物 |
AU2015200995B2 (en) * | 2010-04-23 | 2016-09-08 | Baxter Healthcare S.A. | Methods and compositions for reducing or preventing vascular calcification during peritoneal dialysis therapy |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3530216A (en) * | 1967-10-05 | 1970-09-22 | Hoffmann La Roche | Vitamin compositions comprising riboflavin-5-phosphate and ferric pyrophosphate soluble |
US3911915A (en) * | 1972-09-05 | 1975-10-14 | Einstein Coll Med | Dialytic introduction of maltose into bloodstream |
JPS5125238B2 (ja) * | 1973-08-14 | 1976-07-29 | ||
US4756838A (en) * | 1980-02-21 | 1988-07-12 | Veltman Preston Leonard | Preparation of dry dialysate products |
JPH0696586B2 (ja) * | 1987-03-17 | 1994-11-30 | 花王株式会社 | ヘキソ−スリン酸第一鉄塩及びその製造法並びにこれを含有する鉄供給剤 |
JPH0525051A (ja) * | 1991-07-19 | 1993-02-02 | Meiji Seika Kaisha Ltd | 貧血予防・治療剤 |
JP3167402B2 (ja) * | 1992-02-25 | 2001-05-21 | 仙味エキス株式会社 | 鉄吸収促進組成物 |
-
1997
- 1997-12-30 AT AT97952598T patent/ATE311180T1/de active
- 1997-12-30 WO PCT/US1997/023719 patent/WO1998029434A1/en active IP Right Grant
- 1997-12-30 EP EP97952598A patent/EP0951470B1/en not_active Expired - Lifetime
- 1997-12-30 CA CA2276442A patent/CA2276442C/en not_active Expired - Lifetime
- 1997-12-30 PL PL334437A patent/PL191377B1/pl unknown
- 1997-12-30 JP JP53014898A patent/JP3955639B2/ja not_active Expired - Lifetime
- 1997-12-30 SI SI9720087A patent/SI20151A/sl unknown
- 1997-12-30 TR TR1999/01518T patent/TR199901518T2/xx unknown
- 1997-12-30 DE DE69734781T patent/DE69734781T2/de not_active Expired - Lifetime
- 1997-12-30 EA EA199900609A patent/EA002479B1/ru not_active IP Right Cessation
- 1997-12-30 DK DK97952598T patent/DK0951470T3/da active
- 1997-12-30 NZ NZ336319A patent/NZ336319A/xx not_active IP Right Cessation
- 1997-12-30 ES ES97952598T patent/ES2255115T3/es not_active Expired - Lifetime
- 1997-12-30 YU YU31299A patent/YU31299A/sh unknown
- 1997-12-30 BR BRPI9713653-0A patent/BR9713653B1/pt not_active IP Right Cessation
- 1997-12-30 AU AU56172/98A patent/AU736053B2/en not_active Expired
-
1999
- 1999-06-29 NO NO19993235A patent/NO317873B1/no not_active IP Right Cessation
-
2000
- 2000-04-26 HK HK00102462A patent/HK1023350A1/xx not_active IP Right Cessation
-
2007
- 2007-01-12 JP JP2007004535A patent/JP4753379B2/ja not_active Expired - Lifetime
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007524629A (ja) * | 2003-06-24 | 2007-08-30 | アドバンスド レナル テクノロジーズ | 透析のための緩衝組成物 |
JP2011144199A (ja) * | 2003-06-24 | 2011-07-28 | Advanced Renal Technologies | 透析のための緩衝組成物 |
JP4838139B2 (ja) * | 2003-10-28 | 2011-12-14 | エモリー ユニバーシティー | 透析液並びに透析液に関連した方法及びシステム |
JP2009510402A (ja) * | 2005-09-24 | 2009-03-12 | ベックマン コールター, インコーポレイテッド | エリスロポエチン治療に対する反応性の決定法 |
JP2009108027A (ja) * | 2007-07-20 | 2009-05-21 | Rockwell Medical Technologies Inc | ピロリン酸クエン酸第二鉄キレート組成物の調製及び使用の方法 |
JP2011500578A (ja) * | 2007-10-11 | 2011-01-06 | バクスター・インターナショナル・インコーポレイテッド | ピロホスフェートを含む滅菌透析溶液 |
KR20160004257A (ko) * | 2013-02-01 | 2016-01-12 | 차락 엘엘씨 | 가용성 제이철 피로인산염으로 철 결핍을 치료하는 방법 |
JP2016507527A (ja) * | 2013-02-01 | 2016-03-10 | チャラク エルエルシー | 可溶性ピロリン酸第二鉄を用いて鉄欠乏症を治療する方法 |
JP2019151669A (ja) * | 2013-02-01 | 2019-09-12 | チャラク エルエルシー | 可溶性ピロリン酸第二鉄を用いて鉄欠乏症を治療する方法 |
KR102236714B1 (ko) | 2013-02-01 | 2021-04-06 | 차락 엘엘씨 | 가용성 제이철 피로인산염으로 철 결핍을 치료하는 방법 |
JP2016535783A (ja) * | 2013-11-05 | 2016-11-17 | ロックウェル メディカル,インコーポレイテッド | 反応性が低下した患者のエリトロポエチン刺激剤の用量を減少させる方法 |
Also Published As
Publication number | Publication date |
---|---|
CA2276442C (en) | 2012-01-17 |
YU31299A (sh) | 2002-08-12 |
CA2276442A1 (en) | 1998-07-09 |
NZ336319A (en) | 2000-12-22 |
EA002479B1 (ru) | 2002-06-27 |
AU5617298A (en) | 1998-07-31 |
EP0951470B1 (en) | 2005-11-30 |
SI20151A (sl) | 2000-08-31 |
HK1023350A1 (en) | 2000-09-08 |
EP0951470A1 (en) | 1999-10-27 |
NO993235D0 (no) | 1999-06-29 |
PL191377B1 (pl) | 2006-05-31 |
BR9713653A (pt) | 2000-04-11 |
EP0951470A4 (en) | 2003-05-02 |
PL334437A1 (en) | 2000-02-28 |
JP4753379B2 (ja) | 2011-08-24 |
EA199900609A1 (ru) | 1999-12-29 |
DE69734781T2 (de) | 2006-07-20 |
JP2007106775A (ja) | 2007-04-26 |
WO1998029434A1 (en) | 1998-07-09 |
JP3955639B2 (ja) | 2007-08-08 |
AU736053B2 (en) | 2001-07-26 |
DE69734781D1 (de) | 2006-01-05 |
TR199901518T2 (xx) | 1999-12-21 |
NO317873B1 (no) | 2004-12-27 |
ATE311180T1 (de) | 2005-12-15 |
DK0951470T3 (da) | 2006-03-27 |
ES2255115T3 (es) | 2006-06-16 |
NO993235L (no) | 1999-08-27 |
BR9713653B1 (pt) | 2013-05-21 |
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