JP2002530325A - 非インスリン依存型真性糖尿病の治療へのベンゾイルグアニジンの使用 - Google Patents

非インスリン依存型真性糖尿病の治療へのベンゾイルグアニジンの使用

Info

Publication number
JP2002530325A
JP2002530325A JP2000583507A JP2000583507A JP2002530325A JP 2002530325 A JP2002530325 A JP 2002530325A JP 2000583507 A JP2000583507 A JP 2000583507A JP 2000583507 A JP2000583507 A JP 2000583507A JP 2002530325 A JP2002530325 A JP 2002530325A
Authority
JP
Japan
Prior art keywords
het
hal
methyl
carbon atoms
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000583507A
Other languages
English (en)
Japanese (ja)
Inventor
ロルフ ゲイリカ、
マンフレット バオムガース、
クラウス ミンク、
ディディエ メサンジョ、
リリアン ドアル、
ミシュリン ケルゴア、
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of JP2002530325A publication Critical patent/JP2002530325A/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/402—1-aryl substituted, e.g. piretanide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
JP2000583507A 1998-11-26 1999-11-16 非インスリン依存型真性糖尿病の治療へのベンゾイルグアニジンの使用 Pending JP2002530325A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP98122419 1998-11-26
EP98122419.9 1998-11-26
PCT/EP1999/008795 WO2000030624A2 (fr) 1998-11-26 1999-11-16 Utilisation de benzoylguanidines pour le traitement du diabete non insulino-dependant

Publications (1)

Publication Number Publication Date
JP2002530325A true JP2002530325A (ja) 2002-09-17

Family

ID=8233036

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000583507A Pending JP2002530325A (ja) 1998-11-26 1999-11-16 非インスリン依存型真性糖尿病の治療へのベンゾイルグアニジンの使用

Country Status (14)

Country Link
EP (1) EP1131064A2 (fr)
JP (1) JP2002530325A (fr)
KR (1) KR20010080597A (fr)
CN (1) CN1328452A (fr)
AR (1) AR023064A1 (fr)
AU (1) AU1553500A (fr)
BR (1) BR9915667A (fr)
CA (1) CA2352154A1 (fr)
CZ (1) CZ20011785A3 (fr)
HU (1) HUP0104418A2 (fr)
ID (1) ID29523A (fr)
NO (1) NO20012563D0 (fr)
PL (1) PL348152A1 (fr)
WO (1) WO2000030624A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2488342A1 (fr) * 2002-06-05 2003-12-18 Institute Of Medicinal Molecular Design, Inc. Medicaments therapeutiques destines au diabete
US7381841B2 (en) 2003-08-22 2008-06-03 Sanofi-Aventis Deutschland Gmbh Pentafluorosulfanylphenyl-substituted benzoylguanidines, processes for their preparation, their use as medicament or diagnostic aid, and medicament comprising them
DE102004054847A1 (de) * 2004-11-13 2006-05-24 Sanofi-Aventis Deutschland Gmbh Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4430916A1 (de) * 1994-08-31 1996-03-07 Merck Patent Gmbh Alkyl-benzoylguanidin-Derivate
DE4430861A1 (de) * 1994-08-31 1996-03-07 Merck Patent Gmbh Heterocyclyl-benzoylguanidine
DE4437874A1 (de) * 1994-10-22 1996-04-25 Merck Patent Gmbh Alkyl-5-methylsulfonyl-benzoylguanidin-Derivate
DE19502644A1 (de) * 1995-01-28 1996-08-01 Merck Patent Gmbh 4-Amino-benzoylguanidin-Derivate
DE19502895A1 (de) * 1995-01-31 1996-08-01 Merck Patent Gmbh 4-Mercapto-benzoylguanidin-Derivate
DE19517848A1 (de) * 1995-05-16 1996-11-21 Merck Patent Gmbh Fluorhaltige Benzoylguanidine
DE19531138A1 (de) * 1995-08-24 1997-02-27 Merck Patent Gmbh Alkenyl-benzoylguanidin-Derivate

Also Published As

Publication number Publication date
BR9915667A (pt) 2001-08-14
PL348152A1 (en) 2002-05-06
AU1553500A (en) 2000-06-13
ID29523A (id) 2001-09-06
CZ20011785A3 (cs) 2001-10-17
NO20012563L (no) 2001-05-25
WO2000030624A2 (fr) 2000-06-02
KR20010080597A (ko) 2001-08-22
CA2352154A1 (fr) 2000-06-02
NO20012563D0 (no) 2001-05-25
CN1328452A (zh) 2001-12-26
WO2000030624A3 (fr) 2000-10-05
AR023064A1 (es) 2002-09-04
HUP0104418A2 (hu) 2002-04-29
EP1131064A2 (fr) 2001-09-12

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