AR023064A1 - Uso de benzoilguanidinas para tratar la diabetes mellitus no insulinadependiente. - Google Patents
Uso de benzoilguanidinas para tratar la diabetes mellitus no insulinadependiente.Info
- Publication number
- AR023064A1 AR023064A1 ARP990106043A ARP990106043A AR023064A1 AR 023064 A1 AR023064 A1 AR 023064A1 AR P990106043 A ARP990106043 A AR P990106043A AR P990106043 A ARP990106043 A AR P990106043A AR 023064 A1 AR023064 A1 AR 023064A1
- Authority
- AR
- Argentina
- Prior art keywords
- hal
- het
- numbers
- substituted
- nha
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/402—1-aryl substituted, e.g. piretanide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
Abstract
Se proporne el uso de benzoilguanidinas de formula 1 en la que R1 representa A; R2 representa Het, CnFmH2n+1-mOp, R4, OR4, OH, bencilo, CN, Hal, SOq-R5,Ph, O-PH, O-Het, NH-Het, NH2, NHA, NA2 o NH-Ph; R3 representa SO2-A; R4 representa un resto dealq uilo de cadena recta o ramificada y C1-8, cicloalquilo C3-8,no, sustituidos o sustituidos uno, dos o tres veces con A; R5 representa A o Ph; A y A independientemente, representan alquilo C1-6; Het representa unheterociclo mono o bicíclico,saturado, no saturado o aromático, con C1-4 de N, O y/o S, eventualmente sustituido una, dos o tres veces con Hal, CF3, A, CN,NO2, NH2 y/o carboniloxi; Hal representa F, Cl, Br o I; Ph representa fenilo no sustituido o sustituido una, dos o tresveces con A, O A, Hal, CF3, NH2, NHA oNA2; m representa los numeros 1, 2, 3, 4, 5, 6, 7 pero a lo sumo 2n + 1; n representa los numeros 1, 2 o 3; p representa los numeros 0 o 1; y q representa losnumeros 0, 1 o 2, y/o de sus sales y solvatosaceptables desde el pun to de vista fisiologico, para producir un medicamento para tratar la diabetes mellitus noinsulinadependiente. Estos compuestos reducen y regulan los niveles de azucar en sangre, y también los de insulina, ácidos grasos libresy triglicéridos, deperso nas DMNID.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98122419 | 1998-11-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR023064A1 true AR023064A1 (es) | 2002-09-04 |
Family
ID=8233036
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990106043A AR023064A1 (es) | 1998-11-26 | 1999-11-26 | Uso de benzoilguanidinas para tratar la diabetes mellitus no insulinadependiente. |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP1131064A2 (es) |
| JP (1) | JP2002530325A (es) |
| KR (1) | KR20010080597A (es) |
| CN (1) | CN1328452A (es) |
| AR (1) | AR023064A1 (es) |
| AU (1) | AU1553500A (es) |
| BR (1) | BR9915667A (es) |
| CA (1) | CA2352154A1 (es) |
| CZ (1) | CZ20011785A3 (es) |
| HU (1) | HUP0104418A2 (es) |
| ID (1) | ID29523A (es) |
| NO (1) | NO20012563D0 (es) |
| PL (1) | PL348152A1 (es) |
| WO (1) | WO2000030624A2 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2488342A1 (en) * | 2002-06-05 | 2003-12-18 | Institute Of Medicinal Molecular Design, Inc. | Therapeutic drug for diabetes |
| US7381841B2 (en) | 2003-08-22 | 2008-06-03 | Sanofi-Aventis Deutschland Gmbh | Pentafluorosulfanylphenyl-substituted benzoylguanidines, processes for their preparation, their use as medicament or diagnostic aid, and medicament comprising them |
| DE102004054847A1 (de) * | 2004-11-13 | 2006-05-24 | Sanofi-Aventis Deutschland Gmbh | Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4430916A1 (de) * | 1994-08-31 | 1996-03-07 | Merck Patent Gmbh | Alkyl-benzoylguanidin-Derivate |
| DE4430861A1 (de) * | 1994-08-31 | 1996-03-07 | Merck Patent Gmbh | Heterocyclyl-benzoylguanidine |
| DE4437874A1 (de) * | 1994-10-22 | 1996-04-25 | Merck Patent Gmbh | Alkyl-5-methylsulfonyl-benzoylguanidin-Derivate |
| DE19502644A1 (de) * | 1995-01-28 | 1996-08-01 | Merck Patent Gmbh | 4-Amino-benzoylguanidin-Derivate |
| DE19502895A1 (de) * | 1995-01-31 | 1996-08-01 | Merck Patent Gmbh | 4-Mercapto-benzoylguanidin-Derivate |
| DE19517848A1 (de) * | 1995-05-16 | 1996-11-21 | Merck Patent Gmbh | Fluorhaltige Benzoylguanidine |
| DE19531138A1 (de) * | 1995-08-24 | 1997-02-27 | Merck Patent Gmbh | Alkenyl-benzoylguanidin-Derivate |
-
1999
- 1999-11-16 ID IDW00200101318A patent/ID29523A/id unknown
- 1999-11-16 AU AU15535/00A patent/AU1553500A/en not_active Abandoned
- 1999-11-16 HU HU0104418A patent/HUP0104418A2/hu unknown
- 1999-11-16 BR BR9915667-9A patent/BR9915667A/pt not_active Application Discontinuation
- 1999-11-16 KR KR1020017006615A patent/KR20010080597A/ko not_active Application Discontinuation
- 1999-11-16 EP EP99958047A patent/EP1131064A2/en not_active Ceased
- 1999-11-16 CN CN99813826A patent/CN1328452A/zh active Pending
- 1999-11-16 CZ CZ20011785A patent/CZ20011785A3/cs unknown
- 1999-11-16 WO PCT/EP1999/008795 patent/WO2000030624A2/en not_active Application Discontinuation
- 1999-11-16 JP JP2000583507A patent/JP2002530325A/ja active Pending
- 1999-11-16 PL PL99348152A patent/PL348152A1/xx unknown
- 1999-11-16 CA CA002352154A patent/CA2352154A1/en not_active Abandoned
- 1999-11-26 AR ARP990106043A patent/AR023064A1/es unknown
-
2001
- 2001-05-25 NO NO20012563A patent/NO20012563D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| BR9915667A (pt) | 2001-08-14 |
| PL348152A1 (en) | 2002-05-06 |
| AU1553500A (en) | 2000-06-13 |
| ID29523A (id) | 2001-09-06 |
| CZ20011785A3 (cs) | 2001-10-17 |
| JP2002530325A (ja) | 2002-09-17 |
| NO20012563L (no) | 2001-05-25 |
| WO2000030624A2 (en) | 2000-06-02 |
| KR20010080597A (ko) | 2001-08-22 |
| CA2352154A1 (en) | 2000-06-02 |
| NO20012563D0 (no) | 2001-05-25 |
| CN1328452A (zh) | 2001-12-26 |
| WO2000030624A3 (en) | 2000-10-05 |
| HUP0104418A2 (hu) | 2002-04-29 |
| EP1131064A2 (en) | 2001-09-12 |
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