WO2000030624A3 - Use of benzoylguanidines for the treatment of non-insulin-dependent diabetes mellitus - Google Patents

Use of benzoylguanidines for the treatment of non-insulin-dependent diabetes mellitus Download PDF

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Publication number
WO2000030624A3
WO2000030624A3 PCT/EP1999/008795 EP9908795W WO0030624A3 WO 2000030624 A3 WO2000030624 A3 WO 2000030624A3 EP 9908795 W EP9908795 W EP 9908795W WO 0030624 A3 WO0030624 A3 WO 0030624A3
Authority
WO
WIPO (PCT)
Prior art keywords
benzoylguanidines
insulin
treatment
diabetes mellitus
dependent diabetes
Prior art date
Application number
PCT/EP1999/008795
Other languages
French (fr)
Other versions
WO2000030624A2 (en
Inventor
Rolf Gericke
Manfred Baumgarth
Klaus Minck
Didier Mesangeau
Liliane Doare
Micheline Kergoat
Original Assignee
Merck Patent Gmbh
Rolf Gericke
Manfred Baumgarth
Klaus Minck
Didier Mesangeau
Liliane Doare
Micheline Kergoat
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh, Rolf Gericke, Manfred Baumgarth, Klaus Minck, Didier Mesangeau, Liliane Doare, Micheline Kergoat filed Critical Merck Patent Gmbh
Priority to BR9915667-9A priority Critical patent/BR9915667A/en
Priority to CA002352154A priority patent/CA2352154A1/en
Priority to EP99958047A priority patent/EP1131064A2/en
Priority to JP2000583507A priority patent/JP2002530325A/en
Priority to KR1020017006615A priority patent/KR20010080597A/en
Priority to HU0104418A priority patent/HUP0104418A2/en
Priority to AU15535/00A priority patent/AU1553500A/en
Publication of WO2000030624A2 publication Critical patent/WO2000030624A2/en
Publication of WO2000030624A3 publication Critical patent/WO2000030624A3/en
Priority to NO20012563A priority patent/NO20012563D0/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/402—1-aryl substituted, e.g. piretanide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

(57) Abstract The invention relates to the use of benzoylguanidines of formula (I) wherein R1 is A; R2 is Het, C¿n?FmH2n+1-mOp, R?4, OR4¿, OH, benzyl, CN, Hal, SO¿q-R?5, Ph, O-Ph, O-Het, NH-Het, NH¿2?, NHA, NA2 or NH-Ph; R?3¿ is SO¿2A'; R?4 is a straight-chain or branched alkyl radical having 1 to 8 C atoms or cycloalkyl having 3 to 8 C atoms which can be unsubstituted or mono-, di- or trisubstituted by A; R5 is A or Ph; A, A' in each case independently of one another are alkyl having 1 to 6 C atoms, and/or their physiologically acceptable salts and solvates for the production of a medicament for the treatment of non-insulin-dependent diabetes mellitus.
PCT/EP1999/008795 1998-11-26 1999-11-16 Use of benzoylguanidines for the treatment of non-insulin-dependent diabetes mellitus WO2000030624A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
BR9915667-9A BR9915667A (en) 1998-11-26 1999-11-16 Use of benzoylguanidines for the treatment of non-insulin-dependent diabetes mellitus
CA002352154A CA2352154A1 (en) 1998-11-26 1999-11-16 Use of benzoylguanidines for the treatment of non-insulin-dependent diabetes mellitus
EP99958047A EP1131064A2 (en) 1998-11-26 1999-11-16 Use of benzoylguanidines for the treatment of non-insulin-dependent diabetes mellitus
JP2000583507A JP2002530325A (en) 1998-11-26 1999-11-16 Use of benzoylguanidine for the treatment of non-insulin-dependent diabetes mellitus
KR1020017006615A KR20010080597A (en) 1998-11-26 1999-11-16 Use of benzoylguanidines for the treatment of non-insulin-dependent diabetes mellitus
HU0104418A HUP0104418A2 (en) 1998-11-26 1999-11-16 Use of benzoylguanidines for the treatment of non-insulin-dependent diabetes mellitus
AU15535/00A AU1553500A (en) 1998-11-26 1999-11-16 Use of benzoylguanidines for the treatment of non-insulin-dependent diabetes mellitus
NO20012563A NO20012563D0 (en) 1998-11-26 2001-05-25 Use of benzoylguanidines for the treatment of non-insulin-dependent diabetes mellitus

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98122419 1998-11-26
EP98122419.9 1998-11-26

Publications (2)

Publication Number Publication Date
WO2000030624A2 WO2000030624A2 (en) 2000-06-02
WO2000030624A3 true WO2000030624A3 (en) 2000-10-05

Family

ID=8233036

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/008795 WO2000030624A2 (en) 1998-11-26 1999-11-16 Use of benzoylguanidines for the treatment of non-insulin-dependent diabetes mellitus

Country Status (14)

Country Link
EP (1) EP1131064A2 (en)
JP (1) JP2002530325A (en)
KR (1) KR20010080597A (en)
CN (1) CN1328452A (en)
AR (1) AR023064A1 (en)
AU (1) AU1553500A (en)
BR (1) BR9915667A (en)
CA (1) CA2352154A1 (en)
CZ (1) CZ20011785A3 (en)
HU (1) HUP0104418A2 (en)
ID (1) ID29523A (en)
NO (1) NO20012563D0 (en)
PL (1) PL348152A1 (en)
WO (1) WO2000030624A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA008769B1 (en) * 2002-06-05 2007-08-31 Инститьют Оф Медисинал Молекьюлар Дизайн. Инк. Therapeutic drug for diabetes
US7381841B2 (en) 2003-08-22 2008-06-03 Sanofi-Aventis Deutschland Gmbh Pentafluorosulfanylphenyl-substituted benzoylguanidines, processes for their preparation, their use as medicament or diagnostic aid, and medicament comprising them
DE102004054847A1 (en) * 2004-11-13 2006-05-24 Sanofi-Aventis Deutschland Gmbh Substituted benzoylguanidines, process for their preparation, their use as medicament or diagnostic agent, and medicament containing them

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0699663A1 (en) * 1994-08-31 1996-03-06 MERCK PATENT GmbH Alkyl-benzoylguanidine derivatives
EP0699666A1 (en) * 1994-08-31 1996-03-06 MERCK PATENT GmbH Heterocyclic substituted benzoylguanidine
EP0708088A1 (en) * 1994-10-22 1996-04-24 MERCK PATENT GmbH Alkyl-5-methylsulphonyl-benzoyl-guanidine derivatives
EP0723963A1 (en) * 1995-01-28 1996-07-31 MERCK PATENT GmbH 4-amino-benzoylguanidine derivatives
EP0725062A1 (en) * 1995-01-31 1996-08-07 MERCK PATENT GmbH 4-mercapto-benzoylguanidine derivatives
EP0743301A2 (en) * 1995-05-16 1996-11-20 MERCK PATENT GmbH Benzoylguanidines containing fluorine
EP0760365A2 (en) * 1995-08-24 1997-03-05 MERCK PATENT GmbH Alkenyl-benzoylguanidines

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0699663A1 (en) * 1994-08-31 1996-03-06 MERCK PATENT GmbH Alkyl-benzoylguanidine derivatives
EP0699666A1 (en) * 1994-08-31 1996-03-06 MERCK PATENT GmbH Heterocyclic substituted benzoylguanidine
EP0708088A1 (en) * 1994-10-22 1996-04-24 MERCK PATENT GmbH Alkyl-5-methylsulphonyl-benzoyl-guanidine derivatives
EP0723963A1 (en) * 1995-01-28 1996-07-31 MERCK PATENT GmbH 4-amino-benzoylguanidine derivatives
EP0725062A1 (en) * 1995-01-31 1996-08-07 MERCK PATENT GmbH 4-mercapto-benzoylguanidine derivatives
EP0743301A2 (en) * 1995-05-16 1996-11-20 MERCK PATENT GmbH Benzoylguanidines containing fluorine
EP0760365A2 (en) * 1995-08-24 1997-03-05 MERCK PATENT GmbH Alkenyl-benzoylguanidines

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BAUMGARTH M ET AL: "(2-Methyl-5(methylsufonyl)benzoyl) guanidine Na+/H+ antiporter inhibitors", JOURNAL OF MEDICINAL CHEMISTRY,US,AMERICAN CHEMICAL SOCIETY. WASHINGTON, vol. 40, no. 13, 20 June 1997 (1997-06-20), pages 2017 - 2034-34, XP002121770, ISSN: 0022-2623 *

Also Published As

Publication number Publication date
CN1328452A (en) 2001-12-26
BR9915667A (en) 2001-08-14
HUP0104418A2 (en) 2002-04-29
NO20012563L (en) 2001-05-25
ID29523A (en) 2001-09-06
JP2002530325A (en) 2002-09-17
AR023064A1 (en) 2002-09-04
EP1131064A2 (en) 2001-09-12
PL348152A1 (en) 2002-05-06
KR20010080597A (en) 2001-08-22
WO2000030624A2 (en) 2000-06-02
NO20012563D0 (en) 2001-05-25
CA2352154A1 (en) 2000-06-02
CZ20011785A3 (en) 2001-10-17
AU1553500A (en) 2000-06-13

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