WO2000030624A3 - Use of benzoylguanidines for the treatment of non-insulin-dependent diabetes mellitus - Google Patents

Use of benzoylguanidines for the treatment of non-insulin-dependent diabetes mellitus Download PDF

Info

Publication number
WO2000030624A3
WO2000030624A3 PCT/EP1999/008795 EP9908795W WO0030624A3 WO 2000030624 A3 WO2000030624 A3 WO 2000030624A3 EP 9908795 W EP9908795 W EP 9908795W WO 0030624 A3 WO0030624 A3 WO 0030624A3
Authority
WO
WIPO (PCT)
Prior art keywords
benzoylguanidines
insulin
treatment
diabetes mellitus
dependent diabetes
Prior art date
Application number
PCT/EP1999/008795
Other languages
French (fr)
Other versions
WO2000030624A2 (en
Inventor
Rolf Gericke
Manfred Baumgarth
Klaus Minck
Didier Mesangeau
Liliane Doare
Micheline Kergoat
Original Assignee
Merck Patent Gmbh
Rolf Gericke
Manfred Baumgarth
Klaus Minck
Didier Mesangeau
Liliane Doare
Micheline Kergoat
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh, Rolf Gericke, Manfred Baumgarth, Klaus Minck, Didier Mesangeau, Liliane Doare, Micheline Kergoat filed Critical Merck Patent Gmbh
Priority to HU0104418A priority Critical patent/HUP0104418A2/en
Priority to AU15535/00A priority patent/AU1553500A/en
Priority to JP2000583507A priority patent/JP2002530325A/en
Priority to CA002352154A priority patent/CA2352154A1/en
Priority to BR9915667-9A priority patent/BR9915667A/en
Priority to KR1020017006615A priority patent/KR20010080597A/en
Priority to EP99958047A priority patent/EP1131064A2/en
Publication of WO2000030624A2 publication Critical patent/WO2000030624A2/en
Publication of WO2000030624A3 publication Critical patent/WO2000030624A3/en
Priority to NO20012563A priority patent/NO20012563D0/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/402—1-aryl substituted, e.g. piretanide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

(57) Abstract The invention relates to the use of benzoylguanidines of formula (I) wherein R1 is A; R2 is Het, C¿n?FmH2n+1-mOp, R?4, OR4¿, OH, benzyl, CN, Hal, SO¿q-R?5, Ph, O-Ph, O-Het, NH-Het, NH¿2?, NHA, NA2 or NH-Ph; R?3¿ is SO¿2A'; R?4 is a straight-chain or branched alkyl radical having 1 to 8 C atoms or cycloalkyl having 3 to 8 C atoms which can be unsubstituted or mono-, di- or trisubstituted by A; R5 is A or Ph; A, A' in each case independently of one another are alkyl having 1 to 6 C atoms, and/or their physiologically acceptable salts and solvates for the production of a medicament for the treatment of non-insulin-dependent diabetes mellitus.
PCT/EP1999/008795 1998-11-26 1999-11-16 Use of benzoylguanidines for the treatment of non-insulin-dependent diabetes mellitus WO2000030624A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
HU0104418A HUP0104418A2 (en) 1998-11-26 1999-11-16 Use of benzoylguanidines for the treatment of non-insulin-dependent diabetes mellitus
AU15535/00A AU1553500A (en) 1998-11-26 1999-11-16 Use of benzoylguanidines for the treatment of non-insulin-dependent diabetes mellitus
JP2000583507A JP2002530325A (en) 1998-11-26 1999-11-16 Use of benzoylguanidine for the treatment of non-insulin-dependent diabetes mellitus
CA002352154A CA2352154A1 (en) 1998-11-26 1999-11-16 Use of benzoylguanidines for the treatment of non-insulin-dependent diabetes mellitus
BR9915667-9A BR9915667A (en) 1998-11-26 1999-11-16 Use of benzoylguanidines for the treatment of non-insulin-dependent diabetes mellitus
KR1020017006615A KR20010080597A (en) 1998-11-26 1999-11-16 Use of benzoylguanidines for the treatment of non-insulin-dependent diabetes mellitus
EP99958047A EP1131064A2 (en) 1998-11-26 1999-11-16 Use of benzoylguanidines for the treatment of non-insulin-dependent diabetes mellitus
NO20012563A NO20012563D0 (en) 1998-11-26 2001-05-25 Use of benzoylguanidines for the treatment of non-insulin-dependent diabetes mellitus

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98122419 1998-11-26
EP98122419.9 1998-11-26

Publications (2)

Publication Number Publication Date
WO2000030624A2 WO2000030624A2 (en) 2000-06-02
WO2000030624A3 true WO2000030624A3 (en) 2000-10-05

Family

ID=8233036

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/008795 WO2000030624A2 (en) 1998-11-26 1999-11-16 Use of benzoylguanidines for the treatment of non-insulin-dependent diabetes mellitus

Country Status (14)

Country Link
EP (1) EP1131064A2 (en)
JP (1) JP2002530325A (en)
KR (1) KR20010080597A (en)
CN (1) CN1328452A (en)
AR (1) AR023064A1 (en)
AU (1) AU1553500A (en)
BR (1) BR9915667A (en)
CA (1) CA2352154A1 (en)
CZ (1) CZ20011785A3 (en)
HU (1) HUP0104418A2 (en)
ID (1) ID29523A (en)
NO (1) NO20012563D0 (en)
PL (1) PL348152A1 (en)
WO (1) WO2000030624A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100379410C (en) * 2002-06-05 2008-04-09 株式会社医药分子设计研究所 Therapeutic drug for diabetes
US7381841B2 (en) 2003-08-22 2008-06-03 Sanofi-Aventis Deutschland Gmbh Pentafluorosulfanylphenyl-substituted benzoylguanidines, processes for their preparation, their use as medicament or diagnostic aid, and medicament comprising them
DE102004054847A1 (en) * 2004-11-13 2006-05-24 Sanofi-Aventis Deutschland Gmbh Substituted benzoylguanidines, process for their preparation, their use as medicament or diagnostic agent, and medicament containing them

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0699666A1 (en) * 1994-08-31 1996-03-06 MERCK PATENT GmbH Heterocyclic substituted benzoylguanidine
EP0699663A1 (en) * 1994-08-31 1996-03-06 MERCK PATENT GmbH Alkyl-benzoylguanidine derivatives
EP0708088A1 (en) * 1994-10-22 1996-04-24 MERCK PATENT GmbH Alkyl-5-methylsulphonyl-benzoyl-guanidine derivatives
EP0723963A1 (en) * 1995-01-28 1996-07-31 MERCK PATENT GmbH 4-amino-benzoylguanidine derivatives
EP0725062A1 (en) * 1995-01-31 1996-08-07 MERCK PATENT GmbH 4-mercapto-benzoylguanidine derivatives
EP0743301A2 (en) * 1995-05-16 1996-11-20 MERCK PATENT GmbH Benzoylguanidines containing fluorine
EP0760365A2 (en) * 1995-08-24 1997-03-05 MERCK PATENT GmbH Alkenyl-benzoylguanidines

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0699666A1 (en) * 1994-08-31 1996-03-06 MERCK PATENT GmbH Heterocyclic substituted benzoylguanidine
EP0699663A1 (en) * 1994-08-31 1996-03-06 MERCK PATENT GmbH Alkyl-benzoylguanidine derivatives
EP0708088A1 (en) * 1994-10-22 1996-04-24 MERCK PATENT GmbH Alkyl-5-methylsulphonyl-benzoyl-guanidine derivatives
EP0723963A1 (en) * 1995-01-28 1996-07-31 MERCK PATENT GmbH 4-amino-benzoylguanidine derivatives
EP0725062A1 (en) * 1995-01-31 1996-08-07 MERCK PATENT GmbH 4-mercapto-benzoylguanidine derivatives
EP0743301A2 (en) * 1995-05-16 1996-11-20 MERCK PATENT GmbH Benzoylguanidines containing fluorine
EP0760365A2 (en) * 1995-08-24 1997-03-05 MERCK PATENT GmbH Alkenyl-benzoylguanidines

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BAUMGARTH M ET AL: "(2-Methyl-5(methylsufonyl)benzoyl) guanidine Na+/H+ antiporter inhibitors", JOURNAL OF MEDICINAL CHEMISTRY,US,AMERICAN CHEMICAL SOCIETY. WASHINGTON, vol. 40, no. 13, 20 June 1997 (1997-06-20), pages 2017 - 2034-34, XP002121770, ISSN: 0022-2623 *

Also Published As

Publication number Publication date
HUP0104418A2 (en) 2002-04-29
ID29523A (en) 2001-09-06
CZ20011785A3 (en) 2001-10-17
PL348152A1 (en) 2002-05-06
NO20012563L (en) 2001-05-25
CA2352154A1 (en) 2000-06-02
JP2002530325A (en) 2002-09-17
CN1328452A (en) 2001-12-26
KR20010080597A (en) 2001-08-22
BR9915667A (en) 2001-08-14
WO2000030624A2 (en) 2000-06-02
AU1553500A (en) 2000-06-13
NO20012563D0 (en) 2001-05-25
EP1131064A2 (en) 2001-09-12
AR023064A1 (en) 2002-09-04

Similar Documents

Publication Publication Date Title
WO1999014202A3 (en) Novel pyrimidin-4-one and pyrimidin-4-thione as fungicide
AU7350694A (en) Remedy for nervous diseases
DE69111619D1 (en) 1,4-BENZOTHIAZEDINE DERIVATIVE.
IL113112A0 (en) Pyridine type thiazolidines
CA2063938A1 (en) Novel azadecalin amides and thioamides as inhibitors of cholesterol biosynthesis
IL98745A (en) Thioalkylthio cephalosporins and process for their preparation
ES2014385A4 (en) ANTIMICROBIAL COMPOSITION.
WO2000030624A3 (en) Use of benzoylguanidines for the treatment of non-insulin-dependent diabetes mellitus
ATE92040T1 (en) N-PHENYL ALKYL BENZAMIDE WITH FUNGICIDAL ACTIVITY.
BR0111199A (en) Heterocyclic Compounds
AU583763B2 (en) Antiarrhythmic agents
EP0308515A4 (en) Thienocinnoline compounds and their medicinal application
AU2853889A (en) Therapeutic agents for the treatment of peptic ulcer disease
EP0285284A3 (en) N-phenethylaminoalkyl-benzamide anti-arrhythmia agents
ATE64392T1 (en) THIAZOLIDIN-4-ONE DERIVATIVES AND THEIR ACID ADDITIONAL SALTS.
EP0551527A4 (en)
CA2210533A1 (en) Imidazole derivatives, their preparation and their use as s-adenosylmethionine decarboxylase (=samdc) inhibitors
EP0297593A3 (en) Treating agent for heart failure
PT785787E (en) USES OF 1,5-BENZODIAZEPINE DERIVATIVES FOR THE CONTROL OF GASTRIC EMPLOYMENT IN PATIENTS WITH NAO-INSULIN DEPENDENT MELLITUS DIABETES
IE821192L (en) N-(aryloxyalkyl)-n'-(aminoalkyl) ureas
ZA906446B (en) Therapeutic agents for the treatment of peptic ulcer disease
WO1996033723A3 (en) Use of benzamide derivatives for treating and/or preventing meniere's syndrome and motion sickness
EP0651945A4 (en) Termite-proofing agent.
EP0358880A3 (en) Use of retinoids
EP0619312A4 (en) Anilide derivative.

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 99813826.6

Country of ref document: CN

ENP Entry into the national phase

Ref document number: 2000 15535

Country of ref document: AU

Kind code of ref document: A

AK Designated states

Kind code of ref document: A2

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 1999958047

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 7002001

Country of ref document: SK

WWE Wipo information: entry into national phase

Ref document number: PV2001-1785

Country of ref document: CZ

WWE Wipo information: entry into national phase

Ref document number: 09856547

Country of ref document: US

ENP Entry into the national phase

Ref document number: 2352154

Country of ref document: CA

Ref document number: 2352154

Country of ref document: CA

Kind code of ref document: A

Ref document number: 2000 583507

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: PA/a/2001/005295

Country of ref document: MX

WWE Wipo information: entry into national phase

Ref document number: 1020017006615

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: IN/PCT/2001/648/KOL

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 200105217

Country of ref document: ZA

Ref document number: 15535/00

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 1200100599

Country of ref document: VN

WWP Wipo information: published in national office

Ref document number: 1020017006615

Country of ref document: KR

WWP Wipo information: published in national office

Ref document number: 1999958047

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: PV2001-1785

Country of ref document: CZ

WWR Wipo information: refused in national office

Ref document number: 1999958047

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 1999958047

Country of ref document: EP

WWR Wipo information: refused in national office

Ref document number: PV2001-1785

Country of ref document: CZ

WWW Wipo information: withdrawn in national office

Ref document number: 1020017006615

Country of ref document: KR