JP2002526075A5 - - Google Patents
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- Publication number
- JP2002526075A5 JP2002526075A5 JP2000574252A JP2000574252A JP2002526075A5 JP 2002526075 A5 JP2002526075 A5 JP 2002526075A5 JP 2000574252 A JP2000574252 A JP 2000574252A JP 2000574252 A JP2000574252 A JP 2000574252A JP 2002526075 A5 JP2002526075 A5 JP 2002526075A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- ucp4
- dna
- sequence
- molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 description 51
- 108090000765 processed proteins & peptides Proteins 0.000 description 51
- 102000004196 processed proteins & peptides Human genes 0.000 description 51
- 108020004414 DNA Proteins 0.000 description 38
- 101000777117 Homo sapiens Mitochondrial uncoupling protein 4 Proteins 0.000 description 37
- 102100031307 Mitochondrial uncoupling protein 4 Human genes 0.000 description 33
- 150000007523 nucleic acids Chemical class 0.000 description 27
- 102000039446 nucleic acids Human genes 0.000 description 26
- 108020004707 nucleic acids Proteins 0.000 description 26
- 102000053602 DNA Human genes 0.000 description 21
- 239000000523 sample Substances 0.000 description 19
- 238000000034 method Methods 0.000 description 16
- 230000000295 complement effect Effects 0.000 description 13
- 210000004027 cell Anatomy 0.000 description 12
- 125000000539 amino acid group Chemical group 0.000 description 9
- 239000002299 complementary DNA Substances 0.000 description 8
- 210000001700 mitochondrial membrane Anatomy 0.000 description 8
- 238000009396 hybridization Methods 0.000 description 7
- 125000003275 alpha amino acid group Chemical group 0.000 description 6
- 101001121408 Homo sapiens L-amino-acid oxidase Proteins 0.000 description 5
- 102100026388 L-amino-acid oxidase Human genes 0.000 description 5
- 239000002773 nucleotide Substances 0.000 description 5
- 125000003729 nucleotide group Chemical group 0.000 description 5
- 210000004962 mammalian cell Anatomy 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- -1 Amino Chemical group 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 210000004556 brain Anatomy 0.000 description 3
- 239000006143 cell culture medium Substances 0.000 description 3
- 238000012258 culturing Methods 0.000 description 3
- 239000012634 fragment Substances 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 2
- 108060003951 Immunoglobulin Proteins 0.000 description 2
- 101100012902 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) FIG2 gene Proteins 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 102000018358 immunoglobulin Human genes 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 108020004999 messenger RNA Proteins 0.000 description 2
- 238000007423 screening assay Methods 0.000 description 2
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
- 108020004491 Antisense DNA Proteins 0.000 description 1
- 108020005544 Antisense RNA Proteins 0.000 description 1
- 108090001008 Avidin Proteins 0.000 description 1
- 108091026890 Coding region Proteins 0.000 description 1
- 108020003215 DNA Probes Proteins 0.000 description 1
- 239000003298 DNA probe Substances 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 108010050258 Mitochondrial Uncoupling Proteins Proteins 0.000 description 1
- 102000015494 Mitochondrial Uncoupling Proteins Human genes 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 230000000692 anti-sense effect Effects 0.000 description 1
- 239000003816 antisense DNA Substances 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 description 1
- 210000000349 chromosome Anatomy 0.000 description 1
- 239000003184 complementary RNA Substances 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- 230000037323 metabolic rate Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 238000010188 recombinant method Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10127998P | 1998-09-22 | 1998-09-22 | |
| US60/101,279 | 1998-09-22 | ||
| US11422398P | 1998-12-30 | 1998-12-30 | |
| US60/114,223 | 1998-12-30 | ||
| US12967499P | 1999-04-16 | 1999-04-16 | |
| US60/129,674 | 1999-04-16 | ||
| PCT/US1999/021194 WO2000017353A1 (en) | 1998-09-22 | 1999-09-15 | Ucp4 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002526075A JP2002526075A (ja) | 2002-08-20 |
| JP2002526075A5 true JP2002526075A5 (enExample) | 2009-12-03 |
| JP4709383B2 JP4709383B2 (ja) | 2011-06-22 |
Family
ID=27379161
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000574252A Expired - Lifetime JP4709383B2 (ja) | 1998-09-22 | 1999-09-15 | Ｕｃｐ４ |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US8067229B2 (enExample) |
| EP (1) | EP1115863B1 (enExample) |
| JP (1) | JP4709383B2 (enExample) |
| AU (1) | AU6041399A (enExample) |
| CA (1) | CA2344467C (enExample) |
| DE (1) | DE69937644T2 (enExample) |
| DK (1) | DK1115863T3 (enExample) |
| ES (1) | ES2297947T3 (enExample) |
| PT (1) | PT1115863E (enExample) |
| WO (1) | WO2000017353A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6670138B2 (en) * | 2000-11-01 | 2003-12-30 | Agy Therapeutics, Inc. | Method of diagnosing ischemic stroke via UCP-2 detection |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4775662A (en) | 1983-03-07 | 1988-10-04 | Smithkline Beckman Corporation | Leukotriene antagonists |
| US5010010A (en) | 1986-10-22 | 1991-04-23 | Selmer-Sande, A.S. | Production of human parathyroid hormone from microorganisms |
| IL87737A (en) | 1987-09-11 | 1993-08-18 | Genentech Inc | Method for culturing polypeptide factor dependent vertebrate recombinant cells |
| US5663304A (en) | 1993-08-20 | 1997-09-02 | Genentech, Inc. | Refolding of misfolded insulin-like growth factor-I |
| US5407810A (en) | 1993-08-20 | 1995-04-18 | Genentech, Inc. | Aqueous multiple-phase isolation of polypeptide |
| EP0822830B1 (en) * | 1995-04-27 | 2008-04-02 | Amgen Fremont Inc. | Human anti-IL-8 antibodies, derived from immunized xenomice |
| AU2809797A (en) * | 1997-01-15 | 1998-08-07 | Centre National De La Recherche Scientifique Centre De Recherche Sur L'endocrinologie Moleculaire Et Le Developpement | Respiration uncoupling protein |
| US7001742B1 (en) * | 1997-05-20 | 2006-02-21 | Merck & Co., Inc. | Human uncoupling protein 3 |
| CA2289945A1 (en) | 1997-05-20 | 1998-11-26 | Merck & Co., Inc. | Human uncoupling protein 3 |
| CA2339043A1 (en) * | 1998-09-01 | 2000-03-09 | Genentech, Inc. | Further pro polypeptides and sequences thereof |
| US7026455B2 (en) | 1998-09-01 | 2006-04-11 | Genentech, Inc. | Anti-pro 1343 antibodies |
-
1999
- 1999-09-15 EP EP99969439A patent/EP1115863B1/en not_active Expired - Lifetime
- 1999-09-15 CA CA2344467A patent/CA2344467C/en not_active Expired - Lifetime
- 1999-09-15 DK DK99969439T patent/DK1115863T3/da active
- 1999-09-15 WO PCT/US1999/021194 patent/WO2000017353A1/en not_active Ceased
- 1999-09-15 PT PT99969439T patent/PT1115863E/pt unknown
- 1999-09-15 JP JP2000574252A patent/JP4709383B2/ja not_active Expired - Lifetime
- 1999-09-15 DE DE69937644T patent/DE69937644T2/de not_active Expired - Lifetime
- 1999-09-15 AU AU60413/99A patent/AU6041399A/en not_active Abandoned
- 1999-09-15 ES ES99969439T patent/ES2297947T3/es not_active Expired - Lifetime
-
2005
- 2005-11-03 US US11/265,966 patent/US8067229B2/en not_active Expired - Fee Related
-
2011
- 2011-09-19 US US13/236,459 patent/US8313927B2/en not_active Expired - Fee Related
-
2012
- 2012-11-08 US US13/672,232 patent/US8648174B2/en not_active Expired - Fee Related
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