JP2002511263A5 - - Google Patents
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- Publication number
- JP2002511263A5 JP2002511263A5 JP2000543606A JP2000543606A JP2002511263A5 JP 2002511263 A5 JP2002511263 A5 JP 2002511263A5 JP 2000543606 A JP2000543606 A JP 2000543606A JP 2000543606 A JP2000543606 A JP 2000543606A JP 2002511263 A5 JP2002511263 A5 JP 2002511263A5
- Authority
- JP
- Japan
- Prior art keywords
- patched
- sequence
- polypeptide
- human
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108010071083 Patched-2 Receptor Proteins 0.000 description 45
- 102000007497 Patched-2 Receptor Human genes 0.000 description 42
- 210000004027 cell Anatomy 0.000 description 19
- 108090000765 processed proteins & peptides Proteins 0.000 description 18
- 229920001184 polypeptide Polymers 0.000 description 17
- 102000004196 processed proteins & peptides Human genes 0.000 description 17
- 108020004414 DNA Proteins 0.000 description 14
- 150000007523 nucleic acids Chemical class 0.000 description 13
- 108020004707 nucleic acids Proteins 0.000 description 11
- 102000039446 nucleic acids Human genes 0.000 description 11
- 101001135776 Homo sapiens Protein patched homolog 2 Proteins 0.000 description 10
- 102000044588 human PTCH2 Human genes 0.000 description 10
- 239000000523 sample Substances 0.000 description 10
- 125000003275 alpha amino acid group Chemical group 0.000 description 8
- 239000000556 agonist Substances 0.000 description 7
- 230000004071 biological effect Effects 0.000 description 7
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 6
- 102000053602 DNA Human genes 0.000 description 6
- 239000005557 antagonist Substances 0.000 description 6
- 239000002299 complementary DNA Substances 0.000 description 6
- 230000000295 complement effect Effects 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- 238000009396 hybridization Methods 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 125000000539 amino acid group Chemical group 0.000 description 4
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 239000002773 nucleotide Substances 0.000 description 3
- 125000003729 nucleotide group Chemical group 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 238000012216 screening Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- 108091026890 Coding region Proteins 0.000 description 2
- 108091028043 Nucleic acid sequence Proteins 0.000 description 2
- 238000012258 culturing Methods 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 239000003446 ligand Substances 0.000 description 2
- 238000010188 recombinant method Methods 0.000 description 2
- 230000019491 signal transduction Effects 0.000 description 2
- 230000011664 signaling Effects 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
- 108700028369 Alleles Proteins 0.000 description 1
- 108090001008 Avidin Proteins 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 101150004367 Il4i1 gene Proteins 0.000 description 1
- 102000009786 Immunoglobulin Constant Regions Human genes 0.000 description 1
- 108010009817 Immunoglobulin Constant Regions Proteins 0.000 description 1
- 108091092195 Intron Proteins 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 102000000017 Patched Receptors Human genes 0.000 description 1
- 108010069873 Patched Receptors Proteins 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000000692 anti-sense effect Effects 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 description 1
- 210000000349 chromosome Anatomy 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 230000003405 preventing effect Effects 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/060,939 | 1998-04-15 | ||
| US09/060,939 US6709838B1 (en) | 1998-04-15 | 1998-04-15 | Nucleic acid encoding patched-2 |
| PCT/US1999/007417 WO1999053058A1 (en) | 1998-04-15 | 1999-04-02 | Vertebrate patched-2 protein |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009240086A Division JP2010046077A (ja) | 1998-04-15 | 2009-10-19 | 脊椎動物ｐａｔｃｈｅｄ−２タンパク質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002511263A JP2002511263A (ja) | 2002-04-16 |
| JP2002511263A5 true JP2002511263A5 (enExample) | 2006-06-01 |
| JP4693237B2 JP4693237B2 (ja) | 2011-06-01 |
Family
ID=22032676
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000543606A Expired - Lifetime JP4693237B2 (ja) | 1998-04-15 | 1999-04-02 | 脊椎動物ｐａｔｃｈｅｄ−２タンパク質 |
| JP2009240086A Withdrawn JP2010046077A (ja) | 1998-04-15 | 2009-10-19 | 脊椎動物ｐａｔｃｈｅｄ−２タンパク質 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009240086A Withdrawn JP2010046077A (ja) | 1998-04-15 | 2009-10-19 | 脊椎動物ｐａｔｃｈｅｄ−２タンパク質 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6709838B1 (enExample) |
| EP (1) | EP1071779B1 (enExample) |
| JP (2) | JP4693237B2 (enExample) |
| AT (1) | ATE410513T1 (enExample) |
| AU (1) | AU765918B2 (enExample) |
| CA (1) | CA2323572C (enExample) |
| CY (1) | CY1108619T1 (enExample) |
| DE (1) | DE69939694D1 (enExample) |
| DK (1) | DK1071779T3 (enExample) |
| ES (1) | ES2316192T3 (enExample) |
| IL (3) | IL138585A0 (enExample) |
| PT (1) | PT1071779E (enExample) |
| WO (1) | WO1999053058A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1716599A (en) * | 1997-12-08 | 1999-06-28 | Curis, Inc. | Human patched genes and proteins, and uses related thereto |
| SE9803393D0 (sv) * | 1998-10-06 | 1998-10-06 | Karolinska Innovations Ab | A novel component in the hedgehog signalling pathway |
| GB9908798D0 (en) * | 1999-04-16 | 1999-06-09 | Pharmacia & Upjohn Spa | Human homologues of fused gene |
| US6903073B2 (en) * | 1999-12-10 | 2005-06-07 | The General Hospital Corporation | Methods to stimulate insulin production by pancreatic beta-cells |
| SE0000345D0 (sv) * | 2000-02-03 | 2000-02-03 | Karolinska Innovations Ab | New matter |
| EP1229046A3 (en) * | 2001-01-30 | 2004-02-25 | Aeomica, Inc. | Human testis expressed patched like protein |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| WO1995018856A1 (en) | 1993-12-30 | 1995-07-13 | President And Fellows Of Harvard College | Vertebrate embryonic pattern-inducing hedgehog-like proteins |
| DE69534310T2 (de) | 1994-10-07 | 2006-04-27 | The Board Of Trustees Of The Leland Stanford Junior University, Palo Alto | Ptc gene und ihre verwendung |
| US6027882A (en) | 1994-10-07 | 2000-02-22 | The Regents Of The University Of California | Patched genes and their use for diagnostics |
| US6051400A (en) | 1997-05-23 | 2000-04-18 | Smithkline Beecham Plc | Patched-2 polypeptides and polynucleotides |
| AU1716599A (en) | 1997-12-08 | 1999-06-28 | Curis, Inc. | Human patched genes and proteins, and uses related thereto |
| US6022708A (en) | 1998-02-26 | 2000-02-08 | Genentech, Inc. | Fused |
| SE9803393D0 (sv) * | 1998-10-06 | 1998-10-06 | Karolinska Innovations Ab | A novel component in the hedgehog signalling pathway |
-
1998
- 1998-04-15 US US09/060,939 patent/US6709838B1/en not_active Expired - Lifetime
-
1999
- 1999-04-02 AT AT99945688T patent/ATE410513T1/de active
- 1999-04-02 PT PT99945688T patent/PT1071779E/pt unknown
- 1999-04-02 CA CA2323572A patent/CA2323572C/en not_active Expired - Lifetime
- 1999-04-02 IL IL13858599A patent/IL138585A0/xx unknown
- 1999-04-02 ES ES99945688T patent/ES2316192T3/es not_active Expired - Lifetime
- 1999-04-02 DK DK99945688T patent/DK1071779T3/da active
- 1999-04-02 AU AU52657/99A patent/AU765918B2/en not_active Expired
- 1999-04-02 JP JP2000543606A patent/JP4693237B2/ja not_active Expired - Lifetime
- 1999-04-02 EP EP99945688A patent/EP1071779B1/en not_active Expired - Lifetime
- 1999-04-02 DE DE69939694T patent/DE69939694D1/de not_active Expired - Lifetime
- 1999-04-02 WO PCT/US1999/007417 patent/WO1999053058A1/en not_active Ceased
-
2000
- 2000-09-20 IL IL138585A patent/IL138585A/en not_active IP Right Cessation
-
2008
- 2008-12-03 CY CY20081101409T patent/CY1108619T1/el unknown
-
2009
- 2009-10-19 JP JP2009240086A patent/JP2010046077A/ja not_active Withdrawn
-
2010
- 2010-05-16 IL IL205793A patent/IL205793A/en not_active IP Right Cessation
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