DE69939694D1 - 'patched-2' protein aus wirbeltieren - Google Patents
'patched-2' protein aus wirbeltierenInfo
- Publication number
- DE69939694D1 DE69939694D1 DE69939694T DE69939694T DE69939694D1 DE 69939694 D1 DE69939694 D1 DE 69939694D1 DE 69939694 T DE69939694 T DE 69939694T DE 69939694 T DE69939694 T DE 69939694T DE 69939694 D1 DE69939694 D1 DE 69939694D1
- Authority
- DE
- Germany
- Prior art keywords
- patched
- swivel
- protein out
- immunoadhesins
- ests
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000007497 Patched-2 Receptor Human genes 0.000 title abstract 2
- 108010071083 Patched-2 Receptor Proteins 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 108091060211 Expressed sequence tag Proteins 0.000 abstract 2
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 108020005187 Oligonucleotide Probes Proteins 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- -1 antibodies Substances 0.000 abstract 1
- 239000002751 oligonucleotide probe Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Psychology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Dermatology (AREA)
- Gynecology & Obstetrics (AREA)
- Hematology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/060,939 US6709838B1 (en) | 1998-04-15 | 1998-04-15 | Nucleic acid encoding patched-2 |
| PCT/US1999/007417 WO1999053058A1 (en) | 1998-04-15 | 1999-04-02 | Vertebrate patched-2 protein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE69939694D1 true DE69939694D1 (de) | 2008-11-20 |
Family
ID=22032676
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69939694T Expired - Lifetime DE69939694D1 (de) | 1998-04-15 | 1999-04-02 | 'patched-2' protein aus wirbeltieren |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6709838B1 (enExample) |
| EP (1) | EP1071779B1 (enExample) |
| JP (2) | JP4693237B2 (enExample) |
| AT (1) | ATE410513T1 (enExample) |
| AU (1) | AU765918B2 (enExample) |
| CA (1) | CA2323572C (enExample) |
| CY (1) | CY1108619T1 (enExample) |
| DE (1) | DE69939694D1 (enExample) |
| DK (1) | DK1071779T3 (enExample) |
| ES (1) | ES2316192T3 (enExample) |
| IL (3) | IL138585A0 (enExample) |
| PT (1) | PT1071779E (enExample) |
| WO (1) | WO1999053058A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1716599A (en) * | 1997-12-08 | 1999-06-28 | Curis, Inc. | Human patched genes and proteins, and uses related thereto |
| SE9803393D0 (sv) * | 1998-10-06 | 1998-10-06 | Karolinska Innovations Ab | A novel component in the hedgehog signalling pathway |
| GB9908798D0 (en) * | 1999-04-16 | 1999-06-09 | Pharmacia & Upjohn Spa | Human homologues of fused gene |
| US6903073B2 (en) * | 1999-12-10 | 2005-06-07 | The General Hospital Corporation | Methods to stimulate insulin production by pancreatic beta-cells |
| SE0000345D0 (sv) * | 2000-02-03 | 2000-02-03 | Karolinska Innovations Ab | New matter |
| EP1229046A3 (en) * | 2001-01-30 | 2004-02-25 | Aeomica, Inc. | Human testis expressed patched like protein |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| WO1995018856A1 (en) | 1993-12-30 | 1995-07-13 | President And Fellows Of Harvard College | Vertebrate embryonic pattern-inducing hedgehog-like proteins |
| DE69534310T2 (de) | 1994-10-07 | 2006-04-27 | The Board Of Trustees Of The Leland Stanford Junior University, Palo Alto | Ptc gene und ihre verwendung |
| US6027882A (en) | 1994-10-07 | 2000-02-22 | The Regents Of The University Of California | Patched genes and their use for diagnostics |
| US6051400A (en) | 1997-05-23 | 2000-04-18 | Smithkline Beecham Plc | Patched-2 polypeptides and polynucleotides |
| AU1716599A (en) | 1997-12-08 | 1999-06-28 | Curis, Inc. | Human patched genes and proteins, and uses related thereto |
| US6022708A (en) | 1998-02-26 | 2000-02-08 | Genentech, Inc. | Fused |
| SE9803393D0 (sv) * | 1998-10-06 | 1998-10-06 | Karolinska Innovations Ab | A novel component in the hedgehog signalling pathway |
-
1998
- 1998-04-15 US US09/060,939 patent/US6709838B1/en not_active Expired - Lifetime
-
1999
- 1999-04-02 AT AT99945688T patent/ATE410513T1/de active
- 1999-04-02 PT PT99945688T patent/PT1071779E/pt unknown
- 1999-04-02 CA CA2323572A patent/CA2323572C/en not_active Expired - Lifetime
- 1999-04-02 IL IL13858599A patent/IL138585A0/xx unknown
- 1999-04-02 ES ES99945688T patent/ES2316192T3/es not_active Expired - Lifetime
- 1999-04-02 DK DK99945688T patent/DK1071779T3/da active
- 1999-04-02 AU AU52657/99A patent/AU765918B2/en not_active Expired
- 1999-04-02 JP JP2000543606A patent/JP4693237B2/ja not_active Expired - Lifetime
- 1999-04-02 EP EP99945688A patent/EP1071779B1/en not_active Expired - Lifetime
- 1999-04-02 DE DE69939694T patent/DE69939694D1/de not_active Expired - Lifetime
- 1999-04-02 WO PCT/US1999/007417 patent/WO1999053058A1/en not_active Ceased
-
2000
- 2000-09-20 IL IL138585A patent/IL138585A/en not_active IP Right Cessation
-
2008
- 2008-12-03 CY CY20081101409T patent/CY1108619T1/el unknown
-
2009
- 2009-10-19 JP JP2009240086A patent/JP2010046077A/ja not_active Withdrawn
-
2010
- 2010-05-16 IL IL205793A patent/IL205793A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2316192T3 (es) | 2009-04-01 |
| WO1999053058A1 (en) | 1999-10-21 |
| JP2010046077A (ja) | 2010-03-04 |
| JP4693237B2 (ja) | 2011-06-01 |
| CA2323572C (en) | 2011-10-18 |
| AU765918B2 (en) | 2003-10-02 |
| EP1071779A1 (en) | 2001-01-31 |
| JP2002511263A (ja) | 2002-04-16 |
| EP1071779B1 (en) | 2008-10-08 |
| IL205793A (en) | 2015-01-29 |
| CA2323572A1 (en) | 1999-10-21 |
| DK1071779T3 (da) | 2009-02-16 |
| US6709838B1 (en) | 2004-03-23 |
| ATE410513T1 (de) | 2008-10-15 |
| PT1071779E (pt) | 2009-01-13 |
| CY1108619T1 (el) | 2014-04-09 |
| AU5265799A (en) | 1999-11-01 |
| IL138585A0 (en) | 2001-10-31 |
| IL138585A (en) | 2010-11-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |