JP4693237B2 - 脊椎動物ｐａｔｃｈｅｄ−２タンパク質 - Google Patents

脊椎動物ｐａｔｃｈｅｄ−２タンパク質 Download PDF

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Publication number
JP4693237B2
JP4693237B2 JP2000543606A JP2000543606A JP4693237B2 JP 4693237 B2 JP4693237 B2 JP 4693237B2 JP 2000543606 A JP2000543606 A JP 2000543606A JP 2000543606 A JP2000543606 A JP 2000543606A JP 4693237 B2 JP4693237 B2 JP 4693237B2
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patched
seq
cells
sequence
polypeptide
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JP2002511263A (ja
JP2002511263A5 (enExample
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ソーバージュ， フレデリック ジェー デ
デービッド エー カーペンター，
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ジェネンテック， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hematology (AREA)
JP2000543606A 1998-04-15 1999-04-02 脊椎動物ｐａｔｃｈｅｄ−２タンパク質 Expired - Lifetime JP4693237B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/060,939 US6709838B1 (en) 1998-04-15 1998-04-15 Nucleic acid encoding patched-2
US09/060,939 1998-04-15
PCT/US1999/007417 WO1999053058A1 (en) 1998-04-15 1999-04-02 Vertebrate patched-2 protein

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2009240086A Division JP2010046077A (ja) 1998-04-15 2009-10-19 脊椎動物ｐａｔｃｈｅｄ−２タンパク質

Publications (3)

Publication Number Publication Date
JP2002511263A JP2002511263A (ja) 2002-04-16
JP2002511263A5 JP2002511263A5 (enExample) 2006-06-01
JP4693237B2 true JP4693237B2 (ja) 2011-06-01

Family

ID=22032676

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2000543606A Expired - Lifetime JP4693237B2 (ja) 1998-04-15 1999-04-02 脊椎動物ｐａｔｃｈｅｄ−２タンパク質
JP2009240086A Withdrawn JP2010046077A (ja) 1998-04-15 2009-10-19 脊椎動物ｐａｔｃｈｅｄ−２タンパク質

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2009240086A Withdrawn JP2010046077A (ja) 1998-04-15 2009-10-19 脊椎動物ｐａｔｃｈｅｄ−２タンパク質

Country Status (13)

Country Link
US (1) US6709838B1 (enExample)
EP (1) EP1071779B1 (enExample)
JP (2) JP4693237B2 (enExample)
AT (1) ATE410513T1 (enExample)
AU (1) AU765918B2 (enExample)
CA (1) CA2323572C (enExample)
CY (1) CY1108619T1 (enExample)
DE (1) DE69939694D1 (enExample)
DK (1) DK1071779T3 (enExample)
ES (1) ES2316192T3 (enExample)
IL (3) IL138585A0 (enExample)
PT (1) PT1071779E (enExample)
WO (1) WO1999053058A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1716599A (en) * 1997-12-08 1999-06-28 Curis, Inc. Human patched genes and proteins, and uses related thereto
SE9803393D0 (sv) * 1998-10-06 1998-10-06 Karolinska Innovations Ab A novel component in the hedgehog signalling pathway
GB9908798D0 (en) * 1999-04-16 1999-06-09 Pharmacia & Upjohn Spa Human homologues of fused gene
WO2001041786A1 (en) * 1999-12-10 2001-06-14 The General Hospital Corporation METHODS TO STIMULATE INSULIN PRODUCTION BY PANCREATIC β-CELLS
SE0000345D0 (sv) * 2000-02-03 2000-02-03 Karolinska Innovations Ab New matter
EP1229046A3 (en) * 2001-01-30 2004-02-25 Aeomica, Inc. Human testis expressed patched like protein

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
CA2179029C (en) 1993-12-30 2009-02-24 Philip W. Ingham Vertebrate embryonic pattern-inducing hedgehog-like proteins
DE69534310T2 (de) 1994-10-07 2006-04-27 The Board Of Trustees Of The Leland Stanford Junior University, Palo Alto Ptc gene und ihre verwendung
US6027882A (en) 1994-10-07 2000-02-22 The Regents Of The University Of California Patched genes and their use for diagnostics
US6051400A (en) 1997-05-23 2000-04-18 Smithkline Beecham Plc Patched-2 polypeptides and polynucleotides
AU1716599A (en) 1997-12-08 1999-06-28 Curis, Inc. Human patched genes and proteins, and uses related thereto
US6022708A (en) 1998-02-26 2000-02-08 Genentech, Inc. Fused
SE9803393D0 (sv) * 1998-10-06 1998-10-06 Karolinska Innovations Ab A novel component in the hedgehog signalling pathway

Also Published As

Publication number Publication date
CA2323572A1 (en) 1999-10-21
EP1071779B1 (en) 2008-10-08
PT1071779E (pt) 2009-01-13
DK1071779T3 (da) 2009-02-16
JP2002511263A (ja) 2002-04-16
CA2323572C (en) 2011-10-18
AU5265799A (en) 1999-11-01
WO1999053058A1 (en) 1999-10-21
IL138585A0 (en) 2001-10-31
CY1108619T1 (el) 2014-04-09
AU765918B2 (en) 2003-10-02
IL138585A (en) 2010-11-30
DE69939694D1 (de) 2008-11-20
EP1071779A1 (en) 2001-01-31
US6709838B1 (en) 2004-03-23
ATE410513T1 (de) 2008-10-15
IL205793A (en) 2015-01-29
JP2010046077A (ja) 2010-03-04
ES2316192T3 (es) 2009-04-01

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