JP2002523470A5 - - Google Patents
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- Publication number
- JP2002523470A5 JP2002523470A5 JP2000567236A JP2000567236A JP2002523470A5 JP 2002523470 A5 JP2002523470 A5 JP 2002523470A5 JP 2000567236 A JP2000567236 A JP 2000567236A JP 2000567236 A JP2000567236 A JP 2000567236A JP 2002523470 A5 JP2002523470 A5 JP 2002523470A5
- Authority
- JP
- Japan
- Prior art keywords
- vaccine formulation
- microparticles
- nanoparticles
- antigen
- biodegradable polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000009472 formulation Methods 0.000 description 12
- 239000000203 mixture Substances 0.000 description 12
- 229960005486 vaccine Drugs 0.000 description 12
- 239000000427 antigen Substances 0.000 description 8
- 102000036639 antigens Human genes 0.000 description 8
- 108091007433 antigens Proteins 0.000 description 8
- 239000011859 microparticle Substances 0.000 description 7
- 239000002105 nanoparticle Substances 0.000 description 7
- 229920002988 biodegradable polymer Polymers 0.000 description 6
- 239000004621 biodegradable polymer Substances 0.000 description 6
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 2
- 241000588832 Bordetella pertussis Species 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 235000014655 lactic acid Nutrition 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000005354 coacervation Methods 0.000 description 1
- 238000000935 solvent evaporation Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9875998P | 1998-09-01 | 1998-09-01 | |
| US60/098,759 | 1998-09-01 | ||
| PCT/IE1999/000086 WO2000012124A1 (en) | 1998-09-01 | 1999-08-31 | Oral vaccine compositions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002523470A JP2002523470A (ja) | 2002-07-30 |
| JP2002523470A5 true JP2002523470A5 (enExample) | 2006-11-02 |
| JP4601823B2 JP4601823B2 (ja) | 2010-12-22 |
Family
ID=22270760
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000567236A Expired - Fee Related JP4601823B2 (ja) | 1998-09-01 | 1999-08-31 | 経口ワクチン組成物 |
Country Status (7)
| Country | Link |
|---|---|
| EP (2) | EP1107782B1 (enExample) |
| JP (1) | JP4601823B2 (enExample) |
| AT (1) | ATE452651T1 (enExample) |
| AU (1) | AU5441199A (enExample) |
| CA (1) | CA2341352C (enExample) |
| DE (1) | DE69941848D1 (enExample) |
| WO (1) | WO2000012124A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPR011700A0 (en) | 2000-09-14 | 2000-10-05 | Austin Research Institute, The | Composition comprising immunogenic virus sized particles (VSP) |
| US7998507B2 (en) | 2000-09-21 | 2011-08-16 | Elan Pharma International Ltd. | Nanoparticulate compositions of mitogen-activated protein (MAP) kinase inhibitors |
| US6951656B2 (en) | 2000-12-22 | 2005-10-04 | Baxter International Inc. | Microprecipitation method for preparing submicron suspensions |
| US6607784B2 (en) | 2000-12-22 | 2003-08-19 | Baxter International Inc. | Microprecipitation method for preparing submicron suspensions |
| US7193084B2 (en) | 2000-12-22 | 2007-03-20 | Baxter International Inc. | Polymorphic form of itraconazole |
| US6977085B2 (en) | 2000-12-22 | 2005-12-20 | Baxter International Inc. | Method for preparing submicron suspensions with polymorph control |
| US9700866B2 (en) | 2000-12-22 | 2017-07-11 | Baxter International Inc. | Surfactant systems for delivery of organic compounds |
| US8067032B2 (en) | 2000-12-22 | 2011-11-29 | Baxter International Inc. | Method for preparing submicron particles of antineoplastic agents |
| US6884436B2 (en) | 2000-12-22 | 2005-04-26 | Baxter International Inc. | Method for preparing submicron particle suspensions |
| US20060003012A9 (en) | 2001-09-26 | 2006-01-05 | Sean Brynjelsen | Preparation of submicron solid particle suspensions by sonication of multiphase systems |
| CN1558755A (zh) | 2001-09-26 | 2004-12-29 | ���ع��ʹ�˾ | 通过分散和除去溶剂或液相制备亚微米大小的纳米颗粒 |
| DE60222160T2 (de) | 2001-10-12 | 2008-06-12 | Elan Pharma International Ltd., Athlone | Zusammensetzungen mit einer kombination aus eigenschaften sofortiger freisetzung und kontrollierter freisetzung |
| US7112340B2 (en) | 2001-10-19 | 2006-09-26 | Baxter International Inc. | Compositions of and method for preparing stable particles in a frozen aqueous matrix |
| AU2003230692A1 (en) * | 2002-03-20 | 2003-10-08 | Elan Pharma International Ltd. | Nanoparticulate compositions of map kinase inhibitors |
| FR2857592B1 (fr) * | 2003-07-18 | 2006-02-24 | Sod Conseils Rech Applic | Nouveau procede de preparation de microparticules |
| ES2396240T3 (es) * | 2005-04-20 | 2013-02-20 | Mitsuru Akashi | Poliaminoácido para usar como adyuvante |
| JP4621218B2 (ja) * | 2007-02-09 | 2011-01-26 | 有限会社バイオ研 | Ｔｈ１誘導剤及びその製造方法 |
| WO2011026111A1 (en) * | 2009-08-31 | 2011-03-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Oral delivery of a vaccine to the large intestine to induce mucosal immunity |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5417986A (en) | 1984-03-16 | 1995-05-23 | The United States Of America As Represented By The Secretary Of The Army | Vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres |
| US5075109A (en) | 1986-10-24 | 1991-12-24 | Southern Research Institute | Method of potentiating an immune response |
| IL84167A (en) | 1986-10-24 | 1991-04-15 | Southern Res Inst | Oral delivery of bioactive agents to and through the peyer's patch by use of microencapsulation |
| JP2743177B2 (ja) * | 1987-04-24 | 1998-04-22 | 財団法人阪大微生物病研究会 | 百日咳菌の培養方法、及び百日咳トキソイドとその混合ワクチン |
| ES2080941T3 (es) * | 1990-02-12 | 1996-02-16 | Smithkline Beecham Biolog | Nueva vacuna y procedimiento para la misma. |
| GB9209118D0 (en) * | 1992-04-28 | 1992-06-10 | Sb 120 Amsterdam Bv | Vaccine compositions |
| DE69332031T2 (de) | 1993-01-08 | 2002-12-19 | Csl Ltd., Parkville | Impfstoffpräparate |
| DK0724431T3 (da) | 1993-10-22 | 2003-01-06 | Genentech Inc | Fremgangsmåder og sammensætninger til mikroindkapsling af adjuvanser |
| ATE199316T1 (de) | 1993-12-23 | 2001-03-15 | Bruno Gander | Mit antigen beladene mikropartikel und pharmazeutische zubereitungen, die diese mikropartikel enthalten. |
| JP3747077B2 (ja) * | 1994-04-28 | 2006-02-22 | 武田薬品工業株式会社 | 百日咳菌由来感染防御成分の分離取得方法 |
| EP0805678B1 (en) * | 1995-01-05 | 2003-10-29 | THE BOARD OF REGENTS acting for and on behalf of THE UNIVERSITY OF MICHIGAN | Surface-modified nanoparticles and method of making and using same |
| GB9713156D0 (en) * | 1997-06-20 | 1997-08-27 | Microbiological Res Authority | Vaccines |
-
1999
- 1999-08-31 WO PCT/IE1999/000086 patent/WO2000012124A1/en not_active Ceased
- 1999-08-31 CA CA2341352A patent/CA2341352C/en not_active Expired - Fee Related
- 1999-08-31 AT AT99940438T patent/ATE452651T1/de not_active IP Right Cessation
- 1999-08-31 AU AU54411/99A patent/AU5441199A/en not_active Abandoned
- 1999-08-31 DE DE69941848T patent/DE69941848D1/de not_active Expired - Lifetime
- 1999-08-31 EP EP99940438A patent/EP1107782B1/en not_active Expired - Lifetime
- 1999-08-31 JP JP2000567236A patent/JP4601823B2/ja not_active Expired - Fee Related
- 1999-08-31 EP EP09013789A patent/EP2168593A1/en not_active Withdrawn
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