JP2002523471A5 - - Google Patents
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- Publication number
- JP2002523471A5 JP2002523471A5 JP2000567237A JP2000567237A JP2002523471A5 JP 2002523471 A5 JP2002523471 A5 JP 2002523471A5 JP 2000567237 A JP2000567237 A JP 2000567237A JP 2000567237 A JP2000567237 A JP 2000567237A JP 2002523471 A5 JP2002523471 A5 JP 2002523471A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- vaccine
- microparticles
- nanoparticles
- biodegradable polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229960005486 vaccine Drugs 0.000 description 12
- 238000009472 formulation Methods 0.000 description 11
- 239000000203 mixture Substances 0.000 description 11
- 239000000427 antigen Substances 0.000 description 10
- 102000036639 antigens Human genes 0.000 description 10
- 108091007433 antigens Proteins 0.000 description 10
- 239000011859 microparticle Substances 0.000 description 8
- 229920002988 biodegradable polymer Polymers 0.000 description 6
- 239000004621 biodegradable polymer Substances 0.000 description 6
- 239000002105 nanoparticle Substances 0.000 description 6
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 2
- 241000588832 Bordetella pertussis Species 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 230000028993 immune response Effects 0.000 description 2
- 235000014655 lactic acid Nutrition 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000005354 coacervation Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000000935 solvent evaporation Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9876098P | 1998-09-01 | 1998-09-01 | |
| US60/098,760 | 1998-09-01 | ||
| PCT/IE1999/000087 WO2000012125A1 (en) | 1998-09-01 | 1999-08-31 | Method for inducing a cell-mediated immune response and parenteral vaccine formulations therefor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002523471A JP2002523471A (ja) | 2002-07-30 |
| JP2002523471A5 true JP2002523471A5 (enExample) | 2006-11-02 |
| JP4526708B2 JP4526708B2 (ja) | 2010-08-18 |
Family
ID=22270768
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000567237A Expired - Fee Related JP4526708B2 (ja) | 1998-09-01 | 1999-08-31 | 細胞を媒介した免疫応答を誘導する方法及びそのための非経口ワクチン製剤 |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1107783B1 (enExample) |
| JP (1) | JP4526708B2 (enExample) |
| AT (1) | ATE322285T1 (enExample) |
| AU (1) | AU5441299A (enExample) |
| CA (2) | CA2341358C (enExample) |
| DE (1) | DE69930753D1 (enExample) |
| WO (1) | WO2000012125A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2156718A1 (en) | 1993-12-23 | 1995-06-29 | Bruno Gander | Immunological response potentiation process |
| US7193084B2 (en) | 2000-12-22 | 2007-03-20 | Baxter International Inc. | Polymorphic form of itraconazole |
| US6607784B2 (en) | 2000-12-22 | 2003-08-19 | Baxter International Inc. | Microprecipitation method for preparing submicron suspensions |
| US8067032B2 (en) | 2000-12-22 | 2011-11-29 | Baxter International Inc. | Method for preparing submicron particles of antineoplastic agents |
| US6951656B2 (en) | 2000-12-22 | 2005-10-04 | Baxter International Inc. | Microprecipitation method for preparing submicron suspensions |
| US6977085B2 (en) | 2000-12-22 | 2005-12-20 | Baxter International Inc. | Method for preparing submicron suspensions with polymorph control |
| US6884436B2 (en) | 2000-12-22 | 2005-04-26 | Baxter International Inc. | Method for preparing submicron particle suspensions |
| US9700866B2 (en) | 2000-12-22 | 2017-07-11 | Baxter International Inc. | Surfactant systems for delivery of organic compounds |
| US20060003012A9 (en) | 2001-09-26 | 2006-01-05 | Sean Brynjelsen | Preparation of submicron solid particle suspensions by sonication of multiphase systems |
| WO2003026611A2 (en) | 2001-09-26 | 2003-04-03 | Baxter International Inc. | Preparation of submicron sized nanoparticles via dispersion and solvent or liquid phase removal |
| US7112340B2 (en) | 2001-10-19 | 2006-09-26 | Baxter International Inc. | Compositions of and method for preparing stable particles in a frozen aqueous matrix |
| JP4851067B2 (ja) * | 2004-01-28 | 2012-01-11 | ホソカワミクロン株式会社 | ナノ粒子含有組成物およびその製造方法 |
| ES2246695B1 (es) | 2004-04-29 | 2007-05-01 | Instituto Cientifico Y Tecnologico De Navarra, S.A. | Composicion estimuladora de la respuesta inmunitaria que comprende nanoparticulas a base de un copolimero de metil vinil eter y anhidrido maleico. |
| CN101646455A (zh) * | 2007-02-07 | 2010-02-10 | 财团法人阪大微生物病研究会 | 用于癌症的治疗剂 |
| EP2139513B1 (en) * | 2007-03-28 | 2012-09-05 | National Institute of Immunology | Polymer particles based vaccine |
| JP6910949B2 (ja) * | 2014-08-14 | 2021-07-28 | ブラウン ユニバーシティ | タンパク質を安定化させ、送達するための組成物 |
| CA2966850C (en) * | 2014-11-05 | 2024-03-26 | Selecta Biosciences, Inc. | Methods and compositions related to the use of low hlb surfactants in the production of synthetic nanocarriers comprising a rapalog |
| GB201918963D0 (en) | 2019-12-20 | 2020-02-05 | Provost Fellows Scholars And Other Members Of Board Of Trinity College Dublin | Polymeric nanoparticles as vaccine adjuvants |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9209118D0 (en) * | 1992-04-28 | 1992-06-10 | Sb 120 Amsterdam Bv | Vaccine compositions |
| CA2207961A1 (en) * | 1995-01-05 | 1996-07-11 | Robert J. Levy | Surface-modified nanoparticles and method of making and using same |
| GB9713156D0 (en) * | 1997-06-20 | 1997-08-27 | Microbiological Res Authority | Vaccines |
-
1999
- 1999-08-31 DE DE69930753T patent/DE69930753D1/de not_active Expired - Lifetime
- 1999-08-31 AT AT99940439T patent/ATE322285T1/de not_active IP Right Cessation
- 1999-08-31 CA CA2341358A patent/CA2341358C/en not_active Expired - Fee Related
- 1999-08-31 WO PCT/IE1999/000087 patent/WO2000012125A1/en not_active Ceased
- 1999-08-31 CA CA2731995A patent/CA2731995C/en not_active Expired - Fee Related
- 1999-08-31 JP JP2000567237A patent/JP4526708B2/ja not_active Expired - Fee Related
- 1999-08-31 EP EP99940439A patent/EP1107783B1/en not_active Expired - Lifetime
- 1999-08-31 AU AU54412/99A patent/AU5441299A/en not_active Abandoned
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