JP2002522512A5 - - Google Patents

Info

Publication number

JP2002522512A5

JP2002522512A5 JP2000564666A JP2000564666A JP2002522512A5 JP 2002522512 A5 JP2002522512 A5 JP 2002522512A5 JP 2000564666 A JP2000564666 A JP 2000564666A JP 2000564666 A JP2000564666 A JP 2000564666A JP 2002522512 A5 JP2002522512 A5 JP 2002522512A5

Authority

JP

Japan

Prior art keywords

dextran

leptin

conjugate

moiety

moieties

Prior art date

1999-08-10

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 229940039781 leptin Drugs 0.000 description 62
• NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical group O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 description 37
• 150000001413 amino acids Chemical group 0.000 description 15
• 125000003275 alpha amino acid group Chemical group 0.000 description 12
• 239000008194 pharmaceutical composition Substances 0.000 description 12
• 239000000203 mixture Substances 0.000 description 11
• 102000016267 Leptin Human genes 0.000 description 10
• 108010092277 Leptin Proteins 0.000 description 10
• 125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 description 10
• 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 description 8
• 229920002307 Dextran Polymers 0.000 description 6
• 208000031226 Hyperlipidaemia Diseases 0.000 description 4
• 208000008589 Obesity Diseases 0.000 description 4
• 206010012601 diabetes mellitus Diseases 0.000 description 4
• 239000003937 drug carrier Substances 0.000 description 4
• 235000020824 obesity Nutrition 0.000 description 4
• 230000002378 acidificating effect Effects 0.000 description 3
• 230000003213 activating effect Effects 0.000 description 3
• 150000001412 amines Chemical group 0.000 description 3
• 125000003277 amino group Chemical group 0.000 description 3
• 230000008878 coupling Effects 0.000 description 3
• 238000010168 coupling process Methods 0.000 description 3
• 238000005859 coupling reaction Methods 0.000 description 3
• ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 3
• 238000000034 method Methods 0.000 description 3
• 238000007920 subcutaneous administration Methods 0.000 description 1
• 238000006467 substitution reaction Methods 0.000 description 1