CA2337667C - Dextran-leptin conjugates, pharmaceutical compositions and related methods - Google Patents
Dextran-leptin conjugates, pharmaceutical compositions and related methods Download PDFInfo
- Publication number
- CA2337667C CA2337667C CA002337667A CA2337667A CA2337667C CA 2337667 C CA2337667 C CA 2337667C CA 002337667 A CA002337667 A CA 002337667A CA 2337667 A CA2337667 A CA 2337667A CA 2337667 C CA2337667 C CA 2337667C
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- Prior art keywords
- dextran
- leptin
- moiety
- conjugate
- attached
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/5759—Products of obesity genes, e.g. leptin, obese (OB), tub, fat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Emergency Medicine (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9619498P | 1998-08-10 | 1998-08-10 | |
| US60/096,194 | 1998-08-10 | ||
| US37068499A | 1999-08-09 | 1999-08-09 | |
| US09/370,684 | 1999-08-09 | ||
| PCT/US1999/018129 WO2000009165A1 (en) | 1998-08-10 | 1999-08-10 | Dextran-leptin conjugates, pharmaceutical compositions and related methods |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2337667A1 CA2337667A1 (en) | 2000-02-24 |
| CA2337667C true CA2337667C (en) | 2008-04-29 |
Family
ID=26791397
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002337667A Expired - Lifetime CA2337667C (en) | 1998-08-10 | 1999-08-10 | Dextran-leptin conjugates, pharmaceutical compositions and related methods |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1107793B1 (enExample) |
| JP (1) | JP4199421B2 (enExample) |
| AT (1) | ATE280588T1 (enExample) |
| AU (1) | AU5347099A (enExample) |
| CA (1) | CA2337667C (enExample) |
| DE (1) | DE69921486T2 (enExample) |
| ES (1) | ES2228082T3 (enExample) |
| PT (1) | PT1107793E (enExample) |
| WO (1) | WO2000009165A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6420339B1 (en) | 1998-10-14 | 2002-07-16 | Amgen Inc. | Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility |
| CA2359840C (en) * | 1999-02-12 | 2012-10-23 | Amgen Inc. | Glycosylated leptin compositions and related methods |
| GB0116860D0 (en) * | 2001-07-10 | 2001-09-05 | Univ Montfort | Gel compositions |
| WO2005094898A2 (en) * | 2004-03-23 | 2005-10-13 | Amgen Inc. | Chemically modified protein compositions and methods |
| US8716220B2 (en) | 2005-09-07 | 2014-05-06 | Nikolaos Tezapsidis | Leptin compositions and methods for treating progressive cognitive function disorders resulting from accumulation of neurofibrillary tangles and amyloid beta |
| US8642543B2 (en) | 2005-09-07 | 2014-02-04 | Neurotez, Inc. | Methods for treating progressive cognitive disorders related to neurofibrillary tangles |
| CN101143894A (zh) * | 2007-06-22 | 2008-03-19 | 中国药科大学 | 高效抑制血管生成多肽及其物理化学修饰方法和应用 |
| WO2009149379A2 (en) | 2008-06-05 | 2009-12-10 | Regents Of The University Of Michigan | Use of leptin for the treatment of fatty liver diseases and conditions |
| MX351128B (es) | 2010-09-28 | 2017-10-03 | Aegerion Pharmaceuticals Inc | Polipeptidos manipulados que tienen duracion de accion incrementada. |
| US9968575B2 (en) | 2012-09-27 | 2018-05-15 | The Children's Medical Center Corporation | Compounds for the treatment of obesity and methods of use thereof |
| LT3074033T (lt) | 2013-11-26 | 2019-02-25 | The Children`S Medical Center Corporation | Junginiai, skirti nutukimo gydymui ir jų panaudojimo būdai |
| US20170209408A1 (en) | 2014-04-03 | 2017-07-27 | The Children's Medical Center Corporation | Hsp90 inhibitors for the treatment of obesity and methods of use thereof |
| DK3509624T3 (da) | 2016-09-12 | 2023-11-13 | Amryt Pharmaceuticals Inc | Fremgangsmåder til detektering af anti-leptin-neutraliserende antistoffer |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0865294B1 (en) * | 1995-08-17 | 2004-02-18 | Amgen Inc. | Methods of reducing or maintaining reduced levels of blood lipids using ob protein compositions |
| WO1997038014A1 (en) * | 1996-04-04 | 1997-10-16 | Amgen Inc. | Fibulin pharmaceutical compositions and related methods |
-
1999
- 1999-08-10 WO PCT/US1999/018129 patent/WO2000009165A1/en not_active Ceased
- 1999-08-10 DE DE69921486T patent/DE69921486T2/de not_active Expired - Lifetime
- 1999-08-10 JP JP2000564666A patent/JP4199421B2/ja not_active Expired - Lifetime
- 1999-08-10 ES ES99939127T patent/ES2228082T3/es not_active Expired - Lifetime
- 1999-08-10 AU AU53470/99A patent/AU5347099A/en not_active Abandoned
- 1999-08-10 CA CA002337667A patent/CA2337667C/en not_active Expired - Lifetime
- 1999-08-10 PT PT99939127T patent/PT1107793E/pt unknown
- 1999-08-10 EP EP99939127A patent/EP1107793B1/en not_active Expired - Lifetime
- 1999-08-10 AT AT99939127T patent/ATE280588T1/de active
Also Published As
| Publication number | Publication date |
|---|---|
| PT1107793E (pt) | 2005-02-28 |
| EP1107793A1 (en) | 2001-06-20 |
| ATE280588T1 (de) | 2004-11-15 |
| AU5347099A (en) | 2000-03-06 |
| EP1107793B1 (en) | 2004-10-27 |
| JP2002522512A (ja) | 2002-07-23 |
| CA2337667A1 (en) | 2000-02-24 |
| WO2000009165A1 (en) | 2000-02-24 |
| ES2228082T3 (es) | 2005-04-01 |
| DE69921486D1 (de) | 2004-12-02 |
| DE69921486T2 (de) | 2006-02-02 |
| JP4199421B2 (ja) | 2008-12-17 |
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| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20190812 |