JP2002521425A5 - - Google Patents
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- Publication number
- JP2002521425A5 JP2002521425A5 JP2000561979A JP2000561979A JP2002521425A5 JP 2002521425 A5 JP2002521425 A5 JP 2002521425A5 JP 2000561979 A JP2000561979 A JP 2000561979A JP 2000561979 A JP2000561979 A JP 2000561979A JP 2002521425 A5 JP2002521425 A5 JP 2002521425A5
- Authority
- JP
- Japan
- Prior art keywords
- microparticle
- microparticles
- particles
- surfactant
- polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000011859 microparticle Substances 0.000 description 78
- 238000000034 method Methods 0.000 description 41
- 239000002245 particle Substances 0.000 description 25
- 229920000642 polymer Polymers 0.000 description 23
- 239000000427 antigen Substances 0.000 description 17
- 102000036639 antigens Human genes 0.000 description 17
- 108091007433 antigens Proteins 0.000 description 17
- 229920002521 macromolecule Polymers 0.000 description 17
- 239000000203 mixture Substances 0.000 description 17
- 239000004094 surface-active agent Substances 0.000 description 16
- 239000002671 adjuvant Substances 0.000 description 11
- 108091033319 polynucleotide Proteins 0.000 description 9
- 102000040430 polynucleotide Human genes 0.000 description 9
- 239000002157 polynucleotide Substances 0.000 description 9
- 239000010419 fine particle Substances 0.000 description 8
- 238000001179 sorption measurement Methods 0.000 description 7
- 239000004372 Polyvinyl alcohol Substances 0.000 description 6
- 229920002451 polyvinyl alcohol Polymers 0.000 description 6
- 102000004169 proteins and genes Human genes 0.000 description 6
- 108090000623 proteins and genes Proteins 0.000 description 6
- 230000003053 immunization Effects 0.000 description 5
- 238000002649 immunization Methods 0.000 description 5
- 229920001184 polypeptide Polymers 0.000 description 5
- 102000004196 processed proteins & peptides Human genes 0.000 description 5
- 108090000765 processed proteins & peptides Proteins 0.000 description 5
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 description 4
- 229940061720 alpha hydroxy acid Drugs 0.000 description 4
- 150000001280 alpha hydroxy acids Chemical class 0.000 description 4
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 241000711549 Hepacivirus C Species 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 3
- 229920001710 Polyorthoester Polymers 0.000 description 3
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 3
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical group O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 239000000839 emulsion Substances 0.000 description 3
- 229940088597 hormone Drugs 0.000 description 3
- 239000005556 hormone Substances 0.000 description 3
- 230000028993 immune response Effects 0.000 description 3
- 239000002955 immunomodulating agent Substances 0.000 description 3
- 229940121354 immunomodulator Drugs 0.000 description 3
- 230000006698 induction Effects 0.000 description 3
- 239000000543 intermediate Substances 0.000 description 3
- 239000002745 poly(ortho ester) Substances 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 238000013518 transcription Methods 0.000 description 3
- 230000035897 transcription Effects 0.000 description 3
- 101710154606 Hemagglutinin Proteins 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 101710093908 Outer capsid protein VP4 Proteins 0.000 description 2
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 description 2
- 229920001244 Poly(D,L-lactide) Polymers 0.000 description 2
- 101710176177 Protein A56 Proteins 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000003945 anionic surfactant Substances 0.000 description 2
- 239000003093 cationic surfactant Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 229940088598 enzyme Drugs 0.000 description 2
- 150000002191 fatty alcohols Chemical class 0.000 description 2
- 239000000185 hemagglutinin Substances 0.000 description 2
- 230000005847 immunogenicity Effects 0.000 description 2
- 208000037797 influenza A Diseases 0.000 description 2
- 239000002563 ionic surfactant Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000002503 metabolic effect Effects 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 229920001432 poly(L-lactide) Polymers 0.000 description 2
- 229920001610 polycaprolactone Polymers 0.000 description 2
- 239000004632 polycaprolactone Substances 0.000 description 2
- 229920002721 polycyanoacrylate Polymers 0.000 description 2
- 241000700198 Cavia Species 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 101710125507 Integrase/recombinase Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- 229920002732 Polyanhydride Polymers 0.000 description 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
- 239000004473 Threonine Substances 0.000 description 1
- 229940037003 alum Drugs 0.000 description 1
- 150000008064 anhydrides Chemical class 0.000 description 1
- 230000030741 antigen processing and presentation Effects 0.000 description 1
- 229920002988 biodegradable polymer Polymers 0.000 description 1
- 239000004621 biodegradable polymer Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000000779 depleting effect Effects 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 230000028996 humoral immune response Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 230000002584 immunomodulator Effects 0.000 description 1
- 230000021633 leukocyte mediated immunity Effects 0.000 description 1
- 210000001165 lymph node Anatomy 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000037353 metabolic pathway Effects 0.000 description 1
- -1 polynucleoside Proteins 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12453398A | 1998-07-29 | 1998-07-29 | |
| US09/124,533 | 1998-07-29 | ||
| US28585599A | 1999-04-02 | 1999-04-02 | |
| US09/285,855 | 1999-04-02 | ||
| PCT/US1999/017308 WO2000006123A1 (en) | 1998-07-29 | 1999-07-29 | Microparticles with adsorbent surfaces, methods of making same, and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010058491A Division JP2010168392A (ja) | 1998-07-29 | 2010-03-15 | 吸着表面を有する微小粒子、それを作製する方法、およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002521425A JP2002521425A (ja) | 2002-07-16 |
| JP2002521425A5 true JP2002521425A5 (enExample) | 2010-05-06 |
| JP4601168B2 JP4601168B2 (ja) | 2010-12-22 |
Family
ID=26822700
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000561979A Expired - Fee Related JP4601168B2 (ja) | 1998-07-29 | 1999-07-29 | 吸着表面を有する微小粒子、それを作製する方法、およびその使用 |
| JP2010058491A Withdrawn JP2010168392A (ja) | 1998-07-29 | 2010-03-15 | 吸着表面を有する微小粒子、それを作製する方法、およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010058491A Withdrawn JP2010168392A (ja) | 1998-07-29 | 2010-03-15 | 吸着表面を有する微小粒子、それを作製する方法、およびその使用 |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1100468B1 (enExample) |
| JP (2) | JP4601168B2 (enExample) |
| AT (1) | ATE321535T1 (enExample) |
| AU (1) | AU763975B2 (enExample) |
| CA (1) | CA2338646C (enExample) |
| CY (1) | CY1107326T1 (enExample) |
| DE (1) | DE69930642T2 (enExample) |
| DK (1) | DK1100468T3 (enExample) |
| ES (1) | ES2260923T3 (enExample) |
| NZ (1) | NZ509853A (enExample) |
| PT (1) | PT1100468E (enExample) |
| WO (1) | WO2000006123A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1156781B1 (en) | 1999-02-26 | 2005-06-08 | Chiron Corporation | Microemulsions with adsorbed macromolecules and microparticles |
| US7713739B1 (en) | 2000-11-17 | 2010-05-11 | Novartis Vaccines And Diagnostics, Inc. | Microparticle-based transfection and activation of dendritic cells |
| AU2001281921A1 (en) * | 2000-06-29 | 2002-01-08 | Bernina Biosystems Gmbh | Bdellosomes |
| MXPA03002643A (es) | 2000-09-28 | 2003-06-19 | Chiron Corp | Composiciones de microparticulas y metodos para producirlas. |
| EP1438323A4 (en) * | 2001-10-03 | 2007-08-01 | Novartis Vaccines & Diagnostic | ADJUVOUS MENINGOCOCCUS COMPOSITIONS |
| US7838015B2 (en) * | 2001-10-03 | 2010-11-23 | Novartis Vaccines And Diagnostics, Inc. | Adjuvanted meningococcus compositions |
| AR045702A1 (es) * | 2001-10-03 | 2005-11-09 | Chiron Corp | Composiciones de adyuvantes. |
| EP2572707A3 (en) | 2002-02-20 | 2013-11-06 | Novartis Vaccines and Diagnostics, Inc. | Microparticles with adsorbed polypeptide-containing molecules |
| CA2501476A1 (en) * | 2002-10-07 | 2004-04-22 | Chiron Corporation | Hiv vaccine formulations |
| EP2263687B1 (en) | 2002-12-27 | 2015-03-25 | Novartis Vaccines and Diagnostics, Inc. | Immunogenic compositions containing phospholipid |
| US7731967B2 (en) | 2003-04-30 | 2010-06-08 | Novartis Vaccines And Diagnostics, Inc. | Compositions for inducing immune responses |
| JP5557415B2 (ja) | 2003-06-02 | 2014-07-23 | ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド | 吸着させたトキソイドおよび多糖類含有抗原を含む微粒子に基づく免疫原性組成物 |
| FR2859909B1 (fr) | 2003-09-22 | 2007-09-07 | Biomerieux Sa | Procede de preparation de microparticules bioresorbables, microparticules obtenues et utilisation |
| US7899527B2 (en) * | 2004-05-13 | 2011-03-01 | Palo Alto Investors | Treatment of conditions through modulation of the autonomic nervous system during at least one predetermined menstrual cycle phase |
| CN101072585A (zh) | 2004-11-01 | 2007-11-14 | 诺华疫苗和诊断公司 | 产生免疫应答的组合方法 |
| EP1812056B1 (en) | 2004-11-15 | 2013-08-07 | Novartis Vaccines and Diagnostics, Inc. | Immunogenic compositions containing anthrax antigen, biodegradable polymer microparticles, and polynucleotide-containing immunological adjuvant |
| CA2631714C (en) | 2005-12-02 | 2014-09-16 | Novartis Ag | Nanoparticles for use in immunogenic compositions |
| US8431160B2 (en) | 2006-02-24 | 2013-04-30 | Novartis Ag | Microparticles containing biodegradable polymer and cationic polysaccharide for use in immunogenic compositions |
| EP3067048B1 (en) | 2007-12-07 | 2018-02-14 | GlaxoSmithKline Biologicals SA | Compositions for inducing immune responses |
| EP2282771B1 (en) | 2008-04-28 | 2014-06-25 | Novartis AG | Method for producing nanoparticles |
| BRPI1012036A2 (pt) | 2009-05-27 | 2017-10-10 | Selecta Biosciences Inc | nanocarreadores que possuem componentes com diferentes taxas de liberação |
| JP5867952B2 (ja) | 2009-06-10 | 2016-02-24 | ノバルティス アーゲー | ベンゾナフチリジン含有ワクチン |
| EP2525815B1 (en) * | 2010-01-24 | 2015-02-25 | Novartis AG | Irradiated biodegradable polymer microparticles |
| CA2798739A1 (en) | 2010-05-26 | 2011-12-01 | Selecta Biosciences, Inc. | Nanocarrier compositions with uncoupled adjuvant |
| KR20130121699A (ko) | 2010-05-28 | 2013-11-06 | 테트리스 온라인, 인코포레이티드 | 상호작용 혼성 비동기 컴퓨터 게임 기반구조 |
| US9192661B2 (en) | 2010-07-06 | 2015-11-24 | Novartis Ag | Delivery of self-replicating RNA using biodegradable polymer particles |
| EA201390660A1 (ru) | 2010-11-05 | 2013-11-29 | Селекта Байосайенсиз, Инк. | Модифицированные никотиновые соединения и связанные способы |
| MX350258B (es) | 2011-07-06 | 2017-08-31 | Novartis Ag | Emulsiones cationicas de aceite en agua. |
| JP6059220B2 (ja) | 2011-07-06 | 2017-01-18 | ノバルティス アーゲー | 核酸を含む水中油型エマルジョン |
| KR20140050698A (ko) | 2011-07-29 | 2014-04-29 | 셀렉타 바이오사이언시즈, 인크. | 체액성 및 세포독성 t 림프구(ctl) 면역 반응을 발생시키는 합성 나노운반체 |
| EP2968510B1 (en) | 2013-03-14 | 2019-10-09 | President and Fellows of Harvard College | Nanoparticle-based compositions |
| CA3246538A1 (en) | 2022-03-30 | 2023-10-05 | Evonik Operations Gmbh | Formulations composed of cationic lipids and poly(lactic-co-glycolic acid) for the administration of polynucleotides into cells |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE252894T1 (de) * | 1995-01-05 | 2003-11-15 | Univ Michigan | Oberflächen-modifizierte nanopartikel und verfahren für ihre herstellung und verwendung |
| GB9514285D0 (en) * | 1995-07-13 | 1995-09-13 | Univ Nottingham | Polymeric lamellar substrate particles for drug delivery |
| US5759583A (en) * | 1995-08-30 | 1998-06-02 | Syntex (U.S.A.) Inc. | Sustained release poly (lactic/glycolic) matrices |
| ATE235890T1 (de) * | 1997-01-30 | 2003-04-15 | Chiron Corp | Verwendung von mikropartikeln mit adsorbiertem antigen zur stimulierung der immunabwehr |
-
1999
- 1999-07-29 DE DE69930642T patent/DE69930642T2/de not_active Expired - Lifetime
- 1999-07-29 JP JP2000561979A patent/JP4601168B2/ja not_active Expired - Fee Related
- 1999-07-29 ES ES99937664T patent/ES2260923T3/es not_active Expired - Lifetime
- 1999-07-29 CA CA002338646A patent/CA2338646C/en not_active Expired - Fee Related
- 1999-07-29 EP EP99937664A patent/EP1100468B1/en not_active Expired - Lifetime
- 1999-07-29 WO PCT/US1999/017308 patent/WO2000006123A1/en not_active Ceased
- 1999-07-29 PT PT99937664T patent/PT1100468E/pt unknown
- 1999-07-29 DK DK99937664T patent/DK1100468T3/da active
- 1999-07-29 AT AT99937664T patent/ATE321535T1/de active
- 1999-07-29 NZ NZ509853A patent/NZ509853A/en not_active IP Right Cessation
- 1999-07-29 AU AU52452/99A patent/AU763975B2/en not_active Ceased
-
2006
- 2006-06-05 CY CY20061100736T patent/CY1107326T1/el unknown
-
2010
- 2010-03-15 JP JP2010058491A patent/JP2010168392A/ja not_active Withdrawn
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