JP2002520101A - 電気的に補助される化粧用薬剤の局部送達法および装置 - Google Patents
電気的に補助される化粧用薬剤の局部送達法および装置Info
- Publication number
- JP2002520101A JP2002520101A JP2000558877A JP2000558877A JP2002520101A JP 2002520101 A JP2002520101 A JP 2002520101A JP 2000558877 A JP2000558877 A JP 2000558877A JP 2000558877 A JP2000558877 A JP 2000558877A JP 2002520101 A JP2002520101 A JP 2002520101A
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- skin
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
- A61N1/0416—Anode and cathode
- A61N1/0424—Shape of the electrode
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0432—Anode and cathode
- A61N1/0436—Material of the electrode
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0448—Drug reservoir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0468—Specially adapted for promoting wound healing
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Radiology & Medical Imaging (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Electrotherapy Devices (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9254198P | 1998-07-13 | 1998-07-13 | |
| US60/092,541 | 1998-07-13 | ||
| PCT/US1999/015754 WO2000002620A1 (en) | 1998-07-13 | 1999-07-13 | Method and apparatus for electrically assisted topical delivery of agents for cosmetic applications |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002520101A true JP2002520101A (ja) | 2002-07-09 |
| JP2002520101A5 JP2002520101A5 (https=) | 2006-08-24 |
Family
ID=22233728
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000558877A Pending JP2002520101A (ja) | 1998-07-13 | 1999-07-13 | 電気的に補助される化粧用薬剤の局部送達法および装置 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US6302874B1 (https=) |
| EP (1) | EP1102608A4 (https=) |
| JP (1) | JP2002520101A (https=) |
| AU (1) | AU761522B2 (https=) |
| CA (1) | CA2337129A1 (https=) |
| WO (1) | WO2000002620A1 (https=) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007521258A (ja) * | 2003-06-23 | 2007-08-02 | トランスファーマ メディカル リミテッド | 化粧剤用経皮送達システム |
| JP2011041705A (ja) * | 2009-08-21 | 2011-03-03 | Kyushu Hitachi Maxell Ltd | 美容装置 |
| JP2011519640A (ja) * | 2008-05-09 | 2011-07-14 | フェンジアン・リミテッド | 患者の健康の回復に用いる複数の電子 |
| JP2013158441A (ja) * | 2012-02-03 | 2013-08-19 | Hitachi Maxell Ltd | 唇用美容器具、および唇の美容方法 |
| JP2020137720A (ja) * | 2019-02-27 | 2020-09-03 | パナソニックＩｐマネジメント株式会社 | 美容装置およびその経路形成機構 |
Families Citing this family (154)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1102608A4 (en) * | 1998-07-13 | 2008-09-17 | Genetronics Inc | METHOD AND APPARATUS FOR THE ELECTRICALLY SUPPORTED SURFACE APPLICATION OF COSMETIC MEANS |
| US7922709B2 (en) | 1998-07-13 | 2011-04-12 | Genetronics, Inc. | Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation |
| US6678556B1 (en) * | 1998-07-13 | 2004-01-13 | Genetronics, Inc. | Electrical field therapy with reduced histopathological change in muscle |
| EP1100579B1 (en) * | 1998-07-13 | 2015-09-02 | Inovio Pharmaceuticals, Inc. | Skin and muscle-targeted gene therapy by pulsed electrical field |
| US9192780B2 (en) | 1998-11-30 | 2015-11-24 | L'oreal | Low intensity light therapy for treatment of retinal, macular, and visual pathway disorders |
| US20060212025A1 (en) * | 1998-11-30 | 2006-09-21 | Light Bioscience, Llc | Method and apparatus for acne treatment |
| US6283956B1 (en) * | 1998-11-30 | 2001-09-04 | David H. McDaniels | Reduction, elimination, or stimulation of hair growth |
| US6936044B2 (en) * | 1998-11-30 | 2005-08-30 | Light Bioscience, Llc | Method and apparatus for the stimulation of hair growth |
| US6887260B1 (en) * | 1998-11-30 | 2005-05-03 | Light Bioscience, Llc | Method and apparatus for acne treatment |
| EP1150741A1 (en) * | 1999-02-10 | 2001-11-07 | GMP Drug Delivery, Inc. | Iontophoresis, electroporation and combination patches for local drug delivery |
| DE60031709T2 (de) | 1999-10-14 | 2007-06-28 | Pola Chemical Industries, Inc. | Zusammensetzungen für die elektroporation |
| US7110826B2 (en) * | 2000-01-18 | 2006-09-19 | Shingo Motoi | Cosmetic use alternating current wave forms and cosmetic device |
| CN1406125A (zh) * | 2000-02-25 | 2003-03-26 | 健康研究股份有限公司 | 分子材料透皮或皮内输递的方法 |
| US6882884B1 (en) * | 2000-10-13 | 2005-04-19 | Soundskin, L.L.C. | Process for the stimulation of production of extracellular dermal proteins in human tissue |
| US20050274322A1 (en) * | 2001-02-26 | 2005-12-15 | Lee Chung J | Reactor for producing reactive intermediates for low dielectric constant polymer thin films |
| US20040255862A1 (en) * | 2001-02-26 | 2004-12-23 | Lee Chung J. | Reactor for producing reactive intermediates for low dielectric constant polymer thin films |
| US6881447B2 (en) * | 2002-04-04 | 2005-04-19 | Dielectric Systems, Inc. | Chemically and electrically stabilized polymer films |
| US6743215B2 (en) | 2001-04-06 | 2004-06-01 | Mattioli Engineering Ltd. | Method and apparatus for skin absorption enhancement and cellulite reduction |
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| US6980854B2 (en) | 2001-04-06 | 2005-12-27 | Mattioli Engineering Ltd. | Method and apparatus for skin absorption enhancement and transdermal drug delivery of lidocaine and/or other drugs |
| US7520875B2 (en) | 2001-04-06 | 2009-04-21 | Mattioli Engineering Ltd. | Method and apparatus for skin absorption enhancement and transdermal drug delivery |
| WO2002081025A1 (en) | 2001-04-06 | 2002-10-17 | Mattioli Engineering Ltd. | Apparatus for skin absorption enhancement |
| US7010343B2 (en) | 2001-04-06 | 2006-03-07 | Mattioli Engineering Ltd. | Method and apparatus for skin absorption enhancement and transdermal drug delivery |
| US6748266B2 (en) * | 2001-04-06 | 2004-06-08 | Mattioli Engineering Ltd. | Method and apparatus for skin absorption enhancement and transdermal drug delivery |
| US6687537B2 (en) * | 2001-04-06 | 2004-02-03 | Mattioli Engineering Ltd. | Method and apparatus for skin absorption enhancement and cellulite reduction |
| US7496401B2 (en) * | 2001-04-06 | 2009-02-24 | Mattioli Engineering Ltd | Method and apparatus for skin absorption enhancement and transdermal drug delivery |
| ITTO20010534A1 (it) * | 2001-06-04 | 2002-12-04 | Igea Srl | Dispositivo e metodo per elettroporazione che riduce la contrazione muscolare e la sensazione di dolore. |
| US8209006B2 (en) | 2002-03-07 | 2012-06-26 | Vgx Pharmaceuticals, Inc. | Constant current electroporation device and methods of use |
| US7245963B2 (en) * | 2002-03-07 | 2007-07-17 | Advisys, Inc. | Electrode assembly for constant-current electroporation and use |
| FR2840533B1 (fr) * | 2002-06-11 | 2005-04-15 | Guinot | Dispositif d'ionophorese transcutanee utilisant un champ electrique de surface |
| GB2390022A (en) * | 2002-06-27 | 2003-12-31 | Kieron Loy | Hand-held iontophoresis device for application to skin pre-treated with a medicament or cosmetic |
| US7785623B2 (en) * | 2002-10-01 | 2010-08-31 | Keller Brian C | Compositions and methods useful for the reduction of fine lines and wrinkles |
| US20040267240A1 (en) * | 2003-01-29 | 2004-12-30 | Yossi Gross | Active drug delivery in the gastrointestinal tract |
| US20050058701A1 (en) * | 2003-01-29 | 2005-03-17 | Yossi Gross | Active drug delivery in the gastrointestinal tract |
| AU2004208580A1 (en) * | 2003-01-29 | 2004-08-12 | E-Pill Pharma Ltd. | Active drug delivery in the gastrointestinal tract |
| KR20060041161A (ko) | 2003-04-10 | 2006-05-11 | 라이트 바이오사이언스, 엘엘씨 | 세포 증식 및 유전자 발현의 조절을 위한 광조절 방법 및광조절 장치 |
| US8734421B2 (en) | 2003-06-30 | 2014-05-27 | Johnson & Johnson Consumer Companies, Inc. | Methods of treating pores on the skin with electricity |
| US7479133B2 (en) * | 2003-06-30 | 2009-01-20 | Johnson & Johnson Consumer Companies, Inc. | Methods of treating acne and rosacea with galvanic generated electricity |
| US7476222B2 (en) | 2003-06-30 | 2009-01-13 | Johnson & Johnson Consumer Companies, Inc. | Methods of reducing the appearance of pigmentation with galvanic generated electricity |
| US7477938B2 (en) * | 2003-06-30 | 2009-01-13 | Johnson & Johnson Cosumer Companies, Inc. | Device for delivery of active agents to barrier membranes |
| US7486989B2 (en) * | 2003-06-30 | 2009-02-03 | Johnson & Johnson Consumer Companies, Inc. | Device for delivery of oxidizing agents to barrier membranes |
| US20040265395A1 (en) * | 2003-06-30 | 2004-12-30 | Ying Sun | Device for delivery of reducing agents to barrier membranes |
| US7480530B2 (en) * | 2003-06-30 | 2009-01-20 | Johnson & Johnson Consumer Companies, Inc. | Device for treatment of barrier membranes |
| US7507228B2 (en) * | 2003-06-30 | 2009-03-24 | Johnson & Johnson Consumer Companies, Inc. | Device containing a light emitting diode for treatment of barrier membranes |
| US7477940B2 (en) * | 2003-06-30 | 2009-01-13 | J&J Consumer Companies, Inc. | Methods of administering an active agent to a human barrier membrane with galvanic generated electricity |
| US7477939B2 (en) * | 2003-06-30 | 2009-01-13 | Johnson & Johnson Consumer Companies, Inc. | Methods of treating a wound with galvanic generated electricity |
| US7477941B2 (en) * | 2003-06-30 | 2009-01-13 | Johnson & Johnson Consumer Companies, Inc. | Methods of exfoliating the skin with electricity |
| EP1648385B1 (en) | 2003-07-31 | 2016-05-04 | Gentlewaves Llc | System and method for the photodynamic treatment of skin |
| US6962871B2 (en) * | 2004-03-31 | 2005-11-08 | Dielectric Systems, Inc. | Composite polymer dielectric film |
| US7094661B2 (en) * | 2004-03-31 | 2006-08-22 | Dielectric Systems, Inc. | Single and dual damascene techniques utilizing composite polymer dielectric film |
| US7309395B2 (en) | 2004-03-31 | 2007-12-18 | Dielectric Systems, Inc. | System for forming composite polymer dielectric film |
| CA2563817C (en) * | 2004-04-23 | 2018-07-10 | Yoram Palti | Treating a tumor or the like with electric fields at different frequencies |
| US20060201426A1 (en) * | 2004-05-25 | 2006-09-14 | Lee Chung J | Reactor for Producing Reactive Intermediates for Transport Polymerization |
| US7315758B2 (en) * | 2004-06-03 | 2008-01-01 | Lynntech, Inc. | Transdermal delivery of therapeutic agent |
| EP1768742A4 (en) * | 2004-07-06 | 2007-10-17 | Transpharma Medical Ltd | ADMINISTRATION SYSTEM FOR TRANSDERMAL IMMUNIZATION |
| US20060046044A1 (en) * | 2004-08-24 | 2006-03-02 | Lee Chung J | Porous composite polymer dielectric film |
| US20060264804A1 (en) * | 2005-04-07 | 2006-11-23 | Yoram Karmon | Device and kit for delivery of encapsulated substances and methods of use thereof |
| CN101175529A (zh) * | 2005-05-19 | 2008-05-07 | 埃-皮尔制药公司 | 用于在组织中产生一氧化氮的可摄入装置 |
| US20060275547A1 (en) * | 2005-06-01 | 2006-12-07 | Lee Chung J | Vapor Phase Deposition System and Method |
| US20060274474A1 (en) * | 2005-06-01 | 2006-12-07 | Lee Chung J | Substrate Holder |
| US20070009542A1 (en) * | 2005-07-05 | 2007-01-11 | Galit Levin | Method and device for transdermal immunization |
| US20070021803A1 (en) | 2005-07-22 | 2007-01-25 | The Foundry Inc. | Systems and methods for neuromodulation for treatment of pain and other disorders associated with nerve conduction |
| US20070185431A1 (en) * | 2006-02-03 | 2007-08-09 | Kern Dale G | Galvanic Current Skin Treatment |
| ES2993941T3 (en) | 2006-10-17 | 2025-01-14 | Inovio Pharmaceuticals Inc | Electroporation devices for electroporation of cells in mammals |
| US20100076367A1 (en) * | 2006-11-24 | 2010-03-25 | Koninklijke Philips Electronics N. V. | Iontophoretic device |
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| US8197844B2 (en) | 2007-06-08 | 2012-06-12 | Activatek, Inc. | Active electrode for transdermal medicament administration |
| CA2704740C (en) * | 2007-10-09 | 2016-05-17 | Transpharma Ltd. | Magnetic patch coupling |
| JP2011505899A (ja) | 2007-12-05 | 2011-03-03 | シネロン メディカル リミテッド | 使い捨て可能な電磁気エネルギーアプリケータ及びそれを使用する方法 |
| EP2240105B1 (en) | 2008-01-17 | 2012-09-26 | Syneron Medical Ltd. | A hair removal apparatus for personal use and the method of using same |
| US8862223B2 (en) | 2008-01-18 | 2014-10-14 | Activatek, Inc. | Active transdermal medicament patch and circuit board for same |
| CN101951851B (zh) | 2008-01-24 | 2013-02-06 | 赛诺龙医疗公司 | 肥胖组织治疗的装置和器具 |
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| US8150525B2 (en) | 2008-08-27 | 2012-04-03 | Johnson & Johnson Consumer Companies, Inc. | Treatment of hyperhydrosis |
| WO2010032235A1 (en) | 2008-09-21 | 2010-03-25 | Syneron Medical Ltd. | A method and apparatus for personal skin treatment |
| TWM352263U (en) * | 2008-10-29 | 2009-03-11 | Hong-Jiang Shao | Micro-current massage bra pad |
| US8606366B2 (en) | 2009-02-18 | 2013-12-10 | Syneron Medical Ltd. | Skin treatment apparatus for personal use and method for using same |
| US20120089232A1 (en) | 2009-03-27 | 2012-04-12 | Jennifer Hagyoung Kang Choi | Medical devices with galvanic particulates |
| US8414559B2 (en) | 2009-05-07 | 2013-04-09 | Rainbow Medical Ltd. | Gastroretentive duodenal pill |
| US20100286587A1 (en) * | 2009-05-07 | 2010-11-11 | Yossi Gross | Sublingual electrical drug delivery |
| EP2498867B1 (en) | 2009-11-13 | 2016-12-21 | Johnson & Johnson Consumer Inc. | Galvanic skin treatment device |
| US9227021B2 (en) | 2010-06-29 | 2016-01-05 | Genesis Biosystems, Inc. | Microneedle roller (MNR) infusion system |
| US11191953B2 (en) * | 2010-08-19 | 2021-12-07 | Electrocore, Inc. | Systems and methods for vagal nerve stimulation |
| US10765882B2 (en) * | 2010-09-05 | 2020-09-08 | Madryn Heatlh Partners, Lp | Self operated esthetic device with a substrate |
| CN103200959A (zh) | 2010-09-27 | 2013-07-10 | 中国农业大学 | 预防和治疗自身免疫性疾病的联合抗原和dna疫苗 |
| CA2848370C (en) * | 2011-09-22 | 2020-01-14 | Djo, Llc | Devices and systems for treating pain with electrical stimulation |
| RU2014119857A (ru) * | 2011-10-19 | 2015-11-27 | Ньюро Рисорс Груп, Инк. | Самонаправляющийся электрод для стимуляции |
| US20130158547A1 (en) * | 2011-12-19 | 2013-06-20 | Jonathan David | Fluid Skin Treatment Device |
| CN103239734B (zh) | 2012-02-10 | 2016-02-24 | 北京艾棣维欣生物技术有限公司 | 用于预防和/或治疗呼吸道合胞病毒感染的疫苗 |
| CA2888648C (en) | 2012-12-13 | 2021-06-08 | The Trustees Of The University Of Pennsylvania | Wt1 vaccine |
| WO2014194244A1 (en) | 2013-05-30 | 2014-12-04 | Duke University | Enzyme-catalyzed synthesis of site-specific and stoichiometric biomolecule-polymer conjugates |
| US10392611B2 (en) | 2013-05-30 | 2019-08-27 | Duke University | Polymer conjugates having reduced antigenicity and methods of using the same |
| US10364451B2 (en) | 2013-05-30 | 2019-07-30 | Duke University | Polymer conjugates having reduced antigenicity and methods of using the same |
| WO2014201511A1 (en) * | 2013-06-21 | 2014-12-24 | Gary David Housley | Method and apparatus for close-field electroporation |
| WO2015054012A1 (en) | 2013-10-07 | 2015-04-16 | The Trustees Of The University Of Pennsylvania | Vaccines with interleukin-33 as an adjuvant |
| US10370664B2 (en) | 2013-11-07 | 2019-08-06 | University Of Southern California | Use of IKK epsilon inhibitors to activate NFAT and T cell response |
| KR20220061285A (ko) | 2013-11-14 | 2022-05-12 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | HIV-1 EnV DNA 백신과 단백질 부스터 |
| KR20160091350A (ko) | 2013-11-29 | 2016-08-02 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 중동 호흡기 증후군 코로나바이러스(MERS-CoV) 백신 |
| KR20220062143A (ko) | 2014-01-06 | 2022-05-13 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | Pd1 및 pdl1 항체 및 백신 조합 및 면역요법을 위한 이들의 사용 |
| RU2699278C2 (ru) * | 2014-05-02 | 2019-09-04 | Конинклейке Филипс Н.В. | Устройство для инактивации бактерий |
| AU2015323944B2 (en) | 2014-10-01 | 2018-11-29 | Inovio Pharmaceuticals, Inc. | Vaccines having an antigen and interleukin-21 as an adjuvant |
| CA2974956A1 (en) | 2015-01-29 | 2016-08-04 | The Trustees Of The University Of Pennsylvania | Checkpoint inhibitor and vaccine combinations and use of same for immunotherapy |
| US10385115B2 (en) | 2015-03-26 | 2019-08-20 | Duke University | Fibronectin type III domain-based fusion proteins |
| JP6882782B2 (ja) | 2015-08-04 | 2021-06-02 | デューク ユニバーシティ | 遺伝子コードされた本質的に無秩序な送達用ステルスポリマーおよびその使用方法 |
| FR3045289B1 (fr) | 2015-12-17 | 2021-09-03 | Oreal | Dispositif de traitement des matieres keratiniques humaines, notamment a l'aide d'un courant electrique |
| FR3045296B1 (fr) * | 2015-12-17 | 2018-01-26 | L'oreal | Dispositif de traitement des matieres keratiniques humaines, notamment a l'aide d'un courant electrique |
| FR3045298B1 (fr) | 2015-12-17 | 2018-01-26 | L'oreal | Appareil de traitement des matieres keratiniques humaines |
| WO2017112825A2 (en) | 2015-12-21 | 2017-06-29 | Duke University | Polymer conjugates having reduced antigenicity and methods of using the same |
| US11752213B2 (en) | 2015-12-21 | 2023-09-12 | Duke University | Surfaces having reduced non-specific binding and antigenicity |
| US20170266457A1 (en) * | 2016-03-17 | 2017-09-21 | Syneron Medical Ltd. | Skin Treatment Method And Apparatus |
| US11246924B2 (en) | 2016-04-01 | 2022-02-15 | Duke University | Alpha-helical peptide nanofibers as a self-adjuvanting vaccine platform |
| KR102624967B1 (ko) | 2016-04-29 | 2024-01-16 | 이노비오 파마수티컬즈, 인크. | 제제의 전달을 향상시키기 위한 콘드로이티나제 및/또는 히알루로니다제의 생체내 용도 |
| WO2017210476A1 (en) | 2016-06-01 | 2017-12-07 | Duke University | Nonfouling biosensors |
| US10233419B2 (en) | 2016-06-30 | 2019-03-19 | Zymergen Inc. | Apparatuses and methods for electroporation |
| RU2019110848A (ru) | 2016-09-14 | 2020-10-15 | Дьюк Юниверсити | Наночастицы на основе триблочных полипептидов для доставки гидрофильных лекарственных средств |
| EP3515928B1 (en) | 2016-09-23 | 2026-01-28 | Duke University | Unstructured non-repetitive polypeptides having lcst behavior |
| US10376495B2 (en) | 2016-11-23 | 2019-08-13 | University Of South Florida | Small molecules that mimic or antagonize actions of granulocyte colony-stimulating-factor (G-CSF) |
| US20180161562A1 (en) * | 2016-12-09 | 2018-06-14 | Eduard Gorenshteyn | Methods for cosmetic, galvanic bath-assisted transfer of biologically-active substances |
| WO2018132732A1 (en) | 2017-01-12 | 2018-07-19 | Duke University | Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature triggered hierarchical self-assembly |
| US10813935B2 (en) | 2017-02-23 | 2020-10-27 | Transgenex Nanobiotech, Inc. | Methods and compositions for treating drug resistance in cancer |
| WO2018156989A1 (en) | 2017-02-24 | 2018-08-30 | University Of South Florida | The hsp90 activator aha1 drives production of pathological tau aggregates |
| US10272052B2 (en) | 2017-02-24 | 2019-04-30 | University Of South Florida | Compositions and methods for the treatment of tauopathies |
| WO2018213320A1 (en) | 2017-05-15 | 2018-11-22 | Duke University | Recombinant production of hybrid lipid-biopolymer materials that self-assemble and encapsulate agents |
| WO2019006374A1 (en) | 2017-06-30 | 2019-01-03 | Duke University | ORDER AND DISORDER AS A DESIGN PRINCIPLE FOR STIMULI-SENSITIVE BIOPOLYMER NETWORKS |
| GB201710973D0 (en) | 2017-07-07 | 2017-08-23 | Avacta Life Sciences Ltd | Scaffold proteins |
| US11441994B2 (en) * | 2017-07-27 | 2022-09-13 | Tata Consultancy Services Limited | Method and system for in-silico design of skin electroporation |
| CN111194197A (zh) * | 2017-09-18 | 2020-05-22 | 因科波实验室有限责任公司 | 用于经皮递送美容剂的离子导入系统、套件和方法 |
| US12296018B2 (en) | 2018-01-26 | 2025-05-13 | Duke University | Albumin binding peptide-drug (AlBiPeD) conjugates and methods of making and using same |
| EP3788343B1 (en) | 2018-04-30 | 2024-03-27 | Duke University | Stimuli-responsive peg-like polymer-based drug delivery platform |
| CN108853720A (zh) * | 2018-05-16 | 2018-11-23 | 邱骅轩 | 一种用于美容领域的自适应透皮离子电渗法导入系统 |
| EP3829622A4 (en) | 2018-08-02 | 2022-05-11 | Duke University | DOUBLE AGONIST FUSION PROTEINS |
| WO2020051541A1 (en) | 2018-09-07 | 2020-03-12 | Duke University | Nanoparticulate drug delivery systems |
| JP7542202B2 (ja) * | 2019-02-27 | 2024-08-30 | パナソニックＩｐマネジメント株式会社 | 美容装置 |
| US11512314B2 (en) | 2019-07-12 | 2022-11-29 | Duke University | Amphiphilic polynucleotides |
| WO2021074695A1 (en) | 2019-10-16 | 2021-04-22 | Avacta Life Sciences Limited | PD-L1 INHIBITOR - TGFβ INHIBITOR BISPECIFIC DRUG MOIETIES. |
| CN115867349A (zh) | 2020-02-25 | 2023-03-28 | 艾诺奥医药品有限公司 | 针对冠状病毒的疫苗和使用方法 |
| PH12022553102A1 (en) | 2020-05-14 | 2023-11-20 | Inovio Pharmaceuticals Inc | Vaccines for recurrent respiratory papillomatosis and methods of using the same |
| GB202101299D0 (en) | 2020-06-09 | 2021-03-17 | Avacta Life Sciences Ltd | Diagnostic polypetides and methods |
| EP4165183A1 (en) | 2020-06-12 | 2023-04-19 | University of Rochester | Encoding and expression of ace-trnas |
| WO2022234003A1 (en) | 2021-05-07 | 2022-11-10 | Avacta Life Sciences Limited | Cd33 binding polypeptides with stefin a protein |
| FR3123192B1 (fr) * | 2021-05-28 | 2025-04-04 | Oreal | Procédé d’électroporation pour délivrer une composition comprenant au moins un composé hydroxyacide |
| FR3123193B1 (fr) * | 2021-05-28 | 2025-11-07 | Oreal | Procédé d’électroporation pour délivrer une composition comprenant au moins un peptide de poids moléculaire allant de 500 Da à 20 kDa |
| IL310808A (en) | 2021-08-13 | 2024-04-01 | Inovio Pharmaceuticals Inc | Combination therapy to treat brain cancer |
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| EP4634373A1 (en) | 2022-12-16 | 2025-10-22 | University of Rochester | Repairment of barrier dysfunction in esophagus |
| WO2025101685A1 (en) | 2023-11-09 | 2025-05-15 | University Of Rochester | Suppression of nonsense mutations using anticodon engineered (ace)-trnas |
| WO2026030209A1 (en) | 2024-07-29 | 2026-02-05 | University Of Rochester | Use of decoding trnas to boost protein expression or function |
Family Cites Families (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2400171A (en) | 1935-09-26 | 1946-05-14 | Frances R Ruskin | Stabilized metal ascorbates |
| US2442461A (en) | 1944-03-09 | 1948-06-01 | Hoffmann La Roche | Stable solutions of calcium ascorbate |
| US2585580A (en) | 1947-06-12 | 1952-02-12 | Opplt Jan | Stabilizing ascorbic acid with thio-sugars |
| DE863111C (de) | 1951-07-03 | 1953-01-15 | Walter Hallegger | Instrument zur transkutanen und subkutanen Erwaermung und Iontophorese und Verfahrenzu seiner Anwendung |
| US3163166A (en) * | 1961-04-28 | 1964-12-29 | Colgate Palmolive Co | Iontophoresis apparatus |
| DE2800039C2 (de) | 1978-01-02 | 1984-06-20 | Horst Dr.Med. 6700 Ludwigshafen Kief | Akupunkturgerät |
| US4367157A (en) | 1979-05-10 | 1983-01-04 | Sherman Laboratories, Inc. | Soft contact lens ambient temperature disinfectant solution containing ascorbic acid or salt thereof |
| JPS5810066A (ja) * | 1981-07-10 | 1983-01-20 | 株式会社アドバンス | イオントフオレ−ゼ用プラスタ−構造体 |
| US5421819A (en) | 1992-08-12 | 1995-06-06 | Vidamed, Inc. | Medical probe device |
| US4856188A (en) * | 1984-10-12 | 1989-08-15 | Drug Delivery Systems Inc. | Method for making disposable and/or replenishable transdermal drug applicators |
| US5224928A (en) * | 1983-08-18 | 1993-07-06 | Drug Delivery Systems Inc. | Mounting system for transdermal drug applicator |
| US5042975A (en) * | 1986-07-25 | 1991-08-27 | Rutgers, The State University Of New Jersey | Iontotherapeutic device and process and iontotherapeutic unit dose |
| US5389069A (en) | 1988-01-21 | 1995-02-14 | Massachusetts Institute Of Technology | Method and apparatus for in vivo electroporation of remote cells and tissue |
| US5547467A (en) | 1988-01-21 | 1996-08-20 | Massachusettes Institute Of Technology | Method for rapid temporal control of molecular transport across tissue |
| EP0398960B1 (en) * | 1988-01-21 | 1995-12-06 | Massachusetts Institute Of Technology | Transport of molecules across tissue using electroporation |
| US5749847A (en) | 1988-01-21 | 1998-05-12 | Massachusetts Institute Of Technology | Delivery of nucleotides into organisms by electroporation |
| US5108363A (en) * | 1988-02-19 | 1992-04-28 | Gensia Pharmaceuticals, Inc. | Diagnosis, evaluation and treatment of coronary artery disease by exercise simulation using closed loop drug delivery of an exercise simulating agent beta agonist |
| EP0346513A1 (de) | 1988-06-15 | 1989-12-20 | Etama Ag | Anordnung zur Elektrotherapie |
| ES2012944A6 (es) | 1989-01-09 | 1990-04-16 | Tomas Justribo Jose Ramon | Procedimiento y su dispositivo para la admionistracion de farmacos mediante ionoforesis, para tratamiento loco-regionales. |
| CS275292B2 (en) | 1989-02-22 | 1992-02-19 | Cvut Fakulta Elektrotechnick | Private rehabilitation apparatus with ion transcutaneous acceleration |
| US5135478A (en) * | 1989-05-10 | 1992-08-04 | Drug Delivery Systems Inc. | Multi-signal electrical transdermal drug applicator |
| US6001617A (en) | 1989-06-07 | 1999-12-14 | Queen's University At Kingston | Electroporation device and method of use |
| EP0429842B1 (en) * | 1989-10-27 | 1996-08-28 | Korea Research Institute Of Chemical Technology | Device for the transdermal administration of protein or peptide drug |
| US5215088A (en) | 1989-11-07 | 1993-06-01 | The University Of Utah | Three-dimensional electrode device |
| DE4000893A1 (de) | 1990-01-15 | 1991-07-18 | Bosch Gmbh Robert | Mehrkanaliges geraet zur elektrostimulation |
| US5137817A (en) * | 1990-10-05 | 1992-08-11 | Amoco Corporation | Apparatus and method for electroporation |
| US5279544A (en) * | 1990-12-13 | 1994-01-18 | Sil Medics Ltd. | Transdermal or interdermal drug delivery devices |
| US5328451A (en) | 1991-08-15 | 1994-07-12 | Board Of Regents, The University Of Texas System | Iontophoretic device and method for killing bacteria and other microbes |
| NZ245015A (en) | 1991-11-05 | 1995-12-21 | Transkaryotic Therapies Inc | Delivery of human growth hormone through the administration of transfected cell lines encoding human growth hormone, which are physically protected from host immune response; the transfected cells and their production |
| US5425752A (en) | 1991-11-25 | 1995-06-20 | Vu'nguyen; Dung D. | Method of direct electrical myostimulation using acupuncture needles |
| US5304120A (en) | 1992-07-01 | 1994-04-19 | Btx Inc. | Electroporation method and apparatus for insertion of drugs and genes into endothelial cells |
| US5507724A (en) | 1992-07-01 | 1996-04-16 | Genetronics, Inc. | Electroporation and iontophoresis apparatus and method for insertion of drugs and genes into cells |
| US5514131A (en) | 1992-08-12 | 1996-05-07 | Stuart D. Edwards | Method for the ablation treatment of the uvula |
| US5273525A (en) | 1992-08-13 | 1993-12-28 | Btx Inc. | Injection and electroporation apparatus for drug and gene delivery |
| US5688233A (en) * | 1992-08-17 | 1997-11-18 | Genetronics, Inc. | Electronincorporation enhanced transdermal delivery of molecules |
| US5464386A (en) * | 1992-08-17 | 1995-11-07 | Genetronics, Inc. | Transdermal drug delivery by electroincorporation of vesicles |
| US5468223A (en) | 1992-11-30 | 1995-11-21 | C.N.R.S. Paris | Electrochemotherapy |
| AU685086B2 (en) | 1993-02-02 | 1998-01-15 | Vidamed, Inc. | Transurethral needle ablation device |
| FR2703253B1 (fr) | 1993-03-30 | 1995-06-23 | Centre Nat Rech Scient | Applicateur d'impulsions electriques pour traitement de tissus biologiques. |
| US5702359A (en) | 1995-06-06 | 1997-12-30 | Genetronics, Inc. | Needle electrodes for mediated delivery of drugs and genes |
| US5439440A (en) | 1993-04-01 | 1995-08-08 | Genetronics, Inc. | Electroporation system with voltage control feedback for clinical applications |
| US5993434A (en) | 1993-04-01 | 1999-11-30 | Genetronics, Inc. | Method of treatment using electroporation mediated delivery of drugs and genes |
| US5667487A (en) * | 1993-04-07 | 1997-09-16 | Henley; Julian L. | Ionosonic drug delivery apparatus |
| WO1994027670A1 (en) | 1993-06-02 | 1994-12-08 | Cardiac Pathways Corporation | Catheter having tip with fixation means |
| US5536267A (en) | 1993-11-08 | 1996-07-16 | Zomed International | Multiple electrode ablation apparatus |
| US5445611A (en) * | 1993-12-08 | 1995-08-29 | Non-Invasive Monitoring Company (Nimco) | Enhancement of transdermal delivery with ultrasound and chemical enhancers |
| US5814599A (en) | 1995-08-04 | 1998-09-29 | Massachusetts Insitiute Of Technology | Transdermal delivery of encapsulated drugs |
| IL108775A (en) | 1994-02-25 | 2003-09-17 | Univ Ramot | Method for efficient incorporation of molecules into cells |
| US5728094A (en) | 1996-02-23 | 1998-03-17 | Somnus Medical Technologies, Inc. | Method and apparatus for treatment of air way obstructions |
| US5786454A (en) | 1994-09-16 | 1998-07-28 | Washington University School Of Medicine | Modified SH2 domains |
| US5720921A (en) | 1995-03-10 | 1998-02-24 | Entremed, Inc. | Flow electroporation chamber and method |
| US5868740A (en) | 1995-03-24 | 1999-02-09 | Board Of Regents-Univ Of Nebraska | Method for volumetric tissue ablation |
| US5810762A (en) | 1995-04-10 | 1998-09-22 | Genetronics, Inc. | Electroporation system with voltage control feedback for clinical applications |
| US5780052A (en) | 1995-04-24 | 1998-07-14 | Northeastern University | Compositions and methods useful for inhibiting cell death and for delivering an agent into a cell |
| US5789213A (en) | 1995-05-11 | 1998-08-04 | Health Research Inc. | Method and compositions for high efficiency loading, transfection and fusion of cells by electric pulses |
| US6002961A (en) | 1995-07-25 | 1999-12-14 | Massachusetts Institute Of Technology | Transdermal protein delivery using low-frequency sonophoresis |
| US5983131A (en) | 1995-08-11 | 1999-11-09 | Massachusetts Institute Of Technology | Apparatus and method for electroporation of tissue |
| US5980517A (en) | 1995-08-15 | 1999-11-09 | Rita Medical Systems, Inc. | Cell necrosis apparatus |
| AU6855796A (en) | 1995-08-29 | 1997-03-19 | Cbr Laboratories, Inc. | In vivo electroporation of cells |
| US6283951B1 (en) * | 1996-10-11 | 2001-09-04 | Transvascular, Inc. | Systems and methods for delivering drugs to selected locations within the body |
| US5676648A (en) * | 1996-05-08 | 1997-10-14 | The Aps Organization, Llp | Iontophoretic drug delivery apparatus and method for use |
| WO1997047355A1 (en) | 1996-06-12 | 1997-12-18 | Alza Corporation | Reduction of skin sensitization in electrotransport drug delivery |
| GB2314274A (en) | 1996-06-20 | 1997-12-24 | Gyrus Medical Ltd | Electrode construction for an electrosurgical instrument |
| US5911223A (en) | 1996-08-09 | 1999-06-15 | Massachusetts Institute Of Technology | Introduction of modifying agents into skin by electroporation |
| US5869326A (en) | 1996-09-09 | 1999-02-09 | Genetronics, Inc. | Electroporation employing user-configured pulsing scheme |
| US5874268A (en) | 1996-09-23 | 1999-02-23 | Duke University | Method of introducing exogenous compounds into cells by electroporation and apparatus for same |
| US5908753A (en) | 1996-10-04 | 1999-06-01 | Merck & Co., Inc. | Transformation of Candida albicans by electroporation |
| US5845646A (en) | 1996-11-05 | 1998-12-08 | Lemelson; Jerome | System and method for treating select tissue in a living being |
| US5873849A (en) | 1997-04-24 | 1999-02-23 | Ichor Medical Systems, Inc. | Electrodes and electrode arrays for generating electroporation inducing electrical fields |
| US5879891A (en) | 1997-09-17 | 1999-03-09 | Merck & Co., Inc. | Transformation of saccharomyces cerevisiae by electroporation |
| TW368420B (en) | 1997-11-04 | 1999-09-01 | Genetronics Inc | Apparatus and method for transdermal molecular delivery by applying sufficient amplitude of electric field to induce migration of molecules through pores in the stratum corneum |
| US6022316A (en) | 1998-03-06 | 2000-02-08 | Spectrx, Inc. | Apparatus and method for electroporation of microporated tissue for enhancing flux rates for monitoring and delivery applications |
| NZ507185A (en) | 1998-04-14 | 2002-09-27 | Gmp Drug Delivery Inc | Iontophoresis, electroporation and combination catheters for local drug delivery to arteries and other body tissues |
| EP1102608A4 (en) * | 1998-07-13 | 2008-09-17 | Genetronics Inc | METHOD AND APPARATUS FOR THE ELECTRICALLY SUPPORTED SURFACE APPLICATION OF COSMETIC MEANS |
| US6192270B1 (en) | 1998-08-14 | 2001-02-20 | Genetronics, Inc. | Apparatus and method for the delivery of drugs and genes into tissue |
-
1999
- 1999-07-13 EP EP99933936A patent/EP1102608A4/en not_active Withdrawn
- 1999-07-13 WO PCT/US1999/015754 patent/WO2000002620A1/en not_active Ceased
- 1999-07-13 US US09/352,818 patent/US6302874B1/en not_active Expired - Fee Related
- 1999-07-13 JP JP2000558877A patent/JP2002520101A/ja active Pending
- 1999-07-13 AU AU49882/99A patent/AU761522B2/en not_active Ceased
- 1999-07-13 CA CA002337129A patent/CA2337129A1/en not_active Abandoned
-
2001
- 2001-09-27 US US09/966,390 patent/US6947791B2/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007521258A (ja) * | 2003-06-23 | 2007-08-02 | トランスファーマ メディカル リミテッド | 化粧剤用経皮送達システム |
| JP2011519640A (ja) * | 2008-05-09 | 2011-07-14 | フェンジアン・リミテッド | 患者の健康の回復に用いる複数の電子 |
| JP2011041705A (ja) * | 2009-08-21 | 2011-03-03 | Kyushu Hitachi Maxell Ltd | 美容装置 |
| JP2013158441A (ja) * | 2012-02-03 | 2013-08-19 | Hitachi Maxell Ltd | 唇用美容器具、および唇の美容方法 |
| JP2020137720A (ja) * | 2019-02-27 | 2020-09-03 | パナソニックＩｐマネジメント株式会社 | 美容装置およびその経路形成機構 |
| JP7241300B2 (ja) | 2019-02-27 | 2023-03-17 | パナソニックＩｐマネジメント株式会社 | 美容装置およびその経路形成機構 |
Also Published As
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|---|---|
| WO2000002620A1 (en) | 2000-01-20 |
| AU4988299A (en) | 2000-02-01 |
| EP1102608A4 (en) | 2008-09-17 |
| US6302874B1 (en) | 2001-10-16 |
| EP1102608A1 (en) | 2001-05-30 |
| CA2337129A1 (en) | 2000-01-20 |
| US20030097118A1 (en) | 2003-05-22 |
| AU761522B2 (en) | 2003-06-05 |
| US6947791B2 (en) | 2005-09-20 |
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