CA2337129A1 - Method and apparatus for electrically assisted topical delivery of agents for cosmetic applications - Google Patents

Method and apparatus for electrically assisted topical delivery of agents for cosmetic applications Download PDF

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Publication number
CA2337129A1
CA2337129A1 CA002337129A CA2337129A CA2337129A1 CA 2337129 A1 CA2337129 A1 CA 2337129A1 CA 002337129 A CA002337129 A CA 002337129A CA 2337129 A CA2337129 A CA 2337129A CA 2337129 A1 CA2337129 A1 CA 2337129A1
Authority
CA
Canada
Prior art keywords
skin
electrode
handheld
ascorbic acid
pulser
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002337129A
Other languages
English (en)
French (fr)
Inventor
Lei Zhang
Gunter A. Hofmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Genetronics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetronics Inc filed Critical Genetronics Inc
Publication of CA2337129A1 publication Critical patent/CA2337129A1/en
Abandoned legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0408Use-related aspects
    • A61N1/0412Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A61N1/0416Anode and cathode
    • A61N1/0424Shape of the electrode
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0408Use-related aspects
    • A61N1/0428Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0408Use-related aspects
    • A61N1/0428Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0432Anode and cathode
    • A61N1/0436Material of the electrode
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0408Use-related aspects
    • A61N1/0428Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0448Drug reservoir
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0408Use-related aspects
    • A61N1/0468Specially adapted for promoting wound healing

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Electrotherapy Devices (AREA)
CA002337129A 1998-07-13 1999-07-13 Method and apparatus for electrically assisted topical delivery of agents for cosmetic applications Abandoned CA2337129A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9254198P 1998-07-13 1998-07-13
US60/092,541 1998-07-13
PCT/US1999/015754 WO2000002620A1 (en) 1998-07-13 1999-07-13 Method and apparatus for electrically assisted topical delivery of agents for cosmetic applications

Publications (1)

Publication Number Publication Date
CA2337129A1 true CA2337129A1 (en) 2000-01-20

Family

ID=22233728

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002337129A Abandoned CA2337129A1 (en) 1998-07-13 1999-07-13 Method and apparatus for electrically assisted topical delivery of agents for cosmetic applications

Country Status (6)

Country Link
US (2) US6302874B1 (https=)
EP (1) EP1102608A4 (https=)
JP (1) JP2002520101A (https=)
AU (1) AU761522B2 (https=)
CA (1) CA2337129A1 (https=)
WO (1) WO2000002620A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11191953B2 (en) * 2010-08-19 2021-12-07 Electrocore, Inc. Systems and methods for vagal nerve stimulation

Families Citing this family (158)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6697669B2 (en) * 1998-07-13 2004-02-24 Genetronics, Inc. Skin and muscle-targeted gene therapy by pulsed electrical field
US6678556B1 (en) * 1998-07-13 2004-01-13 Genetronics, Inc. Electrical field therapy with reduced histopathological change in muscle
JP2002520101A (ja) * 1998-07-13 2002-07-09 ジェネトロニクス、インコーポレーテッド 電気的に補助される化粧用薬剤の局部送達法および装置
US7922709B2 (en) 1998-07-13 2011-04-12 Genetronics, Inc. Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation
US6936044B2 (en) * 1998-11-30 2005-08-30 Light Bioscience, Llc Method and apparatus for the stimulation of hair growth
US9192780B2 (en) 1998-11-30 2015-11-24 L'oreal Low intensity light therapy for treatment of retinal, macular, and visual pathway disorders
US6283956B1 (en) 1998-11-30 2001-09-04 David H. McDaniels Reduction, elimination, or stimulation of hair growth
US6887260B1 (en) 1998-11-30 2005-05-03 Light Bioscience, Llc Method and apparatus for acne treatment
US20060212025A1 (en) 1998-11-30 2006-09-21 Light Bioscience, Llc Method and apparatus for acne treatment
BR0008123A (pt) * 1999-02-10 2001-11-13 Gmp Drug Delivery Inc Dispositivo baseado em emplastro para aumentar aliberação local de um agente de tratamento paradentro de tecidos alvo, e, processo de liberaçãode um agente de tratamento para dentro detecidos alvo de uma vesìcula corporal
EP1222930B1 (en) 1999-10-14 2006-11-02 Pola Chemical Industries Inc. Compositions for electroporation
US7110826B2 (en) * 2000-01-18 2006-09-19 Shingo Motoi Cosmetic use alternating current wave forms and cosmetic device
US7805201B2 (en) * 2000-02-17 2010-09-28 Standen Ltd. Treating a tumor or the like with an electric field
AU4174301A (en) * 2000-02-25 2001-09-03 Health Research Inc Method for transdermal or intradermal delivery of molecules
US6882884B1 (en) * 2000-10-13 2005-04-19 Soundskin, L.L.C. Process for the stimulation of production of extracellular dermal proteins in human tissue
US20050274322A1 (en) * 2001-02-26 2005-12-15 Lee Chung J Reactor for producing reactive intermediates for low dielectric constant polymer thin films
US20040255862A1 (en) * 2001-02-26 2004-12-23 Lee Chung J. Reactor for producing reactive intermediates for low dielectric constant polymer thin films
US6881447B2 (en) * 2002-04-04 2005-04-19 Dielectric Systems, Inc. Chemically and electrically stabilized polymer films
US6743215B2 (en) * 2001-04-06 2004-06-01 Mattioli Engineering Ltd. Method and apparatus for skin absorption enhancement and cellulite reduction
US6748266B2 (en) * 2001-04-06 2004-06-08 Mattioli Engineering Ltd. Method and apparatus for skin absorption enhancement and transdermal drug delivery
US6687537B2 (en) * 2001-04-06 2004-02-03 Mattioli Engineering Ltd. Method and apparatus for skin absorption enhancement and cellulite reduction
US7496401B2 (en) * 2001-04-06 2009-02-24 Mattioli Engineering Ltd Method and apparatus for skin absorption enhancement and transdermal drug delivery
US6980854B2 (en) * 2001-04-06 2005-12-27 Mattioli Engineering Ltd. Method and apparatus for skin absorption enhancement and transdermal drug delivery of lidocaine and/or other drugs
US7083580B2 (en) 2001-04-06 2006-08-01 Mattioli Engineering Ltd. Method and apparatus for skin absorption enhancement and transdermal drug delivery
US7010343B2 (en) * 2001-04-06 2006-03-07 Mattioli Engineering Ltd. Method and apparatus for skin absorption enhancement and transdermal drug delivery
DE60123842T2 (de) * 2001-04-06 2007-09-06 Mattioli Engineering Ltd. Vorrichtung zum verbessern der absorption durch die haut
US7520875B2 (en) 2001-04-06 2009-04-21 Mattioli Engineering Ltd. Method and apparatus for skin absorption enhancement and transdermal drug delivery
ITTO20010534A1 (it) * 2001-06-04 2002-12-04 Igea Srl Dispositivo e metodo per elettroporazione che riduce la contrazione muscolare e la sensazione di dolore.
US8209006B2 (en) 2002-03-07 2012-06-26 Vgx Pharmaceuticals, Inc. Constant current electroporation device and methods of use
US7245963B2 (en) * 2002-03-07 2007-07-17 Advisys, Inc. Electrode assembly for constant-current electroporation and use
FR2840533B1 (fr) * 2002-06-11 2005-04-15 Guinot Dispositif d'ionophorese transcutanee utilisant un champ electrique de surface
GB2390022A (en) * 2002-06-27 2003-12-31 Kieron Loy Hand-held iontophoresis device for application to skin pre-treated with a medicament or cosmetic
US7785623B2 (en) * 2002-10-01 2010-08-31 Keller Brian C Compositions and methods useful for the reduction of fine lines and wrinkles
US20050058701A1 (en) * 2003-01-29 2005-03-17 Yossi Gross Active drug delivery in the gastrointestinal tract
US20040267240A1 (en) * 2003-01-29 2004-12-30 Yossi Gross Active drug delivery in the gastrointestinal tract
CN1774239A (zh) * 2003-01-29 2006-05-17 埃-皮尔制药公司 用于胃肠道的有效药物递送
JP2006522660A (ja) 2003-04-10 2006-10-05 ライト バイオサイエンス,エルエルシー 細胞増殖及び遺伝子発現を調節するためのフォトモジュレーション方法及び装置
EP1720605A4 (en) * 2003-06-23 2007-10-24 Transpharma Medical Ltd TRANSDERMAL DELIVERY SYSTEM FOR COSMETIC AGENTS
US7480530B2 (en) * 2003-06-30 2009-01-20 Johnson & Johnson Consumer Companies, Inc. Device for treatment of barrier membranes
US7507228B2 (en) * 2003-06-30 2009-03-24 Johnson & Johnson Consumer Companies, Inc. Device containing a light emitting diode for treatment of barrier membranes
US7476222B2 (en) 2003-06-30 2009-01-13 Johnson & Johnson Consumer Companies, Inc. Methods of reducing the appearance of pigmentation with galvanic generated electricity
US7477940B2 (en) * 2003-06-30 2009-01-13 J&J Consumer Companies, Inc. Methods of administering an active agent to a human barrier membrane with galvanic generated electricity
US7479133B2 (en) * 2003-06-30 2009-01-20 Johnson & Johnson Consumer Companies, Inc. Methods of treating acne and rosacea with galvanic generated electricity
US20040265395A1 (en) * 2003-06-30 2004-12-30 Ying Sun Device for delivery of reducing agents to barrier membranes
US7477938B2 (en) * 2003-06-30 2009-01-13 Johnson & Johnson Cosumer Companies, Inc. Device for delivery of active agents to barrier membranes
US7486989B2 (en) * 2003-06-30 2009-02-03 Johnson & Johnson Consumer Companies, Inc. Device for delivery of oxidizing agents to barrier membranes
US7477939B2 (en) * 2003-06-30 2009-01-13 Johnson & Johnson Consumer Companies, Inc. Methods of treating a wound with galvanic generated electricity
US7477941B2 (en) * 2003-06-30 2009-01-13 Johnson & Johnson Consumer Companies, Inc. Methods of exfoliating the skin with electricity
US8734421B2 (en) 2003-06-30 2014-05-27 Johnson & Johnson Consumer Companies, Inc. Methods of treating pores on the skin with electricity
ES2572976T3 (es) 2003-07-31 2016-06-03 Gentlewaves Llc Sistema y método para el tratamiento fotodinámico de la piel
US7309395B2 (en) 2004-03-31 2007-12-18 Dielectric Systems, Inc. System for forming composite polymer dielectric film
US6962871B2 (en) * 2004-03-31 2005-11-08 Dielectric Systems, Inc. Composite polymer dielectric film
US7094661B2 (en) * 2004-03-31 2006-08-22 Dielectric Systems, Inc. Single and dual damascene techniques utilizing composite polymer dielectric film
US20060201426A1 (en) * 2004-05-25 2006-09-14 Lee Chung J Reactor for Producing Reactive Intermediates for Transport Polymerization
US7315758B2 (en) * 2004-06-03 2008-01-01 Lynntech, Inc. Transdermal delivery of therapeutic agent
CA2572870A1 (en) * 2004-07-06 2006-01-12 Transpharma Medical Ltd. Delivery system for transdermal immunization
US20060046044A1 (en) * 2004-08-24 2006-03-02 Lee Chung J Porous composite polymer dielectric film
US20060264804A1 (en) * 2005-04-07 2006-11-23 Yoram Karmon Device and kit for delivery of encapsulated substances and methods of use thereof
JP2008540023A (ja) * 2005-05-19 2008-11-20 イー−ピル ファーマ リミティド 組織における一酸化窒素生成のための摂取可能デバイス
US20060275547A1 (en) * 2005-06-01 2006-12-07 Lee Chung J Vapor Phase Deposition System and Method
US20060274474A1 (en) * 2005-06-01 2006-12-07 Lee Chung J Substrate Holder
US20070009542A1 (en) * 2005-07-05 2007-01-11 Galit Levin Method and device for transdermal immunization
US20070021803A1 (en) * 2005-07-22 2007-01-25 The Foundry Inc. Systems and methods for neuromodulation for treatment of pain and other disorders associated with nerve conduction
US20070185431A1 (en) * 2006-02-03 2007-08-09 Kern Dale G Galvanic Current Skin Treatment
CA2666501C (en) 2006-10-17 2017-03-21 Vgx Pharmaceuticals, Inc. Electroporation devices and methods of using same for electroporation of cells in mammals
WO2008062365A2 (en) * 2006-11-24 2008-05-29 Koninklijke Philips Electronics N.V. Iontophoretic device
US7930036B1 (en) 2007-02-23 2011-04-19 Pravin Joshi Tactile application of herboelectrical stimulation to augment mammary glands
CA2684134C (en) * 2007-05-21 2016-03-15 Cyto Pulse Sciences, Inc. Method and apparatus for the delivery of polynucleotide vaccines to mammalian skin
WO2008146224A2 (en) 2007-05-25 2008-12-04 Compex Medical S.A. Wound healing electrode set
US8197844B2 (en) 2007-06-08 2012-06-12 Activatek, Inc. Active electrode for transdermal medicament administration
US9037229B2 (en) * 2007-10-09 2015-05-19 Syneron Medical Ltd Magnetic patch coupling
KR101287351B1 (ko) 2007-12-05 2013-07-23 시네론 메디컬 리미티드 피부 치료장치용 캐리어
WO2009090632A2 (en) 2008-01-17 2009-07-23 Syneron Medical Ltd. A hair removal apparatus for personal use and the method of using same
US8862223B2 (en) 2008-01-18 2014-10-14 Activatek, Inc. Active transdermal medicament patch and circuit board for same
MX2010007407A (es) 2008-01-24 2010-08-16 Syneron Medical Ltd Dispositivo, aparato, y metodo para tratamiento de tejido adiposo.
EP2116275A1 (en) * 2008-05-09 2009-11-11 Eumedic Limited A plurality of electrons for use in the restoration of a patient's health
US20090299266A1 (en) * 2008-06-02 2009-12-03 Mattioli Engineering Ltd. Method and apparatus for skin absorption enhancement and transdermal drug delivery
US20100030058A1 (en) * 2008-07-31 2010-02-04 Thomas Mammone Methods of Treating Wrinkles, Developing Wrinkle Treatments And Evaluating Treatment Efficacy, Based On Newly Discovered Similarities Between Wrinkles And Skin Wounds
US8150525B2 (en) 2008-08-27 2012-04-03 Johnson & Johnson Consumer Companies, Inc. Treatment of hyperhydrosis
WO2010032235A1 (en) 2008-09-21 2010-03-25 Syneron Medical Ltd. A method and apparatus for personal skin treatment
TWM352263U (en) * 2008-10-29 2009-03-11 Hong-Jiang Shao Micro-current massage bra pad
US8606366B2 (en) 2009-02-18 2013-12-10 Syneron Medical Ltd. Skin treatment apparatus for personal use and method for using same
US20120089232A1 (en) 2009-03-27 2012-04-12 Jennifer Hagyoung Kang Choi Medical devices with galvanic particulates
US8414559B2 (en) 2009-05-07 2013-04-09 Rainbow Medical Ltd. Gastroretentive duodenal pill
US20100286587A1 (en) * 2009-05-07 2010-11-11 Yossi Gross Sublingual electrical drug delivery
JP2011041705A (ja) * 2009-08-21 2011-03-03 Kyushu Hitachi Maxell Ltd 美容装置
US8744567B2 (en) 2009-11-13 2014-06-03 Johnson & Johnson Consumer Companies, Inc. Galvanic skin treatment device
US9227021B2 (en) 2010-06-29 2016-01-05 Genesis Biosystems, Inc. Microneedle roller (MNR) infusion system
US10765882B2 (en) * 2010-09-05 2020-09-08 Madryn Heatlh Partners, Lp Self operated esthetic device with a substrate
EP2621522A2 (en) 2010-09-27 2013-08-07 China Agricultural University Combined antigen and dna vaccine for preventing and treating autoimmune diseases
US9061148B2 (en) 2011-09-22 2015-06-23 Djo, Llc Devices, systems and methods for treating pain with electrical stimulation
WO2013059704A1 (en) * 2011-10-19 2013-04-25 Neuro Resource Group, Inc. Self directing stimulation electrode
US20130158547A1 (en) * 2011-12-19 2013-06-20 Jonathan David Fluid Skin Treatment Device
JP6105847B2 (ja) * 2012-02-03 2017-03-29 日立マクセル株式会社 唇用美容器具、および唇の美容方法
CN103239734B (zh) 2012-02-10 2016-02-24 北京艾棣维欣生物技术有限公司 用于预防和/或治疗呼吸道合胞病毒感染的疫苗
CN104812401B (zh) 2012-12-13 2017-10-13 宾夕法尼亚大学理事会 Wt1疫苗
US10364451B2 (en) 2013-05-30 2019-07-30 Duke University Polymer conjugates having reduced antigenicity and methods of using the same
WO2014194244A1 (en) 2013-05-30 2014-12-04 Duke University Enzyme-catalyzed synthesis of site-specific and stoichiometric biomolecule-polymer conjugates
US10392611B2 (en) 2013-05-30 2019-08-27 Duke University Polymer conjugates having reduced antigenicity and methods of using the same
US11013917B2 (en) * 2013-06-21 2021-05-25 Newsouth Innovations Pty Limited Method and apparatus for close-field electroporation
DK3054972T3 (da) 2013-10-07 2019-06-11 Univ Pennsylvania Vacciner med interleukin-33 som et adjuvans
WO2015070027A1 (en) 2013-11-07 2015-05-14 University Of Southern California Use of ikk epsilon inhibitors to activate nfat and t cell response
US20160256539A1 (en) 2013-11-14 2016-09-08 The Trustees Of The University Of Pennsylvania HIV-1 ENV DNA Vaccine Plus Protein Boost Delivered by EP Expands B- and T-Cell Response and Neutralizing
WO2015081155A1 (en) 2013-11-29 2015-06-04 The Trustees Of The University Of Pennsylvania Mers-cov vaccine
US10835595B2 (en) 2014-01-06 2020-11-17 The Trustees Of The University Of Pennsylvania PD1 and PDL1 antibodies and vaccine combinations and use of same for immunotherapy
RU2699278C2 (ru) * 2014-05-02 2019-09-04 Конинклейке Филипс Н.В. Устройство для инактивации бактерий
KR20230145241A (ko) 2014-10-01 2023-10-17 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 항원 및 어쥬번트로서 인터류킨-21을 갖는 백신
WO2016123285A1 (en) 2015-01-29 2016-08-04 The Trustees Of The University Of Pennsylvania Checkpoint inhibitor and vaccine combinations and use of same for immunotherapy
US10385115B2 (en) 2015-03-26 2019-08-20 Duke University Fibronectin type III domain-based fusion proteins
EA037478B1 (ru) 2015-08-04 2021-04-01 Дьюк Юниверсити Генетически кодируемые внутренне неупорядоченные полимеры-"невидимки" для доставки и способы их применения
FR3045298B1 (fr) 2015-12-17 2018-01-26 L'oreal Appareil de traitement des matieres keratiniques humaines
FR3045296B1 (fr) 2015-12-17 2018-01-26 L'oreal Dispositif de traitement des matieres keratiniques humaines, notamment a l'aide d'un courant electrique
FR3045289B1 (fr) 2015-12-17 2021-09-03 Oreal Dispositif de traitement des matieres keratiniques humaines, notamment a l'aide d'un courant electrique
US11752213B2 (en) 2015-12-21 2023-09-12 Duke University Surfaces having reduced non-specific binding and antigenicity
WO2017112826A2 (en) 2015-12-21 2017-06-29 Duke University Polymer conjugates having reduced antigenicity and methods of using the same
US20170266457A1 (en) * 2016-03-17 2017-09-21 Syneron Medical Ltd. Skin Treatment Method And Apparatus
US11246924B2 (en) 2016-04-01 2022-02-15 Duke University Alpha-helical peptide nanofibers as a self-adjuvanting vaccine platform
KR102624967B1 (ko) 2016-04-29 2024-01-16 이노비오 파마수티컬즈, 인크. 제제의 전달을 향상시키기 위한 콘드로이티나제 및/또는 히알루로니다제의 생체내 용도
WO2017210476A1 (en) 2016-06-01 2017-12-07 Duke University Nonfouling biosensors
US10233419B2 (en) 2016-06-30 2019-03-19 Zymergen Inc. Apparatuses and methods for electroporation
WO2018053201A1 (en) 2016-09-14 2018-03-22 Duke University Triblock polypeptide-based nanoparticles for the delivery of hydrophilic drugs
JP2020500150A (ja) 2016-09-23 2020-01-09 デューク ユニバーシティ 下限臨界溶液温度挙動を有する非反復かつ非構造的ポリペプチド
US10376495B2 (en) 2016-11-23 2019-08-13 University Of South Florida Small molecules that mimic or antagonize actions of granulocyte colony-stimulating-factor (G-CSF)
WO2018106344A1 (en) * 2016-12-09 2018-06-14 Gorenshteyn Eduard Methods for cosmetic, galvanic bath-assisted transfer of biologically-active substances
WO2018132732A1 (en) 2017-01-12 2018-07-19 Duke University Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature triggered hierarchical self-assembly
US10813935B2 (en) 2017-02-23 2020-10-27 Transgenex Nanobiotech, Inc. Methods and compositions for treating drug resistance in cancer
WO2018156989A1 (en) 2017-02-24 2018-08-30 University Of South Florida The hsp90 activator aha1 drives production of pathological tau aggregates
US10272052B2 (en) 2017-02-24 2019-04-30 University Of South Florida Compositions and methods for the treatment of tauopathies
WO2018213320A1 (en) 2017-05-15 2018-11-22 Duke University Recombinant production of hybrid lipid-biopolymer materials that self-assemble and encapsulate agents
WO2019006374A1 (en) 2017-06-30 2019-01-03 Duke University ORDER AND DISORDER AS A DESIGN PRINCIPLE FOR STIMULI-SENSITIVE BIOPOLYMER NETWORKS
GB201710973D0 (en) 2017-07-07 2017-08-23 Avacta Life Sciences Ltd Scaffold proteins
US11441994B2 (en) * 2017-07-27 2022-09-13 Tata Consultancy Services Limited Method and system for in-silico design of skin electroporation
US20190083782A1 (en) * 2017-09-18 2019-03-21 Incube Labs, Llc Iontophoretic systems, kits and methods for transdermal delivery of cosmetic agents
WO2019147954A1 (en) 2018-01-26 2019-08-01 Duke University Albumin binding peptide-drug (aibiped) conjugates and methods of making and using same
EP3788343B1 (en) 2018-04-30 2024-03-27 Duke University Stimuli-responsive peg-like polymer-based drug delivery platform
CN108853720A (zh) * 2018-05-16 2018-11-23 邱骅轩 一种用于美容领域的自适应透皮离子电渗法导入系统
US11649275B2 (en) 2018-08-02 2023-05-16 Duke University Dual agonist fusion proteins
US12594347B2 (en) 2018-09-07 2026-04-07 Duke University Nanoparticulate drug delivery systems
JP7542202B2 (ja) * 2019-02-27 2024-08-30 パナソニックIpマネジメント株式会社 美容装置
JP7241300B2 (ja) * 2019-02-27 2023-03-17 パナソニックIpマネジメント株式会社 美容装置およびその経路形成機構
US11512314B2 (en) 2019-07-12 2022-11-29 Duke University Amphiphilic polynucleotides
WO2021074695A1 (en) 2019-10-16 2021-04-22 Avacta Life Sciences Limited PD-L1 INHIBITOR - TGFβ INHIBITOR BISPECIFIC DRUG MOIETIES.
JP2023511780A (ja) 2020-02-25 2023-03-22 イノビオ ファーマシューティカルズ,インコーポレイティド コロナウイルスに対するワクチンおよび使用方法
BR112022022719A2 (pt) 2020-05-14 2023-02-14 Inovio Pharmaceuticals Inc Vacinas para papilomatose respiratória recorrente e métodos de usar a mesma
GB202101299D0 (en) 2020-06-09 2021-03-17 Avacta Life Sciences Ltd Diagnostic polypetides and methods
CA3181680A1 (en) 2020-06-12 2021-12-16 University Of Rochester Encoding and expression of ace-trnas
WO2022234003A1 (en) 2021-05-07 2022-11-10 Avacta Life Sciences Limited Cd33 binding polypeptides with stefin a protein
FR3123192B1 (fr) * 2021-05-28 2025-04-04 Oreal Procédé d’électroporation pour délivrer une composition comprenant au moins un composé hydroxyacide
FR3123193B1 (fr) * 2021-05-28 2025-11-07 Oreal Procédé d’électroporation pour délivrer une composition comprenant au moins un peptide de poids moléculaire allant de 500 Da à 20 kDa
IL310808A (en) 2021-08-13 2024-04-01 Inovio Pharmaceuticals Inc Combination therapy to treat brain cancer
US20240409638A1 (en) 2021-10-07 2024-12-12 Avacta Life Sciences Limited Serum half-life extended pd-l1 binding polypeptides
EP4413038A1 (en) 2021-10-07 2024-08-14 Avacta Life Sciences Limited Pd-l1 binding affimers
AU2023215397A1 (en) 2022-02-07 2024-08-22 University Of Rochester Optimized sequences for enhanced trna expression or/and nonsense mutation suppression.
CN119213021A (zh) 2022-02-10 2024-12-27 艾菲赛尔治疗株式会社 与CD40L特异性结合的Stefin A蛋白变体及其用途
AU2023378712A1 (en) 2022-11-07 2025-05-01 Pinetree Therapeutics, Inc. Combination therapy comprising bispecific antibodies comprising an nrp1 binding domain
EP4634373A1 (en) 2022-12-16 2025-10-22 University of Rochester Repairment of barrier dysfunction in esophagus
WO2025101685A1 (en) 2023-11-09 2025-05-15 University Of Rochester Suppression of nonsense mutations using anticodon engineered (ace)-trnas
WO2026030209A1 (en) 2024-07-29 2026-02-05 University Of Rochester Use of decoding trnas to boost protein expression or function

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2400171A (en) 1935-09-26 1946-05-14 Frances R Ruskin Stabilized metal ascorbates
US2442461A (en) 1944-03-09 1948-06-01 Hoffmann La Roche Stable solutions of calcium ascorbate
US2585580A (en) 1947-06-12 1952-02-12 Opplt Jan Stabilizing ascorbic acid with thio-sugars
DE863111C (de) 1951-07-03 1953-01-15 Walter Hallegger Instrument zur transkutanen und subkutanen Erwaermung und Iontophorese und Verfahrenzu seiner Anwendung
US3163166A (en) * 1961-04-28 1964-12-29 Colgate Palmolive Co Iontophoresis apparatus
DE2800039C2 (de) 1978-01-02 1984-06-20 Horst Dr.Med. 6700 Ludwigshafen Kief Akupunkturgerät
US4367157A (en) 1979-05-10 1983-01-04 Sherman Laboratories, Inc. Soft contact lens ambient temperature disinfectant solution containing ascorbic acid or salt thereof
JPS5810066A (ja) * 1981-07-10 1983-01-20 株式会社アドバンス イオントフオレ−ゼ用プラスタ−構造体
US5421819A (en) 1992-08-12 1995-06-06 Vidamed, Inc. Medical probe device
US4856188A (en) * 1984-10-12 1989-08-15 Drug Delivery Systems Inc. Method for making disposable and/or replenishable transdermal drug applicators
US5224928A (en) * 1983-08-18 1993-07-06 Drug Delivery Systems Inc. Mounting system for transdermal drug applicator
US5042975A (en) * 1986-07-25 1991-08-27 Rutgers, The State University Of New Jersey Iontotherapeutic device and process and iontotherapeutic unit dose
US5389069A (en) 1988-01-21 1995-02-14 Massachusetts Institute Of Technology Method and apparatus for in vivo electroporation of remote cells and tissue
DE68925030T2 (de) * 1988-01-21 1996-07-25 Massachusetts Inst Technology Molekültransport durch gewebe mit der verwendung von elektroporation.
US5547467A (en) 1988-01-21 1996-08-20 Massachusettes Institute Of Technology Method for rapid temporal control of molecular transport across tissue
US5749847A (en) 1988-01-21 1998-05-12 Massachusetts Institute Of Technology Delivery of nucleotides into organisms by electroporation
US5108363A (en) * 1988-02-19 1992-04-28 Gensia Pharmaceuticals, Inc. Diagnosis, evaluation and treatment of coronary artery disease by exercise simulation using closed loop drug delivery of an exercise simulating agent beta agonist
EP0346513A1 (de) 1988-06-15 1989-12-20 Etama Ag Anordnung zur Elektrotherapie
ES2012944A6 (es) 1989-01-09 1990-04-16 Tomas Justribo Jose Ramon Procedimiento y su dispositivo para la admionistracion de farmacos mediante ionoforesis, para tratamiento loco-regionales.
CS275292B2 (en) 1989-02-22 1992-02-19 Cvut Fakulta Elektrotechnick Private rehabilitation apparatus with ion transcutaneous acceleration
US5135478A (en) * 1989-05-10 1992-08-04 Drug Delivery Systems Inc. Multi-signal electrical transdermal drug applicator
US6001617A (en) 1989-06-07 1999-12-14 Queen's University At Kingston Electroporation device and method of use
EP0429842B1 (en) * 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Device for the transdermal administration of protein or peptide drug
US5215088A (en) 1989-11-07 1993-06-01 The University Of Utah Three-dimensional electrode device
DE4000893A1 (de) 1990-01-15 1991-07-18 Bosch Gmbh Robert Mehrkanaliges geraet zur elektrostimulation
US5137817A (en) * 1990-10-05 1992-08-11 Amoco Corporation Apparatus and method for electroporation
US5279544A (en) * 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
US5328451A (en) 1991-08-15 1994-07-12 Board Of Regents, The University Of Texas System Iontophoretic device and method for killing bacteria and other microbes
PT101031B (pt) 1991-11-05 2002-07-31 Transkaryotic Therapies Inc Processo para o fornecimento de proteinas por terapia genetica
US5425752A (en) 1991-11-25 1995-06-20 Vu'nguyen; Dung D. Method of direct electrical myostimulation using acupuncture needles
US5304120A (en) 1992-07-01 1994-04-19 Btx Inc. Electroporation method and apparatus for insertion of drugs and genes into endothelial cells
US5507724A (en) 1992-07-01 1996-04-16 Genetronics, Inc. Electroporation and iontophoresis apparatus and method for insertion of drugs and genes into cells
US5514131A (en) 1992-08-12 1996-05-07 Stuart D. Edwards Method for the ablation treatment of the uvula
US5273525A (en) 1992-08-13 1993-12-28 Btx Inc. Injection and electroporation apparatus for drug and gene delivery
US5464386A (en) * 1992-08-17 1995-11-07 Genetronics, Inc. Transdermal drug delivery by electroincorporation of vesicles
US5688233A (en) * 1992-08-17 1997-11-18 Genetronics, Inc. Electronincorporation enhanced transdermal delivery of molecules
US5468223A (en) 1992-11-30 1995-11-21 C.N.R.S. Paris Electrochemotherapy
JPH08506259A (ja) 1993-02-02 1996-07-09 ヴィーダメッド インコーポレイテッド 経尿道ニードル切除装置および方法
FR2703253B1 (fr) 1993-03-30 1995-06-23 Centre Nat Rech Scient Applicateur d'impulsions electriques pour traitement de tissus biologiques.
US5439440A (en) 1993-04-01 1995-08-08 Genetronics, Inc. Electroporation system with voltage control feedback for clinical applications
US5702359A (en) 1995-06-06 1997-12-30 Genetronics, Inc. Needle electrodes for mediated delivery of drugs and genes
US5993434A (en) 1993-04-01 1999-11-30 Genetronics, Inc. Method of treatment using electroporation mediated delivery of drugs and genes
US5667487A (en) * 1993-04-07 1997-09-16 Henley; Julian L. Ionosonic drug delivery apparatus
WO1994027670A1 (en) 1993-06-02 1994-12-08 Cardiac Pathways Corporation Catheter having tip with fixation means
US5536267A (en) 1993-11-08 1996-07-16 Zomed International Multiple electrode ablation apparatus
US5445611A (en) * 1993-12-08 1995-08-29 Non-Invasive Monitoring Company (Nimco) Enhancement of transdermal delivery with ultrasound and chemical enhancers
US5814599A (en) 1995-08-04 1998-09-29 Massachusetts Insitiute Of Technology Transdermal delivery of encapsulated drugs
IL108775A (en) 1994-02-25 2003-09-17 Univ Ramot Method for efficient incorporation of molecules into cells
US5807308A (en) 1996-02-23 1998-09-15 Somnus Medical Technologies, Inc. Method and apparatus for treatment of air way obstructions
US5786454A (en) 1994-09-16 1998-07-28 Washington University School Of Medicine Modified SH2 domains
US5720921A (en) 1995-03-10 1998-02-24 Entremed, Inc. Flow electroporation chamber and method
US5868740A (en) 1995-03-24 1999-02-09 Board Of Regents-Univ Of Nebraska Method for volumetric tissue ablation
US5810762A (en) 1995-04-10 1998-09-22 Genetronics, Inc. Electroporation system with voltage control feedback for clinical applications
US5780052A (en) 1995-04-24 1998-07-14 Northeastern University Compositions and methods useful for inhibiting cell death and for delivering an agent into a cell
US5789213A (en) 1995-05-11 1998-08-04 Health Research Inc. Method and compositions for high efficiency loading, transfection and fusion of cells by electric pulses
US6002961A (en) 1995-07-25 1999-12-14 Massachusetts Institute Of Technology Transdermal protein delivery using low-frequency sonophoresis
US5983131A (en) 1995-08-11 1999-11-09 Massachusetts Institute Of Technology Apparatus and method for electroporation of tissue
US5980517A (en) 1995-08-15 1999-11-09 Rita Medical Systems, Inc. Cell necrosis apparatus
AU6855796A (en) 1995-08-29 1997-03-19 Cbr Laboratories, Inc. In vivo electroporation of cells
US6283951B1 (en) * 1996-10-11 2001-09-04 Transvascular, Inc. Systems and methods for delivering drugs to selected locations within the body
US5676648A (en) * 1996-05-08 1997-10-14 The Aps Organization, Llp Iontophoretic drug delivery apparatus and method for use
WO1997047355A1 (en) 1996-06-12 1997-12-18 Alza Corporation Reduction of skin sensitization in electrotransport drug delivery
GB2314274A (en) 1996-06-20 1997-12-24 Gyrus Medical Ltd Electrode construction for an electrosurgical instrument
US5911223A (en) 1996-08-09 1999-06-15 Massachusetts Institute Of Technology Introduction of modifying agents into skin by electroporation
US5869326A (en) 1996-09-09 1999-02-09 Genetronics, Inc. Electroporation employing user-configured pulsing scheme
US5874268A (en) 1996-09-23 1999-02-23 Duke University Method of introducing exogenous compounds into cells by electroporation and apparatus for same
US5908753A (en) 1996-10-04 1999-06-01 Merck & Co., Inc. Transformation of Candida albicans by electroporation
US5845646A (en) 1996-11-05 1998-12-08 Lemelson; Jerome System and method for treating select tissue in a living being
US5873849A (en) 1997-04-24 1999-02-23 Ichor Medical Systems, Inc. Electrodes and electrode arrays for generating electroporation inducing electrical fields
US5879891A (en) 1997-09-17 1999-03-09 Merck & Co., Inc. Transformation of saccharomyces cerevisiae by electroporation
TW368420B (en) 1997-11-04 1999-09-01 Genetronics Inc Apparatus and method for transdermal molecular delivery by applying sufficient amplitude of electric field to induce migration of molecules through pores in the stratum corneum
US6022316A (en) 1998-03-06 2000-02-08 Spectrx, Inc. Apparatus and method for electroporation of microporated tissue for enhancing flux rates for monitoring and delivery applications
AU742057B2 (en) 1998-04-14 2001-12-13 Gmp Drug Delivery, Inc. Iontophoresis, electroporation and combination catheters for local drug delivery to arteries and other body tissues
JP2002520101A (ja) * 1998-07-13 2002-07-09 ジェネトロニクス、インコーポレーテッド 電気的に補助される化粧用薬剤の局部送達法および装置
US6192270B1 (en) 1998-08-14 2001-02-20 Genetronics, Inc. Apparatus and method for the delivery of drugs and genes into tissue

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11191953B2 (en) * 2010-08-19 2021-12-07 Electrocore, Inc. Systems and methods for vagal nerve stimulation

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