JP2002512602A5 - - Google Patents
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- Publication number
- JP2002512602A5 JP2002512602A5 JP1998531325A JP53132598A JP2002512602A5 JP 2002512602 A5 JP2002512602 A5 JP 2002512602A5 JP 1998531325 A JP1998531325 A JP 1998531325A JP 53132598 A JP53132598 A JP 53132598A JP 2002512602 A5 JP2002512602 A5 JP 2002512602A5
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/800,929 | 1997-02-13 | ||
| US08/800,929 US6133437A (en) | 1997-02-13 | 1997-02-13 | Modulation of IAPs for the treatment of proliferative diseases |
| PCT/IB1998/000781 WO1998035693A2 (en) | 1997-02-13 | 1998-02-13 | Detection and modulation of the iaps and naip for the diagnosis and treatment of proliferative disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002512602A JP2002512602A (ja) | 2002-04-23 |
| JP2002512602A5 true JP2002512602A5 (https=) | 2005-12-02 |
Family
ID=25179735
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP53132598A Pending JP2002512602A (ja) | 1997-02-13 | 1998-02-13 | 増殖性疾患の診断および治療のためのiap類およびnaipの検出および調節 |
Country Status (11)
| Country | Link |
|---|---|
| US (7) | US6133437A (https=) |
| EP (2) | EP1277836A1 (https=) |
| JP (1) | JP2002512602A (https=) |
| AT (1) | ATE223727T1 (https=) |
| AU (1) | AU7074698A (https=) |
| CA (1) | CA2273821C (https=) |
| DE (1) | DE69807878T2 (https=) |
| DK (1) | DK0991421T3 (https=) |
| ES (1) | ES2182297T3 (https=) |
| PT (1) | PT991421E (https=) |
| WO (1) | WO1998035693A2 (https=) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030073159A1 (en) * | 1992-05-11 | 2003-04-17 | Human Genome Sciences, Inc. | Human inhibitor of apoptosis gene 1 |
| US6087173A (en) * | 1999-09-09 | 2000-07-11 | Isis Pharmaceuticals Inc. | Antisense modulation of X-linked inhibitor of apoptosis expression |
| US5958771A (en) * | 1998-12-03 | 1999-09-28 | Isis Pharmaceuticals, Inc. | Antisense modulation of cellular inhibitor of Apoptosis-2 expression |
| US20030083300A1 (en) * | 1998-12-03 | 2003-05-01 | Bennett C Frank | Antisense modulation of cellular inhibitor of Apoptosis-2 expression |
| US5958772A (en) * | 1998-12-03 | 1999-09-28 | Isis Pharmaceuticals Inc. | Antisense inhibition of cellular inhibitor of apoptosis-1 expression |
| US6156535A (en) * | 1995-08-04 | 2000-12-05 | University Of Ottawa | Mammalian IAP gene family, primers, probes, and detection methods |
| GB9601108D0 (en) * | 1996-01-19 | 1996-03-20 | Univ Ottawa | Neuronal apoptosis inhibitor protein (NAIP) |
| US6133437A (en) * | 1997-02-13 | 2000-10-17 | Apoptogen, Inc. | Modulation of IAPs for the treatment of proliferative diseases |
| US6511828B1 (en) | 1996-05-31 | 2003-01-28 | Arch Development Corporation | Human and drosophila inhibitors of apoptosis proteins (IAPs) |
| US6245523B1 (en) * | 1996-11-20 | 2001-06-12 | Yale University | Survivin, a protein that inhibits cellular apoptosis, and its modulation |
| US6270980B1 (en) * | 1997-06-05 | 2001-08-07 | Idun Pharmaceuticals, Inc. | Rapid methods for identifying modifiers of cellular apoptosis activity |
| US6171821B1 (en) * | 1998-07-24 | 2001-01-09 | Apoptogen, Inc. | XIAP IRES and uses thereof |
| US6472172B1 (en) * | 1998-07-31 | 2002-10-29 | Schering Aktiengesellschaft | DNA encoding a novel human inhibitor-of-apoptosis protein |
| WO2001023568A2 (en) * | 1999-09-30 | 2001-04-05 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health & Human Services, The National Institutes Of Health | Members of the iap gene family |
| EP1118334A1 (en) * | 2000-01-11 | 2001-07-25 | Aventis Behring Gesellschaft mit beschränkter Haftung | Method for the production of conjugates and uses thereof for the prevention and treatment of allergic reactions and autoimmune diseases |
| US20030106084A1 (en) * | 2000-03-29 | 2003-06-05 | Yang Liu | Methods of blocking tissue destruction by autoreactive T cells |
| ES2349137T3 (es) * | 2000-06-20 | 2010-12-28 | Dainippon Sumitomo Pharma Co., Ltd. | Preparación para transferir oligonucleótidos. |
| JP2004504841A (ja) * | 2000-07-28 | 2004-02-19 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | アポトーシスタンパク質の新規タンパク質性阻害剤 |
| US6673917B1 (en) * | 2000-09-28 | 2004-01-06 | University Of Ottawa | Antisense IAP nucleic acids and uses thereof |
| US20050214290A1 (en) * | 2001-03-29 | 2005-09-29 | Yang Liu | Methods of blocking tissue destruction by autoreactive T cells |
| JP2004532245A (ja) * | 2001-05-15 | 2004-10-21 | ページ ダブル フォーク | 癌を治療するための生体影響性化合物の標的送達 |
| WO2003012030A2 (en) * | 2001-08-01 | 2003-02-13 | University Of Utah, Technology Transfer Office | Isoform-selective inhibitors and activators of pde3 cyclic |
| US7704700B2 (en) * | 2002-02-12 | 2010-04-27 | Burnham Institute For Medical Research | Methods for determining the prognosis for patients with a prostate neoplastic condition using inhibitor of apoptosis polypeptides |
| US7897753B2 (en) * | 2002-02-20 | 2011-03-01 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of XIAP gene expression using short interfering nucleic acid (siNA) |
| CA2480308C (en) * | 2002-03-27 | 2011-10-04 | Aegera Therapeutics Inc. | Antisense iap nucleobase oligomers and uses thereof |
| US20050215498A1 (en) * | 2002-05-31 | 2005-09-29 | Guenther Eissner | Method for the protection of endothelial and epithclial cells during chemotherapy |
| US20040005565A1 (en) * | 2002-07-02 | 2004-01-08 | Isis Pharmaceuticals Inc. | Antisense modulation of livin expression |
| WO2004017991A1 (en) * | 2002-08-13 | 2004-03-04 | Cell Center Cologne Gmbh | Use of iap for the diagnosis and of iap-inhibitors for the treatment of hodgkin’s lymphomas |
| US20040132554A1 (en) * | 2003-01-02 | 2004-07-08 | Patrick Schulze | Golf tee holder |
| US20080199439A1 (en) * | 2003-02-12 | 2008-08-21 | Mclendon George L | IAP-binding cargo molecules and peptidomimetics for use in diagnostic and therapeutic methods |
| WO2004092407A1 (en) * | 2003-04-17 | 2004-10-28 | Genesis Group Inc. | Pygopus in diagnosis and treatment of cancer |
| US8012944B2 (en) * | 2003-10-30 | 2011-09-06 | Pharmascience Inc. | Method for treating cancer using IAP antisense oligomer and chemotherapeutic agent |
| US20050227302A1 (en) * | 2004-01-07 | 2005-10-13 | Sarit Larisch | Induction of apoptosis via ARTS-IAP complexes |
| TWI350373B (en) * | 2004-01-23 | 2011-10-11 | Oncotherapy Science Inc | Methods of detecting methyl transferase activity and methods of screening formethyl transferase activity modulators |
| AU2005274937B2 (en) * | 2004-07-15 | 2011-08-18 | Medivir Ab | IAP binding compounds |
| US7252482B2 (en) * | 2004-08-24 | 2007-08-07 | Beckett Corporation | Motor driven pump with improved motor cooling air flow |
| CA2584986A1 (en) * | 2004-10-22 | 2006-05-04 | Neurologix, Inc. | Use of apoptosis inhibiting compounds in degenerative neurological disorders |
| WO2006060898A1 (en) * | 2004-12-06 | 2006-06-15 | Aegera Therapeutics Inc | Method for treating inflammatory disorders |
| WO2006082866A1 (ja) * | 2005-02-01 | 2006-08-10 | Banyu Pharmaceutical Co., Ltd. | p53の機能異常の検出方法、癌の分子診断方法及び癌治療に有効な化合物の評価方法 |
| ES2456671T3 (es) | 2005-02-25 | 2014-04-23 | Tetralogic Pharmaceuticals Corporation | Inhibidores diméricos de IAP |
| TW200741009A (en) * | 2005-07-01 | 2007-11-01 | Oncotherapy Science Inc | Methods of modulating SMYD3 for treatment of cancer |
| US20100256046A1 (en) * | 2009-04-03 | 2010-10-07 | Tetralogic Pharmaceuticals Corporation | Treatment of proliferative disorders |
| WO2007021825A2 (en) * | 2005-08-09 | 2007-02-22 | Tetralogic Pharmaceuticals Corporation | Treatment of proliferative disorders |
| AU2007250443B2 (en) | 2006-05-16 | 2013-06-13 | Pharmascience Inc. | IAP BIR domain binding compounds |
| KR20090041391A (ko) * | 2006-07-24 | 2009-04-28 | 테트랄로직 파마슈티칼스 | 이량체성 iap 길항제 |
| US20100056495A1 (en) * | 2006-07-24 | 2010-03-04 | Tetralogic Pharmaceuticals Corporation | Dimeric iap inhibitors |
| CL2007002166A1 (es) * | 2006-07-24 | 2008-01-25 | Tetralogic Pharm Corp | Compuestos derivados de heterociclos de nitrogeno, antagonistas de los inhibidores de las proteinas de la apoptosis; sus composiciones farmaceuticas; y uso de dichos compuestos para el tratamiento del cancer. |
| WO2008014229A2 (en) * | 2006-07-24 | 2008-01-31 | Tetralogic Pharmaceuticals Corporation | Dimeric iap inhibitors |
| WO2008014240A2 (en) * | 2006-07-24 | 2008-01-31 | Tetralogic Pharmaceuticals Corporation | Dimeric iap inhibitors |
| WO2008014238A2 (en) * | 2006-07-24 | 2008-01-31 | Tetralogic Pharmaceuticals Corporation | Dimeric iap inhibitors |
| US7725622B2 (en) * | 2006-11-29 | 2010-05-25 | Townsend Analytics, Ltd. | Data distribution system and method |
| JP2010528587A (ja) * | 2007-05-07 | 2010-08-26 | テトラロジック ファーマシューティカルズ コーポレーション | アポトーシス阻害タンパク質のアンタゴニストに対する感受性のバイオマーカーとしてTNFα遺伝子の発現を用いる方法 |
| US9750729B2 (en) * | 2008-05-16 | 2017-09-05 | Dana-Farber Cancer Institute, Inc. | Immunomodulation by IAP inhibitors |
| US8283372B2 (en) | 2009-07-02 | 2012-10-09 | Tetralogic Pharmaceuticals Corp. | 2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic |
| WO2011098904A1 (en) | 2010-02-12 | 2011-08-18 | Aegera Therapeutics, Inc. | Iap bir domain binding compounds |
| WO2012052758A1 (en) * | 2010-10-22 | 2012-04-26 | Astrazeneca Ab | Response biomarkers for iap antagonists in human cancers |
| FI20115640A0 (fi) * | 2011-06-22 | 2011-06-22 | Turun Yliopisto | Yhdistelmähoito |
| DK2872631T3 (en) | 2012-07-13 | 2017-06-12 | Turun Yliopisto | COMBINATION THERAPY |
| WO2015109391A1 (en) | 2014-01-24 | 2015-07-30 | Children's Hospital Of Eastern Ontario Research Institute Inc. | Smc combination therapy for the treatment of cancer |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5665550A (en) * | 1990-10-19 | 1997-09-09 | Board Of Trustees Of The University Of Illinois-Urbana | Genes and genetic elements associated with sensitivity to chemotherapeutic drugs |
| WO1994008003A1 (en) * | 1991-06-14 | 1994-04-14 | Isis Pharmaceuticals, Inc. | ANTISENSE OLIGONUCLEOTIDE INHIBITION OF THE ras GENE |
| US5594076A (en) * | 1991-09-24 | 1997-01-14 | The Pennsylvania Research Foundation | Hydrodegradable polyesters |
| US6265157B1 (en) * | 1991-12-03 | 2001-07-24 | Allegheny University Of The Health Sciences | Compositions and methods for detecting altered COL1A1 gene sequences |
| WO1996035703A1 (en) * | 1995-05-11 | 1996-11-14 | Human Genome Sciences, Inc. | Human inhibitor of apoptosis gene 1 |
| US20030073159A1 (en) * | 1992-05-11 | 2003-04-17 | Human Genome Sciences, Inc. | Human inhibitor of apoptosis gene 1 |
| EP0625159B1 (en) * | 1992-09-14 | 2003-03-26 | The General Hospital Corporation | Ikaros: a regulatory gene involved in t-cell differentiation |
| US5958771A (en) * | 1998-12-03 | 1999-09-28 | Isis Pharmaceuticals, Inc. | Antisense modulation of cellular inhibitor of Apoptosis-2 expression |
| US5958772A (en) * | 1998-12-03 | 1999-09-28 | Isis Pharmaceuticals Inc. | Antisense inhibition of cellular inhibitor of apoptosis-1 expression |
| US6087173A (en) * | 1999-09-09 | 2000-07-11 | Isis Pharmaceuticals Inc. | Antisense modulation of X-linked inhibitor of apoptosis expression |
| US5718883A (en) * | 1993-04-14 | 1998-02-17 | The United States Of America As Represented By The Secretary Of The Navy | Transgenic animal model for autoimmune diseases |
| US5691179A (en) * | 1993-08-26 | 1997-11-25 | Washington University | Cell death regulators |
| US5624803A (en) * | 1993-10-14 | 1997-04-29 | The Regents Of The University Of California | In vivo oligonucleotide generator, and methods of testing the binding affinity of triplex forming oligonucleotides derived therefrom |
| US5510239A (en) * | 1993-10-18 | 1996-04-23 | Isis Pharmaceuticals, Inc. | Oligonucleotide modulation of multidrug resistance-associated protein |
| US5801154A (en) * | 1993-10-18 | 1998-09-01 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide modulation of multidrug resistance-associated protein |
| DE69534629D1 (de) * | 1994-01-18 | 2005-12-29 | Scripps Research Inst | Derivate von zinkfingerproteinen und methoden |
| WO1995028497A1 (en) * | 1994-04-13 | 1995-10-26 | La Jolla Cancer Research Foundation | Interaction of proteins involved in a cell death pathway |
| JP3944654B2 (ja) * | 1994-10-18 | 2007-07-11 | ザ ユニバーシティー オブ オタワ | 神経細胞アポトーシスの抑制タンパクとその遺伝子配列、並びに脊髄性筋萎縮症の原因となる当該遺伝子の突然変異 |
| US5770690A (en) * | 1995-06-27 | 1998-06-23 | Neurex Corporation | Bax omega protein and methods |
| US5877021A (en) * | 1995-07-07 | 1999-03-02 | Ribozyme Pharmaceuticals, Inc. | B7-1 targeted ribozymes |
| US5919912A (en) * | 1995-08-04 | 1999-07-06 | University Of Ottawa | Mammalian IAP antibodies and diagnostic kits |
| US6156535A (en) * | 1995-08-04 | 2000-12-05 | University Of Ottawa | Mammalian IAP gene family, primers, probes, and detection methods |
| AU6692996A (en) * | 1995-08-08 | 1997-03-05 | Tularik Inc. | Inhibitors of apoptosis |
| US6187557B1 (en) * | 1995-08-08 | 2001-02-13 | Tularik Inc. | c-IAP1 and c-IAP2: inhibitors of apoptosis |
| US5834216A (en) * | 1995-09-06 | 1998-11-10 | Arch Development Corporation | Screening methods for the identification of inducers and inhibitors of programmed cell death (apoptosis) |
| US5605022A (en) * | 1995-12-26 | 1997-02-25 | Nci Building Systems, Inc. | Vented closure |
| GB9601108D0 (en) * | 1996-01-19 | 1996-03-20 | Univ Ottawa | Neuronal apoptosis inhibitor protein (NAIP) |
| US6133437A (en) * | 1997-02-13 | 2000-10-17 | Apoptogen, Inc. | Modulation of IAPs for the treatment of proliferative diseases |
| AU5065098A (en) * | 1996-11-15 | 1998-06-10 | University Of Ottawa | Modulators of ovarial apoptosis related to iap |
| US5994076A (en) * | 1997-05-21 | 1999-11-30 | Clontech Laboratories, Inc. | Methods of assaying differential expression |
| US6228603B1 (en) * | 1997-05-22 | 2001-05-08 | The Burnham Institute | Screening assays for agents that alter inhibitor of apoptosis (IAP) protein regulation of caspase activity |
| CA2225187A1 (en) * | 1997-07-14 | 1999-01-14 | Universite D'ottawa/ University Of Ottawa | Xaf genes and polypeptides: methods and reagents for modulating apoptosis |
| US6133246A (en) * | 1997-08-13 | 2000-10-17 | Isis Pharmaceuticals Inc. | Antisense oligonucleotide compositions and methods for the modulation of JNK proteins |
| US6417160B1 (en) * | 1997-10-14 | 2002-07-09 | Nadine A. Tatton | Methods for increasing schwann cell survival |
| US6506559B1 (en) * | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| EP1117391A2 (en) * | 1998-10-09 | 2001-07-25 | L. Sai Latha Shankar | Methods for treating multiple sclerosis |
| US5998148A (en) * | 1999-04-08 | 1999-12-07 | Isis Pharmaceuticals Inc. | Antisense modulation of microtubule-associated protein 4 expression |
| US6395771B1 (en) * | 2000-05-31 | 2002-05-28 | Dabur Research Foundation | Paclitaxel derivatives for the treatment of cancer |
| US6673917B1 (en) * | 2000-09-28 | 2004-01-06 | University Of Ottawa | Antisense IAP nucleic acids and uses thereof |
| US20020119168A1 (en) * | 2001-02-20 | 2002-08-29 | Rudnic Edward M. | Therapeutic agent delivery |
| KR100397275B1 (ko) * | 2001-03-08 | 2003-09-17 | 주식회사 웰진 | 단방향성 안티센스 cDNA 라이브러리 구축을 통한 신규대규모 유전자 검색 및 기능 분석 시스템 |
| CA2480308C (en) * | 2002-03-27 | 2011-10-04 | Aegera Therapeutics Inc. | Antisense iap nucleobase oligomers and uses thereof |
| JP2007506440A (ja) * | 2003-09-29 | 2007-03-22 | トピジェン・ファルマスーティック・インコーポレーテッド | 炎症性症状を含む疾患を治療するための、オリゴヌクレオチド組成物および方法 |
-
1997
- 1997-02-13 US US08/800,929 patent/US6133437A/en not_active Expired - Lifetime
-
1998
- 1998-02-13 EP EP02003348A patent/EP1277836A1/en not_active Ceased
- 1998-02-13 PT PT98917563T patent/PT991421E/pt unknown
- 1998-02-13 DK DK98917563T patent/DK0991421T3/da active
- 1998-02-13 DE DE69807878T patent/DE69807878T2/de not_active Expired - Lifetime
- 1998-02-13 EP EP98917563A patent/EP0991421B1/en not_active Expired - Lifetime
- 1998-02-13 ES ES98917563T patent/ES2182297T3/es not_active Expired - Lifetime
- 1998-02-13 WO PCT/IB1998/000781 patent/WO1998035693A2/en not_active Ceased
- 1998-02-13 AT AT98917563T patent/ATE223727T1/de active
- 1998-02-13 AU AU70746/98A patent/AU7074698A/en not_active Abandoned
- 1998-02-13 JP JP53132598A patent/JP2002512602A/ja active Pending
- 1998-02-13 CA CA2273821A patent/CA2273821C/en not_active Expired - Fee Related
- 1998-12-16 US US09/212,971 patent/US6107041A/en not_active Expired - Lifetime
-
2000
- 2000-07-14 US US09/617,053 patent/US6300492B1/en not_active Expired - Fee Related
-
2001
- 2001-10-09 US US09/974,592 patent/US7087584B2/en not_active Expired - Fee Related
-
2006
- 2006-03-20 US US11/384,739 patent/US20060189563A1/en not_active Abandoned
- 2006-08-25 US US11/509,784 patent/US20070203088A1/en not_active Abandoned
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2008
- 2008-04-28 US US12/111,013 patent/US20090142334A1/en not_active Abandoned