JP2002504105A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2002504105A5 JP2002504105A5 JP1999501538A JP50153899A JP2002504105A5 JP 2002504105 A5 JP2002504105 A5 JP 2002504105A5 JP 1999501538 A JP1999501538 A JP 1999501538A JP 50153899 A JP50153899 A JP 50153899A JP 2002504105 A5 JP2002504105 A5 JP 2002504105A5
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9711982.0 | 1997-06-10 | ||
| GBGB9711982.0A GB9711982D0 (en) | 1997-06-10 | 1997-06-10 | Benzimidazole derivatives |
| GB9714552.8 | 1997-07-11 | ||
| GBGB9714552.8A GB9714552D0 (en) | 1997-07-11 | 1997-07-11 | Benzimidazole derivatives |
| PCT/EP1998/003380 WO1998056761A2 (en) | 1997-06-10 | 1998-06-08 | Benzimidazole derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002504105A JP2002504105A (ja) | 2002-02-05 |
| JP2002504105A5 true JP2002504105A5 (https=) | 2006-01-05 |
| JP4548866B2 JP4548866B2 (ja) | 2010-09-22 |
Family
ID=26311687
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP50153899A Expired - Lifetime JP4548866B2 (ja) | 1997-06-10 | 1998-06-08 | ベンゾイミダゾール誘導体 |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US6455507B1 (https=) |
| EP (1) | EP0994890B1 (https=) |
| JP (1) | JP4548866B2 (https=) |
| KR (1) | KR20010020465A (https=) |
| CN (1) | CN1265665A (https=) |
| AP (1) | AP1262A (https=) |
| AR (1) | AR012964A1 (https=) |
| AT (1) | ATE246700T1 (https=) |
| AU (1) | AU740792C (https=) |
| BR (1) | BR9810745A (https=) |
| CA (1) | CA2293470C (https=) |
| CO (1) | CO4970737A1 (https=) |
| DE (1) | DE69816992T2 (https=) |
| DK (1) | DK0994890T3 (https=) |
| EA (1) | EA002305B1 (https=) |
| EE (1) | EE9900564A (https=) |
| ES (1) | ES2205527T3 (https=) |
| HR (1) | HRP980303B1 (https=) |
| HU (1) | HUP0002224A3 (https=) |
| ID (1) | ID24054A (https=) |
| IL (1) | IL133285A0 (https=) |
| IS (1) | IS5285A (https=) |
| MA (1) | MA26504A1 (https=) |
| MY (1) | MY132872A (https=) |
| NO (1) | NO314847B1 (https=) |
| NZ (1) | NZ501415A (https=) |
| OA (1) | OA11230A (https=) |
| PE (1) | PE84099A1 (https=) |
| PL (1) | PL337773A1 (https=) |
| PT (1) | PT994890E (https=) |
| SK (1) | SK171499A3 (https=) |
| TR (1) | TR199903053T2 (https=) |
| TW (1) | TW565566B (https=) |
| WO (1) | WO1998056761A2 (https=) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6214801B1 (en) | 1996-01-23 | 2001-04-10 | The Regents Of The University Of Michigan | Imidazo[1,2-a]pyridine C-nucleosides as antiviral agents |
| AU744176B2 (en) | 1997-07-30 | 2002-02-14 | Glaxo Group Limited | Lyxofuranosyl benzimidazoles as antiviral agents |
| DE19741715A1 (de) * | 1997-09-22 | 1999-03-25 | Hoechst Ag | Pentopyranosyl-Nucleosid, seine Herstellung und Verwendung |
| GB0008939D0 (en) * | 2000-04-11 | 2000-05-31 | Glaxo Group Ltd | Process for preparing substituted benzimidazole compounds |
| BR0208010A (pt) | 2001-03-12 | 2004-12-21 | Avanir Pharmaceuticals | Composto de benzimidazol para modulação de ige e inibição de proliferação celular |
| AU2003270426A1 (en) | 2002-09-12 | 2004-04-30 | Avanir Pharmaceuticals | PHENYL-INDOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION |
| TWI276631B (en) | 2002-09-12 | 2007-03-21 | Avanir Pharmaceuticals | Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation |
| TW200524951A (en) * | 2003-08-01 | 2005-08-01 | Janssen Pharmaceutica Nv | Substituted benzimidazole-, benztriazole-, and benzimidazolone-O-glucosides |
| WO2005049582A1 (en) * | 2003-11-14 | 2005-06-02 | Auspex Pharmaceuticals, Inc. | Method of preparation of novel nucleoside analogs and uses |
| KR100944301B1 (ko) * | 2005-02-22 | 2010-02-24 | 더 리젠츠 오브 더 유니버시티 오브 미시간 | Ｍｄｍ２의 소분자 억제제 및 이의 용도 |
| DE102005019549A1 (de) * | 2005-04-25 | 2006-12-14 | Beiersdorf Ag | Kosmetische oder dermatologische Zubereitungen mit einem Gehalt an Diaminobenzimidazol |
| US7989422B2 (en) * | 2005-12-22 | 2011-08-02 | Alchemia Limited | Antibacterial agents |
| US7951845B2 (en) | 2006-01-19 | 2011-05-31 | The Regents Of The University Of Michigan | Composition and method of treating hearing loss |
| US9770433B2 (en) | 2006-01-19 | 2017-09-26 | The Regents Of The University Of Michigan | Composition and method for treating tinnitus |
| US8338397B2 (en) | 2006-01-19 | 2012-12-25 | The Regents Of The University Of Michigan | Composition and method of treating side effects from antibiotic treatment |
| US9919008B2 (en) | 2006-01-19 | 2018-03-20 | The Regents Of The University Of Michigan | Method for treating age-related hearing loss (ARHL) |
| USRE46372E1 (en) | 2006-01-19 | 2017-04-25 | The Regents Of The Univerity Of Michigan | Method for treating hearing loss |
| US10238599B2 (en) | 2006-01-19 | 2019-03-26 | The Regents Of The University Of Michigan | Composition and method for treating congenital cytomegalovirus induced hearing loss |
| US8927528B2 (en) | 2006-01-19 | 2015-01-06 | The Regents Of The University Of Michigan | Composition for treating hearing loss |
| US9889156B2 (en) | 2006-01-19 | 2018-02-13 | The Regents Of The University Of Michigan | Method for treating noise-induced hearing loss (NIHL) |
| WO2009023855A2 (en) | 2007-08-15 | 2009-02-19 | Isis Pharmaceuticals, Inc. | Tetrahydropyran nucleic acid analogs |
| WO2009100045A1 (en) * | 2008-02-04 | 2009-08-13 | Translational Genomics Research Institute | Compounds, pharmaceutical compositions and methods of use of hydroxamic acid derivatives |
| WO2009100320A2 (en) | 2008-02-07 | 2009-08-13 | Isis Pharmaceuticals, Inc. | Bicyclic cyclohexitol nucleic acid analogs |
| CN102361857B (zh) | 2008-09-26 | 2015-09-16 | 默沙东公司 | 可用作抗糖尿病剂的环状苯并咪唑衍生物 |
| WO2010047982A1 (en) | 2008-10-22 | 2010-04-29 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| WO2010051176A1 (en) | 2008-10-29 | 2010-05-06 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| JP5557845B2 (ja) | 2008-10-31 | 2014-07-23 | メルク・シャープ・アンド・ドーム・コーポレーション | 糖尿病用剤として有用な新規環状ベンゾイミダゾール誘導体 |
| US8536320B2 (en) | 2009-02-06 | 2013-09-17 | Isis Pharmaceuticals, Inc. | Tetrahydropyran nucleic acid analogs |
| US20120021515A1 (en) | 2009-02-06 | 2012-01-26 | Swayze Eric E | Oligomeric compounds and methods |
| US8895596B2 (en) | 2010-02-25 | 2014-11-25 | Merck Sharp & Dohme Corp | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
| KR101869570B1 (ko) | 2010-04-28 | 2018-06-20 | 아이오니스 파마수티컬즈, 인코포레이티드 | 변형된 뉴클레오사이드 및 그로부터 제조된 올리고머 화합물 |
| US8546344B2 (en) | 2010-10-28 | 2013-10-01 | Viropharma Incorporated | Crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl)-1H-benzimidazole |
| WO2014134493A1 (en) * | 2013-03-01 | 2014-09-04 | Los Alamos National Security, Llc | Broad spectrum antibiotic compounds and use thereof |
| DK3137476T3 (da) | 2014-04-28 | 2019-11-18 | Ionis Pharmaceuticals Inc | Linker-modificerede oligomerforbindelser |
| US10077242B2 (en) * | 2014-12-01 | 2018-09-18 | Virginia Commonwealth University | Convergent approach to the total synthesis of telmisartan via a suzuki cross-coupling reaction |
| RU2629670C2 (ru) * | 2016-08-04 | 2017-08-31 | Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) | 2-Амино-5,6-дифтор-1-(бета-D-рибофуранозил)-бензимидазол, способ получения и противовирусная активность его в отношении вируса герпеса простого 1-го типа |
| KR102583547B1 (ko) | 2020-03-30 | 2023-10-06 | (주)바이오메트릭스 테크놀로지 | 신규한 벤지미다졸 유도체, 이의 제조방법 및 이의 항암제 용도 |
| EP3907230B1 (en) * | 2020-03-30 | 2024-08-28 | Biometrix Technology Inc. | Novel benzimidazole derivatives, preparation method thereof and use thereof as anti-cancer agent comprising the same |
| KR102449266B1 (ko) | 2020-06-23 | 2022-09-30 | (주)바이오메트릭스 테크놀로지 | 항암 활성 그리고 항바이러스 활성을 갖는 신규한 벤지미다졸-탄수화물 결합체 화합물(Benzimidazole carbohydrate conjugate compound) 및 이의 제조 방법 |
| US12043644B2 (en) | 2020-06-23 | 2024-07-23 | Biometrix Technology Inc | Benzimidazole derivatives, preparation method thereof and use thereof as anti-cancer agent or anti-virus agent comprising the same |
| KR102342313B1 (ko) | 2021-08-27 | 2021-12-24 | (주)바이오메트릭스 테크놀로지 | 벤지미다졸-탄수화물 결합체 화합물을 포함하는 미셀, 이의 제조방법, 이의 항암제 또는 항바이러스제로서의 용도 |
| CN119119151A (zh) * | 2024-09-04 | 2024-12-13 | 斯坦德药典标准物质研发(湖北)有限公司 | 一种马立巴韦的制备方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1491244A (fr) | 1966-03-09 | 1967-08-11 | Nouveaux benzimidazoles solubles | |
| FR1476350A (fr) | 1966-04-18 | 1967-04-07 | Yale & Towne G M B H | Ferme-porte automatique à frein |
| US3655901A (en) | 1970-07-30 | 1972-04-11 | Merck & Co Inc | Method of inhibiting the formation of phenylethanalamine-n-methyl transferase with 2-aminobenzimidazoles |
| DE2130030A1 (de) | 1971-06-18 | 1972-12-21 | Bayer Ag | Fungizide und bakterizide Mittel |
| ES482789A0 (es) | 1978-08-25 | 1980-12-01 | Thomae Gmbh Dr K | Procedimiento para la preparacion de nuevos bencimidazoles sustituidos en posicion 5 o 6 con un anillo de piridazinona |
| EP0304624A3 (de) | 1987-07-29 | 1989-03-22 | F. Hoffmann-La Roche Ag | Benzimidazol-2-yl-pyridiniumverbindungen |
| IT1226100B (it) | 1988-07-07 | 1990-12-10 | Dompe Farmaceutici Spa | Derivati benzimidazolici farmacologicamente attivi. |
| US5248672A (en) | 1990-11-01 | 1993-09-28 | The Regents Of The University Of Michigan | Polysubstituted benzimidazole nucleosides as antiviral agents |
| ZA923640B (en) | 1991-05-21 | 1993-02-24 | Iaf Biochem Int | Processes for the diastereoselective synthesis of nucleosides |
| EP0521463A3 (en) * | 1991-07-04 | 1993-04-14 | Hoechst Aktiengesellschaft | Substituted cyclic cycloalkyltriols, process, intermediates for their preparation and their use as antiviral and antiparasitic agents |
| GB9205071D0 (en) | 1992-03-09 | 1992-04-22 | Wellcome Found | Therapeutic nucleosides |
| WO1994008456A1 (en) | 1992-10-21 | 1994-04-28 | The Regents Of The University Of Michigan | Polysubstituted benzimidazoles as antiviral agents |
| US5399580A (en) | 1993-03-08 | 1995-03-21 | Burroughs Wellcome Co. | Therapeutic nucleosides-uses |
| GB9413724D0 (en) * | 1994-07-07 | 1994-08-24 | Wellcome Found | Therapeutic nucleosides |
-
1998
- 1998-06-08 DE DE69816992T patent/DE69816992T2/de not_active Expired - Lifetime
- 1998-06-08 US US09/424,934 patent/US6455507B1/en not_active Expired - Lifetime
- 1998-06-08 HU HU0002224A patent/HUP0002224A3/hu unknown
- 1998-06-08 EP EP98936306A patent/EP0994890B1/en not_active Expired - Lifetime
- 1998-06-08 PT PT98936306T patent/PT994890E/pt unknown
- 1998-06-08 PL PL98337773A patent/PL337773A1/xx unknown
- 1998-06-08 DK DK98936306T patent/DK0994890T3/da active
- 1998-06-08 AT AT98936306T patent/ATE246700T1/de not_active IP Right Cessation
- 1998-06-08 EA EA199901031A patent/EA002305B1/ru not_active IP Right Cessation
- 1998-06-08 ES ES98936306T patent/ES2205527T3/es not_active Expired - Lifetime
- 1998-06-08 EE EEP199900564A patent/EE9900564A/xx unknown
- 1998-06-08 IL IL13328598A patent/IL133285A0/xx unknown
- 1998-06-08 MA MA25102A patent/MA26504A1/fr unknown
- 1998-06-08 CA CA002293470A patent/CA2293470C/en not_active Expired - Lifetime
- 1998-06-08 CN CN98807910A patent/CN1265665A/zh active Pending
- 1998-06-08 WO PCT/EP1998/003380 patent/WO1998056761A2/en not_active Ceased
- 1998-06-08 KR KR1019997011599A patent/KR20010020465A/ko not_active Ceased
- 1998-06-08 AU AU85360/98A patent/AU740792C/en not_active Ceased
- 1998-06-08 BR BR9810745-3A patent/BR9810745A/pt not_active IP Right Cessation
- 1998-06-08 JP JP50153899A patent/JP4548866B2/ja not_active Expired - Lifetime
- 1998-06-08 SK SK1714-99A patent/SK171499A3/sk unknown
- 1998-06-08 ID IDW20000038A patent/ID24054A/id unknown
- 1998-06-08 NZ NZ501415A patent/NZ501415A/en unknown
- 1998-06-08 AP APAP/P/1999/001707A patent/AP1262A/en active
- 1998-06-08 TR TR1999/03053T patent/TR199903053T2/xx unknown
- 1998-06-09 TW TW087109162A patent/TW565566B/zh not_active IP Right Cessation
- 1998-06-09 PE PE1998000488A patent/PE84099A1/es not_active Application Discontinuation
- 1998-06-09 MY MYPI98002560A patent/MY132872A/en unknown
- 1998-06-09 HR HR980303A patent/HRP980303B1/xx not_active IP Right Cessation
- 1998-06-09 CO CO98032828A patent/CO4970737A1/es unknown
- 1998-06-10 AR ARP980102756A patent/AR012964A1/es not_active Application Discontinuation
-
1999
- 1999-12-06 IS IS5285A patent/IS5285A/is unknown
- 1999-12-09 OA OA9900275A patent/OA11230A/en unknown
- 1999-12-09 NO NO19996086A patent/NO314847B1/no not_active IP Right Cessation