JP2002512602A - 増殖性疾患の診断および治療のためのｉａｐ類およびｎａｉｐの検出および調節 - Google Patents

増殖性疾患の診断および治療のためのｉａｐ類およびｎａｉｐの検出および調節

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Publication number
JP2002512602A
JP2002512602A JP53132598A JP53132598A JP2002512602A JP 2002512602 A JP2002512602 A JP 2002512602A JP 53132598 A JP53132598 A JP 53132598A JP 53132598 A JP53132598 A JP 53132598A JP 2002512602 A JP2002512602 A JP 2002512602A
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Prior art keywords
polypeptide
hiap
cells
iap
naip
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Pending
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JP53132598A
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Japanese (ja)
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JP2002512602A5 (enExample
Inventor
ロバート コルネラック
アレクサンダー イー． マッケンジー
ピーター リストン
ステファン バード
ベンジャミン トゥサン
クリスティン プラット
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University of Ottawa
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University of Ottawa
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Publication of JP2002512602A publication Critical patent/JP2002512602A/ja
Publication of JP2002512602A5 publication Critical patent/JP2002512602A5/ja
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57496—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving intracellular compounds
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    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
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    • C12Q2600/00—Oligonucleotides characterized by their use
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JP53132598A 1997-02-13 1998-02-13 増殖性疾患の診断および治療のためのｉａｐ類およびｎａｉｐの検出および調節 Pending JP2002512602A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/800,929 1997-02-13
US08/800,929 US6133437A (en) 1997-02-13 1997-02-13 Modulation of IAPs for the treatment of proliferative diseases
PCT/IB1998/000781 WO1998035693A2 (en) 1997-02-13 1998-02-13 Detection and modulation of the iaps and naip for the diagnosis and treatment of proliferative disease

Publications (2)

Publication Number Publication Date
JP2002512602A true JP2002512602A (ja) 2002-04-23
JP2002512602A5 JP2002512602A5 (enExample) 2005-12-02

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JP53132598A Pending JP2002512602A (ja) 1997-02-13 1998-02-13 増殖性疾患の診断および治療のためのｉａｐ類およびｎａｉｐの検出および調節

Country Status (11)

Country Link
US (7) US6133437A (enExample)
EP (2) EP0991421B1 (enExample)
JP (1) JP2002512602A (enExample)
AT (1) ATE223727T1 (enExample)
AU (1) AU7074698A (enExample)
CA (1) CA2273821C (enExample)
DE (1) DE69807878T2 (enExample)
DK (1) DK0991421T3 (enExample)
ES (1) ES2182297T3 (enExample)
PT (1) PT991421E (enExample)
WO (1) WO1998035693A2 (enExample)

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US6107041A (en) 2000-08-22
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US20070203088A1 (en) 2007-08-30
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US6300492B1 (en) 2001-10-09
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