JP2002511856A - 炎症および線維症状態の治療における組換えヒトウテログロビンの使用 - Google Patents
炎症および線維症状態の治療における組換えヒトウテログロビンの使用Info
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- JP2002511856A JP2002511856A JP50097999A JP50097999A JP2002511856A JP 2002511856 A JP2002511856 A JP 2002511856A JP 50097999 A JP50097999 A JP 50097999A JP 50097999 A JP50097999 A JP 50097999A JP 2002511856 A JP2002511856 A JP 2002511856A
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. 組換えヒトウテログロビン(rhUG)、またはその断片、またはその誘導体 の、PLA2阻害有効量、および医薬として許容される担体または稀釈剤を含む医薬 組成物。 2. 肺表面活性物質を更に含む請求項1記載の医薬組成物。 3. 該rhUGが約75%ないし約100%の純度を有している請求項1記載の医薬組成 物。 4. 該rhUGが約90%ないし約100%の純度を有している請求項1記載の医薬組成 物。 5. 該rhUGが少なくとも95%の純度を有している請求項1記載の医薬組成物。 6. 組換えヒトウテログロビン(rhUG)、またはその断片、またはその誘導体 の、フィブロネクチン結合有効量、および医薬として許容される担体または稀釈 剤を含む医薬組成物。 7. 肺表面活性物質を更に含む請求項6記載の医薬組成物。 8. 該rhUGが約75%ないし約100%の純度を有している請求項6記載の医薬組成 物。 9. 該rhUGが約90%ないし約100%の純度を有している請求項6記載の医薬組成 物。 10.該rhUGが少なくとも95%の純度を有している請求項6記載の医薬組成物。 11.標的適応症の治療用活性剤との混合物として、UGのPLA2阻害またはフィブ ロネクチン結合有効量を含む医薬組成物。 12.rhUGの該PLA2阻害またはフィブロネクチン結合有効量が炎症を減少し、そ れにより該活性剤の有効量が治療部位に到着することを確実にする請求項11記 載の医薬組成物。 13.PLA2酵素を阻害する治療を必要とする哺乳類において、in vivoでPLA2酵 素を阻害する方法であって、該哺乳類に天然または組換えヒトウテログロビン( UG)、またはその断片または誘導体のPLA2阻害有効量を投与することを含む上記 方法。 14.該UGが約75%ないし約100%の間の純度を有している請求項13記載の方法 。 15.該UGが約90%ないし約100%の間の純度を有している請求項13記載の方法 。 16.該UGが少なくとも95%の純度を有している請求項13記載の方法。 17.該UGが、天然ヒトウテログロビンと実質的に同じ配列を有する組換え体( rhUG)である請求項13記載の方法。 18.UGの該PLA2阻害有効量が20ng/kgないし500mg/kgである請求項13記載の 方法。 19.該UGが肺表面活性物質と共同して投与される請求項13記載の方法。 20.肺表面活性物質が約20重量%ないし約80重量%の量で存在する請求項19記載 の方法。 21.該UGが気管内、眼内、静脈内、全身、腹腔内、筋肉内、または経口経路に より投与される請求項13記載の方法。 22.該UGが気管内経由で液体または半エーロゾルとして投与される請求項13記 載の方法。 23.該方法が、全身性炎症、喘息、嚢胞性線維症、眼炎症、早産、不妊症、慢 性関節リウマチ、I型糖尿病、腎症、炎症性腸疾患、クローン病、潰瘍性大腸炎 、膵炎、腹膜炎、アレルギー、多臓器不全、ARDS、急性腎不全、感染または外科 手術に従属的な炎症、および移植臓器拒絶からなる群から選択された状態の治療 のためである請求項13記載の方法。 24.眼炎症が自己免疫ブドウ膜炎および角膜移植手術由来である請求項23記 載の方法。 25.該方法が炎症および免疫変調の治療である請求項13記載の方法。 26.患者の炎症状態の治療または予防方法であって、そのような処置を必要と する患者において、該患者に、天然または組換えUG、またはその断片またはその 誘導体の抗炎症有効量を投与することを含む上記方法。 27.該UGが約75%ないし約100%の間の純度を有している請求項26記載の方法 。 28.該UGが約90%ないし約100%の間の純度を有している請求項26記載の方法 。 29.該UGが少なくとも95%の純度を有している請求項26記載の方法。 30.該UGが組換え体(rhUG)であり、天然ヒトウテログロビンと実質的に同じ 配列を有する請求項26記載の方法。 31.UGの該PLA2阻害有効量が20ng/kgないし500mg/kgである請求項26記載の 方法。 32.該UGが肺表面活性物質と共同して投与される請求項26記載の方法。 33.肺表面活性物質が約20重量%ないし約80重量%の量で存在する請求項32記載 の方法。 34.該UGが気管内、眼内、静脈内、全身、腹腔内、筋肉内、または経口経路に より投与される請求項26記載の方法。 35.該UGが気管内経由で液体または半エーロゾルとして投与される請求項26記 載の方法。 36.該炎症状態が新生児RDSである請求項26記載の方法。 37.該炎症状態が成人RDSである請求項26記載の方法。 38.該炎症状態がウイルス感染、細菌感染、寄生虫感染、または真菌感染に起 因するものである請求項26記載の方法。 39.該方法が、全身炎症、喘息、嚢胞性線維症、眼炎症、早産、遠隔性臓器不 全、慢性関節リウマチ、膵炎、敗血症性ショック、膠原血管病、アナフィラキシ ーショック、外傷誘発ショック、急性腎不全、膀胱炎、尿道の炎症、輸尿管の炎 症、膀胱炎症、間質性膀胱炎、膣炎、炎症性頚部、骨盤炎症疾患、卵巣卵管炎の 炎症、卵管の炎症、陰茎炎症、前立腺炎症、精細管および精嚢の炎症、精巣炎症 、精管、精巣上体および前立腺の炎症、網膜炎、火による熱傷または化学薬品熱 傷、気管支喘息、ARDS、新生児RDS、二蜂巣胃炎(direticulitis)、新生児壊死 性全腸炎、胃潰瘍、胃腸逆流病、扁桃炎、痔核、中耳炎、乾癬、蕁麻疹、アレル ギー性皮膚炎、接触皮膚炎、化学薬品皮膚炎、心内膜炎、および不妊症からなる 群から選択された炎症状態の治療に対するものである請求項26記載の方法。 40.該炎症が、自己免疫ブドウ膜炎、CMV網膜炎、細菌感染、ウイルス感染、 寄生虫感染、感染病因の存在、網膜芽細胞腫、放射線曝露、アレルギー反応、お よび角膜移植手術に起因する眼炎症である請求項39記載の方法。 41.患者の線維症の状態の治療または予防方法であって、そのような処置を必 要とする患者において、患者に、天然または組換えUG、またはその断片、または 誘導体の、フィブロネクチン結合有効量を投与するステップを含む方法。 42.該UGが約75%ないし約100%の間の純度を有している請求項41記載の方法 。 43.該UGが約90%ないし約100%の間の純度を有している請求項41記載の方法 。 44.該UGが少なくとも95%の純度を有している請求項41記載の方法。 45.該UGが組換え体(rhUG)であり、天然ヒトウテログロビンと実質的に同じ 配列を有する請求項41記載の方法。 46.UGの該フィブロネクチン結合有効量が20ng/kgないし500mg/kgである請 求項41記載の方法。 47.該UGが肺表面活性物質と共同して投与される請求項41記載の方法。 48.肺表面活性物質が約20重量%ないし約80重量%の量で存在する請求項47記載 の方法。 49.該UGが気管内、眼内、静脈内、腹腔内、筋肉内、液体または経口経路によ り投与される請求項41記載の方法。 50.該UGが気管内管経由で液体または半エーロゾルとして投与される請求項41 記載の方法。 51.該線維症状態が肺線維症である請求項41記載の方法。 52.該線維症状態が腎線維症である請求項41記載の方法。 53.該線維症状態が血管線維症である請求項41記載の方法。 54.内因性UGの欠損により特徴づけられた炎症性または線維症性状態の治療ま たは予防方法であって、そのような処置を必要とする患者に、天然または組換え UG、またはその断片またはその誘導体の補償量を投与することを含む上記方法。 55.該UGが約75%ないし約100%の間の純度を有している請求項54記載の方法 。 56.該UGが約90%ないし約100%の間の純度を有している請求項54記載の方法 。 57.該UGが少なくとも95%の純度を有している請求項54記載の方法。 58.該UGが組換え体(rhUG)であり、天然ヒトウテログロビンと実質的に同じ 配列を有する請求項54記載の方法。 59.該補償量のUGが20ng/kgないし500mg/kgである請求項54記載の方法。 60.該UGが肺表面活性物質と共同して投与される請求項54記載の方法。 61.肺表面活性物質が約20重量%ないし約80重量%の量で存在する請求項60記載 の方法。 62.該UGが気管内、眼内、静脈内、全身、腹腔内、筋肉内、または経口経路に より投与される請求項54記載の方法。 63.該UGが気管内管経由で液体または半エーロゾルとして投与される請求項54 記載の方法。 64.該方法が、内因性UGの欠損により特徴づけられる炎症性または線維症性状 態の治療に対するものであって、該状態が新生児気管支異形成症、血液透析合併 症、ブレオマイシン肺慢性閉塞性肺疾患、および遺伝性腎糸球体症からなる群か ら選択されたものである請求項54記載の方法。 65.UGが、ステロイド、非ステロイド性抗炎症剤、化学療法剤、鎮痛剤、抗体 、抗寄生虫剤、抗ウイルス剤、抗生物質、抗真菌剤、ワクチン、ガンワクチン、 免疫抑制剤、造血性増殖因子、抗血栓症薬、心血管薬、一ないしそれ以上のビタ ミンおよびミネラル補助剤、ならびに排卵誘発剤からなる群から選択された活性 剤と組み合せて投与する請求項26記載の方法。 66.UGが、ステロイド、非ステロイド性抗炎症剤、化学療法剤、鎮痛剤、抗体 、抗寄生虫剤、抗ウイルス剤、抗生物質、抗真菌剤、ワクチン、ガンワクチン、 免疫抑制剤、増殖因子、抗血栓症薬、心血管薬、一ないしそれ以上のビタミンお よびミネラル補助剤、ならびに排卵誘発剤からなる群から選択された活性剤と組 み合せて投与される請求項44記載の方法。 67.UGが、ステロイド、非ステロイド性抗炎症剤、化学療法剤、鎮痛剤、抗体 、抗寄生虫剤、抗ウイルス剤、抗生物質、抗真菌剤、ワクチン、ガンワクチン、 免疫抑制剤、増殖因子、抗血栓症薬、心血管薬、一ないしそれ以上のビタミンお よびミネラル補助剤、ならびに排卵誘発剤からなる群から選択された活性剤と組 み合せて投与される請求項54記載の方法。 68.天然または組換えヒトウテログロビン(UG)、またはその断片、またはそ の誘導体のPLA2阻害有効量、および医薬として許容される担体または稀釈剤を含 む化粧料組成物。 69.肺表面活性物質を更に含む請求項68記載の化粧料組成物。 70.該UGが約75%ないし約100%の純度を有している請求項68記載の化粧料組 成物。 71.該UGが約90%ないし約100%の純度を有している請求項68記載の化粧料組 成物。 72.該UGが少なくとも95%の純度を有している請求項68記載の化粧料組成物 。 73.天然または組換えヒトウテログロビン(UG)、またはその断片、またはそ の誘導体のフィブロネクチン結合有効量、および許容される担体または稀釈剤を 含む化粧料組成物。 74.肺表面活性物質を更に含む請求項73記載の化粧料組成物。 75.該UGが約75%ないし約100%の純度を有している請求項73記載の化粧料組 成物。 76.該UGが約90%ないし約100%の純度を有している請求項73記載の化粧料組 成物。 77.該UGが少なくとも95%の純度を有している請求項73記載の化粧料組成物 。 78.天然または組換えヒトウテログロビン(UG)、またはその断片、またはそ の誘導体のPLA2阻害有効量、および医薬として許容される担体または稀釈剤を含 む血液補助剤。 79.肺表面活性物質を更に含む請求項78記載の血液補助剤。 80.該UGが約75%ないし約100%の純度を有している請求項78記載の血液補助 剤。 81.該UGが約90%ないし約100%の純度を有している請求項78記載の血液補助 剤。 82.該UGが少なくとも95%の純度を有している請求項78記載の血液補助剤。 83.天然または組換えヒトウテログロビン(UG)、またはその断片、またはそ の誘導体のフィブロネクチン結合有効量、および医薬として許容される担体また は稀釈剤を含む血液補助剤。 84.肺表面活性物質を更に含む請求項83記載の血液補助剤。 85.該UGが約75%ないし約100%の純度を有している請求項83記載の血液補助 剤。 86.該UGが約90%ないし約100%の純度を有している請求項83記載の血液補助 剤。 87.該UGが少なくとも95%の純度を有している請求項83記載の血液補助剤。 88.臨床試料中のウテログロビン−フィブロネクチン複合体を定量するための 測定法であって、1またはそれ以上のウテログロビン−フィブロネクチン複合体 が存在すると推定される臨床試料を (a)抗原捕捉試薬と接触させ、 (b)該試料に抗原検出試薬を加え、そして (c)該捕捉試薬に結合した複合体のいずれの存在をも、化学的部分(chemica l moiety)と反応する化合物の添加により検出し得る部分(moiety)に結合した 第2抗体を用いて検出する上記測定法。 89.該抗原捕捉試薬が、不溶性支持体に固定化された単一特異性ウサギポリク ローナル抗体である請求項88記載の測定法。 90.第2抗体が酵素に結合した抗IgG抗体であり、化学的部分に反応する化合物 が、酵素と反応して色素性または蛍光性化合物に変換される、酵素に対する基質 である請求項88記載の測定法。 91.酵素が西洋ワサビペルオキシダーゼである請求項90記載の測定法。 92.抗原検出試薬がフィブロネクチンに対して特異的な抗体である請求項88 記載の測定法。 93.患者の原線維形成の治療または予防方法であって、そのような処置を必要 とする患者において、患者に、天然または組換えUG、またはその断片、またはそ の誘導体の、フィブロネクチン結合有効量を投与するステップを含む方法。 94.該UGが約75%ないし約100%の間の純度を有している請求項93記載の方法 。 95.該UGが約90%ないし約100%の間の純度を有している請求項93記載の方法 。 96.該UGが少なくとも95%の純度を有している請求項93記載の方法。 97.該UGが組換え体(rhUG)であり、天然ヒトウテログロビンと実質的に同じ 配列を有する請求項93記載の方法。 98.UGの該フィブロネクチン結合有効量が20ng/kgないし500mg/kgである請 求項97記載の方法。 99.該UGが肺表面活性物質と共同して投与される請求項97記載の方法。 100.肺表面活性物質が約20重量%ないし約80重量%の量で存在する請求項99記 載の方法。 101.該UGが気管内、眼内、静脈内、腹腔内、筋肉内、液体または経口経路に より投与される請求項93記載の方法。 102.該UGが気管内管経由で液体または半エーロゾルとして投与される請求項9 3記載の方法。 103.該線維症状態が肺線維症である請求項93記載の方法。 104.該線維症状態が腎線維症である請求項93記載の方法。 105.該線維症状態が血管線維症である請求項93記載の方法。 106.該ウイルス感染がCMV網膜炎である請求項38記載の方法。 107.該細菌感染が肺炎または膀胱炎である請求項38記載の方法。 108.該寄生虫感染が住血吸虫症である請求項38記載の方法。 109.該真菌感染が膣カンジダ症である請求項38記載の方法。
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US08/864,357 US6255281B1 (en) | 1997-05-28 | 1997-05-28 | Use of recombinant human uteroglobin in treatment of inflammatory and fibrotic conditions |
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PCT/US1998/011026 WO1998053846A1 (en) | 1997-05-28 | 1998-05-28 | Use of recombinant human uteroglobin in treatment of inflammatory and fibrotic conditions |
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JP (1) | JP4334023B2 (ja) |
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US20060025348A1 (en) * | 1997-05-28 | 2006-02-02 | Pilon Aprile L | Methods and compositions for the treatment of fibrotic conditions & impaired lung function & to enhance lymphocyte production |
US20040047857A1 (en) * | 1997-05-28 | 2004-03-11 | Pilon Aprile L. | Methods and compositions for the treatment of fibrotic conditions & impaired lung function & to enhance lymphocyte production |
US20060281681A1 (en) * | 1997-05-28 | 2006-12-14 | Pilon Aprile L | Methods and compositions for the reduction of neutrophil influx and for the treatment of bronchpulmonary dysplasia, respiratory distress syndrome, chronic lung disease, pulmonary fibrosis, asthma and chronic obstructive pulmonary disease |
US6255281B1 (en) * | 1997-05-28 | 2001-07-03 | Claragen, Inc. And U.S. Government | Use of recombinant human uteroglobin in treatment of inflammatory and fibrotic conditions |
ATE375167T1 (de) * | 1999-04-21 | 2007-10-15 | Us Gov Health & Human Serv | Uteroglobin zur behandlung von iga vermittelten autoimmunerkrankungen |
CN1297942A (zh) * | 1999-11-30 | 2001-06-06 | 上海博容基因开发有限公司 | 一种新的多肽——人子宫珠蛋白13和编码这种多肽的多核苷酸 |
CN1323824A (zh) * | 2000-05-16 | 2001-11-28 | 上海博德基因开发有限公司 | 一种新的多肽——人子宫珠蛋白9和编码这种多肽的多核苷酸 |
CN1323809A (zh) * | 2000-05-16 | 2001-11-28 | 上海博德基因开发有限公司 | 一种新的多肽——人子宫珠蛋白12和编码这种多肽的多核苷酸 |
EP1664304A1 (en) | 2003-09-22 | 2006-06-07 | BioSpecific GmbH & Co.KG. | Method for neutralizing effects of secreted pla2 iia |
US8133859B2 (en) | 2006-09-27 | 2012-03-13 | The United States Of America As Represented By The Department Of Health And Human Services | SCGB3A2 as a growth factor and anti-apoptotic agent |
KR20110014199A (ko) | 2008-05-13 | 2011-02-10 | 클라라산스, 인크. | 비강 비염 치료용 재조합 인간 cc10 및 이의 조성물 |
US9168285B2 (en) | 2009-10-15 | 2015-10-27 | Therabron Therapeutics, Inc. | Recombinant human CC10 protein for treatment of influenza and ebola |
KR101597391B1 (ko) | 2009-10-15 | 2016-02-24 | 클라라산스, 인크. | 인플루엔자 치료용 재조합 사람 cc10 단백질 |
US9546200B2 (en) | 2011-06-09 | 2017-01-17 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Peptide for protection of allergic respiratory disorders |
CN103333257A (zh) * | 2013-07-09 | 2013-10-02 | 许颖 | 对大剂量辐射具有高效防护效果的融合蛋白及其制备方法 |
CN103816534A (zh) * | 2014-03-25 | 2014-05-28 | 王斌 | 一种防治胃肠溃疡的纤连蛋白口服剂 |
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SE461616B (sv) * | 1987-05-08 | 1990-03-05 | Biocarb Ab | Foerfarande och testsats vid diagnos av iga nefropati med bestaemning av fibronektin-iga-komplex |
US5266562A (en) * | 1987-11-19 | 1993-11-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Anti-inflammatory agents |
BE1006919A3 (nl) | 1993-03-15 | 1995-01-24 | Ley Marc Jozef Philemon De | Farmaceutisch preparaat op basis van clara celeiwit cc10, en het gebruik daarvan als geneesmiddel en diagnosticum. |
US5470885A (en) * | 1993-09-29 | 1995-11-28 | The Research Foundation Of The State University Of New York | Fluorocarbons as anti-inflammatory agents |
US5935860A (en) * | 1995-03-07 | 1999-08-10 | The George Washington University | Use of uteroglobin expression as a molecular marker for prostatic intraepithelial neoplasia |
US5696092A (en) | 1995-03-07 | 1997-12-09 | George Washington University | Methods and compositions for inhibiting metastasis of epithelial cell-derived cancers |
US6255281B1 (en) * | 1997-05-28 | 2001-07-03 | Claragen, Inc. And U.S. Government | Use of recombinant human uteroglobin in treatment of inflammatory and fibrotic conditions |
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- 1997-05-28 US US08/864,357 patent/US6255281B1/en not_active Expired - Lifetime
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CA2291740A1 (en) | 1998-12-03 |
KR20010013056A (ko) | 2001-02-26 |
CN1250280C (zh) | 2006-04-12 |
DE69838509D1 (de) | 2007-11-15 |
CA2291740C (en) | 2011-07-19 |
US20080064633A1 (en) | 2008-03-13 |
JP4334023B2 (ja) | 2009-09-16 |
EP1023081B1 (en) | 2007-10-03 |
US6255281B1 (en) | 2001-07-03 |
EP1023081A4 (en) | 2001-05-16 |
WO1998053846A9 (en) | 2000-03-30 |
NZ501090A (en) | 2005-04-29 |
AU7707498A (en) | 1998-12-30 |
WO1998053846A1 (en) | 1998-12-03 |
CN1281367A (zh) | 2001-01-24 |
ATE374618T1 (de) | 2007-10-15 |
ES2296335T3 (es) | 2008-04-16 |
IL133178A0 (en) | 2001-03-19 |
KR20060132030A (ko) | 2006-12-20 |
EP1023081A1 (en) | 2000-08-02 |
US20020173460A1 (en) | 2002-11-21 |
DE69838509T2 (de) | 2008-07-03 |
CN1846718A (zh) | 2006-10-18 |
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