|
GB9801392D0
(en)
*
|
1998-01-22 |
1998-03-18 |
Smithkline Beecham Plc |
Novel compounds
|
|
GB9803411D0
(en)
*
|
1998-02-18 |
1998-04-15 |
Smithkline Beecham Plc |
Novel compounds
|
|
US6194410B1
(en)
*
|
1998-03-11 |
2001-02-27 |
Hoffman-La Roche Inc. |
Pyrazolopyrimidine and pyrazolines and process for preparation thereof
|
|
AU5235699A
(en)
*
|
1998-07-31 |
2000-02-21 |
Eli Lilly And Company |
Sulfonamide derivatives
|
|
GB9818914D0
(en)
*
|
1998-08-28 |
1998-10-21 |
Smithkline Beecham Plc |
Use
|
|
SE0001899D0
(sv)
|
2000-05-22 |
2000-05-22 |
Pharmacia & Upjohn Ab |
New compounds
|
|
PE20020063A1
(es)
|
2000-06-20 |
2002-01-30 |
Upjohn Co |
Bis-arilsulfonas como ligandos del receptor de 5-ht
|
|
US6586592B2
(en)
|
2000-06-20 |
2003-07-01 |
Pharmacia & Upjohn Company |
Bis-arylsulfones
|
|
US6399617B1
(en)
*
|
2000-07-21 |
2002-06-04 |
Biovitrum Ab |
Use
|
|
SE0002739D0
(sv)
*
|
2000-07-21 |
2000-07-21 |
Pharmacia & Upjohn Ab |
New use
|
|
GB0021450D0
(en)
*
|
2000-08-31 |
2000-10-18 |
Smithkline Beecham Plc |
Novel compounds
|
|
US7034029B2
(en)
|
2000-11-02 |
2006-04-25 |
Wyeth |
1-aryl- or 1-alkylsulfonyl-heterocyclylbenzazoles as 5-hydroxytryptamine-6 ligands
|
|
EP1341783A1
(en)
|
2000-11-21 |
2003-09-10 |
Smithkline Beecham Plc |
Isoquinoline derivatives useful in the treatment of cns disorders
|
|
US7718650B2
(en)
|
2001-05-11 |
2010-05-18 |
Biovitrum Ab |
Aryl sulfonamide compounds for treating obesity
|
|
WO2002092585A1
(en)
|
2001-05-11 |
2002-11-21 |
Biovitrum Ab |
Novel, arylsusfonamide compounds for the treatment of obesity, type ii diabetes and cns-disorders
|
|
IL158590A0
(en)
|
2001-06-11 |
2004-05-12 |
Biovitrum Ab |
Substituted sulfonamide compounds, process for their use as medicament for the treatment of cns disorders, obesity and type ii diabetes
|
|
HRP20040090A2
(en)
*
|
2001-08-10 |
2004-12-31 |
Hoffmann La Roche |
Arylsulfonyl derivatives with 5-ht<sub>6</sub> receptor affinity
|
|
WO2003044000A1
(en)
*
|
2001-11-22 |
2003-05-30 |
Biovitrum Ab |
Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
|
|
RS44204A
(sr)
|
2001-11-22 |
2007-06-04 |
Biovitrum Ab., |
Inhibitori 11-beta- hidroksistereoidne dehidrogenaze tipa 1
|
|
AU2007205749B2
(en)
*
|
2001-11-22 |
2009-04-23 |
Biovitrum Ab |
Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
|
|
RS44304A
(sr)
|
2001-11-22 |
2007-06-04 |
Biovitrum Ab., |
Inhibitori 11-beta- hidroksistereoidne dehidrogenaze tipa 1
|
|
AU2002353718B2
(en)
*
|
2001-11-22 |
2007-05-10 |
Biovitrum Ab |
Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
|
|
US20050085461A1
(en)
*
|
2002-02-13 |
2005-04-21 |
Cooper David G. |
Benzenesulfonamide derivatives
|
|
KR20040081201A
(ko)
*
|
2002-02-13 |
2004-09-20 |
글락소 그룹 리미티드 |
항정신병제로서 벤젠술폰아미드 유도체
|
|
WO2003068751A1
(en)
*
|
2002-02-13 |
2003-08-21 |
Glaxo Group Limited |
7-arylsulfonamido-2,3,4,5-tetrahydro-1h-benzo'diazepine derivatives with 5-ht6 receptor affinity for the reatment of cns disorders
|
|
GB0204720D0
(en)
*
|
2002-02-28 |
2002-04-17 |
Glaxo Group Ltd |
Novel use
|
|
BRPI0308696B8
(pt)
*
|
2002-03-27 |
2021-05-25 |
Axovant Sciences Gmbh |
composto derivado de quinolina, seu processo de preparação, sua composição farmacêutica e seus usos
|
|
HRP20041030B1
(hr)
|
2002-05-13 |
2013-03-31 |
F. Hoffmann - La Roche Ag |
Derivati benzoksazina kao regulatori 5-ht6 i njihova upotreba
|
|
EP2399903A1
(en)
|
2002-05-24 |
2011-12-28 |
Millennium Pharmaceuticals, Inc. |
Ccr9 inhibitors and methods of use thereof
|
|
EP1897881A3
(en)
|
2002-06-20 |
2009-03-18 |
Biovitrum AB (publ) |
Compounds useful for the treatment of obesity, type II diabetes and CNS disorders
|
|
JP4754821B2
(ja)
|
2002-06-20 |
2011-08-24 |
プロキシマゲン・リミテッド |
肥満症、ii型糖尿病およびcns障害の治療に有用な新規化合物
|
|
PL376479A1
(en)
*
|
2002-10-18 |
2005-12-27 |
F.Hoffmann-La Roche Ag |
4-piperazinyl benzenesulfonyl indoles with 5-ht6 receptor affinity
|
|
US6939885B2
(en)
*
|
2002-11-18 |
2005-09-06 |
Chemocentryx |
Aryl sulfonamides
|
|
US7227035B2
(en)
*
|
2002-11-18 |
2007-06-05 |
Chemocentryx |
Bis-aryl sulfonamides
|
|
US7420055B2
(en)
*
|
2002-11-18 |
2008-09-02 |
Chemocentryx, Inc. |
Aryl sulfonamides
|
|
US20070021466A1
(en)
*
|
2002-11-18 |
2007-01-25 |
Solomon Ungashe |
CCR2 inhibitors and methods of use thereof
|
|
US7741519B2
(en)
|
2007-04-23 |
2010-06-22 |
Chemocentryx, Inc. |
Bis-aryl sulfonamides
|
|
PL378754A1
(pl)
*
|
2003-03-03 |
2006-05-15 |
F.Hoffmann-La Roche Ag |
2,5- i 2,6-Podstawione tetrahydroizochinoliny do stosowania jako modulatory 5-HT6
|
|
TWI289141B
(en)
|
2003-03-11 |
2007-11-01 |
Hoffmann La Roche F. Ag. |
Quinolinone derivatives and uses thereof
|
|
GB0305575D0
(en)
|
2003-03-11 |
2003-04-16 |
Glaxo Group Ltd |
Novel compounds
|
|
PT1558582E
(pt)
|
2003-07-22 |
2006-05-31 |
Arena Pharm Inc |
Derivados de diaril- e aril-heteroaril-ureia como moduladores do receptor de serotonina 5-ht2a uteis para a profilaxia e tratamento de desordens relacionadas com o mesmo
|
|
SE0303480D0
(sv)
|
2003-12-19 |
2003-12-19 |
Biovitrum Ab |
Benzofuranes
|
|
US7262318B2
(en)
*
|
2004-03-10 |
2007-08-28 |
Pfizer, Inc. |
Substituted heteroaryl- and phenylsulfamoyl compounds
|
|
US20050201965A1
(en)
*
|
2004-03-11 |
2005-09-15 |
The Procter & Gamble Company |
Personal cleansing compositions
|
|
EP1748989A2
(en)
*
|
2004-05-12 |
2007-02-07 |
ChemoCentryx Inc |
Aryl sulfonamides
|
|
US20050288340A1
(en)
*
|
2004-06-29 |
2005-12-29 |
Pfizer Inc |
Substituted heteroaryl- and phenylsulfamoyl compounds
|
|
CN102114244A
(zh)
|
2004-09-30 |
2011-07-06 |
弗·哈夫曼-拉罗切有限公司 |
治疗认知障碍的组合物和方法
|
|
EP1695971A1
(en)
*
|
2004-12-30 |
2006-08-30 |
Laboratorios Del Dr. Esteve, S.A. |
Substituted phenyl-piperazine compounds, their preparation and use in medicaments
|
|
AR054363A1
(es)
*
|
2005-05-23 |
2007-06-20 |
Astrazeneca Ab |
Compuestos que exhiben actividad moduladora en el receptor 5-hidroxi-triptamina 6
|
|
AR054044A1
(es)
*
|
2005-05-23 |
2007-05-30 |
Astrazeneca Ab |
Derivados de cromano y tetrahidronaftaleno como moduladores del receptor 5 - ht6; intermediarios en su preparacion; composiciones farmaceuticas que los contienen y su empelo en la fabricacion de medicamentos para el tratamiento de enfermedades del snc y de la obesidad.
|
|
EA013875B1
(ru)
|
2005-08-12 |
2010-08-30 |
Сувен Лайф Сайенсиз Лимитед |
Аминоарильные сульфонамидные производные как функциональные 5-нтлиганды
|
|
WO2007020654A1
(en)
|
2005-08-16 |
2007-02-22 |
Suven Life Sciences |
An improved process for the preparation of losartan
|
|
NZ593074A
(en)
*
|
2005-12-21 |
2012-04-27 |
Vertex Pharma |
sulfonamide-pyrrolidone derivatives as Modulators of Ion Channels
|
|
WO2007133580A2
(en)
*
|
2006-05-09 |
2007-11-22 |
Zelos Therapeutics, Inc. |
Use of pth (1-31) and optionally g-csf for hematopoietic stimulation
|
|
AU2007343063B2
(en)
|
2007-01-08 |
2011-02-17 |
Suven Life Sciences Limited |
5-(Heterocyclyl)alkyl-N-(arylsulfonyl)indole compounds and their use as 5-HT6 ligands
|
|
JP2010521516A
(ja)
*
|
2007-03-21 |
2010-06-24 |
グラクソ グループ リミテッド |
疼痛および過敏性腸症候群の治療におけるキノリン誘導体の使用
|
|
CL2008000986A1
(es)
|
2007-04-06 |
2008-10-17 |
Neurocrine Biosciences Inc |
COMPUESTO DERIVADO DE HETEROCICLOS DE NITROGENO, AGONISTAS DEL RECEPTOR GnRH; COMPOSICION FARMACEUTICA QUE COMPRENDE A DICHO COMPUESTO; Y USO PARA TRATAR UNA AFECCION RELACIONADA CON LAS HORMONAS SEXUALES, ENDOMETRIOSIS, DISMENORREA, ENFERMEDAD DE OV
|
|
PE20090044A1
(es)
|
2007-04-06 |
2009-01-23 |
Neurocrine Biosciences Inc |
Antagonistas del receptor de la hormona liberadora de gonadotropina y procedimientos relacionados con los mismos
|
|
BRPI0809873A2
(pt)
|
2007-05-03 |
2018-11-13 |
Suven Life Sciences Ltd |
"composto, processo para a preparação do composto, método para o tratamento de uma desordem do sistema nervoso central, composição farmacêutica, uso do composto, método para testar antagonistas e antagonistas com seletividade para o receptor 5-th6 e método de tratamento"
|
|
US7776877B2
(en)
|
2007-06-22 |
2010-08-17 |
Chemocentryx, Inc. |
N-(2-(hetaryl)aryl) arylsulfonamides and N-(2-(hetaryl) hetaryl arylsulfonamides
|
|
CN101835748B
(zh)
|
2007-10-26 |
2012-11-14 |
苏文生命科学有限公司 |
氨基芳基磺胺化合物及其作为5-ht6配体的用途
|
|
EP2508177A1
(en)
|
2007-12-12 |
2012-10-10 |
Glaxo Group Limited |
Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline
|
|
EP2103596A1
(en)
|
2008-03-18 |
2009-09-23 |
Laboratorios Del. Dr. Esteve, S.A. |
Process for the preparation of N-(phenylethyl) anilines salts and solvates thereof useful as serotonin 5-HT6 antagonists
|
|
WO2009123714A2
(en)
|
2008-04-02 |
2009-10-08 |
Arena Pharmaceuticals, Inc. |
Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor
|
|
WO2009128058A1
(en)
|
2008-04-18 |
2009-10-22 |
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN et al |
Psycho-pharmaceuticals
|
|
DE102008022221A1
(de)
|
2008-05-06 |
2009-11-12 |
Universität des Saarlandes |
Inhibitoren der humanen Aldosteronsynthase CYP11B2
|
|
EP2346847B1
(en)
*
|
2008-09-17 |
2013-05-15 |
Suven Life Sciences Limited |
Aryl sulfonamide amine compounds and their use as 5-ht6 ligands
|
|
WO2010032257A1
(en)
|
2008-09-17 |
2010-03-25 |
Suven Life Sciences Limited |
Aryl indolyl sulfonamide compounds and their use as 5-ht6 ligands
|
|
WO2010062321A1
(en)
|
2008-10-28 |
2010-06-03 |
Arena Pharmaceuticals, Inc. |
Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea and crystalline forms related thereto
|
|
UA100192C2
(en)
*
|
2008-11-11 |
2012-11-26 |
УАЙТ ЭлЭлСи |
1-(arylsulfonyl)-4-(piperazin-1-yl)-1h-benzimidazoles as 5-hydroxytryptamine-6 ligands
|
|
MX2011011520A
(es)
*
|
2009-04-30 |
2012-06-19 |
Abbott Gmbh & Co Kg |
Compuestos de n-fenil-(piperazinil u homopiperazinil)-bencensulfon amida o bencensulfonil-fenil-(piperazina u homopiperazina) adecuados para tratar trastornos que responden a la modulacion del receptor de serotonina 5-ht6.
|
|
US8343959B2
(en)
|
2009-04-30 |
2013-01-01 |
Abbott Gmbh & Co. Kg |
N-phenyl-(piperazinyl or homopiperazinyl)-benzenesulfonamide or benzenesulfonyl-phenyl-(piperazine or homopiperazine) compounds suitable for treating disorders that respond to modulation of the serotonin 5-HT6 receptor
|
|
CN102459199A
(zh)
|
2009-04-30 |
2012-05-16 |
雅培股份有限两合公司 |
适于治疗响应于5-羟色胺5-ht6受体调节的病症的苯磺酰苯胺化合物
|
|
MX2011011519A
(es)
|
2009-04-30 |
2012-01-30 |
Abbott Gmbh & Co Kg |
Compuestos de bencensulfonanilida adecuados para tratar trastornos que responden a la modulacion del receptor de serotonina 5-ht6.
|
|
WO2011011514A1
(en)
*
|
2009-07-21 |
2011-01-27 |
The Board Of Trustees Of The Leland Stanford Junior University |
Heteroaryl benzamides, compositions and methods of use
|
|
US8541404B2
(en)
|
2009-11-09 |
2013-09-24 |
Elexopharm Gmbh |
Inhibitors of the human aldosterone synthase CYP11B2
|
|
CA2786072C
(en)
|
2010-01-05 |
2014-10-28 |
Suven Life Sciences Limited |
Sulfone compounds as 5-ht6 receptor ligands
|
|
GB201002563D0
(en)
|
2010-02-15 |
2010-03-31 |
Cambridge Entpr Ltd |
Compounds
|
|
WO2012059432A1
(en)
*
|
2010-11-01 |
2012-05-10 |
Abbott Gmbh & Co. Kg |
N-phenyl-(homo)piperazinyl-benzenesulfonyl or benzenesulfonamide compounds suitable for treating disorders that respond to the modulation of the 5-ht6 receptor
|
|
WO2012059431A1
(en)
|
2010-11-01 |
2012-05-10 |
Abbott Gmbh & Co. Kg |
Benzenesulfonyl or sulfonamide compounds suitable for treating disorders that respond to the modulation of the serotonin 5-ht6 receptor
|
|
WO2013055793A1
(en)
|
2011-10-12 |
2013-04-18 |
University Of Pittsburg-Of The Commonwealth System Of Higher Education |
Small molecules targeting androgen receptor nuclear localization and/or level in prostate cancer
|
|
CA2871534A1
(en)
*
|
2012-04-27 |
2013-10-31 |
Glaxo Group Limited |
Novel compounds
|
|
US20160257657A1
(en)
|
2013-09-20 |
2016-09-08 |
University Of Pittsburgh - Of The Commonwealth System Of Higher Education |
Small molecule inhibitors of the nuclear translocation of androgen receptor for the treatment of castration-resistant prostate cancer
|
|
CA2924527C
(en)
|
2013-09-20 |
2022-07-12 |
University Of Pittsburgh - Of The Commonwealth System Of Higher Education |
Compounds for treating prostate cancer
|
|
CN104557664B
(zh)
*
|
2013-10-19 |
2020-01-21 |
广东东阳光药业有限公司 |
芳杂环类衍生物及其在药物上的应用
|
|
MX2016005348A
(es)
*
|
2013-10-25 |
2016-08-11 |
Glaxosmithkline Llc |
Compuestos novedosos.
|
|
WO2015090233A1
(en)
|
2013-12-20 |
2015-06-25 |
Sunshine Lake Pharma Co., Ltd. |
Aromatic heterocyclic compounds and their application in pharmaceuticals
|
|
WO2015158313A1
(en)
*
|
2014-04-19 |
2015-10-22 |
Sunshine Lake Pharma Co., Ltd. |
Sulfonamide derivatives and pharmaceutical applications thereof
|
|
CN105367474A
(zh)
*
|
2014-08-12 |
2016-03-02 |
广东东阳光药业有限公司 |
吲哚啉类衍生物及其在药物上的应用
|
|
CN104496987B
(zh)
*
|
2014-12-12 |
2016-03-02 |
广东东阳光药业有限公司 |
取代杂环类化合物及其在药物上的应用
|
|
CN104529866A
(zh)
*
|
2014-12-12 |
2015-04-22 |
广东东阳光药业有限公司 |
吲哚类衍生物及其在药物上的应用
|
|
WO2016201373A1
(en)
|
2015-06-12 |
2016-12-15 |
Axovant Sciences Ltd. |
Diaryl and arylheteroaryl urea derivatives useful for the prophylaxis and treatment of rem sleep behavior disorder
|
|
WO2017011767A2
(en)
|
2015-07-15 |
2017-01-19 |
Axovant Sciences Ltd. |
Diaryl and arylheteroaryl urea derivatives as modulators of the 5-ht2a serotonin receptor useful for the prophylaxis and treatment of hallucinations associated with a neurodegenerative disease
|
|
US10865185B2
(en)
|
2015-08-21 |
2020-12-15 |
Srx Cardio, Llc |
Composition and methods of use of tetrahydroisoquinoline small molecules to bind and modulate PCSK9 protein activity
|
|
HK1257102A1
(zh)
|
2015-08-21 |
2019-10-11 |
Portola Pharmaceuticals, Inc. |
苯基哌嗪前蛋白转化酶枯草杆菌蛋白酶/kexin9型(pcsk9)调节剂及其应用
|
|
US10821106B2
(en)
|
2015-08-21 |
2020-11-03 |
Srx Cardio, Llc |
Composition and methods of use of novel phenylalanine small organic compounds to directly modulate PCSK9 protein activity
|
|
US20190119236A1
(en)
|
2016-02-23 |
2019-04-25 |
Portola Pharmaceuticals, Inc. |
Compounds for binding proprotein convertase subtilisin/kexin type 9 (pcsk9)
|
|
US10980806B2
(en)
|
2016-03-24 |
2021-04-20 |
University of Pittsburgh—of the Commonwealth System of Higher Education |
Small molecule inhibitors of the nuclear translocation of androgen receptor for the treatment of castration-resistant prostate cancer
|
|
CN111517963A
(zh)
*
|
2020-06-02 |
2020-08-11 |
杭州福莱蒽特科技有限公司 |
环保型2,6-二氯-4-硝基苯胺的制备方法
|
|
US12115154B2
(en)
|
2020-12-16 |
2024-10-15 |
Srx Cardio, Llc |
Compounds for the modulation of proprotein convertase subtilisin/kexin type 9 (PCSK9)
|