JP2002510667A5 - - Google Patents
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- Publication number
- JP2002510667A5 JP2002510667A5 JP2000542285A JP2000542285A JP2002510667A5 JP 2002510667 A5 JP2002510667 A5 JP 2002510667A5 JP 2000542285 A JP2000542285 A JP 2000542285A JP 2000542285 A JP2000542285 A JP 2000542285A JP 2002510667 A5 JP2002510667 A5 JP 2002510667A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- propyl
- aryl
- substituent
- embedded image
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 retinoid compound Chemical class 0.000 description 17
- 125000003118 aryl group Chemical group 0.000 description 15
- 125000001424 substituent group Chemical group 0.000 description 10
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 6
- 125000003710 aryl alkyl group Chemical group 0.000 description 5
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- 230000001613 neoplastic effect Effects 0.000 description 5
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 4
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 4
- 230000001747 exhibiting effect Effects 0.000 description 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 3
- 125000003545 alkoxy group Chemical group 0.000 description 2
- 125000002102 aryl alkyloxo group Chemical group 0.000 description 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 2
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 2
- PPGNMFUMZSAZCW-FRCHHHHOSA-N (2e,4e,6e,8e)-8-(3,4-dihydro-2h-naphthalen-1-ylidene)-3,7-dimethylocta-2,4,6-trienoic acid Chemical compound C1=CC=C2C(=C/C(/C)=C/C=C/C(/C)=C/C(O)=O)/CCCC2=C1 PPGNMFUMZSAZCW-FRCHHHHOSA-N 0.000 description 1
- AKJHMTWEGVYYSE-AIRMAKDCSA-N 4-HPR Chemical compound C=1C=C(O)C=CC=1NC(=O)/C=C(\C)/C=C/C=C(C)C=CC1=C(C)CCCC1(C)C AKJHMTWEGVYYSE-AIRMAKDCSA-N 0.000 description 1
- 206010005003 Bladder cancer Diseases 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- 0 CC(C=C1c2ccccc2CCC1)=CC(*c(cc1)ccc1C(O)=O)=O Chemical compound CC(C=C1c2ccccc2CCC1)=CC(*c(cc1)ccc1C(O)=O)=O 0.000 description 1
- 206010009944 Colon cancer Diseases 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 208000000453 Skin Neoplasms Diseases 0.000 description 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 1
- 125000004104 aryloxy group Chemical group 0.000 description 1
- 208000029742 colonic neoplasm Diseases 0.000 description 1
- 125000000753 cycloalkyl group Chemical group 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 201000000849 skin cancer Diseases 0.000 description 1
- 201000005112 urinary bladder cancer Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8086898P | 1998-04-06 | 1998-04-06 | |
| US60/080,868 | 1998-04-06 | ||
| PCT/US1999/007555 WO1999051562A1 (en) | 1998-04-06 | 1999-04-06 | Novel retinoids and use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002510667A JP2002510667A (ja) | 2002-04-09 |
| JP2002510667A5 true JP2002510667A5 (enExample) | 2006-06-08 |
| JP4435418B2 JP4435418B2 (ja) | 2010-03-17 |
Family
ID=22160161
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000542285A Expired - Lifetime JP4435418B2 (ja) | 1998-04-06 | 1999-04-06 | 新規レチノイドおよびその使用法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6172112B1 (enExample) |
| EP (1) | EP1091924B1 (enExample) |
| JP (1) | JP4435418B2 (enExample) |
| AT (1) | ATE471309T1 (enExample) |
| AU (1) | AU3474699A (enExample) |
| DE (1) | DE69942505D1 (enExample) |
| ES (1) | ES2347739T3 (enExample) |
| WO (1) | WO1999051562A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003086374A1 (en) * | 2002-04-05 | 2003-10-23 | University Of Utah Research Foundation | Regulation of a novel colon specific retinol dehydrogenase by apc and cdx2 |
| US7563810B2 (en) * | 2002-11-06 | 2009-07-21 | Celgene Corporation | Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases |
| US8034831B2 (en) * | 2002-11-06 | 2011-10-11 | Celgene Corporation | Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies |
| US7504401B2 (en) | 2003-08-29 | 2009-03-17 | Locus Pharmaceuticals, Inc. | Anti-cancer agents and uses thereof |
| EP2292576B1 (en) | 2004-08-24 | 2014-05-07 | The UAB Research Foundation | Retinoids useful in the treatment of cancer and for reducing serum triglycerides |
| WO2007035755A2 (en) * | 2005-09-19 | 2007-03-29 | Duke University | Methods of treating hematological malignancies |
| US8475775B1 (en) * | 2012-08-24 | 2013-07-02 | The Uab Research Foundation | Retinoids and use thereof |
| US10328040B2 (en) | 2014-01-17 | 2019-06-25 | Arizona Board Of Regents On Behalf Of Arizona State University | Therapeutic methods |
| CN103750916B (zh) * | 2014-01-26 | 2016-05-11 | 徐泽宽 | 一种小鼠胃癌模型的建立方法 |
| US9908856B2 (en) | 2014-02-26 | 2018-03-06 | Arizona Board Of Regents On Behalf Of Arizona State University | Therapeutic compounds |
| US10221143B2 (en) | 2015-03-03 | 2019-03-05 | Arizona Board Of Regents On Behalf Of Arizona State University | Substituted anilines for treatment of animal diseases |
| US10112917B2 (en) | 2015-03-03 | 2018-10-30 | Arizona Board Of Regents On Behalf Of Arizona State University | Therapeutic compounds |
| US10238626B2 (en) | 2017-01-23 | 2019-03-26 | Arizona Board Of Regents On Behalf Of Arizona State University | Therapeutic compounds |
| US10231947B2 (en) | 2017-01-23 | 2019-03-19 | Arizona Board Of Regents On Behalf Of Arizona State University | Isochroman compounds and methods of use thereof |
| US10238655B2 (en) | 2017-01-23 | 2019-03-26 | Arizona Board Of Regents On Behalf Of Arizona State University | Dihydroindene and tetrahydronaphthalene compounds |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5094783A (en) | 1990-06-29 | 1992-03-10 | Uab Research Foundation | Retinoid compounds |
-
1999
- 1999-04-06 JP JP2000542285A patent/JP4435418B2/ja not_active Expired - Lifetime
- 1999-04-06 EP EP99916424A patent/EP1091924B1/en not_active Expired - Lifetime
- 1999-04-06 ES ES99916424T patent/ES2347739T3/es not_active Expired - Lifetime
- 1999-04-06 DE DE69942505T patent/DE69942505D1/de not_active Expired - Lifetime
- 1999-04-06 AU AU34746/99A patent/AU3474699A/en not_active Abandoned
- 1999-04-06 US US09/287,705 patent/US6172112B1/en not_active Expired - Lifetime
- 1999-04-06 WO PCT/US1999/007555 patent/WO1999051562A1/en not_active Ceased
- 1999-04-06 AT AT99916424T patent/ATE471309T1/de not_active IP Right Cessation